DOI: 10.1038/ncb1072. A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility

A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility

10.1038/ncb1072

Crossref journal-article

Springer Science and Business Media LLC

Nature Cell Biology (297)

Bibliography

Wang, D., King, S. M., Quill, T. A., Doolittle, L. K., & Garbers, D. L. (2003). A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility. Nature Cell Biology, 5(12), 1117â1122.

Authors 5

Dan Wang (first)
Shelby M. King (additional)
Timothy A. Quill (additional)
Lynda K. Doolittle (additional)
David L. Garbers (additional)

References 25 Referenced 237

Garbers, D.L., Watkins, H.D., Hansbrough, J.R., Smith, A. & Misono, K.S. The amino acid sequence and chemical synthesis of speract and of speract analogues. J. Biol. Chem. 257, 2734–2737 (1982). (10.1016/S0021-9258(19)81020-7) / J. Biol. Chem. by DL Garbers (1982)
Babcock, D.F., Rufo, G.A., Jr & Lardy, H.A. Potassium-dependent increases in cytosolic pH stimulate metabolism and motility of mammalian sperm. Proc. Natl Acad. Sci. USA 80, 1327–1331 (1983). (10.1073/pnas.80.5.1327) / Proc. Natl Acad. Sci. USA by DF Babcock (1983)
Carr, D.W. & Acott, T.S. Intracellular pH regulates bovine sperm motility and protein phosphorylation. Biol. Reprod. 41, 907–920 (1989). (10.1095/biolreprod41.5.907) / Biol. Reprod. by DW Carr (1989)
Garcia, M.A. & Meizel, S. Regulation of intracellular pH in capacitated human spermatozoa by a Na+/H+ exchanger. Mol. Reprod. Develop. 52, 189–195 (1999). (10.1002/(SICI)1098-2795(199902)52:2<189::AID-MRD10>3.0.CO;2-D) / Mol. Reprod. Develop. by MA Garcia (1999)
Schackmann, R.W. & Chock, P.B. Alteration of intracellular [Ca2+] in sea urchin sperm by the egg peptide speract. Evidence that increased intracellular Ca2+ is coupled to Na+ entry and increased intracellular pH. J. Biol. Chem. 261, 8719–7828 (1986). (10.1016/S0021-9258(19)84440-X) / J. Biol. Chem. by RW Schackmann (1986)
Woo, A.L., James, P.F. & Lingrel, J.B. Roles of the Na,K-ATPase α4 isoform and the Na+/H+ exchanger in sperm motility. Mol. Reprod. Develop. 62, 348–356 (2002). (10.1002/mrd.90002) / Mol. Reprod. Develop. by AL Woo (2002)
Bell, S.M. et al. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am. J. Physiol. 276, C788–C795 (1999). (10.1152/ajpcell.1999.276.4.C788) / Am. J. Physiol. by SM Bell (1999)
Hansbrough, J.R. & Garbers, D.L. Speract. Purification and characterization of a peptide associated with eggs that activates spermatozoa. J. Biol. Chem. 256, 1447–1452 (1981). (10.1016/S0021-9258(19)69983-7) / J. Biol. Chem. by JR Hansbrough (1981)
Moy, G.W. & Vacquier, V.D. Immunoperoxidase localization of bindin during the adhesion of sperm to sea urchin eggs. Curr. Top. Dev. Biol. 13, 31–44 (1979). (10.1016/S0070-2153(08)60688-2) / Curr. Top. Dev. Biol. by GW Moy (1979)
Garbers, D.L. Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands. Cell 71, 1–4 (1992). (10.1016/0092-8674(92)90258-E) / Cell by DL Garbers (1992)
Mengerink, K.J., Moy, G.W. & Vacquier, V.D. suREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosomal region of sea urchin sperm. J. Biol. Chem. 277, 943–948 (2002). (10.1074/jbc.M109673200) / J. Biol. Chem. by KJ Mengerink (2002)
Klein, R.D., Gu, Q., Goddard, A. & Rosenthal, A. Selection for genes encoding secreted proteins and receptors. Proc. Natl Acad. Sci. USA 93, 7108–7113 (1996). (10.1073/pnas.93.14.7108) / Proc. Natl Acad. Sci. USA by RD Klein (1996)
Jacobs, K.A. et al. A genetic selection for isolating cDNAs encoding secreted proteins. Gene 198, 289–296 (1997). (10.1016/S0378-1119(97)00330-2) / Gene by KA Jacobs (1997)
