Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells
10.1038/nature02484
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Söllner, C., Rauch, G.-J., Siemens, J., Geisler, R., Schuster, S. C., Müller, U., & Nicolson, T. (2004). Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature, 428(6986), 955–959.

Authors 8
  1. (first)
  2. Christian Söllner (first)
  3. Gerd-Jörg Rauch (additional)
  4. Jan Siemens (additional)
  5. Robert Geisler (additional)
  6. Stephan C. Schuster (additional)
  7. Ulrich Müller (additional)
  8. Teresa Nicolson (additional)
References 31 Referenced 283
  1. Howard, J. & Hudspeth, A. J. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell. Neuron 3, 189–199 (1988) (10.1016/0896-6273(88)90139-0) / Neuron by J Howard (1988)
  2. Granato, M. et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development 123, 399–413 (1996) (10.1242/dev.123.1.399) / Development by M Granato (1996)
  3. Nicolson, T. et al. Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron 20, 271–283 (1998) (10.1016/S0896-6273(00)80455-9) / Neuron by T Nicolson (1998)
  4. Seiler, C. & Nicolson, T. Defective calmodulin-dependent rapid apical endocytosis in zebrafish sensory hair cell mutants. J. Neurobiol. 41, 424–434 (1999) (10.1002/(SICI)1097-4695(19991115)41:3<424::AID-NEU10>3.0.CO;2-G) / J. Neurobiol. by C Seiler (1999)
  5. Bork, J. et al. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23. Am. J. Genet. 68, 26–37 (2000) / Am. J. Genet. by J Bork (2000)
  6. Bolz, H. et al. Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nature Genet. 27, 108–112 (2001) (10.1038/83667) / Nature Genet. by H Bolz (2001)
  7. Di Palma, F. et al. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nature Genet. 27, 103–107 (2001) (10.1038/83660) / Nature Genet. by F Di Palma (2001)
  8. Wilson, S. et al. Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics 74, 228–233 (2001) (10.1006/geno.2001.6554) / Genomics by S Wilson (2001)
  9. Wada, T. et al. A point mutation in a cadherin gene, Cdh23, causes deafness in a novel mutant, waltzer mouse niigata. Biochem. Biophys. Res. Comm. 283, 113–117 (2001) (10.1006/bbrc.2001.4724) / Biochem. Biophys. Res. Comm. by T Wada (2001)
  10. Siemens, J. et al. The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Proc. Natl Acad. Sci. USA 99, 14946–14951 (2002) (10.1073/pnas.232579599) / Proc. Natl Acad. Sci. USA by J Siemens (2002)
  11. Boeda, B. et al. Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J. 21, 6689–6699 (2002) (10.1093/emboj/cdf689) / EMBO J. by B Boeda (2002)
  12. Pickles, J. et al. The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae. Hear. Res. 41, 31–42 (1989) (10.1016/0378-5955(89)90176-7) / Hear. Res. by J Pickles (1989)
  13. Goodyear, R. & Richardson, G. Distribution of the 275 kD hair cell antigen and cell surface specializations on auditory and vestibular hair bundles in the chicken inner ear. J. Comp. Neurol. 325, 243–256 (1992) (10.1002/cne.903250208) / J. Comp. Neurol. by R Goodyear (1992)
  14. Katori, Y., Tonosaki, A. & Takasaka, T. WGA lectin binding sites of the apical surface of corti epithelium: enhancement by back-scattered electron imaging in guinea-pig inner ear. J. Elec. Microsc. 45, 207–212 (1996) (10.1093/oxfordjournals.jmicro.a023434) / J. Elec. Microsc. by Y Katori (1996)
  15. Goodyear, R. & Richardson, G. The ankle-link antigen: an epitope sensitive to calcium chelation associated with the hair-cell surface and the calycal processes of photoreceptors. J. Neurosci. 19, 3761–3772 (1999) (10.1523/JNEUROSCI.19-10-03761.1999) / J. Neurosci. by R Goodyear (1999)
  16. Goodyear, R. J. & Richardson, G. P. A novel antigen sensitive to calcium chelation that is associated with the tip links and kinocilial links of sensory hair bundles. J. Neurosci. 23, 4878–4887 (2003) (10.1523/JNEUROSCI.23-12-04878.2003) / J. Neurosci. by RJ Goodyear (2003)
