DOI: 10.1038/nature08398. Role of the polycomb protein EED in the propagation of repressive histone marks

Role of the polycomb protein EED in the propagation of repressive histone marks

10.1038/nature08398

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury III, W. J., Voigt, P., Martin, S. R., Taylor, W. R., De Marco, V., Pirrotta, V., Reinberg, D., & Gamblin, S. J. (2009). Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461(7265), 762â767.

Authors 13

Raphael Margueron (first)
Neil Justin (additional)
Katsuhito Ohno (additional)
Miriam L. Sharpe (additional)
Jinsook Son (additional)
William J. Drury III (additional)
Philipp Voigt (additional)
Stephen R. Martin (additional)
William R. Taylor (additional)
Valeria De Marco (additional)
Vincenzo Pirrotta (additional)
Danny Reinberg (additional)
Steven J. Gamblin (additional)

References 40 Referenced 1,037

Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B. & Cavalli, G. Genome regulation by polycomb and trithorax proteins. Cell 128, 735–745 (2007) (10.1016/j.cell.2007.02.009) / Cell by B Schuettengruber (2007)
Czermin, B. et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185–196 (2002) (10.1016/S0092-8674(02)00975-3) / Cell by B Czermin (2002)
Cao, R. et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039–1043 (2002) (10.1126/science.1076997) / Science by R Cao (2002)
Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893–2905 (2002) (10.1101/gad.1035902) / Genes Dev. by A Kuzmichev (2002)
Müller, J. et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197–208 (2002) (10.1016/S0092-8674(02)00976-5) / Cell by J Müller (2002)
Nekrasov, M. et al. Pcl-PRC2 is needed to generate high levels of H3–K27 trimethylation at Polycomb target genes. EMBO J. 26, 4078–4088 (2007) (10.1038/sj.emboj.7601837) / EMBO J. by M Nekrasov (2007)
Sarma, K., Margueron, R., Ivanov, A., Pirrotta, V. & Reinberg, D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo . Mol. Cell. Biol. 28, 2718–2731 (2008) (10.1128/MCB.02017-07) / Mol. Cell. Biol. by K Sarma (2008)
Han, Z. et al. Structural basis of EZH2 recognition by EED. Structure 15, 1306–1315 (2007) (10.1016/j.str.2007.08.007) / Structure by Z Han (2007)
Schiefner, A. et al. Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli . J. Biol. Chem. 279, 5588–5596 (2004) (10.1074/jbc.M309771200) / J. Biol. Chem. by A Schiefner (2004)
Kouzarides, T. Chromatin modifications and their function. Cell 128, 693–705 (2007) (10.1016/j.cell.2007.02.005) / Cell by T Kouzarides (2007)
Nekrasov, M., Wild, B. & Muller, J. Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep. 6, 348–353 (2005) (10.1038/sj.embor.7400376) / EMBO Rep. by M Nekrasov (2005)
Simon, M. D. et al. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 128, 1003–1012 (2007) (10.1016/j.cell.2006.12.041) / Cell by MD Simon (2007)
Tie, F., Stratton, C. A., Kurzhals, R. L. & Harte, P. J. The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27. Mol. Cell. Biol. 27, 2014–2026 (2007) (10.1128/MCB.01822-06) / Mol. Cell. Biol. by F Tie (2007)
Struhl, G. & Brower, D. Early role of the esc+ gene product in the determination of segments in Drosophila . Cell 31, 285–292 (1982) (10.1016/0092-8674(82)90428-7) / Cell by G Struhl (1982)
Ohno, K., McCabe, D., Czermin, B., Imhof, A. & Pirrotta, V. ESC, ESCL and their roles in Polycomb Group mechanisms. Mech. Dev. 125, 527–541 (2008) (10.1016/j.mod.2008.01.002) / Mech. Dev. by K Ohno (2008)
Kurzhals, R. L., Tie, F., Stratton, C. A. & Harte, P. J. Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Dev. Biol. 313, 293–306 (2008) (10.1016/j.ydbio.2007.10.025) / Dev. Biol. by RL Kurzhals (2008)
Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biol. 10, 1291–1300 (2008) (10.1038/ncb1787) / Nature Cell Biol. by KH Hansen (2008)
