DOI: 10.1038/nature746. TREX is a conserved complex coupling transcription with messenger RNA export

TREX is a conserved complex coupling transcription with messenger RNA export

10.1038/nature746

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

StrÃ¤Ãer, K., Masuda, S., Mason, P., Pfannstiel, J., Oppizzi, M., Rodriguez-Navarro, S., RondÃ³n, A. G., Aguilera, A., Struhl, K., Reed, R., & Hurt, E. (2002). TREX is a conserved complex coupling transcription with messenger RNA export. Nature, 417(6886), 304â308.

Authors 11

Katja Sträßer (first)
Seiji Masuda (additional)
Paul Mason (additional)
Jens Pfannstiel (additional)
Marisa Oppizzi (additional)
Susana Rodriguez-Navarro (additional)
Ana G. Rondón (additional)
Andres Aguilera (additional)
Kevin Struhl (additional)
Robin Reed (additional)
Ed Hurt (additional)

References 25 Referenced 705

Sträßer, K. & Hurt, E. C. Yra1p, a conserved nuclear RNA binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19, 410–420 (2000) (10.1093/emboj/19.3.410) / EMBO J. by K Sträßer (2000)
Stutz, F. et al. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6, 638–650 (2000) (10.1017/S1355838200000078) / RNA by F Stutz (2000)
Zhou, Z. L. et al. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407, 401–405 (2000) (10.1038/35030160) / Nature by ZL Zhou (2000)
Gatfield, D. et al. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr. Biol. 11, 1716–1721 (2001) (10.1016/S0960-9822(01)00532-2) / Curr. Biol. by D Gatfield (2001)
Jensen, T. H., Boulay, J., Rosbash, M. & Libri, D. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr. Biol. 11, 1711–1715 (2001) (10.1016/S0960-9822(01)00529-2) / Curr. Biol. by TH Jensen (2001)
Luo, M.-J. et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413, 644–647 (2001) (10.1038/35098106) / Nature by M-J Luo (2001)
Sträßer, K. & Hurt, E. C. Splicing factor Sub2p is required for nuclear export through its interaction with Yra1p. Nature 413, 648–652 (2001) (10.1038/35098113) / Nature by K Sträßer (2001)
Chávez, S. et al. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19, 5824–5834 (2000) (10.1093/emboj/19.21.5824) / EMBO J. by S Chávez (2000)
Chavez, S. & Aguilera, A. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev. 11, 3459–3470 (1997) (10.1101/gad.11.24.3459) / Genes Dev. by S Chavez (1997)
Piruat, J. I. & Aguilera, A. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J. 17, 4859–4872 (1998) (10.1093/emboj/17.16.4859) / EMBO J. by JI Piruat (1998)
West, R. W., Kruger, B., Thomas, S., Ma, J. & Milgrom, E. RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN4. Gene 243, 195–205 (2000) (10.1016/S0378-1119(99)00510-7) / Gene by RW West (2000)
Rigaut, G. et al. A generic protein purification method for protein complex characterization and proteome exploration. Nature Biotechnol. 17, 1030–1032 (1999) (10.1038/13732) / Nature Biotechnol. by G Rigaut (1999)
Chang, M. et al. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signalling. Mol. Cell. Biol. 19, 1056–1067 (1999) (10.1128/MCB.19.2.1056) / Mol. Cell. Biol. by M Chang (1999)
Fan, H. Y., Merker, R. J. & Klein, H. L. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability. Mol. Cell. Biol. 21, 5459–5470 (2001) (10.1128/MCB.21.16.5459-5470.2001) / Mol. Cell. Biol. by HY Fan (2001)
Kulish, D. & Struhl, K. TFIIS enhances transcriptional elongation through an artificial arrest site in vivo. Mol. Cell. Biol. 21, 4162–4168 (2001) (10.1128/MCB.21.13.4162-4168.2001) / Mol. Cell. Biol. by D Kulish (2001)
Piruat, J. I., Chavez, S. & Aguilera, A. The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11. Genetics 147, 1585–1594 (1997) (10.1093/genetics/147.4.1585) / Genetics by JI Piruat (1997)
Reed, R. & Hurt, E. C. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell 108, 523–531 (2002) (10.1016/S0092-8674(02)00627-X) / Cell by R Reed (2002)
Schneiter, R. et al. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Δ is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. Mol. Cell. Biol. 19, 3415–3422 (1999) (10.1128/MCB.19.5.3415) / Mol. Cell. Biol. by R Schneiter (1999)
Fleckner, J., Zhang, M., Valcarcel, J. & Green, M. R. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP–branchpoint interaction. Genes Dev. 11, 1864–1872 (1997) (10.1101/gad.11.14.1864) / Genes Dev. by J Fleckner (1997)
Kistler, A. L. & Guthrie, C. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase. Genes Dev. 15, 42–49 (2001) (10.1101/gad.851301) / Genes Dev. by AL Kistler (2001)
Libri, D., Graziani, N., Saguez, C. & Boulay, J. Multiple roles for the yeast SUB2/yUAP56 gene in splicing. Genes Dev. 15, 36–41 (2001) (10.1101/gad.852101) / Genes Dev. by D Libri (2001)
Zhang, M. & Green, M. R. Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56. Genes Dev. 15, 30–35 (2001) (10.1101/gad.851701) / Genes Dev. by M Zhang (2001)
Lei, E. P., Krebber, H. & Silver, P. A. Messenger RNAs are recruited for nuclear export during transcription. Genes Dev. 15, 1771–1782 (2001) (10.1101/gad.892401) / Genes Dev. by EP Lei (2001)
Baßler, J. et al. Identification of a 60S pre-ribosomal particle that is closely linked to nuclear export. Mol. Cell 8, 517–529 (2001) (10.1016/S1097-2765(01)00342-2) / Mol. Cell by J Baßler (2001)
Kuras, L. & Struhl, K. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 399, 609–613 (1999) (10.1038/21239) / Nature by L Kuras (1999)

