DOI: 10.1038/nature04321. Lipid–protein interactions in double-layered two-dimensional AQP0 crystals

Lipid–protein interactions in double-layered two-dimensional AQP0 crystals

10.1038/nature04321

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Gonen, T., Cheng, Y., Sliz, P., Hiroaki, Y., Fujiyoshi, Y., Harrison, S. C., & Walz, T. (2005). Lipidâprotein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438(7068), 633â638.

Authors 7

Tamir Gonen (first)
Yifan Cheng (additional)
Piotr Sliz (additional)
Yoko Hiroaki (additional)
Yoshinori Fujiyoshi (additional)
Stephen C. Harrison (additional)
Thomas Walz (additional)

References 42 Referenced 583

Agre, P. et al. Aquaporin water channels—from atomic structure to clinical medicine. J. Physiol. (Lond.) 542, 3–16 (2002) (10.1113/jphysiol.2002.020818) / J. Physiol. (Lond.) by P Agre (2002)
Murata, K. et al. Structural determinants of water permeation through aquaporin-1. Nature 407, 599–605 (2000) (10.1038/35036519) / Nature by K Murata (2000)
Fu, D. et al. Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290, 481–486 (2000) (10.1126/science.290.5491.481) / Science by D Fu (2000)
Sui, H., Han, B. G., Lee, J. K., Walian, P. & Jap, B. K. Structural basis of water-specific transport through the AQP1 water channel. Nature 414, 872–878 (2001) (10.1038/414872a) / Nature by H Sui (2001)
Ren, G., Reddy, V. S., Cheng, A., Melnyk, P. & Mitra, A. K. Visualization of a water-selective pore by electron crystallography in vitreous ice. Proc. Natl Acad. Sci. USA 98, 1398–1403 (2001) (10.1073/pnas.98.4.1398) / Proc. Natl Acad. Sci. USA by G Ren (2001)
Savage, D. F., Egea, P. F., Robles-Colmenares, Y., O'Connell, J. D. & Stroud, R. M. Architecture and selectivity in aquaporins: 2.5 Å X-ray structure of aquaporin Z. PLoS Biol. 1, E72 (2003) (10.1371/journal.pbio.0000072) / PLoS Biol. by DF Savage (2003)
Gonen, T., Sliz, P., Kistler, J., Cheng, Y. & Walz, T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature 429, 193–197 (2004) (10.1038/nature02503) / Nature by T Gonen (2004)
Harries, W. E., Akhavan, D., Miercke, L. J., Khademi, S. & Stroud, R. M. The channel architecture of aquaporin 0 at a 2.2-Å resolution. Proc. Natl Acad. Sci. USA 101, 14045–14050 (2004) (10.1073/pnas.0405274101) / Proc. Natl Acad. Sci. USA by WE Harries (2004)
de Groot, B. L. & Grubmuller, H. The dynamics and energetics of water permeation and proton exclusion in aquaporins. Curr. Opin. Struct. Biol. 15, 176–183 (2005) (10.1016/j.sbi.2005.02.003) / Curr. Opin. Struct. Biol. by BL de Groot (2005)
Kistler, J. & Bullivant, S. Lens gap junctions and orthogonal arrays are unrelated. FEBS Lett. 111, 73–78 (1980) (10.1016/0014-5793(80)80764-2) / FEBS Lett. by J Kistler (1980)
Gonen, T., Cheng, Y., Kistler, J. & Walz, T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J. Mol. Biol. 342, 1337–1345 (2004) (10.1016/j.jmb.2004.07.076) / J. Mol. Biol. by T Gonen (2004)
Nemeth-Cahalan, K. L., Kalman, K. & Hall, J. E. Molecular basis of pH and Ca2+ regulation of aquaporin water permeability. J. Gen. Physiol. 123, 573–580 (2004) (10.1085/jgp.200308990) / J. Gen. Physiol. by KL Nemeth-Cahalan (2004)