Huang, Y., Fang, J., Bedford, M. T., Zhang, Y. & Xu, R.-M. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science 312, 748–751 (2006) (10.1126/science.1125162) / Science by Y Huang (2006)
Li, H. et al. Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442, 91–95 (2006) (10.1038/nature04802) / Nature by H Li (2006)
Peña, P. V. et al. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 442, 100–103 (2006) (10.1038/nature04814) / Nature by PV Peña (2006)
Southall, S. M., Wong, P. S., Odho, Z., Roe, S. M. & Wilson, J. R. Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol. Cell 33, 181–191 (2009) (10.1016/j.molcel.2008.12.029) / Mol. Cell by SM Southall (2009)
Verreault, A., Kaufman, P. D., Kobayashi, R. & Stillman, B. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87, 95–104 (1996) (10.1016/S0092-8674(00)81326-4) / Cell by A Verreault (1996)
Murzina, N. V. et al. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure 16, 1077–1085 (2008) (10.1016/j.str.2008.05.006) / Structure by NV Murzina (2008)
Schwartz, Y. B. & Pirrotta, V. Polycomb complexes and epigenetic states. Curr. Opin. Cell Biol. 20, 266–273 (2008) (10.1016/j.ceb.2008.03.002) / Curr. Opin. Cell Biol. by YB Schwartz (2008)
Ringrose, L. & Paro, R. Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134, 223–232 (2007) (10.1242/dev.02723) / Development by L Ringrose (2007)
Papp, B. & Muller, J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 20, 2041–2054 (2006) (10.1101/gad.388706) / Genes Dev. by B Papp (2006)
Schwartz, Y. B. et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster . Nature Genet. 38, 700–705 (2006) (10.1038/ng1817) / Nature Genet. by YB Schwartz (2006)
Otwinowski, Z. & Minor, W. Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 267, 307–326 (1997) (10.1016/S0076-6879(97)76066-X) / Methods Enzymol. by Z Otwinowski (1997)
Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849–861 (1999) (10.1107/S0907444999000839) / Acta Crystallogr. D by TC Terwilliger (1999)
Terwilliger, T. C. Maximum-likelihood density modification. Acta Crystallogr. D 56, 965–972 (2000) (10.1107/S0907444900005072) / Acta Crystallogr. D by TC Terwilliger (2000)
Perrakis, A., Sixma, T. K., Wilson, K. S. & Lamzin, V. S. wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models. Acta Crystallogr. D 53, 448–455 (1997) (10.1107/S0907444997005696) / Acta Crystallogr. D by A Perrakis (1997)
Navaza, J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157–163 (1994) (10.1107/S0108767393007597) / Acta Crystallogr. A by J Navaza (1994)
Collaborative Computational Project. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760–763 (1994) (10.1107/S0907444994003112)
Brünger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998) (10.1107/S0907444998003254) / Acta Crystallogr. D by AT Brünger (1998)
Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991) (10.1107/S0108767390010224) / Acta Crystallogr. A by TA Jones (1991)
Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126–2132 (2004) (10.1107/S0907444904019158) / Acta Crystallogr. D by P Emsley (2004)
Luger, K., Rechsteiner, T. J., Flaus, A. J., Waye, M. M. & Richmond, T. J. Characterization of nucleosome core particles containing histone proteins made in bacteria. J. Mol. Biol. 272, 301–311 (1997) (10.1006/jmbi.1997.1235) / J. Mol. Biol. by K Luger (1997)
Margueron, R. et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 32, 503–518 (2008) (10.1016/j.molcel.2008.11.004) / Mol. Cell by R Margueron (2008)
Bischof, J., Maeda, R. K., Hediger, M., Karch, F. & Basler, K. An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl Acad. Sci. USA 104, 3312–3317 (2007) (10.1073/pnas.0611511104) / Proc. Natl Acad. Sci. USA by J Bischof (2007)
Bateman, J. R., Lee, A. M. & Wu, C. T. Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics 173, 769–777 (2006) (10.1534/genetics.106.056945) / Genetics by JR Bateman (2006)

