DOI: 10.1038/nbt1096. Systematic interpretation of genetic interactions using protein networks

Systematic interpretation of genetic interactions using protein networks

10.1038/nbt1096

Crossref journal-article

Springer Science and Business Media LLC

Nature Biotechnology (297)

Bibliography

Kelley, R., & Ideker, T. (2005). Systematic interpretation of genetic interactions using protein networks. Nature Biotechnology, 23(5), 561â566.

Authors 2

Ryan Kelley (first)
Trey Ideker (additional)

References 37 Referenced 367

Guarente, L. Synthetic enhancement in gene interaction: a genetic tool come of age. Trends Genet. 9, 362–366 (1993). (10.1016/0168-9525(93)90042-G) / Trends Genet. by L Guarente (1993)
Avery, L. & Wasserman, S. Ordering gene function: the interpretation of epistasis in regulatory hierarchies. Trends Genet. 8, 312–316 (1992). (10.1016/0168-9525(92)90263-4) / Trends Genet. by L Avery (1992)
Thomas, J.H. Thinking about genetic redundancy. Trends Genet. 9, 395–399 (1993). (10.1016/0168-9525(93)90140-D) / Trends Genet. by JH Thomas (1993)
Hartman, J.L., Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science 291, 1001–1004 (2001). (10.1126/science.291.5506.1001) / Science by JL Hartman (2001)
Sham, P. Shifting paradigms in gene-mapping methodology for complex traits. Pharmacogenomics 2, 195–202 (2001). (10.1517/14622416.2.3.195) / Pharmacogenomics by P Sham (2001)
Dolma, S., Lessnick, S.L., Hahn, W.C. & Stockwell, B.R. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3, 285–296 (2003). (10.1016/S1535-6108(03)00050-3) / Cancer Cell by S Dolma (2003)
Forsburg, S.L. The art and design of genetic screens: yeast. Nat. Rev. Genet. 2, 659–668 (2001). (10.1038/35088500) / Nat. Rev. Genet. by SL Forsburg (2001)
Tong, A.H. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364–2368 (2001). (10.1126/science.1065810) / Science by AH Tong (2001)
Ooi, S.L., Shoemaker, D.D. & Boeke, J.D. DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat. Genet. 35, 277–286 (2003). (10.1038/ng1258) / Nat. Genet. by SL Ooi (2003)
Tong, A.H. et al. Global mapping of the yeast genetic interaction network. Science 303, 808–813 (2004). (10.1126/science.1091317) / Science by AH Tong (2004)
Li, S. et al. A map of the interactome network of the metazoan C. elegans. Science 303, 540–543 (2004). (10.1126/science.1091403) / Science by S Li (2004)
Rain, J.C. et al. The protein-protein interaction map of Helicobacter pylori. Nature 409, 211–215 (2001). (10.1038/35051615) / Nature by JC Rain (2001)
Uetz, P. et al. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403, 623–627 (2000). (10.1038/35001009) / Nature by P Uetz (2000)
Giot, L. et al. A protein interaction map of Drosophila melanogaster. Science 302, 1727–1736 (2003). (10.1126/science.1090289) / Science by L Giot (2003)
Ito, T. et al. Toward a protein-protein interaction map of the budding yeast: a comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc. Natl. Acad. Sci. USA 97, 1143–1147 (2000). (10.1073/pnas.97.3.1143) / Proc. Natl. Acad. Sci. USA by T Ito (2000)
Ho, Y. et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180–183 (2002). (10.1038/415180a) / Nature by Y Ho (2002)
Gavin, A-C., Bösche, M., Krause, R., Grandi, P. & Marzioch, M. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415, 141–147 (2002). (10.1038/415141a) / Nature by A-C Gavin (2002)
Lee, T.I. et al. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298, 799–804 (2002). (10.1126/science.1075090) / Science by TI Lee (2002)
Harbison, C.T. et al. Transcriptional regulatory code of a eukaryotic genome. Nature 431, 99–104 (2004). (10.1038/nature02800) / Nature by CT Harbison (2004)
Ozier, O., Amin, N. & Ideker, T. Global architecture of genetic interactions on the protein network. Nat. Biotechnol. 21, 490–491 (2003). (10.1038/nbt0503-490) / Nat. Biotechnol. by O Ozier (2003)