Gyobu, N. et al. Improved specimen preparation for cryo-electron microscopy using a symmetric carbon sandwich technique. J. Struct. Biol. 146, 325–333 (2004) (10.1016/j.jsb.2004.01.012) / J. Struct. Biol. by N Gyobu (2004)
Fujiyoshi, Y. The structural study of membrane proteins by electron crystallography. Adv. Biophys. 35, 25–80 (1998) (10.1016/S0065-227X(98)80003-8) / Adv. Biophys. by Y Fujiyoshi (1998)
Brunger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905–921 (1998) (10.1107/S0907444998003254) / Acta Crystallogr. D Biol. Crystallogr. by AT Brunger (1998)
Roy, D., Spector, A. & Farnsworth, P. N. Human lens membrane: comparison of major intrinsic polypeptides from young and old lenses isolated by a new methodology. Exp. Eye Res. 28, 353–358 (1979) (10.1016/0014-4835(79)90097-6) / Exp. Eye Res. by D Roy (1979)
Takemoto, L., Takehana, M. & Horwitz, J. Covalent changes in MIP26K during aging of the human lens membrane. Invest. Ophthalmol. Vis. Sci. 27, 443–446 (1986) / Invest. Ophthalmol. Vis. Sci. by L Takemoto (1986)
Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. PROCHECK: a program to check the stereochemical qaulity of protein structures. J. Appl. Crystallogr. 26, 283–291 (1993) (10.1107/S0021889892009944) / J. Appl. Crystallogr. by RA Laskowski (1993)
Vriend, G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8, 526–529 (1990) / J. Mol. Graph. by G Vriend (1990)
Wang, Y., Schulten, K. & Tajkhorshid, E. What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure 13, 1107–1118 (2005) (10.1016/j.str.2005.05.005) / Structure by Y Wang (2005)
de Groot, B. L. & Grubmuller, H. Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science 294, 2353–2357 (2001) (10.1126/science.1062459) / Science by BL de Groot (2001)
Zhu, F., Tajkhorshid, E. & Schulten, K. Molecular dynamics study of aquaporin-1 water channel in a lipid bilayer. FEBS Lett. 504, 212–218 (2001) (10.1016/S0014-5793(01)02749-1) / FEBS Lett. by F Zhu (2001)
Tajkhorshid, E. et al. Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science 296, 525–530 (2002) (10.1126/science.1067778) / Science by E Tajkhorshid (2002)
Ball, L. E. et al. Water permeability of C-terminally truncated aquaporin 0 (AQP0 1–243) observed in the aging human lens. Invest. Ophthalmol. Vis. Sci. 44, 4820–4828 (2003) (10.1167/iovs.02-1317) / Invest. Ophthalmol. Vis. Sci. by LE Ball (2003)
Luecke, H., Schobert, B., Richter, H. T., Cartailler, J. P. & Lanyi, J. K. Structure of bacteriorhodopsin at 1.55 Å resolution. J. Mol. Biol. 291, 899–911 (1999) (10.1006/jmbi.1999.3027) / J. Mol. Biol. by H Luecke (1999)
Wiener, M. in Protein–Lipid Interactions: From Membrane Domains to Cellular Networks (ed. Tamm, L. K.) 29–49 (Wiley-VCH, Weinheim, 2005) / Protein–Lipid Interactions: From Membrane Domains to Cellular Networks by M Wiener (2005)
Dowhan, W. Molecular basis for membrane phospholipid diversity: why are there so many lipids? Annu. Rev. Biochem. 66, 199–232 (1997) (10.1146/annurev.biochem.66.1.199) / Annu. Rev. Biochem. by W Dowhan (1997)