Quill, T.A., Ren, D., Clapham, D.E. & Garbers, D.L. A voltage-gated ion channel expressed specifically in spermatozoa. Proc. Natl Acad. Sci. USA 98, 12527–12531 (2001). (10.1073/pnas.221454998) / Proc. Natl Acad. Sci. USA by TA Quill (2001)
Counillon, L. & Pouyssegur, J. The expanding family of eucaryotic Na(+)/H(+) exchangers. J. Biol. Chem. 275, 1–4 (2000). (10.1074/jbc.275.1.1) / J. Biol. Chem. by L Counillon (2000)
Numata, M. & Orlowski, J. Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. J. Biol. Chem. 276, 17387–17394 (2001). (10.1074/jbc.M101319200) / J. Biol. Chem. by M Numata (2001)
Goyal, S., Vanden Heuvel, G. & Aronson, P.S. Renal expression of novel Na+/H+ exchanger isoform NHE8. Am. J. Physiol. Renal Physiol. 284, F467–F473 (2003). (10.1152/ajprenal.00352.2002) / Am. J. Physiol. Renal Physiol. by S Goyal (2003)
Lee, H.C. The voltage-sensitive Na+/H+ exchange in sea urchin spermatozoa flagellar membrane vesicles studied with an entrapped pH probe. J. Biol. Chem. 260, 10794–10799 (1985). (10.1016/S0021-9258(19)85152-9) / J. Biol. Chem. by HC Lee (1985)
Ren, D. et al. A sperm ion channel required for sperm motility and male fertility. Nature 413, 603–609 (2001). (10.1038/35098027) / Nature by D Ren (2001)
Watanabe, D. et al. Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development. J. Biol. Chem. 269, 7744–7749 (1994). (10.1016/S0021-9258(17)37349-0) / J. Biol. Chem. by D Watanabe (1994)
Ikawa, M. et al. The putative chaperone calmegin is required for sperm fertility. Nature 387, 607–611 (1997). (10.1038/42484) / Nature by M Ikawa (1997)
Roos, A. & Boron, W.F. Intracellular pH. Physiol. Rev. 61, 296–434 (1981). (10.1152/physrev.1981.61.2.296) / Physiol. Rev. by A Roos (1981)
Howlett, S.K. & Bolton, V.N. Sequence and regulation of morphological and molecular events during the first cell cycle of mouse embryogenesis. J. Embryol. Experiment Morphol. 87, 175–206 (1985). / J. Embryol. Experiment Morphol. by SK Howlett (1985)
Fraser, L.R. In vitro capacitation and fertilization. Methods Enzymol. 225, 239–253 (1993). (10.1016/0076-6879(93)25016-U) / Methods Enzymol. by LR Fraser (1993)
Si, Y. & Olds-Clarke, P. Evidence for the involvement of calmodulin in mouse sperm capacitation. Biol. Reprod. 62, 1231–1239 (2000). (10.1095/biolreprod62.5.1231) / Biol. Reprod. by Y Si (2000)

Dates

Type	When
Created	21 years, 9 months ago (Nov. 23, 2003, 6:22 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 3:22 p.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 12:15 a.m.)
Issued	21 years, 9 months ago (Nov. 23, 2003)
Published	21 years, 9 months ago (Nov. 23, 2003)
Published Online	21 years, 9 months ago (Nov. 23, 2003)
Published Print	21 years, 8 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Wang_2003, title={A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility}, volume={5}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb1072}, DOI={10.1038/ncb1072}, number={12}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Wang, Dan and King, Shelby M. and Quill, Timothy A. and Doolittle, Lynda K. and Garbers, David L.}, year={2003}, month=nov, pages={1117–1122} }

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      "URL": "https://www.nature.com/articles/ncb1072"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        11,
        23
      ]
    ]
  },
  "references-count": 25,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          2003,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "BFncb1072"
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  "URL": "http://dx.doi.org/10.1038/ncb1072",
  "relation": {},
  "ISSN": [
    "1465-7392",
    "1476-4679"
  ],
  "subject": [],
  "container-title-short": "Nat Cell Biol",
  "published": {
    "date-parts": [
      [
        2003,
        11,
        23
      ]
    ]
  }
}