Dates

Type	When
Created	23 years ago (July 26, 2002, 4:56 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2:15 p.m.)
Indexed	3 days, 13 hours ago (Aug. 19, 2025, 6:05 a.m.)
Issued	23 years, 3 months ago (April 28, 2002)
Published	23 years, 3 months ago (April 28, 2002)
Published Online	23 years, 3 months ago (April 28, 2002)
Published Print	23 years, 3 months ago (May 1, 2002)

Funders 0

None

BibTeX

@article{Str_er_2002, title={TREX is a conserved complex coupling transcription with messenger RNA export}, volume={417}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature746}, DOI={10.1038/nature746}, number={6886}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Sträßer, Katja and Masuda, Seiji and Mason, Paul and Pfannstiel, Jens and Oppizzi, Marisa and Rodriguez-Navarro, Susana and Rondón, Ana G. and Aguilera, Andres and Struhl, Kevin and Reed, Robin and Hurt, Ed}, year={2002}, month=apr, pages={304–308} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        19
      ]
    ],
    "date-time": "2025-08-19T10:05:33Z",
    "timestamp": 1755597933158
  },
  "reference-count": 25,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6886",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2002,
            4,
            28
          ]
        ],
        "date-time": "2002-04-28T00:00:00Z",
        "timestamp": 1019952000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        5
      ]
    ]
  },
  "DOI": "10.1038/nature746",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T08:56:51Z",
    "timestamp": 1027673811000
  },
  "page": "304-308",
  "source": "Crossref",
  "is-referenced-by-count": 705,
  "title": "TREX is a conserved complex coupling transcription with messenger RNA export",
  "prefix": "10.1038",
  "volume": "417",
  "author": [
    {
      "given": "Katja",
      "family": "Str\u00e4\u00dfer",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Seiji",
      "family": "Masuda",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Paul",
      "family": "Mason",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jens",
      "family": "Pfannstiel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marisa",
      "family": "Oppizzi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Susana",
      "family": "Rodriguez-Navarro",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ana G.",
      "family": "Rond\u00f3n",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Andres",
      "family": "Aguilera",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kevin",
      "family": "Struhl",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robin",
      "family": "Reed",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ed",
      "family": "Hurt",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2002,
        4,
        28
      ]
    ]
  },
  "reference": [
    {
      "key": "BFnature746_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "410",
      "DOI": "10.1093/emboj/19.3.410",
      "volume": "19",
      "author": "K Str\u00e4\u00dfer",
      "year": "2000",
      "unstructured": "Str\u00e4\u00dfer, K. & Hurt, E. C. Yra1p, a conserved nuclear RNA binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19, 410\u2013420 (2000)",
      "journal-title": "EMBO J."
    },
    {
      "key": "BFnature746_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "638",
      "DOI": "10.1017/S1355838200000078",
      "volume": "6",
      "author": "F Stutz",
      "year": "2000",
      "unstructured": "Stutz, F. et al. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6, 638\u2013650 (2000)",
      "journal-title": "RNA"
    },
    {
      "key": "BFnature746_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "401",
      "DOI": "10.1038/35030160",
      "volume": "407",
      "author": "ZL Zhou",
      "year": "2000",
      "unstructured": "Zhou, Z. L. et al. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407, 401\u2013405 (2000)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature746_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "1716",
      "DOI": "10.1016/S0960-9822(01)00532-2",
      "volume": "11",
      "author": "D Gatfield",
      "year": "2001",
      "unstructured": "Gatfield, D. et al. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr. Biol. 11, 1716\u20131721 (2001)",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "BFnature746_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "1711",
