DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
10.1038/nature03482
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., Ørntoft, T., Lukas, J., & Bartek, J. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434(7035), 864–870.

Authors 13
  1. Jirina Bartkova (first)
  2. Zuzana Hořejší (additional)
  3. Karen Koed (additional)
  4. Alwin Krämer (additional)
  5. Frederic Tort (additional)
  6. Karsten Zieger (additional)
  7. Per Guldberg (additional)
  8. Maxwell Sehested (additional)
  9. Jahn M. Nesland (additional)
  10. Claudia Lukas (additional)
  11. Torben Ørntoft (additional)
  12. Jiri Lukas (additional)
  13. Jiri Bartek (additional)
References 50 Referenced 2,200
  1. Lowe, S. W., Cepero, E. & Evan, G. I. Intrinsic tumour suppression. Nature 432, 307–315 (2004) (10.1038/nature03098) / Nature by SW Lowe (2004)
  2. Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643–649 (1998) (10.1038/25292) / Nature by C Lengauer (1998)
  3. Graeber, T. G. et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264–6277 (1994) (10.1128/MCB.14.9.6264) / Mol. Cell. Biol. by TG Graeber (1994)
  4. Counter, C. M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921–1929 (1992) (10.1002/j.1460-2075.1992.tb05245.x) / EMBO J. by CM Counter (1992)
  5. Zindy, F. et al. Arf tumour suppressor promoter monitors latent oncogenic signals in vivo . Proc. Natl Acad. Sci. USA 100, 15930–15935 (2003) (10.1073/pnas.2536808100) / Proc. Natl Acad. Sci. USA by F Zindy (2003)
  6. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000) (10.1038/35042675) / Nature by B Vogelstein (2000)
  7. DiTullio, R. A. Jr et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biol. 4, 998–1002 (2002) (10.1038/ncb892) / Nature Cell Biol. by RA DiTullio Jr (2002)
  8. Lukas, C., Falck, J., Bartkova, J., Bartek, J. & Lukas, J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biol. 5, 255–260 (2003) (10.1038/ncb945) / Nature Cell Biol. by C Lukas (2003)
  9. Kastan, M. B. & Bartek, J. Cell-cycle checkpoints and cancer. Nature 432, 316–323 (2004) (10.1038/nature03097) / Nature by MB Kastan (2004)
  10. Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nature Rev. Cancer 3, 155–168 (2003) (10.1038/nrc1011) / Nature Rev. Cancer by Y Shiloh (2003)
  11. Vafa, O. et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell 9, 1031–1044 (2002) (10.1016/S1097-2765(02)00520-8) / Mol. Cell by O Vafa (2002)
  12. Lindström, M. S. & Wiman, K. G. Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts. Oncogene 22, 4993–5005 (2003) (10.1038/sj.onc.1206659) / Oncogene by MS Lindström (2003)
  13. Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499–506 (2003) (10.1038/nature01368) / Nature by CJ Bakkenist (2003)
  14. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858–5868 (1998) (10.1074/jbc.273.10.5858) / J. Biol. Chem. by EP Rogakou (1998)
  15. Lindblad-Toh, K. et al. Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nature Biotechnol. 18, 1001–1005 (2000) (10.1038/79269) / Nature Biotechnol. by K Lindblad-Toh (2000)
  16. Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancercous lesions. Nature doi:10.1038/nature03485 (this issue) (10.1038/nature03485)
  17. Spruck, C. H., Won, K. A. & Reed, S. I. Deregulated cyclin E induces chromosome instability. Nature 401, 297–300 (1999) (10.1038/45836) / Nature by CH Spruck (1999)
  18. Minella, A. C. et al. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr. Biol. 12, 1817–1827 (2002) (10.1016/S0960-9822(02)01225-3) / Curr. Biol. by AC Minella (2002)
  19. Ekholm-Reed, S. et al. Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J. Cell Biol. 165, 789–800 (2004) (10.1083/jcb.200404092) / J. Cell Biol. by S Ekholm-Reed (2004)
  20. Reed, S. E. et al. Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer. Cancer Res. 64, 795–800 (2004) (10.1158/0008-5472.CAN-03-3417) / Cancer Res. by SE Reed (2004)
  21. Rajagopalan, H. et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 428, 77–81 (2004) (10.1038/nature02313) / Nature by H Rajagopalan (2004)
  22. Kim, S. T., Xu, B. & Kastan, M. B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16, 560–570 (2002) (10.1101/gad.970602) / Genes Dev. by ST Kim (2002)
  23. Ward, I. M. & Chen, J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276, 47759–47762 (2001) (10.1074/jbc.C100569200) / J. Biol. Chem. by IM Ward (2001)
  24. Mailand, N. et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425–1429 (2000) (10.1126/science.288.5470.1425) / Science by N Mailand (2000)
  25. Cangi, M. G. et al. Role of the Cdc25A phosphatase in human breast cancer. J. Clin. Invest. 106, 753–761 (2000) (10.1172/JCI9174) / J. Clin. Invest. by MG Cangi (2000)
  26. Müller, H. et al. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15, 267–285 (2001) (10.1101/gad.864201) / Genes Dev. by H Müller (2001)
  27. Bartek, J., Bartkova, J. & Lukas, J. The retinoblastoma protein pathway in cell cycle control and cancer. Exp. Cell Res. 237, 1–6 (1997) (10.1006/excr.1997.3776) / Exp. Cell Res. by J Bartek (1997)
