DOI: 10.1038/nbt0396-303. Molecular Beacons: Probes that Fluoresce upon Hybridization

Molecular Beacons: Probes that Fluoresce upon Hybridization

10.1038/nbt0396-303

Crossref journal-article

Springer Science and Business Media LLC

Nature Biotechnology (297)

Bibliography

Tyagi, S., & Kramer, F. R. (1996). Molecular Beacons: Probes that Fluoresce upon Hybridization. Nature Biotechnology, 14(3), 303â308.

Authors 2

Sanjay Tyagi (first)
Fred Russell Kramer (additional)

References 23 Referenced 3,454

Lomeli, H., Tyagi, S., Pritchard, C.G., Lizardi, P.M. and Kramer, F.R. 1989. Quantitative assays based on the use of replicatable hybridization probes. Clin. Chem. 36: 1826–1831. (10.1093/clinchem/35.9.1826) / Clin. Chem. by H Lomeli (1989)
Heller, M.J., Morrison, L.E., Prevatt, W.D. and Akin, C. 1982. Homogeneous nucleic acid hybridization diagnostics by nonradiative energy transfer. European Patent Application 82303699.1.
Morrison, L.E., Hadler, T.C. and Stols, L.M. 1989. Solution phase detection of polynucleotides using interacting fluorescent labels and competitive hybridization. Anal. Biochem. 183: 231–244. (10.1016/0003-2697(89)90473-9) / Anal. Biochem. by LE Morrison (1989)
Cardullo, R.A., Agrawal, S., Flores, C., Zamecnik, P.C. and Wolf, D.E. 1988. Detection of nucleic acids by nonradiative fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. USA 85: 8790–8794. (10.1073/pnas.85.23.8790) / Proc. Natl. Acad. Sci. USA by RA Cardullo (1988)
Morrison, L.E. and Stols, L.M. 1993. Sensitive fluorescence-based thermody-namic and kinetic measurements of DNA hybridization in solution. Biochemistry 32: 3095–3104. (10.1021/bi00063a022) / Biochemistry by LE Morrison (1993)
Sixou, S., Szoka Jr, F.C., Green, G.A., Giusti, B., Zon, G. and Chin, D.J. 1994. Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET). Nucleic Acids Res. 22: 662–668. (10.1093/nar/22.4.662) / Nucleic Acids Res. by S Sixou (1994)
Stryer, L. 1978. Fluorescence energy transfer as a spectroscopic ruler. Ann. Rev. Biochem. 47: 819–846. (10.1146/annurev.bi.47.070178.004131) / Ann. Rev. Biochem. by L Stryer (1978)
Shore, D., Langowski, J. and Baldwin, R.L. 1981. DNA flexibility studied by covalent closure of short fragments into circles. Proc. Natl. Acad. Sci. USA 78: 4833–4837. (10.1073/pnas.78.8.4833) / Proc. Natl. Acad. Sci. USA by D Shore (1981)
Matayoshi, E.D., Wang, G.T., Krafft, G.A. and Erickson, J. 1990. Novel fluoro-genic substrates for assaying retroviral proteases by resonance energy transfer. Science 247: 954–958. (10.1126/science.2106161) / Science by ED Matayoshi (1990)
Wang, G.T., Matayoshi, E.D., Huffaker, H.J. and Krafft, G.A. 1990. Design and synthesis of new fluorogenic HIV protease substrates based on resonance energy transfer. Tetrahedron Lett 31: 6493–6496. (10.1016/S0040-4039(00)97099-0) / Tetrahedron Lett by GT Wang (1990)
Pörschke, D. and Eigen, M. 1971. Cooperative nonenzymic base recognition. III. Kinetics of the helix-coil transition of the oligoribouridylic-oligoriboadenylic acid system and of oligoriboadenylic acid alone at acid pH. J. Mol. Biol. 62: 361–381. (10.1016/0022-2836(71)90433-5) / J. Mol. Biol. by D Pörschke (1971)
Craig, M.E., Crothers, D.M. and Doty, P. 1971. Relaxation kinetics of dimer formation by self complementary oligonucleotides. J. Mol. Biol. 62: 383–401. (10.1016/0022-2836(71)90434-7) / J. Mol. Biol. by ME Craig (1971)
