DOI: 10.1038/nature02436. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries

Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries

10.1038/nature02436

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Kai, T., & Spradling, A. (2004). Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries. Nature, 428(6982), 564â569.

Authors 2

Toshie Kai (first)
Allan Spradling (additional)

References 24 Referenced 284

Spradling, A. C., Drummond-Barbosa, D. & Kai, T. Stem cells find their niche. Nature 414, 98–104 (2001) (10.1038/35102160) / Nature by AC Spradling (2001)
Watt, F. M. & Hogan, B. L. M. Out of Eden: stem cells and their niches. Science 287, 1427–1430 (2000) (10.1126/science.287.5457.1427) / Science by FM Watt (2000)
Stocum, D. L. Amphibian regeneration and stem cells. Curr. Top. Microbiol. Immunol. 280, 1–70 (2000) / Curr. Top. Microbiol. Immunol. by DL Stocum (2000)
Mikkola, I., Heavey, B., Horcher, M. & Busslinger, M. Reversion of B cell commitment upon loss of Pax5 expression. Science 297, 110–113 (2002) (10.1126/science.1067518) / Science by I Mikkola (2002)
Morrison, S. J. et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell 101, 499–510 (2000) (10.1016/S0092-8674(00)80860-0) / Cell by SJ Morrison (2000)
Prohaska, S. S., Scherer, D. C., Weissman, I. L. & Kondo, M. Developmental plasticity of lymphoid progenitors. Semin. Immunol. 14, 377–384 (2002) (10.1016/S1044532302000726) / Semin. Immunol. by SS Prohaska (2002)
Pearson, B. J. & Doe, C. Q. Regulation of neuroblast competence in Drosophila. Nature 425, 624–628 (2003) (10.1038/nature01910) / Nature by BJ Pearson (2003)
Clermont, Y. & Bustos-Obregon, E. Re-examination of spermatogonial renewal in the rat by means of seminiferous tubules mounted ‘in toto’. Am. J. Anat. 122, 237–247 (1968) (10.1002/aja.1001220205) / Am. J. Anat. by Y Clermont (1968)
De Rooij, D. G. & Russell, L. D. All you wanted to know about spermatogonia but were afraid to ask. J. Androl. 21, 776–798 (2000) (10.1002/j.1939-4640.2000.tb03408.x) / J. Androl. by DG De Rooij (2000)
Song, X., Zhu, C. H., Doan, C. & Xie, T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 296, 1855–1857 (2002) (10.1126/science.1069871) / Science by X Song (2002)
Xie, T. & Spradling, A. C. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94, 251–260 (1998) (10.1016/S0092-8674(00)81424-5) / Cell by T Xie (1998)
Chen, D. & McKearin, D. Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol. 13, 1786–1791 (2003) (10.1016/j.cub.2003.09.033) / Curr. Biol. by D Chen (2003)
de Cuevas, M., Lilly, M. A. & Spradling, A. C. Germline cyst formation in Drosophila. Annu. Rev. Genet. 31, 405–428 (1997) (10.1146/annurev.genet.31.1.405) / Annu. Rev. Genet. by M de Cuevas (1997)
de Cuevas, M. & Spradling, A. C. Morphogenesis of the Drosophila fusome and its implications for oocyte specification. Development 125, 2781–2789 (1998) (10.1242/dev.125.15.2781) / Development by M de Cuevas (1998)
Kai, T. & Spradling, A. C. An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc. Natl Acad. Sci. USA 100, 4633–4638 (2003) (10.1073/pnas.0830856100) / Proc. Natl Acad. Sci. USA by T Kai (2003)
Zhu, C. H. & Xie, T. Clonal expansion of stem cells during niche formation in Drosophila. Development 130, 2579–2588 (2003) (10.1242/dev.00499) / Development by CH Zhu (2003)
Ohlstein, B. & McKearin, D. Ectopic expression of the Drosophila Bam protein eliminates oogenic germline stem cells. Development 124, 3651–3662 (1997) (10.1242/dev.124.18.3651) / Development by B Ohlstein (1997)
Godt, D. & Laski, F. A. Mechanisms of cell rearrangement and cell recruitment in Drosophila ovary morphogenesis and the requirement of bric-a-brac. Development 121, 173–187 (1995) (10.1242/dev.121.1.173) / Development by D Godt (1995)
Robinson, D. N., Cant, K. & Cooley, L. Morphogenesis of Drosophila ovarian ring canals. Development 120, 2015–2025 (1994) (10.1242/dev.120.7.2015) / Development by DN Robinson (1994)
Dodson, G. S., Guarnieri, D. J. & Simon, M. A. Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis. Development 125, 2883–2892 (1998) (10.1242/dev.125.15.2883) / Development by GS Dodson (1998)
Roulier, E. M., Panzer, S. & Beckendorf, S. K. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Mol. Cell 1, 819–829 (1998) (10.1016/S1097-2765(00)80081-7) / Mol. Cell by EM Roulier (1998)
Brinster, R. L. Germline stem cell transplantation and transgenesis. Science 296, 2174–2176 (2002) (10.1126/science.1071607) / Science by RL Brinster (2002)
Kramerova, I. A. & Kramerov, A. A. Mucinoprotein is a universal constituent of stable intercellular bridges in Drosophila melanogaster germ line and somatic cells. Dev. Dyn. 216, 349–360 (1999) (10.1002/(SICI)1097-0177(199912)216:4/5<349::AID-DVDY4>3.0.CO;2-X) / Dev. Dyn. by IA Kramerova (1999)
Tanimoto, H., Itoh, S., ten Dijke, P. & Tabata, T. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol. Cell 5, 59–71 (2000) (10.1016/S1097-2765(00)80403-7) / Mol. Cell by H Tanimoto (2000)

Dates

Type	When
Created	21 years, 5 months ago (March 16, 2004, 4:01 a.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:02 p.m.)
Indexed	3 days ago (Aug. 27, 2025, 12:28 p.m.)
Issued	21 years, 5 months ago (March 14, 2004)
Published	21 years, 5 months ago (March 14, 2004)
Published Online	21 years, 5 months ago (March 14, 2004)
Published Print	21 years, 4 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Kai_2004, title={Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries}, volume={428}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature02436}, DOI={10.1038/nature02436}, number={6982}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Kai, Toshie and Spradling, Allan}, year={2004}, month=mar, pages={564–569} }

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        "name": "EthicsHeading",
        "label": "Competing interests"
      }
    }
  ]
}