DOI: 10.1038/nature03232. Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

10.1038/nature03232

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Alvarez-Vasquez, F., Sims, K. J., Cowart, L. A., Okamoto, Y., Voit, E. O., & Hannun, Y. A. (2005). Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature, 433(7024), 425â430.

Authors 6

Fernando Alvarez-Vasquez (first)
Kellie J. Sims (additional)
L. Ashley Cowart (additional)
Yasuo Okamoto (additional)
Eberhard O. Voit (additional)
Yusuf A. Hannun (additional)

References 26 Referenced 137

Heinrich, R. & Schuster, S. The Regulation of Cellular Systems (Chapman and Hall, New York, 1996) (10.1007/978-1-4613-1161-4) / The Regulation of Cellular Systems by R Heinrich (1996)
Schilling, C. H., Edwards, J. S., Letscher, D. & Palsson, B. O. Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems. Biotechnol. Bioeng. 71, 286–306 (2000) (10.1002/1097-0290(2000)71:4<286::AID-BIT1018>3.0.CO;2-R) / Biotechnol. Bioeng. by CH Schilling (2000)
Mulquiney, P. J. & Kuchel, P. W. Modeling Metabolism with Mathematica: Analysis of Human Erythrocyte Metabolism (CRC Press, Boca Raton, Florida, 2003) (10.1201/9780203503935) / Modeling Metabolism with Mathematica: Analysis of Human Erythrocyte Metabolism by PJ Mulquiney (2003)
Fell, D. A. Understanding the Control of Metabolism (Portland, London, 1997) / Understanding the Control of Metabolism by DA Fell (1997)
Savageau, M. A. Biochemical systems analysis. J. Theor. Biol. 25, 365–379 (1969) (10.1016/S0022-5193(69)80026-3) / J. Theor. Biol. by MA Savageau (1969)
Savageau, M. A. Biochemical Systems Analysis. A Study of Function and Design in Molecular Biology (Addison-Wesley, Reading, Massachusetts, 1976) / Biochemical Systems Analysis. A Study of Function and Design in Molecular Biology by MA Savageau (1976)
Voit, E. O. Computational Analysis of Biochemical Systems. A Practical Guide for Biochemists and Molecular Biologists (Cambridge Univ. Press, Cambridge, 2000) / Computational Analysis of Biochemical Systems. A Practical Guide for Biochemists and Molecular Biologists by EO Voit (2000)
Alvarez-Vasquez, F., Sims, K. J., Hannun, Y. A. & Voit, E. O. Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models. J. Theor. Biol. 226, 265–291 (2004) (10.1016/j.jtbi.2003.08.010) / J. Theor. Biol. by F Alvarez-Vasquez (2004)
Hannun, Y. Functions of ceramide in coordinating cellular responses in stress. Science 274, 1855–1859 (1996) (10.1126/science.274.5294.1855) / Science by Y Hannun (1996)
Hannun, Y. A. & Obeid, L. M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277, 25847–25850 (2002) (10.1074/jbc.R200008200) / J. Biol. Chem. by YA Hannun (2002)
Spiegel, S. & Milstien, S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nature Rev. Mol. Cell Biol. 4, 397–407 (2003) (10.1038/nrm1103) / Nature Rev. Mol. Cell Biol. by S Spiegel (2003)
Hannun, Y. A., Luberto, C. & Argraves, K. M. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40, 4893–4903 (2001) (10.1021/bi002836k) / Biochemistry by YA Hannun (2001)
Sims, K. J., Spassieva, S. D., Voit, E. O. & Obeid, L. M. Yeast sphingolipid metabolism: clues and connections. Biochem. Cell Biol. 82, 45–61 (2004) (10.1139/o03-086) / Biochem. Cell Biol. by KJ Sims (2004)
Voit, E. O., Alvarez-Vasquez, F. & Sims, K. J. Analysis of dynamic labeling data. Math. Biosci. 191, 83–99 (2004) (10.1016/j.mbs.2004.04.004) / Math. Biosci. by EO Voit (2004)
Saba, J. D., Nara, F., Bielawska, A., Garrett, S. & Hannun, Y. A. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J. Biol. Chem. 272, 26087–26090 (1997) (10.1074/jbc.272.42.26087) / J. Biol. Chem. by JD Saba (1997)
Skrzypek, M. S., Nagiec, M. M., Lester, R. L. & Dickson, R. C. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. J. Bacteriol. 181, 1134–1140 (1999) (10.1128/JB.181.4.1134-1140.1999) / J. Bacteriol. by MS Skrzypek (1999)
Zhang, X., Skrzypek, M. S., Lester, R. L. & Dickson, R. C. Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells. Curr. Genet. 40, 221–233 (2001) (10.1007/s00294-001-0259-6) / Curr. Genet. by X Zhang (2001)
Loewen, C. J. et al. Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304, 1644–1647 (2004) (10.1126/science.1096083) / Science by CJ Loewen (2004)
Knudsen, J. et al. Role of acyl-CoA binding protein in acyl-CoA transport, metabolism and cell signaling. Mol. Cell. Biochem. 192, 95–103 (1999) (10.1023/A:1006830606060) / Mol. Cell. Biochem. by J Knudsen (1999)
Shirra, M. et al. Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 5710–5722 (2001) (10.1128/MCB.21.17.5710-5722.2001) / Mol. Cell. Biol. by M Shirra (2001)
Rasmussen, J., Rosendal, J. & Knudsen, J. Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor. Biochem. J. 292, 907–913 (1993) (10.1042/bj2920907) / Biochem. J. by J Rasmussen (1993)
Mao, C., Wadleigh, M., Jenkins, G. M., Hannun, Y. A. & Obeid, L. M. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272, 28690–28694 (1997) (10.1074/jbc.272.45.28690) / J. Biol. Chem. by C Mao (1997)
Mandala, S. M. et al. Inhibition of serine palmitoyl-transferase activity by lipoxamycin. J. Antibiot. (Tokyo) 47, 376–379 (1994) (10.7164/antibiotics.47.376) / J. Antibiot. (Tokyo) by SM Mandala (1994)
Jenkins, G. M. & Hannun, Y. A. in Apoptosis: A Practical Guide (ed. Studzinski, G. P.) (Oxford Univ. Press, New York, 1999) / Apoptosis: A Practical Guide by GM Jenkins (1999)
Bielawska, J., Szulc, Z. M., Hannun, Y. A. & Bielawska, A. Simultaneous Quantitative Analysis of Bioactive Sphingolipids by High Performance Liquid Chromatography-Tandem Mass Spectroscopy in Methods (ed. Bankaitis, V.) (Academic press, San Diego, in the press)
Ferreira, A. E. N. PLAS for Windows http://correio.cc.fc.ul.pt/~aenf/plas.html (1995) / PLAS for Windows by AEN Ferreira (1995)

Dates

Type	When
Created	20 years, 7 months ago (Jan. 30, 2005, 1:17 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2:29 p.m.)
Indexed	29 minutes ago (Sept. 3, 2025, 11:35 p.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Alvarez_Vasquez_2005, title={Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae}, volume={433}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature03232}, DOI={10.1038/nature03232}, number={7024}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Alvarez-Vasquez, Fernando and Sims, Kellie J. and Cowart, L. Ashley and Okamoto, Yasuo and Voit, Eberhard O. and Hannun, Yusuf A.}, year={2005}, month=jan, pages={425–430} }

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  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  }
}