  28. Zhao, H. & Piwnica-Worms, H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129–4139 (2001) (10.1128/MCB.21.13.4129-4139.2001) / Mol. Cell. Biol. by H Zhao (2001)
  29. Gatei, M. et al. ATM and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278, 14806–14811 (2003) (10.1074/jbc.M210862200) / J. Biol. Chem. by M Gatei (2003)
  30. Bao, S. et al. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411, 969–974 (2001) (10.1038/35082110) / Nature by S Bao (2001)
  31. Resnitzky, D., Gossen, M., Bujard, H. & Reed, S. I. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14, 1669–1679 (1994) (10.1128/MCB.14.3.1669) / Mol. Cell. Biol. by D Resnitzky (1994)
  32. Santoni-Rugiu, E., Falck, J., Mailand, N., Bartek, J. & Lukas, J. Involvement of Myc activity in a G1/S-promoting mechanism parallel to the pRB/E2F pathway. Mol. Cell. Biol. 20, 3497–3509 (2000) (10.1128/MCB.20.10.3497-3509.2000) / Mol. Cell. Biol. by E Santoni-Rugiu (2000)
  33. Bartek, J., Lukas, C. & Lukas, J. Checking on DNA damage in S phase. Nature Rev. Mol. Cell Biol. 5, 792–804 (2004) (10.1038/nrm1493) / Nature Rev. Mol. Cell Biol. by J Bartek (2004)
  34. Lew, D. J. & Kornbluth, S. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr. Opin. Cell Biol. 8, 795–804 (1996) (10.1016/S0955-0674(96)80080-9) / Curr. Opin. Cell Biol. by DJ Lew (1996)
  35. Merrick, C. J., Jackson, D. & Diffley, J. F. X. Visualization of altered replication dynamics after DNA damage in human cells. J. Biol. Chem. 279, 20067–20075 (2004) (10.1074/jbc.M400022200) / J. Biol. Chem. by CJ Merrick (2004)
  36. Zou, L. & Elledge, S. J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542–1548 (2003) (10.1126/science.1083430) / Science by L Zou (2003)
  37. Binz, S. K., Sheehan, A. M. & Wold, M. S. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst.) 3, 1015–1024 (2004) (10.1016/j.dnarep.2004.03.028) / DNA Repair (Amst.) by SK Binz (2004)
  38. Walter, J. & Newport, J. Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA and DNA polymerase α. Mol. Cell 5, 617–627 (2000) (10.1016/S1097-2765(00)80241-5) / Mol. Cell by J Walter (2000)
  39. Osborn, A. J., Elledge, S. J. & Zou, L. Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12, 509–516 (2002) (10.1016/S0962-8924(02)02380-2) / Trends Cell Biol. by AJ Osborn (2002)
  40. Tanaka, S. & Diffley, J. F. Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev. 16, 2639–2649 (2002) (10.1101/gad.1011002) / Genes Dev. by S Tanaka (2002)
  41. Lengronne, A. & Schwob, E. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G1. Mol. Cell 9, 1067–1078 (2002) (10.1016/S1097-2765(02)00513-0) / Mol. Cell by A Lengronne (2002)
  42. Hart, K. C. et al. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19, 3309–3320 (2000) (10.1038/sj.onc.1203650) / Oncogene by KC Hart (2000)
  43. Casper, A. M., Nghiem, P., Arlt, M. F. & Glover, T. W. ATR regulates fragile site stability. Cell 111, 779–789 (2002) (10.1016/S0092-8674(02)01113-3) / Cell by AM Casper (2002)
  44. Rogoff, H. A. et al. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol. Cell. Biol. 24, 2968–2977 (2004) (10.1128/MCB.24.7.2968-2977.2004) / Mol. Cell. Biol. by HA Rogoff (2004)
  45. Lomonosov, M., Anand, S., Sangrithi, M., Davies, R. & Venkitaraman, A. R. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev. 17, 3017–3022 (2003) (10.1101/gad.279003) / Genes Dev. by M Lomonosov (2003)
  46. Meeker, A. K. et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin. Cancer Res. 10, 3317–3326 (2004) (10.1158/1078-0432.CCR-0984-03) / Clin. Cancer Res. by AK Meeker (2004)
  47. Chin, K. et al. In situ analyses of genome instability in breast cancer. Nature Genet. 36, 984–988 (2004) (10.1038/ng1409) / Nature Genet. by K Chin (2004)
  48. d'Adda di Fagagna, F. et al. DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194–198 (2003) (10.1038/nature02118) / Nature by F d'Adda di Fagagna (2003)
  49. Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549–1556 (2003) (10.1016/S0960-9822(03)00542-6) / Curr. Biol. by H Takai (2003)
  50. Eddy, S. R. Profile hidden Markov models. Bioinformatics 14, 755–763 (1998) (10.1093/bioinformatics/14.9.755) / Bioinformatics by SR Eddy (1998)
Dates
Type When
Created 20 years, 4 months ago (April 13, 2005, 3:38 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 1:44 p.m.)
Indexed 3 days, 3 hours ago (Aug. 22, 2025, 12:46 a.m.)
Issued 20 years, 4 months ago (April 1, 2005)
Published 20 years, 4 months ago (April 1, 2005)
Published Print 20 years, 4 months ago (April 1, 2005)
Funders 0

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@article{Bartkova_2005, title={DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis}, volume={434}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature03482}, DOI={10.1038/nature03482}, number={7035}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Bartkova, Jirina and Hořejší, Zuzana and Koed, Karen and Krämer, Alwin and Tort, Frederic and Zieger, Karsten and Guldberg, Per and Sehested, Maxwell and Nesland, Jahn M. and Lukas, Claudia and Ørntoft, Torben and Lukas, Jiri and Bartek, Jiri}, year={2005}, month=apr, pages={864–870} }