      "DOI": "10.1016/S0960-9822(01)00529-2",
      "volume": "11",
      "author": "TH Jensen",
      "year": "2001",
      "unstructured": "Jensen, T. H., Boulay, J., Rosbash, M. & Libri, D. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr. Biol. 11, 1711\u20131715 (2001)",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "BFnature746_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "644",
      "DOI": "10.1038/35098106",
      "volume": "413",
      "author": "M-J Luo",
      "year": "2001",
      "unstructured": "Luo, M.-J. et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413, 644\u2013647 (2001)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature746_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "648",
      "DOI": "10.1038/35098113",
      "volume": "413",
      "author": "K Str\u00e4\u00dfer",
      "year": "2001",
      "unstructured": "Str\u00e4\u00dfer, K. & Hurt, E. C. Splicing factor Sub2p is required for nuclear export through its interaction with Yra1p. Nature 413, 648\u2013652 (2001)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature746_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "5824",
      "DOI": "10.1093/emboj/19.21.5824",
      "volume": "19",
      "author": "S Ch\u00e1vez",
      "year": "2000",
      "unstructured": "Ch\u00e1vez, S. et al. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19, 5824\u20135834 (2000)",
      "journal-title": "EMBO J."
    },
    {
      "key": "BFnature746_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "3459",
      "DOI": "10.1101/gad.11.24.3459",
      "volume": "11",
      "author": "S Chavez",
      "year": "1997",
      "unstructured": "Chavez, S. & Aguilera, A. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev. 11, 3459\u20133470 (1997)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "4859",
      "DOI": "10.1093/emboj/17.16.4859",
      "volume": "17",
      "author": "JI Piruat",
      "year": "1998",
      "unstructured": "Piruat, J. I. & Aguilera, A. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J. 17, 4859\u20134872 (1998)",
      "journal-title": "EMBO J."
    },
    {
      "key": "BFnature746_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "195",
      "DOI": "10.1016/S0378-1119(99)00510-7",
      "volume": "243",
      "author": "RW West",
      "year": "2000",
      "unstructured": "West, R. W., Kruger, B., Thomas, S., Ma, J. & Milgrom, E. RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN4. Gene 243, 195\u2013205 (2000)",
      "journal-title": "Gene"
    },
    {
      "key": "BFnature746_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "1030",
      "DOI": "10.1038/13732",
      "volume": "17",
      "author": "G Rigaut",
      "year": "1999",
      "unstructured": "Rigaut, G. et al. A generic protein purification method for protein complex characterization and proteome exploration. Nature Biotechnol. 17, 1030\u20131032 (1999)",
      "journal-title": "Nature Biotechnol."
    },
    {
      "key": "BFnature746_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1056",
      "DOI": "10.1128/MCB.19.2.1056",
      "volume": "19",
      "author": "M Chang",
      "year": "1999",
      "unstructured": "Chang, M. et al. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signalling. Mol. Cell. Biol. 19, 1056\u20131067 (1999)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature746_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "5459",
      "DOI": "10.1128/MCB.21.16.5459-5470.2001",
      "volume": "21",
      "author": "HY Fan",
      "year": "2001",
      "unstructured": "Fan, H. Y., Merker, R. J. & Klein, H. L. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability. Mol. Cell. Biol. 21, 5459\u20135470 (2001)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature746_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "4162",
      "DOI": "10.1128/MCB.21.13.4162-4168.2001",
      "volume": "21",
      "author": "D Kulish",
      "year": "2001",
      "unstructured": "Kulish, D. & Struhl, K. TFIIS enhances transcriptional elongation through an artificial arrest site in vivo. Mol. Cell. Biol. 21, 4162\u20134168 (2001)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature746_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "1585",
      "DOI": "10.1093/genetics/147.4.1585",
      "volume": "147",
      "author": "JI Piruat",
      "year": "1997",