Zampighi, G., Simon, S. A., Robertson, J. D., McIntosh, T. J. & Costello, M. J. On the structural organization of isolated bovine lens fiber junctions. J. Cell Biol. 93, 175–189 (1982) (10.1083/jcb.93.1.175) / J. Cell Biol. by G Zampighi (1982)
Kucerka, N. et al. Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. Biophys. J. 88, 2626–2637 (2005) (10.1529/biophysj.104.056606) / Biophys. J. by N Kucerka (2005)
Palsdottir, H. & Hunte, C. Lipids in membrane protein structures. Biochim. Biophys. Acta 1666, 2–18 (2004) (10.1016/j.bbamem.2004.06.012) / Biochim. Biophys. Acta by H Palsdottir (2004)
Schey, K. L., Little, M., Fowler, J. G. & Crouch, R. K. Characterization of human lens major intrinsic protein structure. Invest. Ophthalmol. Vis. Sci. 41, 175–182 (2000) / Invest. Ophthalmol. Vis. Sci. by KL Schey (2000)
Ball, L. E., Garland, D. L., Crouch, R. K. & Schey, K. L. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry 43, 9856–9865 (2004) (10.1021/bi0496034) / Biochemistry by LE Ball (2004)
Shiels, A. & Bassnett, S. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Nature Genet. 12, 212–215 (1996) (10.1038/ng0296-212) / Nature Genet. by A Shiels (1996)
Shiels, A., Mackay, D., Bassnett, S., Al-Ghoul, K. & Kuszak, J. Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein. FASEB J. 14, 2207–2212 (2000) (10.1096/fj.99-1071com) / FASEB J. by A Shiels (2000)
Francis, P. et al. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum. Mol. Genet. 9, 2329–2334 (2000) (10.1093/oxfordjournals.hmg.a018925) / Hum. Mol. Genet. by P Francis (2000)
Francis, P., Berry, V., Bhattacharya, S. & Moore, A. Congenital progressive polymorphic cataract caused by a mutation in the major intrinsic protein of the lens, MIP (AQP0). Br. J. Ophthalmol. 84, 1376–1379 (2000) (10.1136/bjo.84.12.1376) / Br. J. Ophthalmol. by P Francis (2000)
Okamura, T. et al. Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice. Genomics 81, 361–368 (2003) (10.1016/S0888-7543(03)00029-6) / Genomics by T Okamura (2003)
Chepelinsky, A. B. The ocular lens fiber membrane specific protein MIP/aquaporin 0. J. Exp. Zool. A 300, 41–46 (2003) (10.1002/jez.a.10307) / J. Exp. Zool. A by AB Chepelinsky (2003)
Lee, A. G. How lipids affect the activities of integral membrane proteins. Biochim. Biophys. Acta 1666, 62–87 (2004) (10.1016/j.bbamem.2004.05.012) / Biochim. Biophys. Acta by AG Lee (2004)
Jensen, M. O. & Mouritsen, O. G. Lipids do influence protein function—the hydrophobic matching hypothesis revisited. Biochim. Biophys. Acta 1666, 205–226 (2004) (10.1016/j.bbamem.2004.06.009) / Biochim. Biophys. Acta by MO Jensen (2004)
Mitsuoka, K. et al. The structure of bacteriorhodopsin at 3.0 Å resolution based on electron crystallography: implication of the charge distribution. J. Mol. Biol. 286, 861–882 (1999) (10.1006/jmbi.1998.2529) / J. Mol. Biol. by K Mitsuoka (1999)
Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991) (10.1107/S0108767390010224) / Acta Crystallogr. A by TA Jones (1991)

Dates

Type	When
Created	19 years, 8 months ago (Nov. 30, 2005, 1:43 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 1:51 p.m.)
Indexed	3 weeks, 3 days ago (July 28, 2025, 2:44 a.m.)