  17. Goodyear, R. J. et al. A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J. Neurosci. 23, 9208–9219 (2003) (10.1523/JNEUROSCI.23-27-09208.2003) / J. Neurosci. by RJ Goodyear (2003)
  18. Pickles, J. & Corey, D. Mechanoelectrical transduction by hair cells. Trends Neurosci. 15, 254–259 (1992) (10.1016/0166-2236(92)90066-H) / Trends Neurosci. by J Pickles (1992)
  19. Steel, K. & Kros, C. A genetic approach to understanding auditory function. Nature Genet. 27, 143–149 (2001) (10.1038/84758) / Nature Genet. by K Steel (2001)
  20. Ernest, S. et al. Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness. Hum. Mol. Genet. 9, 2189–2196 (2000) (10.1093/hmg/9.14.2189) / Hum. Mol. Genet. by S Ernest (2000)
  21. Riley, B. B., Zhu, C., Janetopoulos, C. & Aufderheide, K. J. A critical period of ear development controlled by distinct populations of ciliated cells in the zebrafish. Dev. Biol. 191, 191–201 (1997) (10.1006/dbio.1997.8736) / Dev. Biol. by BB Riley (1997)
  22. Siemens, J. et al. Cadherin 23 is a component of the tip link in hair cell stereocilia. Nature advance online publication 31 March 2004 (doi:10.1038/nature02483) (10.1038/nature02483)
  23. Neugebauer, D. & Thurm, U. Surface charges of the membrane and cell adhesion substances determine the structural integrity of hair bundles from the inner ear of fish. Cell Tissue Res. 249, 199–207 (1987) (10.1007/BF00215434) / Cell Tissue Res. by D Neugebauer (1987)
  24. Leckband, D. & Sivasankar, S. Mechanism of homophilic cadherin adhesion. Curr. Opin. Cell Biol. 12, 587–592 (2000) (10.1016/S0955-0674(00)00136-8) / Curr. Opin. Cell Biol. by D Leckband (2000)
  25. Assad, J., Shepherd, G. & Corey, D. Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7, 987–994 (1991) (10.1016/0896-6273(91)90343-X) / Neuron by J Assad (1991)
  26. Kachar, B., Parakkal, M., Kurc, M., Zhao, Y. & Gillespie, P. High-resolution structure of hair cell tip links. Proc. Natl Acad. Sci. USA 97, 13336–13341 (2000) (10.1073/pnas.97.24.13336) / Proc. Natl Acad. Sci. USA by B Kachar (2000)
  27. Baumgartner, W. et al. Cadherin interaction probed by atomic force microscopy. Proc. Natl Acad. Sci. USA 97, 4005–4010 (2000) (10.1073/pnas.070052697) / Proc. Natl Acad. Sci. USA by W Baumgartner (2000)
  28. Sivasankar, S., Gumbiner, B. & Leckband, D. Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains. Biophys. J. 80, 1758–1768 (2001) (10.1016/S0006-3495(01)76146-2) / Biophys. J. by S Sivasankar (2001)
  29. Sidi, S., Friedrich, R. & Nicolson, T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301, 96–99 (2003) (10.1126/science.1084370) / Science by S Sidi (2003)
  30. Fleischmann, R. D. et al. Whole-genome random sequencing and assembly of Haemophilus influenzae. Science 269, 496–512 (1995) (10.1126/science.7542800) / Science by RD Fleischmann (1995)
  31. Westerfield, M. The Zebrafish Book 3rd edn (Univ. Oregon Press, Eugene, Oregon, 1995) / The Zebrafish Book by M Westerfield (1995)
Dates
Type When
Created 21 years, 5 months ago (March 31, 2004, 12:03 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 2:22 p.m.)
Indexed 1 day, 3 hours ago (Aug. 30, 2025, 1:07 p.m.)
Issued 21 years, 5 months ago (March 31, 2004)
Published 21 years, 5 months ago (March 31, 2004)
Published Online 21 years, 5 months ago (March 31, 2004)
Published Print 21 years, 4 months ago (April 1, 2004)
Funders 0

None

@article{2004, title={Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells}, volume={428}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature02484}, DOI={10.1038/nature02484}, number={6986}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Söllner, Christian and Rauch, Gerd-Jörg and Siemens, Jan and Geisler, Robert and Schuster, Stephan C. and Müller, Ulrich and Nicolson, Teresa}, year={2004}, month=mar, pages={955–959} }