Crossref journal-article
Springer Science and Business Media LLC
Nature Biotechnology (297)
Bibliography

Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., & Boone, C. (2003). Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nature Biotechnology, 22(1), 62–69.

Authors 10
  1. Ainslie B Parsons (first)
  2. Renée L Brost (additional)
  3. Huiming Ding (additional)
  4. Zhijian Li (additional)
  5. Chaoying Zhang (additional)
  6. Bilal Sheikh (additional)
  7. Grant W Brown (additional)
  8. Patricia M Kane (additional)
  9. Timothy R Hughes (additional)
  10. Charles Boone (additional)
References 42 Referenced 536
  1. Winzeler, E.A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901–906 (1999). (10.1126/science.285.5429.901) / Science by EA Winzeler (1999)
  2. Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109–926 (2000). (10.1016/S0092-8674(00)00015-5) / Cell by TR Hughes (2000)
  3. Marton, M.J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 4, 1293–1301 (1998). (10.1038/3282) / Nat. Med. by MJ Marton (1998)
  4. Hartwell, L.H., Szankasi, P., Roberts, C.J., Murray, A.W. & Friend, S.H. Integrating genetic approaches into the discovery of anticancer drugs. Science 278, 1064–1068 (1997). (10.1126/science.278.5340.1064) / Science by LH Hartwell (1997)
  5. Tong, A.H. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364–2368 (2001). (10.1126/science.1065810) / Science by AH Tong (2001)
  6. Thomas, J.H., Neff, N.F. & Botstein, D. Isolation and characterization of mutations in the β-tubulin gene of Saccharomyces cerevisiae. Genetics 111, 715–734 (1985). (10.1093/genetics/111.4.715) / Genetics by JH Thomas (1985)
  7. Liu, J. et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807–815 (1991). (10.1016/0092-8674(91)90124-H) / Cell by J Liu (1991)
  8. Rittberg, D.A. & Wright, J.A. Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIO) and ribonucleotide reductase RNR2 mRNA levels in strains of Saccharomyces cerevisiae. Biochem. Cell. Biol. 67, 352–357 (1989). (10.1139/o89-055) / Biochem. Cell. Biol. by DA Rittberg (1989)
  9. Hsiang, Y.H., Lihou, M.G. & Liu, L.F. Arrest of replication forks by drug-stabilized topoisomerase I–DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49, 5077–5082 (1989). / Cancer Res. by YH Hsiang (1989)
  10. Turi, T.G. & Loper, J.C. Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14 α-demethylase (ERG11). J. Biol. Chem. 267, 2046–2056 (1992). (10.1016/S0021-9258(18)46051-6) / J. Biol. Chem. by TG Turi (1992)
  11. Truan, G., Epinat, J.C., Rougeulle, C., Cullin, C. & Pompon, D. Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142, 123–127 (1994). (10.1016/0378-1119(94)90366-2) / Gene by G Truan (1994)
  12. Zheng, X.F., Florentino, D., Chen, J., Crabtree, G.R. & Schreiber, S.L. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82, 121–130 (1995). (10.1016/0092-8674(95)90058-6) / Cell by XF Zheng (1995)
  13. Kuo, S.C. & Lampen, J.O. Tunicamycin—an inhibitor of yeast glycoprotein synthesis. Biochem. Biophys. Res. Commun. 58, 287–295 (1974). (10.1016/0006-291X(74)90925-5) / Biochem. Biophys. Res. Commun. by SC Kuo (1974)
  14. Cutler, N.S., Heitman, J. & Cardenas, M.E. STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. J. Biol. Chem. 272, 27671–27677 (1997). (10.1074/jbc.272.44.27671) / J. Biol. Chem. by NS Cutler (1997)
  15. Falco, S.C. & Dumas, K.S. Genetic analysis of mutants of Saccharomyces cerevisiae resistant to the herbicide sulfometuron methyl. Genetics 109, 21–35 (1985). (10.1093/genetics/109.1.21) / Genetics by SC Falco (1985)
  16. Parsons, W.J., Ramkumar, V. & Stiles, G.L. Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. Mol. Pharmacol. 34, 37–41 (1988). / Mol. Pharmacol. by WJ Parsons (1988)
  17. Garrett-Engele, P., Moilanen, B. & Cyert, M.S. Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H+-ATPase. Mol. Cell. Biol. 15, 4103–4114 (1995). (10.1128/MCB.15.8.4103) / Mol. Cell. Biol. by P Garrett-Engele (1995)
  18. Bauer, B.E., Wolfger, H. & Kuchler, K. Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim. Biophys. Acta 1461, 217–236 (1999). (10.1016/S0005-2736(99)00160-1) / Biochim. Biophys. Acta by BE Bauer (1999)
  19. Mukhopadhyay, K., Kohli, A. & Prasad, R. Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob. Agents Chemother. 46, 3695–3705 (2002). (10.1128/AAC.46.12.3695-3705.2002) / Antimicrob. Agents Chemother. by K Mukhopadhyay (2002)
  20. Yoshida, S. & Anraku, Y. Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity. Mol. Gen. Genet. 263, 877–888 (2000). (10.1007/s004380000255) / Mol. Gen. Genet. by S Yoshida (2000)
  21. Simon, S., Roy, D. & Schindler, M. Intracellular pH and the control of multidrug resistance. Proc. Natl. Acad. Sci. USA 91, 1128–1132 (1994). (10.1073/pnas.91.3.1128) / Proc. Natl. Acad. Sci. USA by S Simon (1994)
