IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
10.1038/nature04641
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Hoshino, K., Sugiyama, T., Matsumoto, M., Tanaka, T., Saito, M., Hemmi, H., Ohara, O., Akira, S., & Kaisho, T. (2006). IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature, 440(7086), 949–953.

Authors 9
  1. Katsuaki Hoshino (first)
  2. Takahiro Sugiyama (additional)
  3. Mitsuru Matsumoto (additional)
  4. Takashi Tanaka (additional)
  5. Masuyoshi Saito (additional)
  6. Hiroaki Hemmi (additional)
  7. Osamu Ohara (additional)
  8. Shizuo Akira (additional)
  9. Tsuneyasu Kaisho (additional)
References 30 Referenced 304
  1. Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135–145 (2001) (10.1038/35100529) / Nature Rev. Immunol. by R Medzhitov (2001)
  2. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335–376 (2003) (10.1146/annurev.immunol.21.120601.141126) / Annu. Rev. Immunol. by K Takeda (2003)
  3. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740–745 (2000) (10.1038/35047123) / Nature by H Hemmi (2000)
  4. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis, E. S. C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529–1531 (2004) (10.1126/science.1093616) / Science by SS Diebold (2004)
  5. Heil, F. et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303, 1526–1529 (2004) (10.1126/science.1093620) / Science by F Heil (2004)
  6. Lund, J. M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA 101, 5598–5603 (2004) (10.1073/pnas.0400937101) / Proc. Natl Acad. Sci. USA by JM Lund (2004)
  7. Wagner, H. The immunobiology of the TLR9 subfamily. Trends Immunol. 25, 381–386 (2004) (10.1016/j.it.2004.04.011) / Trends Immunol. by H Wagner (2004)
  8. Colonna, M., Trinchieri, G. & Liu, Y. J. Plasmacytoid dendritic cells in immunity. Nature Immunol. 5, 1219–1226 (2004) (10.1038/ni1141) / Nature Immunol. by M Colonna (2004)
  9. Blanco, P., Palucka, A. K., Gill, M., Pascual, V. & Banchereau, J. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 294, 1540–1543 (2001) (10.1126/science.1064890) / Science by P Blanco (2001)
  10. Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nature Immunol. 5, 1061–1068 (2004) (10.1038/ni1118) / Nature Immunol. by T Kawai (2004)
  11. Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl Acad. Sci. USA 101, 15416–15421 (2004) (10.1073/pnas.0406933101) / Proc. Natl Acad. Sci. USA by K Honda (2004)
  12. Uematsu, S. et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201, 915–923 (2005) (10.1084/jem.20042372) / J. Exp. Med. by S Uematsu (2005)
  13. Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772–777 (2005) (10.1038/nature03464) / Nature by K Honda (2005)
  14. Honda, K. et al. Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction. Nature 434, 1035–1040 (2005) (10.1038/nature03547) / Nature by K Honda (2005)
  15. Hayden, M. S. & Ghosh, S. Signaling to NF-κB. Genes Dev. 18, 2195–2224 (2004) (10.1101/gad.1228704) / Genes Dev. by MS Hayden (2004)
  16. Bonizzi, G. & Karin, M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280–288 (2004) (10.1016/j.it.2004.03.008) / Trends Immunol. by G Bonizzi (2004)
  17. Hemmi, H. et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641–1650 (2004) (10.1084/jem.20040520) / J. Exp. Med. by H Hemmi (2004)
  18. Perry, A. K., Chow, E. K., Goodnough, J. B., Yeh, W. C. & Cheng, G. Differential requirement for TANK-binding kinase-1 in type I interferon responses to Toll-like receptor activation and viral infection. J. Exp. Med. 199, 1651–1658 (2004) (10.1084/jem.20040528) / J. Exp. Med. by AK Perry (2004)
  19. Takeda, K. et al. Limb and skin abnormalities in mice lacking IKKα. Science 284, 313–316 (1999) (10.1126/science.284.5412.313) / Science by K Takeda (1999)
  20. Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316–320 (1999) (10.1126/science.284.5412.316) / Science by Y Hu (1999)
  21. Li, Q. et al. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13, 1322–1328 (1999) (10.1101/gad.13.10.1322) / Genes Dev. by Q Li (1999)
  22. Kaisho, T. et al. IκB kinase α is essential for mature B cell development and function. J. Exp. Med. 193, 417–426 (2001) (10.1084/jem.193.4.417) / J. Exp. Med. by T Kaisho (2001)
  23. Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495–1499 (2001) (10.1126/science.1062677) / Science by U Senftleben (2001)
  24. Matsushima, A. et al. Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193, 631–636 (2001) (10.1084/jem.193.5.631) / J. Exp. Med. by A Matsushima (2001)
  25. Verthelyi, D., Ishii, K. J., Gursel, M., Takeshita, F. & Klinman, D. M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166, 2372–2377 (2001) (10.4049/jimmunol.166.4.2372) / J. Immunol. by D Verthelyi (2001)
  26. Krug, A. et al. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31, 2154–2163 (2001) (10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U) / Eur. J. Immunol. by A Krug (2001)
  27. Hemmi, H., Kaisho, T., Takeda, K. & Akira, S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170, 3059–3064 (2003) (10.4049/jimmunol.170.6.3059) / J. Immunol. by H Hemmi (2003)
  28. Kato, H. et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19–28 (2005) (10.1016/j.immuni.2005.04.010) / Immunity by H Kato (2005)
  29. Hochrein, H. et al. Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and -independent pathways. Proc. Natl Acad. Sci. USA 101, 11416–11421 (2004) (10.1073/pnas.0403555101) / Proc. Natl Acad. Sci. USA by H Hochrein (2004)
  30. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148–1151 (2003) (10.1126/science.1081315) / Science by S Sharma (2003)
Dates
Type When
Created 19 years, 4 months ago (April 13, 2006, 8:37 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 1:54 p.m.)
Indexed 1 week ago (Aug. 30, 2025, 1:08 p.m.)
Issued 19 years, 5 months ago (April 1, 2006)
Published 19 years, 5 months ago (April 1, 2006)
Published Print 19 years, 5 months ago (April 1, 2006)
Funders 0

None

@article{Hoshino_2006, title={IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9}, volume={440}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature04641}, DOI={10.1038/nature04641}, number={7086}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Hoshino, Katsuaki and Sugiyama, Takahiro and Matsumoto, Mitsuru and Tanaka, Takashi and Saito, Masuyoshi and Hemmi, Hiroaki and Ohara, Osamu and Akira, Shizuo and Kaisho, Tsuneyasu}, year={2006}, month=apr, pages={949–953} }