Dates

Type	When
Created	15 years, 11 months ago (Sept. 20, 2009, 12:58 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2:27 p.m.)
Indexed	33 minutes ago (Aug. 21, 2025, 12:35 p.m.)
Issued	15 years, 11 months ago (Sept. 20, 2009)
Published	15 years, 11 months ago (Sept. 20, 2009)
Published Online	15 years, 11 months ago (Sept. 20, 2009)
Published Print	15 years, 10 months ago (Oct. 1, 2009)

Funders 0

None

BibTeX

@article{Margueron_2009, title={Role of the polycomb protein EED in the propagation of repressive histone marks}, volume={461}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature08398}, DOI={10.1038/nature08398}, number={7265}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Margueron, Raphael and Justin, Neil and Ohno, Katsuhito and Sharpe, Miriam L. and Son, Jinsook and Drury III, William J. and Voigt, Philipp and Martin, Stephen R. and Taylor, William R. and De Marco, Valeria and Pirrotta, Vincenzo and Reinberg, Danny and Gamblin, Steven J.}, year={2009}, month=sep, pages={762–767} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        21
      ]
    ],
    "date-time": "2025-08-21T16:35:15Z",
    "timestamp": 1755794115883
  },
  "reference-count": 40,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "7265",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2009,
            9,
            20
          ]
        ],
        "date-time": "2009-09-20T00:00:00Z",
        "timestamp": 1253404800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2009,
        10
      ]
    ]
  },
  "DOI": "10.1038/nature08398",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2009,
        9,
        20
      ]
    ],
    "date-time": "2009-09-20T16:58:56Z",
    "timestamp": 1253465936000
  },
  "page": "762-767",
  "source": "Crossref",
  "is-referenced-by-count": 1037,
  "title": "Role of the polycomb protein EED in the propagation of repressive histone marks",
  "prefix": "10.1038",
  "volume": "461",
  "author": [
    {
      "given": "Raphael",
      "family": "Margueron",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Neil",
      "family": "Justin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Katsuhito",
      "family": "Ohno",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Miriam L.",
      "family": "Sharpe",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jinsook",
      "family": "Son",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "William J.",
      "family": "Drury III",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Philipp",
      "family": "Voigt",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stephen R.",
      "family": "Martin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "William R.",
      "family": "Taylor",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Valeria",
      "family": "De Marco",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Vincenzo",
      "family": "Pirrotta",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Danny",
      "family": "Reinberg",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Steven J.",
      "family": "Gamblin",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2009,
        9,
        20
      ]
    ]
  },
  "reference": [
    {
      "key": "BFnature08398_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "735",
      "DOI": "10.1016/j.cell.2007.02.009",
      "volume": "128",
      "author": "B Schuettengruber",
      "year": "2007",
      "unstructured": "Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B. & Cavalli, G. Genome regulation by polycomb and trithorax proteins. Cell 128, 735\u2013745 (2007)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "185",
      "DOI": "10.1016/S0092-8674(02)00975-3",
      "volume": "111",
      "author": "B Czermin",
      "year": "2002",
      "unstructured": "Czermin, B. et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185\u2013196 (2002)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "1039",
      "DOI": "10.1126/science.1076997",
      "volume": "298",
      "author": "R Cao",
      "year": "2002",
      "unstructured": "Cao, R. et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039\u20131043 (2002)",
      "journal-title": "Science"
    },
    {
      "key": "BFnature08398_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "2893",
      "DOI": "10.1101/gad.1035902",
      "volume": "16",
      "author": "A Kuzmichev",
      "year": "2002",
      "unstructured": "Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893\u20132905 (2002)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature08398_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "197",
      "DOI": "10.1016/S0092-8674(02)00976-5",
      "volume": "111",
      "author": "J M\u00fcller",
      "year": "2002",