Tucker, C.L. & Fields, S. Lethal combinations. Nat. Genet. 35, 204–205 (2003). (10.1038/ng1103-204) / Nat. Genet. by CL Tucker (2003)
Winzeler, E.A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901–906 (1999). (10.1126/science.285.5429.901) / Science by EA Winzeler (1999)
Mewes, H.W. et al. MIPS: a database for genomes and protein sequences. Nucleic Acids Res. 30, 31–34 (2002). (10.1093/nar/30.1.31) / Nucleic Acids Res. by HW Mewes (2002)
Xenarios, I. et al. DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 30, 303–305 (2002). (10.1093/nar/30.1.303) / Nucleic Acids Res. by I Xenarios (2002)
Kanehisa, M., Goto, S., Kawashima, S. & Nakaya, A. The KEGG databases at GenomeNet. Nucleic Acids Res. 30, 42–46 (2002). (10.1093/nar/30.1.42) / Nucleic Acids Res. by M Kanehisa (2002)
Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498–2504 (2003). (10.1101/gr.1239303) / Genome Res. by P Shannon (2003)
Gene Ontology Consortium. Creating the gene ontology resource: design and implementation. Genome Res. 11, 1425–1433 (2001). (10.1101/gr.180801)
Zar, J.H. Biostatistical Analysis, edn. 3 (Prentice Hall, New Jersey, 1996). / Biostatistical Analysis by JH Zar (1996)
Kendall, S.M., Stuart, A. & Ord, J.K. Kendall's Advanced Theory of Statistics, edn. 5 (Oxford University Press, NY, 1987). / Kendall's Advanced Theory of Statistics by SM Kendall (1987)
Milo, R. et al. Network motifs: simple building blocks of complex networks. Science 298, 824–827 (2002). (10.1126/science.298.5594.824) / Science by R Milo (2002)
Geissler, S., Siegers, K. & Schiebel, E. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 17, 952–966 (1998). (10.1093/emboj/17.4.952) / EMBO J. by S Geissler (1998)
Kahana, J.A. et al. The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B. Mol. Biol. Cell 9, 1741–1756 (1998). (10.1091/mbc.9.7.1741) / Mol. Biol. Cell by JA Kahana (1998)
Pidoux, A.L. & Allshire, R.C. Centromeres: getting a grip of chromosomes. Curr. Opin. Cell Biol. 12, 308–319 (2000). (10.1016/S0955-0674(00)00094-6) / Curr. Opin. Cell Biol. by AL Pidoux (2000)
Pfeffer, S.R. Membrane transport: retromer to the rescue. Curr. Biol. 11, R109–R111 (2001). (10.1016/S0960-9822(01)00042-2) / Curr. Biol. by SR Pfeffer (2001)
Siniossoglou, S., Peak-Chew, S.Y. & Pelham, H.R. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. EMBO J. 19, 4885–4894 (2000). (10.1093/emboj/19.18.4885) / EMBO J. by S Siniossoglou (2000)
Hwang, W.W. et al. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol. Cell 11, 261–266 (2003). (10.1016/S1097-2765(02)00826-2) / Mol. Cell by WW Hwang (2003)
Sharan, R., Ideker, T., Kelley, B.P., Shamir, R. & Karp, R.M. Identification of protein complexes by comparative analysis of yeast and bacterial protein interaction data. Proceedings of the Eighth Annual International Conference on Research in Computational Molecular Biology–RECOMB, 282–289 (ACM Press, New York, 2004) / Proceedings of the Eighth Annual International Conference on Research in Computational Molecular Biology–RECOMB by R Sharan (2004)

Dates

Type	When
Created	20 years, 3 months ago (May 5, 2005, 6:09 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 3:36 p.m.)
Indexed	4 days, 1 hour ago (Aug. 19, 2025, 6:20 a.m.)
Issued	20 years, 3 months ago (May 1, 2005)
Published	20 years, 3 months ago (May 1, 2005)
Published Online	20 years, 3 months ago (May 5, 2005)
Published Print	20 years, 3 months ago (May 1, 2005)

Funders 0

None

BibTeX

@article{Kelley_2005, title={Systematic interpretation of genetic interactions using protein networks}, volume={23}, ISSN={1546-1696}, url={http://dx.doi.org/10.1038/nbt1096}, DOI={10.1038/nbt1096}, number={5}, journal={Nature Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Kelley, Ryan and Ideker, Trey}, year={2005}, month=may, pages={561–566} }

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