Polycomb CBX7 has a unifying role in cellular lifespan
10.1038/ncb1077
Crossref journal-article
Springer Science and Business Media LLC
Nature Cell Biology (297)
Bibliography

Gil, J., Bernard, D., Martínez, D., & Beach, D. (2003). Polycomb CBX7 has a unifying role in cellular lifespan. Nature Cell Biology, 6(1), 67–72.

Authors 4
  1. Jesús Gil (first)
  2. David Bernard (additional)
  3. Dolores Martínez (additional)
  4. David Beach (additional)
References 30 Referenced 279
  1. Hayflick, L. The limited in vitro lifespan of human diploid cell strains. Exp. Cell Res. 37, 614–621 (1965). (10.1016/0014-4827(65)90211-9) / Exp. Cell Res. by L Hayflick (1965)
  2. Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, S27–S31 (2001). (10.1016/S0962-8924(01)02151-1) / Trends Cell Biol. by J Campisi (2001)
  3. Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57–70 (2000). (10.1016/S0092-8674(00)81683-9) / Cell by D Hanahan (2000)
  4. Kiyono, T. et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396, 84–88 (1998). (10.1038/23962) / Nature by T Kiyono (1998)
  5. Jacobs, J.J. et al. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nature Genet. 26, 291–299 (2000). (10.1038/81583) / Nature Genet. by JJ Jacobs (2000)
  6. Jacobs, J.J.L., Kieboom, K., Marino, S., DePinho, R.A. & van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164–168 (1999). (10.1038/16476) / Nature by JJL Jacobs (1999)
  7. Hannon, G.J. et al. MaRX: an approach to genetics in mammalian cells. Science 283, 1129–1130 (1999). (10.1126/science.283.5405.1129) / Science by GJ Hannon (1999)
  8. Maestro, R. et al. Twist is a potential oncogene that inhibits apoptosis. Genes Dev. 13, 2207–2217 (1999). (10.1101/gad.13.17.2207) / Genes Dev. by R Maestro (1999)
  9. Kamijo, T.F. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649–659 (1997). (10.1016/S0092-8674(00)80452-3) / Cell by TF Kamijo (1997)
  10. Paro, R. & Hogness, D.S. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl Acad. Sci. USA 88, 263–267 (1991). (10.1073/pnas.88.1.263) / Proc. Natl Acad. Sci. USA by R Paro (1991)
  11. Min, J., Zhang, Y. & Xu, R.-M. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 17, 1823–1828 (2003). (10.1101/gad.269603) / Genes Dev. by J Min (2003)
  12. Jones, D.O., Cowell, I.G. & Singh, P.B. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays 22, 124–137 (2000). (10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E) / Bioessays by DO Jones (2000)
  13. Satijn, D.P. & Otte, A.P. Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim. Biophys. Acta 1447, 1–16 (1999). (10.1016/S0167-4781(99)00130-X) / Biochim. Biophys. Acta by DP Satijn (1999)
  14. Satijn, D.P. et al. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Mol Cell Biol. 17, 4105–4113 (1997). (10.1128/MCB.17.7.4105) / Mol Cell Biol. by DP Satijn (1997)
  15. Saurin, A.J. et al. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J. Cell Biol. 142, 887–898 (1998). (10.1083/jcb.142.4.887) / J. Cell Biol. by AJ Saurin (1998)
  16. Jacobs, J.J. & van Lohuizen, M. Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim. Biophys. Acta 1602, 151–161 (2002). / Biochim. Biophys. Acta by JJ Jacobs (2002)
  17. Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. & Lowe, S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997). (10.1016/S0092-8674(00)81902-9) / Cell by M Serrano (1997)
  18. Quelle, D.E., Zindy, F., Ashmun, R.A. & Sherr, C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993–1000 (1995). (10.1016/0092-8674(95)90214-7) / Cell by DE Quelle (1995)
  19. Zhang, Y., Xiong, Y. & Yarbrough, W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725–734 (1998). (10.1016/S0092-8674(00)81401-4) / Cell by Y Zhang (1998)
  20. Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27–37 (1996). (10.1016/S0092-8674(00)81079-X) / Cell by M Serrano (1996)
  21. Sharpless, N.E. & DePinho, R.A. The INK4A/ARF locus and its two gene products. Curr. Opin. Genet. Dev. 9, 22–30 (1999). (10.1016/S0959-437X(99)80004-5) / Curr. Opin. Genet. Dev. by NE Sharpless (1999)
  22. Alkema, M.J., Jacobs, H., van Lohuizen, M. & Berns, A. Perturbation of B and T cell development and predisposition to lymphomagenesis in E-Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene 15, 899–910 (1997). (10.1038/sj.onc.1201262) / Oncogene by MJ Alkema (1997)
  23. Sewalt, R.G. et al. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol. Cell Biol. 18, 3586–3595 (1998). (10.1128/MCB.18.6.3586) / Mol. Cell Biol. by RG Sewalt (1998)
  24. Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624–629 (2002). (10.1038/nature01075) / Nature by S Varambally (2002)
  25. Gunster, M.J. et al. Differential expression of human Polycomb group proteins in various tissues and cell types. J. Cell Biochem. 81, 129–143 (2001). (10.1002/jcb.1093) / J. Cell Biochem. by MJ Gunster (2001)
  26. Itahana, K. et al. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell Biol. 23, 389–401 (2003). (10.1128/MCB.23.1.389-401.2003) / Mol. Cell Biol. by K Itahana (2003)
  27. Dimri, G.P. et al. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 62, 4736–4745 (2002). / Cancer Res. by GP Dimri (2002)
  28. Satijn, D.P. et al. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol. Cell Biol. 17, 6076–6086 (1997). (10.1128/MCB.17.10.6076) / Mol. Cell Biol. by DP Satijn (1997)
  29. Carnero, A., Hudson, J.D., Hannon, G.J. & Beach, D.H. Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. Nucleic Acids Res. 28, 2234–2241 (2000). (10.1093/nar/28.11.2234) / Nucleic Acids Res. by A Carnero (2000)
  30. Brummelkamp, T.R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002). (10.1126/science.1068999) / Science by TR Brummelkamp (2002)
Dates
Type When
Created 21 years, 8 months ago (Nov. 30, 2003, 8:12 a.m.)
Deposited 3 years ago (Aug. 8, 2022, 2:10 a.m.)
Indexed 4 weeks ago (Aug. 2, 2025, 12:29 a.m.)
Issued 21 years, 9 months ago (Nov. 30, 2003)
Published 21 years, 9 months ago (Nov. 30, 2003)
Published Online 21 years, 9 months ago (Nov. 30, 2003)
Published Print 21 years, 7 months ago (Jan. 1, 2004)
Funders 0

None

@article{Gil_2003, title={Polycomb CBX7 has a unifying role in cellular lifespan}, volume={6}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb1077}, DOI={10.1038/ncb1077}, number={1}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Gil, Jesús and Bernard, David and Martínez, Dolores and Beach, David}, year={2003}, month=nov, pages={67–72} }