Issued	19 years, 8 months ago (Dec. 1, 2005)
Published	19 years, 8 months ago (Dec. 1, 2005)
Published Print	19 years, 8 months ago (Dec. 1, 2005)

Funders 0

None

BibTeX

@article{Gonen_2005, title={Lipid–protein interactions in double-layered two-dimensional AQP0 crystals}, volume={438}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature04321}, DOI={10.1038/nature04321}, number={7068}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Gonen, Tamir and Cheng, Yifan and Sliz, Piotr and Hiroaki, Yoko and Fujiyoshi, Yoshinori and Harrison, Stephen C. and Walz, Thomas}, year={2005}, month=dec, pages={633–638} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        28
      ]
    ],
    "date-time": "2025-07-28T06:44:53Z",
    "timestamp": 1753685093139
  },
  "reference-count": 42,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "7068",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            12,
            1
          ]
        ],
        "date-time": "2005-12-01T00:00:00Z",
        "timestamp": 1133395200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    },
    {
      "start": {
        "date-parts": [
          [
            2005,
            12,
            1
          ]
        ],
        "date-time": "2005-12-01T00:00:00Z",
        "timestamp": 1133395200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        12,
        1
      ]
    ]
  },
  "DOI": "10.1038/nature04321",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        11,
        30
      ]
    ],
    "date-time": "2005-11-30T18:43:00Z",
    "timestamp": 1133376180000
  },
  "page": "633-638",
  "source": "Crossref",
  "is-referenced-by-count": 583,
  "title": "Lipid\u2013protein interactions in double-layered two-dimensional AQP0 crystals",
  "prefix": "10.1038",
  "volume": "438",
  "author": [
    {
      "given": "Tamir",
      "family": "Gonen",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Yifan",
      "family": "Cheng",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Piotr",
      "family": "Sliz",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yoko",
      "family": "Hiroaki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yoshinori",
      "family": "Fujiyoshi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stephen C.",
      "family": "Harrison",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Thomas",
      "family": "Walz",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BFnature04321_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "3",
      "DOI": "10.1113/jphysiol.2002.020818",
      "volume": "542",
      "author": "P Agre",
      "year": "2002",
      "unstructured": "Agre, P. et al. Aquaporin water channels\u2014from atomic structure to clinical medicine. J. Physiol. (Lond.) 542, 3\u201316 (2002)",
      "journal-title": "J. Physiol. (Lond.)"
    },
    {
      "key": "BFnature04321_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "599",
      "DOI": "10.1038/35036519",
      "volume": "407",
      "author": "K Murata",
      "year": "2000",
      "unstructured": "Murata, K. et al. Structural determinants of water permeation through aquaporin-1. Nature 407, 599\u2013605 (2000)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature04321_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "481",
      "DOI": "10.1126/science.290.5491.481",
      "volume": "290",
      "author": "D Fu",
      "year": "2000",
      "unstructured": "Fu, D. et al. Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290, 481\u2013486 (2000)",
      "journal-title": "Science"
    },
    {
      "key": "BFnature04321_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "872",
      "DOI": "10.1038/414872a",
      "volume": "414",
      "author": "H Sui",
      "year": "2001",
      "unstructured": "Sui, H., Han, B. G., Lee, J. K., Walian, P. & Jap, B. K. Structural basis of water-specific transport through the AQP1 water channel. Nature 414, 872\u2013878 (2001)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature04321_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "1398",
      "DOI": "10.1073/pnas.98.4.1398",
      "volume": "98",
      "author": "G Ren",
      "year": "2001",
      "unstructured": "Ren, G., Reddy, V. S., Cheng, A., Melnyk, P. & Mitra, A. K. Visualization of a water-selective pore by electron crystallography in vitreous ice. Proc. Natl Acad. Sci. USA 98, 1398\u20131403 (2001)",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BFnature04321_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "E72",
      "DOI": "10.1371/journal.pbio.0000072",
      "volume": "1",
      "author": "DF Savage",
      "year": "2003",
      "unstructured": "Savage, D. F., Egea, P. F., Robles-Colmenares, Y., O'Connell, J. D. & Stroud, R. M. Architecture and selectivity in aquaporins: 2.5\u2009\u00c5 X-ray structure of aquaporin Z. PLoS Biol. 1, E72 (2003)",
      "journal-title": "PLoS Biol."
