DOI: 10.1038/nbt1122. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

10.1038/nbt1122

Crossref journal-article

Springer Science and Business Media LLC

Nature Biotechnology (297)

Bibliography

Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K., Jensen, K., Breen, W., Hartsough, K., Machemer, L., Radka, S., Jadhav, V., Vaish, N., Zinnen, S., Vargeese, C., Bowman, K., Shaffer, C. S., Jeffs, L. B., Judge, A., MacLachlan, I., & Polisky, B. (2005). Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnology, 23(8), 1002â1007.

Authors 19

David V Morrissey (first)
Jennifer A Lockridge (additional)
Lucinda Shaw (additional)
Karin Blanchard (additional)
Kristi Jensen (additional)
Wendy Breen (additional)
Kimberly Hartsough (additional)
Lynn Machemer (additional)
Susan Radka (additional)
Vasant Jadhav (additional)
Narendra Vaish (additional)
Shawn Zinnen (additional)
Chandra Vargeese (additional)
Keith Bowman (additional)
Chris S Shaffer (additional)
Lloyd B Jeffs (additional)
Adam Judge (additional)
Ian MacLachlan (additional)
Barry Polisky (additional)

References 19 Referenced 958

Chiu, Y.L. & Rana, T.M. siRNA function in RNAi: a chemical modification analysis. RNA 9, 1034–1048 (2003). (10.1261/rna.5103703) / RNA by YL Chiu (2003)
Layzer, J.M. et al. In vivo activity of nuclease-resistant siRNAs. RNA 10, 766–771 (2004). (10.1261/rna.5239604) / RNA by JM Layzer (2004)
Morrissey, D.V. et al. Activity of stabilized siRNAs in a mouse model of HBV replication. Hepatology 41, 1349–1356 (2005). (10.1002/hep.20702) / Hepatology by DV Morrissey (2005)
Ambegia, E. et al. Stabilized plasmid–lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochim. Biophys. Acta 1669, 155–163 (2005). (10.1016/j.bbamem.2005.02.001) / Biochim. Biophys. Acta by E Ambegia (2005)
Bally, M., Mayer, L., Hope, M. & Nayar, R. Pharmacodynamics of liposomal drug carriers: methodological considerations. in Liposome Technology, vol. III, 27–41, (CRC Press, London, 1993). / Liposome Technology by M Bally (1993)
Fenske, D.B., MacLachlan, I. & Cullis, P. Long circulating vectors for the systemic delivery of genes. Curr. Opin. Mol. Ther. 3, 153–158 (2001). / Curr. Opin. Mol. Ther. by DB Fenske (2001)
Fenske, D.B., MacLachlan, I. & Cullis, P.R. Stabilized plasmid-lipid particles: a systemic gene therapy vector. Methods Enzymol. 346, 36–71 (2002). (10.1016/S0076-6879(02)46048-X) / Methods Enzymol. by DB Fenske (2002)
Judge, A. et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457–462 (2005). (10.1038/nbt1081) / Nat. Biotechnol. by A Judge (2005)
Hornung, V. et al. Sequence-specific potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11, 263–270 (2005). (10.1038/nm1191) / Nat. Med. by V Hornung (2005)
Liu, F., Song, Y. & Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6, 1258–1266 (1999). (10.1038/sj.gt.3300947) / Gene Ther. by F Liu (1999)
Yang, P.L., Althage, A., Chung, J. & Chisari, F.V. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc. Natl. Acad. Sci. USA 99, 13825–13830 (2002). (10.1073/pnas.202398599) / Proc. Natl. Acad. Sci. USA by PL Yang (2002)
Samuel, C.E. Antiviral actions of interferons. Clin. Microbiol. Rev. 14, 778–809 (2001). (10.1128/CMR.14.4.778-809.2001) / Clin. Microbiol. Rev. by CE Samuel (2001)
Kim, D.H. et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 22, 321–325 (2004). (10.1038/nbt940) / Nat. Biotechnol. by DH Kim (2004)
Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173–178 (2004). (10.1038/nature03121) / Nature by J Soutschek (2004)
Wincott, F. et al. Synthesis, deprotection, analysis and purification of RNA and ribozymes. Nucleic Acids Res. 23, 2677–2684 (1995). (10.1093/nar/23.14.2677) / Nucleic Acids Res. by F Wincott (1995)
Wheeler, J.J. et al. Stabilized plasmid-lipid particles: construction and characterization. Gene Ther. 6, 271–281 (1999). (10.1038/sj.gt.3300821) / Gene Ther. by JJ Wheeler (1999)
Jeffs, L. et al. A scalable, extrusion free method for efficient liposomal encapsulation of plasmid DNA. Pharm. Res. 22, 362–372 (2005). (10.1007/s11095-004-1873-z) / Pharm. Res. by L Jeffs (2005)
Sandberg, J.A. et al. Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers. J. Clin. Pharmacol. 40, 1462–1469 (2000). (10.1177/009127000004001217) / J. Clin. Pharmacol. by JA Sandberg (2000)
Buckwold, V.E., Xu, Z., Chen, M., Yen, T.S. & Ou, J.H. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J. Virol. 70, 5845–5851 (1996). (10.1128/JVI.70.9.5845-5851.1996) / J. Virol. by VE Buckwold (1996)

Dates

Type	When
Created	20 years, 1 month ago (July 24, 2005, 1:09 p.m.)
Deposited	1 year, 7 months ago (Jan. 27, 2024, 9:08 p.m.)
Indexed	1 day, 20 hours ago (Aug. 29, 2025, 6:29 a.m.)
Issued	20 years, 1 month ago (July 24, 2005)
Published	20 years, 1 month ago (July 24, 2005)
Published Online	20 years, 1 month ago (July 24, 2005)
Published Print	20 years ago (Aug. 1, 2005)

Funders 0

None

BibTeX

@article{Morrissey_2005, title={Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs}, volume={23}, ISSN={1546-1696}, url={http://dx.doi.org/10.1038/nbt1122}, DOI={10.1038/nbt1122}, number={8}, journal={Nature Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Morrissey, David V and Lockridge, Jennifer A and Shaw, Lucinda and Blanchard, Karin and Jensen, Kristi and Breen, Wendy and Hartsough, Kimberly and Machemer, Lynn and Radka, Susan and Jadhav, Vasant and Vaish, Narendra and Zinnen, Shawn and Vargeese, Chandra and Bowman, Keith and Shaffer, Chris S and Jeffs, Lloyd B and Judge, Adam and MacLachlan, Ian and Polisky, Barry}, year={2005}, month=jul, pages={1002–1007} }

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