DOI: 10.1038/nature07772. Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

10.1038/nature07772

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Brinster, S., Lamberet, G., Staels, B., Trieu-Cuot, P., Gruss, A., & Poyart, C. (2009). Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Nature, 458(7234), 83â86.

Authors 6

Sophie Brinster (first)
Gilles Lamberet (additional)
Bart Staels (additional)
Patrick Trieu-Cuot (additional)
Alexandra Gruss (additional)
Claire Poyart (additional)

References 31 Referenced 277

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Marrakchi, H., Zhang, Y. M. & Rock, C. O. Mechanistic diversity and regulation of Type II fatty acid synthesis. Biochem. Soc. Trans. 30, 1050–1055 (2002) (10.1042/bst0301050) / Biochem. Soc. Trans. by H Marrakchi (2002)
Price, A. C. et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J. Biol. Chem. 276, 6551–6559 (2001) (10.1074/jbc.M007101200) / J. Biol. Chem. by AC Price (2001)
Wright, H. T. & Reynolds, K. A. Antibacterial targets in fatty acid biosynthesis. Curr. Opin. Microbiol. 10, 447–453 (2007) (10.1016/j.mib.2007.07.001) / Curr. Opin. Microbiol. by HT Wright (2007)
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Campbell, J. W. & Cronan, J. E. Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu. Rev. Microbiol. 55, 305–332 (2001) (10.1146/annurev.micro.55.1.305) / Annu. Rev. Microbiol. by JW Campbell (2001)
Johnsson, T., Nikkila, P., Toivonen, L., Rosenqvist, H. & Laakso, S. Cellular fatty acid profiles of Lactobacillus and Lactococcus strains in relation to the oleic acid content of the cultivation medium. Appl. Environ. Microbiol. 61, 4497–4499 (1995) (10.1128/AEM.61.12.4497-4499.1995) / Appl. Environ. Microbiol. by T Johnsson (1995)
Altenbern, R. A. Cerulenin-inhibited cells of Staphylococcus aureus resume growth when supplemented with either a saturated or an unsaturated fatty acid. Antimicrob. Agents Chemother. 11, 574–576 (1977) (10.1128/AAC.11.3.574) / Antimicrob. Agents Chemother. by RA Altenbern (1977)
Kankaanpaa, P., Yang, B., Kallio, H., Isolauri, E. & Salminen, S. Effects of polyunsaturated fatty acids in growth medium on lipid composition and on physicochemical surface properties of lactobacilli. Appl. Environ. Microbiol. 70, 129–136 (2004) (10.1128/AEM.70.1.129-136.2004) / Appl. Environ. Microbiol. by P Kankaanpaa (2004)
Yamamoto, Y. et al. The group B streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulence. Mol. Microbiol. 62, 772–785 (2006) (10.1111/j.1365-2958.2006.05406.x) / Mol. Microbiol. by Y Yamamoto (2006)
Campbell, J. W. & Cronan, J. E. Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene. J. Bacteriol. 183, 5982–5990 (2001) (10.1128/JB.183.20.5982-5990.2001) / J. Bacteriol. by JW Campbell (2001)
Lai, C. Y. & Cronan, J. E. Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. J. Biol. Chem. 278, 51494–51503 (2003) (10.1074/jbc.M308638200) / J. Biol. Chem. by CY Lai (2003)
Fozo, E. M. & Quivey, R. G. The fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pH. J. Bacteriol. 186, 4152–4158 (2004) (10.1128/JB.186.13.4152-4158.2004) / J. Bacteriol. by EM Fozo (2004)
Fozo, E. M., Scott-Anne, K., Koo, H. & Quivey, R. G. Role of unsaturated fatty acid biosynthesis in virulence of Streptococcus mutans . Infect. Immun. 75, 1537–1539 (2007) (10.1128/IAI.01938-06) / Infect. Immun. by EM Fozo (2007)
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Moellering, R. C. & Weinberg, A. N. Studies on antibiotic syngerism against enterococci. II. Effect of various antibiotics on the uptake of 14 C-labeled streptomycin by enterococci. J. Clin. Invest. 50, 2580–2584 (1971) (10.1172/JCI106758) / J. Clin. Invest. by RC Moellering (1971)
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Dates

Type	When
Created	16 years, 6 months ago (March 4, 2009, 9:30 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2:22 p.m.)
Indexed	1 day, 14 hours ago (Sept. 3, 2025, 6:16 a.m.)
Issued	16 years, 6 months ago (March 1, 2009)
Published	16 years, 6 months ago (March 1, 2009)
Published Print	16 years, 6 months ago (March 1, 2009)

Funders 0

None

BibTeX

@article{Brinster_2009, title={Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens}, volume={458}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature07772}, DOI={10.1038/nature07772}, number={7234}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Brinster, Sophie and Lamberet, Gilles and Staels, Bart and Trieu-Cuot, Patrick and Gruss, Alexandra and Poyart, Claire}, year={2009}, month=mar, pages={83–86} }

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