  22. Ma, L. & Center, M.S. The gene encoding vacuolar H+-ATPase subunit C is overexpressed in multidrug-resistant HL60 cells. Biochem. Biophys. Res. Commun. 182, 675–681 (1992). (10.1016/0006-291X(92)91785-O) / Biochem. Biophys. Res. Commun. by L Ma (1992)
  23. Drose, S. et al. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosine triphosphatases. Biochemistry 32, 3902–3906 (1993). (10.1021/bi00066a008) / Biochemistry by S Drose (1993)
  24. Ouar, Z. et al. Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells. Biochem. J. 370, 185–193 (2003). (10.1042/bj20021411) / Biochem. J. by Z Ouar (2003)
  25. Dohmen, R.J., Wu, P. & Varshavsky, A. Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science 263, 1273–1276 (1994). (10.1126/science.8122109) / Science by RJ Dohmen (1994)
  26. Cyert, M.S. Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae. Annu. Rev. Genet. 35, 647–672 (2001). (10.1146/annurev.genet.35.102401.091302) / Annu. Rev. Genet. by MS Cyert (2001)
  27. Cyert, M.S. & Thorner, J. Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol. Cell. Biol. 12, 3460–3469 (1992). (10.1128/MCB.12.8.3460) / Mol. Cell. Biol. by MS Cyert (1992)
  28. Tanida, I., Hasegawa, A., Iida, H., Ohya, Y. & Anraku, Y. Cooperation of calcineurin and vacuolar H+-ATPase in intracellular Ca2+ homeostasis of yeast cells. J. Biol. Chem. 270, 10113–10119 (1995). (10.1074/jbc.270.17.10113) / J. Biol. Chem. by I Tanida (1995)
  29. Aasland, R., Stewart, A.F. & Gibson, T. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem. Sci. 21, 87–88 (1996). / Trends Biochem. Sci. by R Aasland (1996)
  30. Boyer, L.A. et al. Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol. Cell. 10, 935–942 (2002). (10.1016/S1097-2765(02)00634-2) / Mol. Cell. by LA Boyer (2002)
  31. Bellaoui, M. et al. Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J. 22, 4304–13 (2003). (10.1093/emboj/cdg406) / EMBO J. by M Bellaoui (2003)
  32. Ben-Aroya, S., Koren, A., Liefshitz, B., Steinlauf, R. & Kupiec, M. ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C. Proc. Natl. Acad. Sci. USA 100, 9906–9911 (2003). (10.1073/pnas.1633757100) / Proc. Natl. Acad. Sci. USA by S Ben-Aroya (2003)
  33. Ersfeld, K. et al. Characterization of the tubulin-tyrosine ligase. J. Cell. Biol. 120, 725–732 (1993). (10.1083/jcb.120.3.725) / J. Cell. Biol. by K Ersfeld (1993)
  34. Shoemaker, D.D., Lashkari, D.A., Morris, D., Mittmann, M. & Davis, R.W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat. Genet. 14, 450–456 (1996). (10.1038/ng1296-450) / Nat. Genet. by DD Shoemaker (1996)
  35. Giaever, G. et al. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 21, 278–283 (1999). (10.1038/6791) / Nat. Genet. by G Giaever (1999)
  36. Barstead, R. Genome-wide RNAi. Curr. Opin. Chem. Biol. 5, 63–66 (2001). (10.1016/S1367-5931(00)00173-3) / Curr. Opin. Chem. Biol. by R Barstead (2001)
  37. Shi, Y. Mammalian RNAi for the masses. Trends Genet. 19, 9–12 (2003). (10.1016/S0168-9525(02)00005-7) / Trends Genet. by Y Shi (2003)
  38. Brachmann, C.B. et al. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115–132 (1998). (10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2) / Yeast by CB Brachmann (1998)
  39. Breitkreutz, B.J., Stark, C. & Tyers, M. Osprey: a network visualization system. Genome Biol. 4, R22 (2003). (10.1186/gb-2003-4-3-r22) / Genome Biol. by BJ Breitkreutz (2003)
  40. Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25–29 (2000). (10.1038/75556) / Nat. Genet. by M Ashburner (2000)
  41. Mewes, H.W., Albermann, K., Heumann, K., Liebl, S. & Pfeiffer, F. MIPS: a database for protein sequences, homology data and yeast genome information. Nucleic Acids Res. 25, 28–30 (1997). (10.1093/nar/25.1.28) / Nucleic Acids Res. by HW Mewes (1997)
  42. Breitkreutz, B.J., Stark, C. & Tyers, M. The GRID: the General Repository for Interaction Datasets. Genome Biol. 4, R23 (2003). (10.1186/gb-2003-4-3-r23) / Genome Biol. by BJ Breitkreutz (2003)
Dates
Type When
Created 21 years, 8 months ago (Dec. 7, 2003, 1:13 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 3:57 p.m.)
Indexed 1 month, 3 weeks ago (July 4, 2025, 8:06 a.m.)
Issued 21 years, 8 months ago (Dec. 7, 2003)
Published 21 years, 8 months ago (Dec. 7, 2003)
Published Online 21 years, 8 months ago (Dec. 7, 2003)
Published Print 21 years, 7 months ago (Jan. 1, 2004)
Funders 0

None

@article{Parsons_2003, title={Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways}, volume={22}, ISSN={1546-1696}, url={http://dx.doi.org/10.1038/nbt919}, DOI={10.1038/nbt919}, number={1}, journal={Nature Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Parsons, Ainslie B and Brost, Renée L and Ding, Huiming and Li, Zhijian and Zhang, Chaoying and Sheikh, Bilal and Brown, Grant W and Kane, Patricia M and Hughes, Timothy R and Boone, Charles}, year={2003}, month=dec, pages={62–69} }