      "unstructured": "Piruat, J. I., Chavez, S. & Aguilera, A. The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11. Genetics 147, 1585\u20131594 (1997)",
      "journal-title": "Genetics"
    },
    {
      "key": "BFnature746_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "523",
      "DOI": "10.1016/S0092-8674(02)00627-X",
      "volume": "108",
      "author": "R Reed",
      "year": "2002",
      "unstructured": "Reed, R. & Hurt, E. C. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell 108, 523\u2013531 (2002)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature746_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "3415",
      "DOI": "10.1128/MCB.19.5.3415",
      "volume": "19",
      "author": "R Schneiter",
      "year": "1999",
      "unstructured": "Schneiter, R. et al. The Saccharomyces cerevisiae hyperrecombination mutant hpr1\u0394 is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. Mol. Cell. Biol. 19, 3415\u20133422 (1999)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature746_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "1864",
      "DOI": "10.1101/gad.11.14.1864",
      "volume": "11",
      "author": "J Fleckner",
      "year": "1997",
      "unstructured": "Fleckner, J., Zhang, M., Valcarcel, J. & Green, M. R. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP\u2013branchpoint interaction. Genes Dev. 11, 1864\u20131872 (1997)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "42",
      "DOI": "10.1101/gad.851301",
      "volume": "15",
      "author": "AL Kistler",
      "year": "2001",
      "unstructured": "Kistler, A. L. & Guthrie, C. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase. Genes Dev. 15, 42\u201349 (2001)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "36",
      "DOI": "10.1101/gad.852101",
      "volume": "15",
      "author": "D Libri",
      "year": "2001",
      "unstructured": "Libri, D., Graziani, N., Saguez, C. & Boulay, J. Multiple roles for the yeast SUB2/yUAP56 gene in splicing. Genes Dev. 15, 36\u201341 (2001)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "30",
      "DOI": "10.1101/gad.851701",
      "volume": "15",
      "author": "M Zhang",
      "year": "2001",
      "unstructured": "Zhang, M. & Green, M. R. Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56. Genes Dev. 15, 30\u201335 (2001)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "1771",
      "DOI": "10.1101/gad.892401",
      "volume": "15",
      "author": "EP Lei",
      "year": "2001",
      "unstructured": "Lei, E. P., Krebber, H. & Silver, P. A. Messenger RNAs are recruited for nuclear export during transcription. Genes Dev. 15, 1771\u20131782 (2001)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature746_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "517",
      "DOI": "10.1016/S1097-2765(01)00342-2",
      "volume": "8",
      "author": "J Ba\u00dfler",
      "year": "2001",
      "unstructured": "Ba\u00dfler, J. et al. Identification of a 60S pre-ribosomal particle that is closely linked to nuclear export. Mol. Cell 8, 517\u2013529 (2001)",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "BFnature746_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "609",
      "DOI": "10.1038/21239",
      "volume": "399",
      "author": "L Kuras",
      "year": "1999",
      "unstructured": "Kuras, L. & Struhl, K. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 399, 609\u2013613 (1999)",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/nature746.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature746",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature746.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        18
      ]
    ],
    "date-time": "2023-05-18T18:15:10Z",
    "timestamp": 1684433710000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/nature746"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        4,
        28
      ]
    ]
  },
  "references-count": 25,
  "journal-issue": {
    "issue": "6886",
    "published-print": {
      "date-parts": [
        [
          2002,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "BFnature746"
  ],
  "URL": "http://dx.doi.org/10.1038/nature746",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1006007.74206",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1006007.80505",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        2002,
        4,
        28
      ]
    ]
  }
}