      "unstructured": "M\u00fcller, J. et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197\u2013208 (2002)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "4078",
      "DOI": "10.1038/sj.emboj.7601837",
      "volume": "26",
      "author": "M Nekrasov",
      "year": "2007",
      "unstructured": "Nekrasov, M. et al. Pcl-PRC2 is needed to generate high levels of H3\u2013K27 trimethylation at Polycomb target genes. EMBO J. 26, 4078\u20134088 (2007)",
      "journal-title": "EMBO J."
    },
    {
      "key": "BFnature08398_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "2718",
      "DOI": "10.1128/MCB.02017-07",
      "volume": "28",
      "author": "K Sarma",
      "year": "2008",
      "unstructured": "Sarma, K., Margueron, R., Ivanov, A., Pirrotta, V. & Reinberg, D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo . Mol. Cell. Biol. 28, 2718\u20132731 (2008)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature08398_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "1306",
      "DOI": "10.1016/j.str.2007.08.007",
      "volume": "15",
      "author": "Z Han",
      "year": "2007",
      "unstructured": "Han, Z. et al. Structural basis of EZH2 recognition by EED. Structure 15, 1306\u20131315 (2007)",
      "journal-title": "Structure"
    },
    {
      "key": "BFnature08398_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "5588",
      "DOI": "10.1074/jbc.M309771200",
      "volume": "279",
      "author": "A Schiefner",
      "year": "2004",
      "unstructured": "Schiefner, A. et al. Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli . J. Biol. Chem. 279, 5588\u20135596 (2004)",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BFnature08398_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "693",
      "DOI": "10.1016/j.cell.2007.02.005",
      "volume": "128",
      "author": "T Kouzarides",
      "year": "2007",
      "unstructured": "Kouzarides, T. Chromatin modifications and their function. Cell 128, 693\u2013705 (2007)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "348",
      "DOI": "10.1038/sj.embor.7400376",
      "volume": "6",
      "author": "M Nekrasov",
      "year": "2005",
      "unstructured": "Nekrasov, M., Wild, B. & Muller, J. Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep. 6, 348\u2013353 (2005)",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "BFnature08398_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "1003",
      "DOI": "10.1016/j.cell.2006.12.041",
      "volume": "128",
      "author": "MD Simon",
      "year": "2007",
      "unstructured": "Simon, M. D. et al. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 128, 1003\u20131012 (2007)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "2014",
      "DOI": "10.1128/MCB.01822-06",
      "volume": "27",
      "author": "F Tie",
      "year": "2007",
      "unstructured": "Tie, F., Stratton, C. A., Kurzhals, R. L. & Harte, P. J. The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27. Mol. Cell. Biol. 27, 2014\u20132026 (2007)",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BFnature08398_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "285",
      "DOI": "10.1016/0092-8674(82)90428-7",
      "volume": "31",
      "author": "G Struhl",
      "year": "1982",
      "unstructured": "Struhl, G. & Brower, D. Early role of the esc+ gene product in the determination of segments in Drosophila . Cell 31, 285\u2013292 (1982)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "527",
      "DOI": "10.1016/j.mod.2008.01.002",
      "volume": "125",
      "author": "K Ohno",
      "year": "2008",
      "unstructured": "Ohno, K., McCabe, D., Czermin, B., Imhof, A. & Pirrotta, V. ESC, ESCL and their roles in Polycomb Group mechanisms. Mech. Dev. 125, 527\u2013541 (2008)",
      "journal-title": "Mech. Dev."
    },
    {
      "key": "BFnature08398_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "293",
      "DOI": "10.1016/j.ydbio.2007.10.025",
      "volume": "313",
      "author": "RL Kurzhals",
      "year": "2008",
      "unstructured": "Kurzhals, R. L., Tie, F., Stratton, C. A. & Harte, P. J. Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Dev. Biol. 313, 293\u2013306 (2008)",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "BFnature08398_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "1291",
      "DOI": "10.1038/ncb1787",
      "volume": "10",
      "author": "KH Hansen",
      "year": "2008",
      "unstructured": "Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biol. 10, 1291\u20131300 (2008)",
      "journal-title": "Nature Cell Biol."
    },
    {
      "key": "BFnature08398_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "748",
      "DOI": "10.1126/science.1125162",
      "volume": "312",
