A FADD-dependent innate immune mechanism in mammalian cells
10.1038/nature03124
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Balachandran, S., Thomas, E., & Barber, G. N. (2004). A FADD-dependent innate immune mechanism in mammalian cells. Nature, 432(7015), 401–405.

Authors 3
  1. Siddharth Balachandran (first)
  2. Emmanuel Thomas (additional)
  3. Glen N. Barber (additional)
References 30 Referenced 226
  1. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335–376 (2003) (10.1146/annurev.immunol.21.120601.141126) / Annu. Rev. Immunol. by K Takeda (2003)
  2. Medzhitov, R. & Janeway, C. Jr. The Toll receptor family and microbial recognition. Trends Microbiol. 8, 452–456 (2000) (10.1016/S0966-842X(00)01845-X) / Trends Microbiol. by R Medzhitov (2000)
  3. Taniguchi, T. & Takaoka, A. The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14, 111–116 (2002) (10.1016/S0952-7915(01)00305-3) / Curr. Opin. Immunol. by T Taniguchi (2002)
  4. Chinnaiyan, A. M., O'Rourke, K., Tewari, M. & Dixit, V. M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505–512 (1995) (10.1016/0092-8674(95)90071-3) / Cell by AM Chinnaiyan (1995)
  5. Yeh, W. C. et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954–1958 (1998) (10.1126/science.279.5358.1954) / Science by WC Yeh (1998)
  6. Hoffmann, J. A. The immune response of Drosophila. Nature 426, 33–38 (2003) (10.1038/nature02021) / Nature by JA Hoffmann (2003)
  7. Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227–264 (1998) (10.1146/annurev.biochem.67.1.227) / Annu. Rev. Biochem. by GR Stark (1998)
  8. Balachandran, S. et al. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J. Virol. 74, 1513–1523 (2000) (10.1128/JVI.74.3.1513-1523.2000) / J. Virol. by S Balachandran (2000)
  9. Varfolomeev, E. E. et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9, 267–276 (1998) (10.1016/S1074-7613(00)80609-3) / Immunity by EE Varfolomeev (1998)
  10. Muzio, M. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85, 817–827 (1996) (10.1016/S0092-8674(00)81266-0) / Cell by M Muzio (1996)
  11. Levy, D. E. & Darnell, J. E. Jr. Stats: transcriptional control and biological impact. Nature Rev. Mol. Cell Biol. 3, 651–662 (2002) (10.1038/nrm909) / Nature Rev. Mol. Cell Biol. by DE Levy (2002)
  12. Williams, B. R. PKR; a sentinel kinase for cellular stress. Oncogene 18, 6112–6120 (1999) (10.1038/sj.onc.1203127) / Oncogene by BR Williams (1999)
  13. Balachandran, S. et al. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 13, 129–141 (2000) (10.1016/S1074-7613(00)00014-5) / Immunity by S Balachandran (2000)
  14. Chu, W. M. et al. JNK2 and IKKβ are required for activating the innate response to viral infection. Immunity 11, 721–731 (1999) (10.1016/S1074-7613(00)80146-6) / Immunity by WM Chu (1999)
  15. Diebold, S. S. et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424, 324–328 (2003) (10.1038/nature01783) / Nature by SS Diebold (2003)
  16. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732–738 (2001) (10.1038/35099560) / Nature by L Alexopoulou (2001)
  17. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nature Immunol. 4, 161–167 (2003) (10.1038/ni886) / Nature Immunol. by H Oshiumi (2003)
  18. Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640–643 (2003) (10.1126/science.1087262) / Science by M Yamamoto (2003)
  19. Hemmi, H. et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641–1650 (2004) (10.1084/jem.20040520) / J. Exp. Med. by H Hemmi (2004)
  20. Honda, K. et al. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl Acad. Sci. USA 100, 10872–10877 (2003) (10.1073/pnas.1934678100) / Proc. Natl Acad. Sci. USA by K Honda (2003)
  21. Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature Immunol. 4, 1223–1229 (2003) (10.1038/ni1010) / Nature Immunol. by K Hoebe (2003)
  22. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730–737 (2004) (10.1038/ni1087) / Nature Immunol. by M Yoneyama (2004)
  23. Leulier, F., Vidal, S., Saigo, K., Ueda, R. & Lemaitre, B. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Curr. Biol. 12, 996–1000 (2002) (10.1016/S0960-9822(02)00873-4) / Curr. Biol. by F Leulier (2002)
  24. Naitza, S. et al. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 17, 575–581 (2002) (10.1016/S1074-7613(02)00454-5) / Immunity by S Naitza (2002)
  25. Kelliher, M. A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297–303 (1998) (10.1016/S1074-7613(00)80535-X) / Immunity by MA Kelliher (1998)
  26. Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nature Immunol. 5, 503–507 (2004) (10.1038/ni1061) / Nature Immunol. by E Meylan (2004)
  27. Wathelet, M. G. et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol. Cell 1, 507–518 (1998) (10.1016/S1097-2765(00)80051-9) / Mol. Cell by MG Wathelet (1998)
  28. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148–1151 (2003) (10.1126/science.1081315) / Science by S Sharma (2003)
  29. Fitzgerald, K. A. et al. IKKɛ and TBK1 are essential components of the IRF3 signaling pathway. Nature Immunol. 4, 491–496 (2003) (10.1038/ni921) / Nature Immunol. by KA Fitzgerald (2003)
  30. McWhirter, S. M. et al. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl Acad. Sci. USA 101, 233–238 (2004) (10.1073/pnas.2237236100) / Proc. Natl Acad. Sci. USA by SM McWhirter (2004)
Dates
Type When
Created 20 years, 9 months ago (Nov. 18, 2004, 1:23 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 2:28 p.m.)
Indexed 2 months ago (June 18, 2025, 7:25 p.m.)
Issued 20 years, 9 months ago (Nov. 1, 2004)
Published 20 years, 9 months ago (Nov. 1, 2004)
Published Print 20 years, 9 months ago (Nov. 1, 2004)
Funders 0

None

@article{Balachandran_2004, title={A FADD-dependent innate immune mechanism in mammalian cells}, volume={432}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature03124}, DOI={10.1038/nature03124}, number={7015}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Balachandran, Siddharth and Thomas, Emmanuel and Barber, Glen N.}, year={2004}, month=nov, pages={401–405} }