DOI: 10.1038/nature04665. Spatiotemporal dynamics of RhoA activity in migrating cells

Spatiotemporal dynamics of RhoA activity in migrating cells

10.1038/nature04665

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Pertz, O., Hodgson, L., Klemke, R. L., & Hahn, K. M. (2006). Spatiotemporal dynamics of RhoA activity in migrating cells. Nature, 440(7087), 1069â1072.

Authors 4

Olivier Pertz (first)
Louis Hodgson (additional)
Richard L. Klemke (additional)
Klaus M. Hahn (additional)

References 21 Referenced 714

Raftopoulou, M. & Hall, A. Cell migration: Rho GTPases lead the way. Dev. Biol. 265, 23–32 (2004) (10.1016/j.ydbio.2003.06.003) / Dev. Biol. by M Raftopoulou (2004)
Burridge, K. & Wennerberg, K. Rho and Rac take center stage. Cell 116, 167–179 (2004) (10.1016/S0092-8674(04)00003-0) / Cell by K Burridge (2004)
Fukata, Y. et al. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J. Cell Biol. 145, 347–361 (1999) (10.1083/jcb.145.2.347) / J. Cell Biol. by Y Fukata (1999)
Palazzo, A. F., Cook, T. A., Alberts, A. S. & Gundersen, G. G. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nature Cell Biol. 3, 723–729 (2001) (10.1038/35087035) / Nature Cell Biol. by AF Palazzo (2001)
Nimnual, A. S., Taylor, L. J. & Bar-Sagi, D. Redox-dependent downregulation of Rho by Rac. Nature Cell Biol. 5, 236–241 (2003) (10.1038/ncb938) / Nature Cell Biol. by AS Nimnual (2003)
Sander, E. E., ten Klooster, J. P., van Delft, S., van der Kammen, R. A. & Collard, J. G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour. J. Cell Biol. 147, 1009–1022 (1999) (10.1083/jcb.147.5.1009) / J. Cell Biol. by EE Sander (1999)
Ren, X. D., Kiosses, W. B. & Schwartz, M. A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578–585 (1999) (10.1093/emboj/18.3.578) / EMBO J. by XD Ren (1999)
Griesbeck, O., Baird, G. S., Campbell, R. E., Zacharias, D. A. & Tsien, R. Y. Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. J. Biol. Chem. 276, 29188–29194 (2001) (10.1074/jbc.M102815200) / J. Biol. Chem. by O Griesbeck (2001)
Miyawaki, A. & Tsien, R. Y. Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol. 327, 472–500 (2000) (10.1016/S0076-6879(00)27297-2) / Methods Enzymol. by A Miyawaki (2000)
Hoffman, G. R., Nassar, N. & Cerione, R. A. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell 100, 345–356 (2000) (10.1016/S0092-8674(00)80670-4) / Cell by GR Hoffman (2000)
Miura, K. et al. ARAP1: a point of convergence for Arf and Rho signaling. Mol. Cell 9, 109–119 (2002) (10.1016/S1097-2765(02)00428-8) / Mol. Cell by K Miura (2002)
Norman, J. C. et al. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. J. Cell Biol. 143, 1981–1995 (1998) (10.1083/jcb.143.7.1981) / J. Cell Biol. by JC Norman (1998)
Cho, S. Y. & Klemke, R. L. Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J. Cell Biol. 156, 725–736 (2002) (10.1083/jcb.200111032) / J. Cell Biol. by SY Cho (2002)
Matsumura, F., Ono, S., Yamakita, Y., Totsukawa, G. & Yamashiro, S. Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells. J. Cell Biol. 140, 119–129 (1998) (10.1083/jcb.140.1.119) / J. Cell Biol. by F Matsumura (1998)
Worthylake, R. A., Lemoine, S., Watson, J. M. & Burridge, K. RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154, 147–160 (2001) (10.1083/jcb.200103048) / J. Cell Biol. by RA Worthylake (2001)
Kurokawa, K. & Matsuda, M. Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol. Biol. Cell 16, 4294–4303 (2005) (10.1091/mbc.e04-12-1076) / Mol. Biol. Cell by K Kurokawa (2005)
Shaw, R. J., Henry, M., Solomon, F. & Jacks, T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol. Biol. Cell 9, 403–419 (1998) (10.1091/mbc.9.2.403) / Mol. Biol. Cell by RJ Shaw (1998)
Fernandez-Borja, M., Janssen, L., Verwoerd, D., Hordijk, P. & Neefjes, J. RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1. J. Cell Sci. 118, 2661–2670 (2005) (10.1242/jcs.02384) / J. Cell Sci. by M Fernandez-Borja (2005)
Merrifield, C. J. et al. Endocytic vesicles move at the tips of actin tails in cultured mast cells. Nature Cell Biol. 1, 72–74 (1999) (10.1038/9048) / Nature Cell Biol. by CJ Merrifield (1999)
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401–410 (1992) (10.1016/0092-8674(92)90164-8) / Cell by AJ Ridley (1992)
Hodgson, L., Nalbant, P., Shen, F. & Hahn, K. M. Imaging and photobleach correction of Mero-CBD, sensor for endogenous Cdc42 activation. Methods Enzymol. 406, 140–156 (2006) (10.1016/S0076-6879(06)06012-5) / Methods Enzymol. by L Hodgson (2006)

Dates

Type	When
Created	19 years, 5 months ago (March 20, 2006, 4:59 a.m.)
Deposited	3 years, 6 months ago (March 2, 2022, 5:27 a.m.)
Indexed	4 hours, 6 minutes ago (Sept. 6, 2025, 4:02 p.m.)
Issued	19 years, 5 months ago (April 1, 2006)
Published	19 years, 5 months ago (April 1, 2006)
Published Online	19 years, 5 months ago (April 1, 2006)
Published Print	19 years, 4 months ago (April 20, 2006)

Funders 0

None

BibTeX

@article{Pertz_2006, title={Spatiotemporal dynamics of RhoA activity in migrating cells}, volume={440}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature04665}, DOI={10.1038/nature04665}, number={7087}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Pertz, Olivier and Hodgson, Louis and Klemke, Richard L. and Hahn, Klaus M.}, year={2006}, month=apr, pages={1069–1072} }

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