    },
    {
      "key": "BFnature04321_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "193",
      "DOI": "10.1038/nature02503",
      "volume": "429",
      "author": "T Gonen",
      "year": "2004",
      "unstructured": "Gonen, T., Sliz, P., Kistler, J., Cheng, Y. & Walz, T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature 429, 193\u2013197 (2004)",
      "journal-title": "Nature"
    },
    {
      "key": "BFnature04321_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "14045",
      "DOI": "10.1073/pnas.0405274101",
      "volume": "101",
      "author": "WE Harries",
      "year": "2004",
      "unstructured": "Harries, W. E., Akhavan, D., Miercke, L. J., Khademi, S. & Stroud, R. M. The channel architecture of aquaporin 0 at a 2.2-\u00c5 resolution. Proc. Natl Acad. Sci. USA 101, 14045\u201314050 (2004)",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BFnature04321_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "176",
      "DOI": "10.1016/j.sbi.2005.02.003",
      "volume": "15",
      "author": "BL de Groot",
      "year": "2005",
      "unstructured": "de Groot, B. L. & Grubmuller, H. The dynamics and energetics of water permeation and proton exclusion in aquaporins. Curr. Opin. Struct. Biol. 15, 176\u2013183 (2005)",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "BFnature04321_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "73",
      "DOI": "10.1016/0014-5793(80)80764-2",
      "volume": "111",
      "author": "J Kistler",
      "year": "1980",
      "unstructured": "Kistler, J. & Bullivant, S. Lens gap junctions and orthogonal arrays are unrelated. FEBS Lett. 111, 73\u201378 (1980)",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "BFnature04321_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "1337",
      "DOI": "10.1016/j.jmb.2004.07.076",
      "volume": "342",
      "author": "T Gonen",
      "year": "2004",
      "unstructured": "Gonen, T., Cheng, Y., Kistler, J. & Walz, T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J. Mol. Biol. 342, 1337\u20131345 (2004)",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BFnature04321_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "573",
      "DOI": "10.1085/jgp.200308990",
      "volume": "123",
      "author": "KL Nemeth-Cahalan",
      "year": "2004",
      "unstructured": "Nemeth-Cahalan, K. L., Kalman, K. & Hall, J. E. Molecular basis of pH and Ca2+ regulation of aquaporin water permeability. J. Gen. Physiol. 123, 573\u2013580 (2004)",
      "journal-title": "J. Gen. Physiol."
    },
    {
      "key": "BFnature04321_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "325",
      "DOI": "10.1016/j.jsb.2004.01.012",
      "volume": "146",
      "author": "N Gyobu",
      "year": "2004",
      "unstructured": "Gyobu, N. et al. Improved specimen preparation for cryo-electron microscopy using a symmetric carbon sandwich technique. J. Struct. Biol. 146, 325\u2013333 (2004)",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "BFnature04321_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "25",
      "DOI": "10.1016/S0065-227X(98)80003-8",
      "volume": "35",
      "author": "Y Fujiyoshi",
      "year": "1998",
      "unstructured": "Fujiyoshi, Y. The structural study of membrane proteins by electron crystallography. Adv. Biophys. 35, 25\u201380 (1998)",
      "journal-title": "Adv. Biophys."
    },
    {
      "key": "BFnature04321_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "volume": "54",
      "author": "AT Brunger",
      "year": "1998",
      "unstructured": "Brunger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905\u2013921 (1998)",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "BFnature04321_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "353",
      "DOI": "10.1016/0014-4835(79)90097-6",
      "volume": "28",
      "author": "D Roy",
      "year": "1979",
      "unstructured": "Roy, D., Spector, A. & Farnsworth, P. N. Human lens membrane: comparison of major intrinsic polypeptides from young and old lenses isolated by a new methodology. Exp. Eye Res. 28, 353\u2013358 (1979)",
      "journal-title": "Exp. Eye Res."
