Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., Kletsas, D., Yoneta, A., Herlyn, M., Kittas, C., & Halazonetis, T. D. (2005). Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 434(7035), 907–913.

Authors 15
  1. Vassilis G. Gorgoulis (first)
  2. Leandros-Vassilios F. Vassiliou (additional)
  3. Panagiotis Karakaidos (additional)
  4. Panayotis Zacharatos (additional)
  5. Athanassios Kotsinas (additional)
  6. Triantafillos Liloglou (additional)
  7. Monica Venere (additional)
  8. Richard A. DiTullio (additional)
  9. Nikolaos G. Kastrinakis (additional)
  10. Brynn Levy (additional)
  11. Dimitris Kletsas (additional)
  12. Akihiro Yoneta (additional)
  13. Meenhard Herlyn (additional)
  14. Christos Kittas (additional)
  15. Thanos D. Halazonetis (additional)
References 30 Referenced 1,648
  1. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C. C. p53 mutations in human cancers. Science 253, 49–53 (1991) (10.1126/science.1905840) / Science by M Hollstein (1991)
  2. Kastan, M. B. & Bartek, J. Cell-cycle checkpoints and cancer. Nature 432, 316–323 (2004) (10.1038/nature03097) / Nature by MB Kastan (2004)
  3. Halazonetis, T. D. Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer. DNA Repair (Amst.) 3, 1057–1062 (2004) (10.1016/j.dnarep.2004.03.036) / DNA Repair (Amst.) by TD Halazonetis (2004)
  4. Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549–1556 (2003) (10.1016/S0960-9822(03)00542-6) / Curr. Biol. by H Takai (2003)
  5. d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194–198 (2003) (10.1038/nature02118) / Nature by F d'Adda di Fagagna (2003)
  6. Graeber, T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88–91 (1996) (10.1038/379088a0) / Nature by TG Graeber (1996)
  7. Gorgoulis, V. G. et al. Alterations of the p16-pRb pathway and the chromosome locus 9p21–22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. Am. J. Pathol. 153, 1749–1765 (1998) (10.1016/S0002-9440(10)65690-8) / Am. J. Pathol. by VG Gorgoulis (1998)
  8. Karakaidos, P. et al. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability—evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165, 1351–1365 (2004) (10.1016/S0002-9440(10)63393-7) / Am. J. Pathol. by P Karakaidos (2004)
  9. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304–6311 (1991) / Cancer Res. by MB Kastan (1991)
  10. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858–5868 (1998) (10.1074/jbc.273.10.5858) / J. Biol. Chem. by EP Rogakou (1998)
  11. Bartek, J. & Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421–429 (2003) (10.1016/S1535-6108(03)00110-7) / Cancer Cell by J Bartek (2003)
  12. Schultz, L. B., Chehab, N. H., Malikzay, A. & Halazonetis, T. D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151, 1381–1390 (2000) (10.1083/jcb.151.7.1381) / J. Cell Biol. by LB Schultz (2000)
  13. Mochan, T. A., Venere, M., DiTullio, R. A. Jr & Halazonetis, T. D. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 63, 8586–8591 (2003) / Cancer Res. by TA Mochan (2003)
  14. Huyen, Y. et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406–411 (2004) (10.1038/nature03114) / Nature by Y Huyen (2004)
  15. DiTullio, R. A. Jr et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biol. 4, 998–1002 (2002) (10.1038/ncb892) / Nature Cell Biol. by RA DiTullio Jr (2002)
  16. Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature doi:10.1038/nature03482 (this issue) (10.1038/nature03482)
  17. Berking, C. et al. Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B. Cancer Res. 64, 807–811 (2004) (10.1158/0008-5472.CAN-03-3438) / Cancer Res. by C Berking (2004)
  18. Spruck, C. H., Won, K. A. & Reed, S. I. Deregulated cyclin E induces chromosome instability. Nature 401, 297–300 (1999) (10.1038/45836) / Nature by CH Spruck (1999)
  19. Lengronne, A. & Schwob, E. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G1. Mol. Cell 9, 1067–1078 (2002) (10.1016/S1097-2765(02)00513-0) / Mol. Cell by A Lengronne (2002)
  20. Tanaka, S. & Diffley, J. F. Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev. 16, 2639–2649 (2002) (10.1101/gad.1011002) / Genes Dev. by S Tanaka (2002)
  21. Vaziri, C. et al. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell 11, 997–1008 (2003) (10.1016/S1097-2765(03)00099-6) / Mol. Cell by C Vaziri (2003)
  22. Ekholm-Reed, S. et al. Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J. Cell Biol. 165, 789–800 (2004) (10.1083/jcb.200404092) / J. Cell Biol. by S Ekholm-Reed (2004)
  23. Tibbetts, R. S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989–3002 (2000) (10.1101/gad.851000) / Genes Dev. by RS Tibbetts (2000)
  24. Cortez, D., Guntuku, S., Qin, J. & Elledge, S. J. ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713–1716 (2001) (10.1126/science.1065521) / Science by D Cortez (2001)
  25. MacPail, S. H., Banath, J. P., Yu, Y., Chu, E. & Olive, P. L. Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-irradiated G1-phase cells. Radiat. Res. 159, 759–767 (2003) (10.1667/RR3003) / Radiat. Res. by SH MacPail (2003)
  26. Arlt, M. F., Casper, A. M. & Glover, T. W. Common fragile sites. Cytogenet. Genome Res. 100, 92–100 (2003) (10.1159/000072843) / Cytogenet. Genome Res. by MF Arlt (2003)
  27. Casper, A. M., Nghiem, P., Arlt, M. F. & Glover, T. W. ATR regulates fragile site stability. Cell 111, 779–789 (2002) (10.1016/S0092-8674(02)01113-3) / Cell by AM Casper (2002)
  28. Mao, L. et al. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nature Med. 2, 682–685 (1996) (10.1038/nm0696-682) / Nature Med. by L Mao (1996)
  29. Wistuba, I. I. et al. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res. 60, 1949–1960 (2000) / Cancer Res. by II Wistuba (2000)
  30. Maitra, A. et al. High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss. Am. J. Pathol. 159, 119–130 (2001) (10.1016/S0002-9440(10)61679-3) / Am. J. Pathol. by A Maitra (2001)
Dates
Type When
Created 20 years, 4 months ago (April 13, 2005, 3:38 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 1:44 p.m.)
Indexed 1 hour, 3 minutes ago (Aug. 27, 2025, 11:51 a.m.)
Issued 20 years, 4 months ago (April 1, 2005)
Published 20 years, 4 months ago (April 1, 2005)
Published Print 20 years, 4 months ago (April 1, 2005)
Funders 0

None

@article{Gorgoulis_2005, title={Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions}, volume={434}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature03485}, DOI={10.1038/nature03485}, number={7035}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Gorgoulis, Vassilis G. and Vassiliou, Leandros-Vassilios F. and Karakaidos, Panagiotis and Zacharatos, Panayotis and Kotsinas, Athanassios and Liloglou, Triantafillos and Venere, Monica and DiTullio, Richard A. and Kastrinakis, Nikolaos G. and Levy, Brynn and Kletsas, Dimitris and Yoneta, Akihiro and Herlyn, Meenhard and Kittas, Christos and Halazonetis, Thanos D.}, year={2005}, month=apr, pages={907–913} }