DOI: 10.1038/nature05315. Klotho converts canonical FGF receptor into a specific receptor for FGF23

Klotho converts canonical FGF receptor into a specific receptor for FGF23

10.1038/nature05315

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006). Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature, 444(7120), 770â774.

Authors 9

Itaru Urakawa (first)
Yuji Yamazaki (additional)
Takashi Shimada (additional)
Kousuke Iijima (additional)
Hisashi Hasegawa (additional)
Katsuya Okawa (additional)
Toshiro Fujita (additional)
Seiji Fukumoto (additional)
Takeyoshi Yamashita (additional)

References 30 Referenced 1,541

The ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nature Genet. 26, 345–348 (2000) (10.1038/81664)
Shimada, T. et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl Acad. Sci. USA 98, 6500–6505 (2001) (10.1073/pnas.101545198) / Proc. Natl Acad. Sci. USA by T Shimada (2001)
Itoh, N. & Ornitz, D. M. Evolution of the Fgf and Fgfr gene families. Trends Genet. 20, 563–569 (2004) (10.1016/j.tig.2004.08.007) / Trends Genet. by N Itoh (2004)
Yamazaki, Y. et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J. Clin. Endocrinol. Metab. 87, 4957–4960 (2002) (10.1210/jc.2002-021105) / J. Clin. Endocrinol. Metab. by Y Yamazaki (2002)
Jonsson, K. B. et al. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N. Engl. J. Med. 348, 1656–1663 (2003) (10.1056/NEJMoa020881) / N. Engl. J. Med. by KB Jonsson (2003)
Shimada, T. et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 19, 429–435 (2004) (10.1359/JBMR.0301264) / J. Bone Miner. Res. by T Shimada (2004)
Kuro-o, M. et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390, 45–51 (1997) (10.1038/36285) / Nature by M Kuro-o (1997)
Riminucci, M. et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 112, 683–692 (2003) (10.1172/JCI18399) / J. Clin. Invest. by M Riminucci (2003)
Murer, H., Hernando, N., Forster, I. & Biber, J. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol. Rev. 80, 1373–1409 (2000) (10.1152/physrev.2000.80.4.1373) / Physiol. Rev. by H Murer (2000)
Wikvall, K. Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form. Int. J. Mol. Med. 7, 201–209 (2001) (10.1007/s008940100035) / Int. J. Mol. Med. by K Wikvall (2001)
Gashler, A. & Sukhatme, V. P. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 50, 191–224 (1995) (10.1016/S0079-6603(08)60815-6) / Prog. Nucleic Acid Res. Mol. Biol. by A Gashler (1995)
Liu, L., Tsai, J. C. & Aird, W. C. Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood 96, 1772–1781 (2000) (10.1182/blood.V96.5.1772) / Blood by L Liu (2000)
Nabeshima, Y. Klotho: a fundamental regulator of aging. Ageing Res. Rev. 1, 627–638 (2002) (10.1016/S1568-1637(02)00027-2) / Ageing Res. Rev. by Y Nabeshima (2002)
Imura, A. et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 565, 143–147 (2004) (10.1016/j.febslet.2004.03.090) / FEBS Lett. by A Imura (2004)
Yu, X. et al. Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology 146, 4647–4656 (2005) (10.1210/en.2005-0670) / Endocrinology by X Yu (2005)
Yamashita, T., Konishi, M., Miyake, A., Inui, K. & Itoh, N. Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway. J. Biol. Chem. 277, 28265–28270 (2002) (10.1074/jbc.M202527200) / J. Biol. Chem. by T Yamashita (2002)
Christy, B. A., Lau, L. F. & Nathans, D. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with ‘zinc finger’ sequences. Proc. Natl Acad. Sci. USA 85, 7857–7861 (1988) (10.1073/pnas.85.21.7857) / Proc. Natl Acad. Sci. USA by BA Christy (1988)
Shimada, T. et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 113, 561–568 (2004) (10.1172/JCI200419081) / J. Clin. Invest. by T Shimada (2004)
Sitara, D. et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 23, 421–432 (2004) (10.1016/j.matbio.2004.09.007) / Matrix Biol. by D Sitara (2004)
Yoshida, T., Fujimori, T. & Nabeshima, Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1α-hydroxylase gene. Endocrinology 143, 683–689 (2002) (10.1210/endo.143.2.8657) / Endocrinology by T Yoshida (2002)
Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K. & Nabeshima, Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol. Endocrinol. 17, 2393–2403 (2003) (10.1210/me.2003-0048) / Mol. Endocrinol. by H Tsujikawa (2003)
Larsson, T., Nisbeth, U., Ljunggren, O., Juppner, H. & Jonsson, K. B. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int. 64, 2272–2279 (2003) (10.1046/j.1523-1755.2003.00328.x) / Kidney Int. by T Larsson (2003)
Vainikka, S. et al. Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. J. Biol. Chem. 269, 18320–18326 (1994) (10.1016/S0021-9258(17)32309-8) / J. Biol. Chem. by S Vainikka (1994)
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Ito, S., Fujimori, T., Hayashizaki, Y. & Nabeshima, Y. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim. Biophys. Acta 1576, 341–345 (2002) (10.1016/S0167-4781(02)00281-6) / Biochim. Biophys. Acta by S Ito (2002)
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Ito, S. et al. Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J. Clin. Invest. 115, 2202–2208 (2005) (10.1172/JCI23076) / J. Clin. Invest. by S Ito (2005)
Shimada, T. et al. Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.. Endocrinology 143, 3179–3182 (2002) (10.1210/endo.143.8.8795) / Endocrinology by T Shimada (2002)

Dates

Type	When
Created	18 years, 9 months ago (Nov. 8, 2006, 4:28 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2 p.m.)
Indexed	3 days, 10 hours ago (Aug. 28, 2025, 8:40 a.m.)
Issued	18 years, 10 months ago (Oct. 29, 2006)
Published	18 years, 10 months ago (Oct. 29, 2006)
Published Online	18 years, 10 months ago (Oct. 29, 2006)
Published Print	18 years, 8 months ago (Dec. 1, 2006)

Funders 0

None

BibTeX

@article{Urakawa_2006, title={Klotho converts canonical FGF receptor into a specific receptor for FGF23}, volume={444}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature05315}, DOI={10.1038/nature05315}, number={7120}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Urakawa, Itaru and Yamazaki, Yuji and Shimada, Takashi and Iijima, Kousuke and Hasegawa, Hisashi and Okawa, Katsuya and Fujita, Toshiro and Fukumoto, Seiji and Yamashita, Takeyoshi}, year={2006}, month=oct, pages={770–774} }

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