    },
    {
      "key": "BFnature04321_CR17",
      "first-page": "443",
      "volume": "27",
      "author": "L Takemoto",
      "year": "1986",
      "unstructured": "Takemoto, L., Takehana, M. & Horwitz, J. Covalent changes in MIP26K during aging of the human lens membrane. Invest. Ophthalmol. Vis. Sci. 27, 443\u2013446 (1986)",
      "journal-title": "Invest. Ophthalmol. Vis. Sci."
    },
    {
      "key": "BFnature04321_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "283",
      "DOI": "10.1107/S0021889892009944",
      "volume": "26",
      "author": "RA Laskowski",
      "year": "1993",
      "unstructured": "Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. PROCHECK: a program to check the stereochemical qaulity of protein structures. J. Appl. Crystallogr. 26, 283\u2013291 (1993)",
      "journal-title": "J. Appl. Crystallogr."
    },
    {
      "key": "BFnature04321_CR19",
      "first-page": "526",
      "volume": "8",
      "author": "G Vriend",
      "year": "1990",
      "unstructured": "Vriend, G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8, 526\u2013529 (1990)",
      "journal-title": "J. Mol. Graph."
    },
    {
      "key": "BFnature04321_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "1107",
      "DOI": "10.1016/j.str.2005.05.005",
      "volume": "13",
      "author": "Y Wang",
      "year": "2005",
      "unstructured": "Wang, Y., Schulten, K. & Tajkhorshid, E. What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure 13, 1107\u20131118 (2005)",
      "journal-title": "Structure"
    },
    {
      "key": "BFnature04321_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "2353",
      "DOI": "10.1126/science.1062459",
      "volume": "294",
      "author": "BL de Groot",
      "year": "2001",
      "unstructured": "de Groot, B. L. & Grubmuller, H. Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science 294, 2353\u20132357 (2001)",
      "journal-title": "Science"
    },
    {
      "key": "BFnature04321_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "212",
      "DOI": "10.1016/S0014-5793(01)02749-1",
      "volume": "504",
      "author": "F Zhu",
      "year": "2001",
      "unstructured": "Zhu, F., Tajkhorshid, E. & Schulten, K. Molecular dynamics study of aquaporin-1 water channel in a lipid bilayer. FEBS Lett. 504, 212\u2013218 (2001)",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "BFnature04321_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "525",
      "DOI": "10.1126/science.1067778",
      "volume": "296",
      "author": "E Tajkhorshid",
      "year": "2002",
      "unstructured": "Tajkhorshid, E. et al. Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science 296, 525\u2013530 (2002)",
      "journal-title": "Science"
    },
    {
      "key": "BFnature04321_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "4820",
      "DOI": "10.1167/iovs.02-1317",
      "volume": "44",
      "author": "LE Ball",
      "year": "2003",
      "unstructured": "Ball, L. E. et al. Water permeability of C-terminally truncated aquaporin 0 (AQP0 1\u2013243) observed in the aging human lens. Invest. Ophthalmol. Vis. Sci. 44, 4820\u20134828 (2003)",
      "journal-title": "Invest. Ophthalmol. Vis. Sci."