      "author": "Y Huang",
      "year": "2006",
      "unstructured": "Huang, Y., Fang, J., Bedford, M. T., Zhang, Y. & Xu, R.-M. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science 312, 748\u2013751 (2006)",
      "journal-title": "Science"
    },
    {
      "key": "BFnature08398_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "91",
      "DOI": "10.1038/nature04802",
      "volume": "442",
      "author": "H Li",
      "year": "2006",
      "unstructured": "Li, H. et al. Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442, 91\u201395 (2006)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature08398_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "100",
      "DOI": "10.1038/nature04814",
      "volume": "442",
      "author": "PV Pe\u00f1a",
      "year": "2006",
      "unstructured": "Pe\u00f1a, P. V. et al. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 442, 100\u2013103 (2006)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature08398_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "181",
      "DOI": "10.1016/j.molcel.2008.12.029",
      "volume": "33",
      "author": "SM Southall",
      "year": "2009",
      "unstructured": "Southall, S. M., Wong, P. S., Odho, Z., Roe, S. M. & Wilson, J. R. Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol. Cell 33, 181\u2013191 (2009)",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "BFnature08398_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "95",
      "DOI": "10.1016/S0092-8674(00)81326-4",
      "volume": "87",
      "author": "A Verreault",
      "year": "1996",
      "unstructured": "Verreault, A., Kaufman, P. D., Kobayashi, R. & Stillman, B. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87, 95\u2013104 (1996)",
      "journal-title": "Cell"
    },
    {
      "key": "BFnature08398_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "1077",
      "DOI": "10.1016/j.str.2008.05.006",
      "volume": "16",
      "author": "NV Murzina",
      "year": "2008",
      "unstructured": "Murzina, N. V. et al. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure 16, 1077\u20131085 (2008)",
      "journal-title": "Structure"
    },
    {
      "key": "BFnature08398_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "266",
      "DOI": "10.1016/j.ceb.2008.03.002",
      "volume": "20",
      "author": "YB Schwartz",
      "year": "2008",
      "unstructured": "Schwartz, Y. B. & Pirrotta, V. Polycomb complexes and epigenetic states. Curr. Opin. Cell Biol. 20, 266\u2013273 (2008)",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "BFnature08398_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "223",
      "DOI": "10.1242/dev.02723",
      "volume": "134",
      "author": "L Ringrose",
      "year": "2007",
      "unstructured": "Ringrose, L. & Paro, R. Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134, 223\u2013232 (2007)",
      "journal-title": "Development"
    },
    {
      "key": "BFnature08398_CR26",
      "doi-asserted-by": "publisher",
      "first-page": "2041",
      "DOI": "10.1101/gad.388706",
      "volume": "20",
      "author": "B Papp",
      "year": "2006",
      "unstructured": "Papp, B. & Muller, J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 20, 2041\u20132054 (2006)",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFnature08398_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "700",
      "DOI": "10.1038/ng1817",
      "volume": "38",
      "author": "YB Schwartz",
      "year": "2006",
      "unstructured": "Schwartz, Y. B. et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster . Nature Genet. 38, 700\u2013705 (2006)",
      "journal-title": "Nature Genet."
    },
    {
      "key": "BFnature08398_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "307",
      "DOI": "10.1016/S0076-6879(97)76066-X",
      "volume": "267",
      "author": "Z Otwinowski",
      "year": "1997",
      "unstructured": "Otwinowski, Z. & Minor, W. Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 267, 307\u2013326 (1997)",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "BFnature08398_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "849",
      "DOI": "10.1107/S0907444999000839",
      "volume": "55",
      "author": "TC Terwilliger",
      "year": "1999",
      "unstructured": "Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849\u2013861 (1999)",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "BFnature08398_CR30",
      "doi-asserted-by": "publisher",
      "first-page": "965",
      "DOI": "10.1107/S0907444900005072",
      "volume": "56",
      "author": "TC Terwilliger",
      "year": "2000",
      "unstructured": "Terwilliger, T. C. Maximum-likelihood density modification. Acta Crystallogr. D 56, 965\u2013972 (2000)",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "BFnature08398_CR31",