Coutts, S.M. 1971. Thermodynamics and kinetics of G:C base pairing in the isolated extra arm of serine-specific tRNA from yeast. Biochim. Biophys. Acta 232: 91–106. (10.1016/0005-2787(71)90494-1) / Biochim. Biophys. Acta by SM Coutts (1971)
Higuchi, R., Fockler, C., Dollinger, G. and Watson, R. 1993. Kinetic PCR analysis: Real-time monitoring of DNA amplification reactions. Bio/Technology 11: 1026–1030. / Bio/Technology by R Higuchi (1993)
Cooper, J.P. and Hagerman, J.P. 1990. Analysis of fluorescence energy transfer in duplex and branched DNA molecules. Biochemistry 29: 9261–9268. (10.1021/bi00491a022) / Biochemistry by JP Cooper (1990)
Meldal, M. and Breddam, K. 1991. Anthranilamide and nitrotyrosine as a donor-acceptor pair in internally quenched fluorescent substrates for endopeptidases. Anal. Biochem. 195: 141–147. (10.1016/0003-2697(91)90309-H) / Anal. Biochem. by M Meldal (1991)
Mergny, J.-L., Boutorine, A.S., Garestier, T., Belloc, F., Rougée, M., Bulychev, N.V., Koshkin, A.A., Bourson, J., Lebedev, A.V., Valeur, B., Thuong, N.T. and Hélène, C. 1994. Fluorescence energy transfer as a probe for nucleic acid structures and sequences. Nucleic Acids Res. 22: 920–928. (10.1093/nar/22.6.920) / Nucleic Acids Res. by J-L Mergny (1994)
Selvin, P.R. and Hearst, J.E. 1994. Luminescence energy transfer using terbium chelate: improvements on fluorescence energy transfer. Proc. Natl. Acad. Sci. USA 91: 10024–10028. (10.1073/pnas.91.21.10024) / Proc. Natl. Acad. Sci. USA by PR Selvin (1994)
Holland, P.M., Abramson, R.D., Watson, R. and Gelfand, D.H. 1991. Detection of specific polymerase chain reaction product by utilizing 5′→3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl. Acad. Sci. USA 88: 7276–7280. (10.1073/pnas.88.16.7276) / Proc. Natl. Acad. Sci. USA by PM Holland (1991)
Lee, L.G., Connell, C.R. and Bloch, W. 1993. Allelic discrimination by nick-translation PCR with fluorogenic probes. Nucleic Acids Res. 21: 3761–3766. (10.1093/nar/21.16.3761) / Nucleic Acids Res. by LG Lee (1993)
Livak, K.J., Flood, S.J.A., Marmaro, J., Giusti, W. and Deetz, K. 1995. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Applic. 4: 357–362. (10.1101/gr.4.6.357) / PCR Methods Applic. by KJ Livak (1995)
Connolly, B.A. and Rider, P. 1985. Chemical synthesis of oligonucleotides containing a free sulfhydryl group and subsequent attachment of thiol specific probes. Nucleic Acids Res. 13: 4485–4502. (10.1093/nar/13.12.4485) / Nucleic Acids Res. by BA Connolly (1985)
Tyagi, S., Landegren, U., Tazi, M., Lizardi, P.M. and Kramer, F.R., 1996. Sensitive, background-free gene detection using binary probes and QB replicase. Proc. Natl. Acad. Sci. USA 93: In press. (10.1073/pnas.93.11.5395)

Dates

Type	When
Created	21 years ago (Aug. 18, 2004, 6:49 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 3:36 p.m.)
Indexed	1 day ago (Aug. 23, 2025, 1 a.m.)
Issued	29 years, 5 months ago (March 1, 1996)
Published	29 years, 5 months ago (March 1, 1996)
Published Print	29 years, 5 months ago (March 1, 1996)

Funders 0

None

BibTeX

@article{Tyagi_1996, title={Molecular Beacons: Probes that Fluoresce upon Hybridization}, volume={14}, ISSN={1546-1696}, url={http://dx.doi.org/10.1038/nbt0396-303}, DOI={10.1038/nbt0396-303}, number={3}, journal={Nature Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Tyagi, Sanjay and Kramer, Fred Russell}, year={1996}, month=mar, pages={303–308} }

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