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Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006). Lysyl oxidase is essential for hypoxia-induced metastasis. Nature, 440(7088), 1222–1226.

Authors 9
  1. Janine T. Erler (first)
  2. Kevin L. Bennewith (additional)
  3. Monica Nicolau (additional)
  4. Nadja Dornhöfer (additional)
  5. Christina Kong (additional)
  6. Quynh-Thu Le (additional)
  7. Jen-Tsan Ashley Chi (additional)
  8. Stefanie S. Jeffrey (additional)
  9. Amato J. Giaccia (additional)
References 29 Referenced 1,107
  1. Cairns, R. A., Khokha, R. & Hill, R. P. Molecular mechanisms of tumor invasion and metastasis: An integrated view. Curr. Mol. Med. 3, 659–671 (2003) (10.2174/1566524033479447) / Curr. Mol. Med. by RA Cairns (2003)
  2. Hockel, M. & Vaupel, P. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93, 266–276 (2001) (10.1093/jnci/93.4.266) / J. Natl Cancer Inst. by M Hockel (2001)
  3. Denko, N. C. et al. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene 22, 5907–5914 (2003) (10.1038/sj.onc.1206703) / Oncogene by NC Denko (2003)
  4. Kagan, H. M. & Li, W. Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell. J. Cell. Biochem. 88, 660–672 (2003) (10.1002/jcb.10413) / J. Cell. Biochem. by HM Kagan (2003)
  5. Kaneda, A. et al. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res. 64, 6410–6415 (2004) (10.1158/0008-5472.CAN-04-1543) / Cancer Res. by A Kaneda (2004)
  6. Csiszar, K. et al. Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. Int. J. Cancer 97, 636–642 (2002) (10.1002/ijc.10035) / Int. J. Cancer by K Csiszar (2002)
  7. Palamakumbura, A. H. et al. The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. J. Biol. Chem. 279, 40593–40600 (2004) (10.1074/jbc.M406639200) / J. Biol. Chem. by AH Palamakumbura (2004)
  8. Kirschmann, D. A. et al. A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res. 62, 4478–4483 (2002) / Cancer Res. by DA Kirschmann (2002)
  9. Payne, S. L. et al. Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res. 65, 11429–11436 (2005) (10.1158/0008-5472.CAN-05-1274) / Cancer Res. by SL Payne (2005)
  10. Chang, H. Y. et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA 102, 3738–3743 (2005) (10.1073/pnas.0409462102) / Proc. Natl Acad. Sci. USA by HY Chang (2005)
  11. Chen, Y. et al. Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res. 64, 7302–7310 (2004) (10.1158/0008-5472.CAN-04-0899) / Cancer Res. by Y Chen (2004)
  12. Chi, J. T. et al. Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers. PLoS Med. 3, e47 (2006) (10.1371/journal.pmed.0030047) / PLoS Med. by JT Chi (2006)
  13. Palmieri, D. et al. Medroxyprogesterone acetate elevation of Nm23–H1 metastasis suppressor expression in hormone receptor-negative breast cancer. J. Natl Cancer Inst. 97, 632–642 (2005) (10.1093/jnci/dji111) / J. Natl Cancer Inst. by D Palmieri (2005)
  14. Csiszar, K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog. Nucleic Acid Res. Mol. Biol. 70, 1–32 (2001) (10.1016/S0079-6603(01)70012-8) / Prog. Nucleic Acid Res. Mol. Biol. by K Csiszar (2001)
  15. Cen, D., Brayton, D., Shahandeh, B., Meyskens, F. L. Jr & Farmer, P. J. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J. Med. Chem. 47, 6914–6920 (2004) (10.1021/jm049568z) / J. Med. Chem. by D Cen (2004)
  16. Janda, E. et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J. Cell Biol. 156, 299–313 (2002) (10.1083/jcb.200109037) / J. Cell Biol. by E Janda (2002)
  17. Friedl, P. & Wolf, K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nature Rev. Cancer 3, 362–374 (2003) (10.1038/nrc1075) / Nature Rev. Cancer by P Friedl (2003)
  18. Krishnamachary, B. et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63, 1138–1143 (2003) / Cancer Res. by B Krishnamachary (2003)
  19. Fogelgren, B. et al. Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation. J. Biol. Chem. 280, 24690–24697 (2005) (10.1074/jbc.M412979200) / J. Biol. Chem. by B Fogelgren (2005)
  20. Yoon, S. O., Shin, S. & Mercurio, A. M. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 integrin. Cancer Res. 65, 2761–2769 (2005) (10.1158/0008-5472.CAN-04-4122) / Cancer Res. by SO Yoon (2005)
  21. Leufgen, H. et al. Collagenase expression and activity is modulated by the interaction of collagen types, hypoxia, and nutrition in human lung cells. J. Cell. Physiol. 204, 146–154 (2005) (10.1002/jcp.20289) / J. Cell. Physiol. by H Leufgen (2005)
  22. Kaplan, R. N. et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820–827 (2005) (10.1038/nature04186) / Nature by RN Kaplan (2005)
  23. Wang, W. et al. Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse. BMC Biotechnol. 3, 13 (2003) (10.1186/1472-6750-3-13) / BMC Biotechnol. by W Wang (2003)
  24. Erler, J. T. et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol. Cell. Biol. 24, 2875–2889 (2004) (10.1128/MCB.24.7.2875-2889.2004) / Mol. Cell. Biol. by JT Erler (2004)
  25. Moody, S. E. et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197–209 (2005) (10.1016/j.ccr.2005.07.009) / Cancer Cell by SE Moody (2005)
  26. Tazuke, S. I. et al. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc. Natl Acad. Sci. USA 95, 10188–10193 (1998) (10.1073/pnas.95.17.10188) / Proc. Natl Acad. Sci. USA by SI Tazuke (1998)
  27. Spicher, A. et al. Highly conserved RNA sequences that are sensors of environmental stress. Mol. Cell. Biol. 18, 7371–7382 (1998) (10.1128/MCB.18.12.7371) / Mol. Cell. Biol. by A Spicher (1998)
  28. Bedogni, B. et al. Topical treatment with inhibitors of the phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Cancer Res. 64, 2552–2560 (2004) (10.1158/0008-5472.CAN-03-3327) / Cancer Res. by B Bedogni (2004)
  29. Gilad, G. M. & Gilad, V. H. Beta-aminopropionitrile treatment can accelerate recovery of mice after spinal cord injury. Eur. J. Pharmacol. 430, 69–72 (2001) (10.1016/S0014-2999(01)01354-1) / Eur. J. Pharmacol. by GM Gilad (2001)
Dates
Type When
Created 19 years, 4 months ago (April 27, 2006, 4 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 1:54 p.m.)
Indexed 15 hours, 57 minutes ago (Sept. 3, 2025, 7:07 a.m.)
Issued 19 years, 4 months ago (April 27, 2006)
Published 19 years, 4 months ago (April 27, 2006)
Published Print 19 years, 4 months ago (April 27, 2006)
Funders 0

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@article{Erler_2006, title={Lysyl oxidase is essential for hypoxia-induced metastasis}, volume={440}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature04695}, DOI={10.1038/nature04695}, number={7088}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Erler, Janine T. and Bennewith, Kevin L. and Nicolau, Monica and Dornhöfer, Nadja and Kong, Christina and Le, Quynh-Thu and Chi, Jen-Tsan Ashley and Jeffrey, Stefanie S. and Giaccia, Amato J.}, year={2006}, month=apr, pages={1222–1226} }