    },
    {
      "key": "BFnature04321_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "899",
      "DOI": "10.1006/jmbi.1999.3027",
      "volume": "291",
      "author": "H Luecke",
      "year": "1999",
      "unstructured": "Luecke, H., Schobert, B., Richter, H. T., Cartailler, J. P. & Lanyi, J. K. Structure of bacteriorhodopsin at 1.55\u2009\u00c5 resolution. J. Mol. Biol. 291, 899\u2013911 (1999)",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BFnature04321_CR26",
      "first-page": "29",
      "volume-title": "Protein\u2013Lipid Interactions: From Membrane Domains to Cellular Networks",
      "author": "M Wiener",
      "year": "2005",
      "unstructured": "Wiener, M. in Protein\u2013Lipid Interactions: From Membrane Domains to Cellular Networks (ed. Tamm, L. K.) 29\u201349 (Wiley-VCH, Weinheim, 2005)"
    },
    {
      "key": "BFnature04321_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "199",
      "DOI": "10.1146/annurev.biochem.66.1.199",
      "volume": "66",
      "author": "W Dowhan",
      "year": "1997",
      "unstructured": "Dowhan, W. Molecular basis for membrane phospholipid diversity: why are there so many lipids? Annu. Rev. Biochem. 66, 199\u2013232 (1997)",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "BFnature04321_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "175",
      "DOI": "10.1083/jcb.93.1.175",
      "volume": "93",
      "author": "G Zampighi",
      "year": "1982",
      "unstructured": "Zampighi, G., Simon, S. A., Robertson, J. D., McIntosh, T. J. & Costello, M. J. On the structural organization of isolated bovine lens fiber junctions. J. Cell Biol. 93, 175\u2013189 (1982)",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "BFnature04321_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "2626",
      "DOI": "10.1529/biophysj.104.056606",
      "volume": "88",
      "author": "N Kucerka",
      "year": "2005",
      "unstructured": "Kucerka, N. et al. Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. Biophys. J. 88, 2626\u20132637 (2005)",
      "journal-title": "Biophys. J."
    },
    {
      "key": "BFnature04321_CR30",
      "doi-asserted-by": "publisher",
      "first-page": "2",
      "DOI": "10.1016/j.bbamem.2004.06.012",
      "volume": "1666",
      "author": "H Palsdottir",
      "year": "2004",
      "unstructured": "Palsdottir, H. & Hunte, C. Lipids in membrane protein structures. Biochim. Biophys. Acta 1666, 2\u201318 (2004)",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "BFnature04321_CR31",
      "first-page": "175",
      "volume": "41",
      "author": "KL Schey",
      "year": "2000",
      "unstructured": "Schey, K. L., Little, M., Fowler, J. G. & Crouch, R. K. Characterization of human lens major intrinsic protein structure. Invest. Ophthalmol. Vis. Sci. 41, 175\u2013182 (2000)",
      "journal-title": "Invest. Ophthalmol. Vis. Sci."
    },
    {
      "key": "BFnature04321_CR32",
      "doi-asserted-by": "publisher",
      "first-page": "9856",
      "DOI": "10.1021/bi0496034",
      "volume": "43",
      "author": "LE Ball",
      "year": "2004",
      "unstructured": "Ball, L. E., Garland, D. L., Crouch, R. K. & Schey, K. L. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry 43, 9856\u20139865 (2004)",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BFnature04321_CR33",
      "doi-asserted-by": "publisher",
      "first-page": "212",
      "DOI": "10.1038/ng0296-212",
      "volume": "12",
      "author": "A Shiels",
      "year": "1996",
      "unstructured": "Shiels, A. & Bassnett, S. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Nature Genet. 12, 212\u2013215 (1996)",
      "journal-title": "Nature Genet."
    },
    {
      "key": "BFnature04321_CR34",
      "doi-asserted-by": "publisher",
      "first-page": "2207",
      "DOI": "10.1096/fj.99-1071com",
      "volume": "14",
      "author": "A Shiels",
      "year": "2000",
      "unstructured": "Shiels, A., Mackay, D., Bassnett, S., Al-Ghoul, K. & Kuszak, J. Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein. FASEB J. 14, 2207\u20132212 (2000)",
      "journal-title": "FASEB J."