      "doi-asserted-by": "publisher",
      "first-page": "448",
      "DOI": "10.1107/S0907444997005696",
      "volume": "53",
      "author": "A Perrakis",
      "year": "1997",
      "unstructured": "Perrakis, A., Sixma, T. K., Wilson, K. S. & Lamzin, V. S. wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models. Acta Crystallogr. D 53, 448\u2013455 (1997)",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "BFnature08398_CR32",
      "doi-asserted-by": "publisher",
      "first-page": "157",
      "DOI": "10.1107/S0108767393007597",
      "volume": "50",
      "author": "J Navaza",
      "year": "1994",
      "unstructured": "Navaza, J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157\u2013163 (1994)",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "BFnature08398_CR33",
      "doi-asserted-by": "crossref",
      "unstructured": "Collaborative Computational Project. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760\u2013763 (1994)",
      "DOI": "10.1107/S0907444994003112"
    },
    {
      "key": "BFnature08398_CR34",
      "doi-asserted-by": "publisher",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "volume": "54",
      "author": "AT Br\u00fcnger",
      "year": "1998",
      "unstructured": "Br\u00fcnger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905\u2013921 (1998)",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "BFnature08398_CR35",
      "doi-asserted-by": "publisher",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "volume": "47",
      "author": "TA Jones",
      "year": "1991",
      "unstructured": "Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110\u2013119 (1991)",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "BFnature08398_CR36",
      "doi-asserted-by": "publisher",
      "first-page": "2126",
      "DOI": "10.1107/S0907444904019158",
      "volume": "60",
      "author": "P Emsley",
      "year": "2004",
      "unstructured": "Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126\u20132132 (2004)",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "BFnature08398_CR37",
      "doi-asserted-by": "publisher",
      "first-page": "301",
      "DOI": "10.1006/jmbi.1997.1235",
      "volume": "272",
      "author": "K Luger",
      "year": "1997",
      "unstructured": "Luger, K., Rechsteiner, T. J., Flaus, A. J., Waye, M. M. & Richmond, T. J. Characterization of nucleosome core particles containing histone proteins made in bacteria. J. Mol. Biol. 272, 301\u2013311 (1997)",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BFnature08398_CR38",
      "doi-asserted-by": "publisher",
      "first-page": "503",
      "DOI": "10.1016/j.molcel.2008.11.004",
      "volume": "32",
      "author": "R Margueron",
      "year": "2008",
      "unstructured": "Margueron, R. et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 32, 503\u2013518 (2008)",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "BFnature08398_CR39",
      "doi-asserted-by": "publisher",
      "first-page": "3312",
      "DOI": "10.1073/pnas.0611511104",
      "volume": "104",
      "author": "J Bischof",
      "year": "2007",
      "unstructured": "Bischof, J., Maeda, R. K., Hediger, M., Karch, F. & Basler, K. An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl Acad. Sci. USA 104, 3312\u20133317 (2007)",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BFnature08398_CR40",
      "doi-asserted-by": "publisher",
      "first-page": "769",
      "DOI": "10.1534/genetics.106.056945",
      "volume": "173",
      "author": "JR Bateman",
      "year": "2006",
      "unstructured": "Bateman, J. R., Lee, A. M. & Wu, C. T. Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics 173, 769\u2013777 (2006)",
      "journal-title": "Genetics"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/nature08398.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature08398",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature08398.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        18
      ]
    ],
    "date-time": "2023-05-18T18:27:35Z",
    "timestamp": 1684434455000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/nature08398"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2009,
        9,
        20
      ]
    ]
  },
  "references-count": 40,
  "journal-issue": {
    "issue": "7265",
    "published-print": {
      "date-parts": [
        [
          2009,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "BFnature08398"
  ],
  "URL": "http://dx.doi.org/10.1038/nature08398",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.718529668.793498640",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        2009,
        9,
        20
      ]
    ]
  }
}