DOI: 10.1038/nature05077. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

10.1038/nature05077

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006). The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature, 443(7108), 214â217.

Authors 5

M. A. Christophorou (first)
I. Ringshausen (additional)
A. J. Finch (additional)
L. Brown Swigart (additional)
G. I. Evan (additional)

References 29 Referenced 317

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Christophorou, M. A. et al. Temporal dissection of p53 function in vitro and in vivo. Nature Genet. 37, 718–726 (2005) (10.1038/ng1572) / Nature Genet. by MA Christophorou (2005)
Lain, S. & Lane, D. Improving cancer therapy by non-genotoxic activation of p53. Eur. J. Cancer 39, 1053–1060 (2003) (10.1016/S0959-8049(03)00063-7) / Eur. J. Cancer by S Lain (2003)
Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1–7 (1994) (10.1016/S0960-9822(00)00002-6) / Curr. Biol. by T Jacks (1994)
Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221 (1992) (10.1038/356215a0) / Nature by LA Donehower (1992)
Kemp, C. J., Wheldon, T. & Balmain, A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nature Genet. 8, 66–69 (1994) (10.1038/ng0994-66) / Nature Genet. by CJ Kemp (1994)
Komarova, E. A. & Gudkov, A. V. Could p53 be a target for therapeutic suppression? Semin. Cancer Biol. 8, 389–400 (1998) (10.1006/scbi.1998.0101) / Semin. Cancer Biol. by EA Komarova (1998)
Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907–913 (2005) (10.1038/nature03485) / Nature by VG Gorgoulis (2005)
Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864–870 (2005) (10.1038/nature03482) / Nature by J Bartkova (2005)
Prowse, K. R. & Greider, C. W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl Acad. Sci. USA 92, 4818–4822 (1995) (10.1073/pnas.92.11.4818) / Proc. Natl Acad. Sci. USA by KR Prowse (1995)
Kipling, D. & Cooke, H. J. Hypervariable ultra-long telomeres in mice. Nature 347, 400–402 (1990) (10.1038/347400a0) / Nature by D Kipling (1990)
Wu, X. & Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl Acad. Sci. USA 91, 3602–3606 (1994) (10.1073/pnas.91.9.3602) / Proc. Natl Acad. Sci. USA by X Wu (1994)
Wagner, A. J., Kokontis, J. M. & Hay, N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev. 8, 2817–2830 (1994) (10.1101/gad.8.23.2817) / Genes Dev. by AJ Wagner (1994)
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997) (10.1016/S0092-8674(00)81902-9) / Cell by M Serrano (1997)
Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307–315 (2004) (10.1038/nature03098) / Nature by SW Lowe (2004)
Hermeking, H. & Eick, D. Mediation of c-Myc-induced apoptosis by p53. Science 265, 2091–2093 (1994) (10.1126/science.8091232) / Science by H Hermeking (1994)
Zindy, F. et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424–2433 (1998) (10.1101/gad.12.15.2424) / Genes Dev. by F Zindy (1998)
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Sluss, H. K., Armata, H., Gallant, J. & Jones, S. N. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol. Cell. Biol. 24, 976–984 (2004) (10.1128/MCB.24.3.976-984.2004) / Mol. Cell. Biol. by HK Sluss (2004)
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Harms, K., Nozell, S. & Chen, X. The common and distinct target genes of the p53 family transcription factors. Cell. Mol. Life Sci. 61, 822–842 (2004) (10.1007/s00018-003-3304-4) / Cell. Mol. Life Sci. by K Harms (2004)
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Dates

Type	When
Created	18 years, 11 months ago (Sept. 6, 2006, 3:26 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 1:58 p.m.)
Indexed	3 months, 4 weeks ago (April 26, 2025, 11:24 a.m.)
Issued	18 years, 11 months ago (Sept. 1, 2006)
Published	18 years, 11 months ago (Sept. 1, 2006)
Published Online	18 years, 11 months ago (Sept. 6, 2006)
Published Print	18 years, 11 months ago (Sept. 1, 2006)

Funders 0

None

BibTeX

@article{Christophorou_2006, title={The pathological response to DNA damage does not contribute to p53-mediated tumour suppression}, volume={443}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature05077}, DOI={10.1038/nature05077}, number={7108}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Christophorou, M. A. and Ringshausen, I. and Finch, A. J. and Swigart, L. Brown and Evan, G. I.}, year={2006}, month=sep, pages={214–217} }

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