    },
    {
      "key": "BFnature04321_CR35",
      "doi-asserted-by": "publisher",
      "first-page": "2329",
      "DOI": "10.1093/oxfordjournals.hmg.a018925",
      "volume": "9",
      "author": "P Francis",
      "year": "2000",
      "unstructured": "Francis, P. et al. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum. Mol. Genet. 9, 2329\u20132334 (2000)",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "BFnature04321_CR36",
      "doi-asserted-by": "publisher",
      "first-page": "1376",
      "DOI": "10.1136/bjo.84.12.1376",
      "volume": "84",
      "author": "P Francis",
      "year": "2000",
      "unstructured": "Francis, P., Berry, V., Bhattacharya, S. & Moore, A. Congenital progressive polymorphic cataract caused by a mutation in the major intrinsic protein of the lens, MIP (AQP0). Br. J. Ophthalmol. 84, 1376\u20131379 (2000)",
      "journal-title": "Br. J. Ophthalmol."
    },
    {
      "key": "BFnature04321_CR37",
      "doi-asserted-by": "publisher",
      "first-page": "361",
      "DOI": "10.1016/S0888-7543(03)00029-6",
      "volume": "81",
      "author": "T Okamura",
      "year": "2003",
      "unstructured": "Okamura, T. et al. Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice. Genomics 81, 361\u2013368 (2003)",
      "journal-title": "Genomics"
    },
    {
      "key": "BFnature04321_CR38",
      "doi-asserted-by": "publisher",
      "first-page": "41",
      "DOI": "10.1002/jez.a.10307",
      "volume": "300",
      "author": "AB Chepelinsky",
      "year": "2003",
      "unstructured": "Chepelinsky, A. B. The ocular lens fiber membrane specific protein MIP/aquaporin 0. J. Exp. Zool. A 300, 41\u201346 (2003)",
      "journal-title": "J. Exp. Zool. A"
    },
    {
      "key": "BFnature04321_CR39",
      "doi-asserted-by": "publisher",
      "first-page": "62",
      "DOI": "10.1016/j.bbamem.2004.05.012",
      "volume": "1666",
      "author": "AG Lee",
      "year": "2004",
      "unstructured": "Lee, A. G. How lipids affect the activities of integral membrane proteins. Biochim. Biophys. Acta 1666, 62\u201387 (2004)",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "BFnature04321_CR40",
      "doi-asserted-by": "publisher",
      "first-page": "205",
      "DOI": "10.1016/j.bbamem.2004.06.009",
      "volume": "1666",
      "author": "MO Jensen",
      "year": "2004",
      "unstructured": "Jensen, M. O. & Mouritsen, O. G. Lipids do influence protein function\u2014the hydrophobic matching hypothesis revisited. Biochim. Biophys. Acta 1666, 205\u2013226 (2004)",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "BFnature04321_CR41",
      "doi-asserted-by": "publisher",
      "first-page": "861",
      "DOI": "10.1006/jmbi.1998.2529",
      "volume": "286",
      "author": "K Mitsuoka",
      "year": "1999",
      "unstructured": "Mitsuoka, K. et al. The structure of bacteriorhodopsin at 3.0\u2009\u00c5 resolution based on electron crystallography: implication of the charge distribution. J. Mol. Biol. 286, 861\u2013882 (1999)",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BFnature04321_CR42",
      "doi-asserted-by": "publisher",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "volume": "47",
      "author": "TA Jones",
      "year": "1991",
      "unstructured": "Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110\u2013119 (1991)",
      "journal-title": "Acta Crystallogr. A"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/nature04321.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature04321",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/nature04321.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        18
      ]
    ],
    "date-time": "2023-05-18T17:51:30Z",
    "timestamp": 1684432290000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/nature04321"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        12,
        1
      ]
    ]
  },
  "references-count": 42,
  "journal-issue": {
    "issue": "7068",
    "published-print": {
      "date-parts": [
        [
          2005,
          12,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "BFnature04321"
  ],
  "URL": "http://dx.doi.org/10.1038/nature04321",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1029502.346566",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1029502.344452",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1029502.346423",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        2005,
        12,
        1
      ]
    ]
  }
}