DOI: 10.1038/nature01898. RanGTP mediates nuclear pore complex assembly

RanGTP mediates nuclear pore complex assembly

10.1038/nature01898

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Walther, T. C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I. W., & Hetzer, M. (2003). RanGTP mediates nuclear pore complex assembly. Nature, 424(6949), 689â694.

Authors 8

Tobias C. Walther (first)
Peter Askjaer (additional)
Marc Gentzel (additional)
Anja Habermann (additional)
Gareth Griffiths (additional)
Matthias Wilm (additional)
Iain W. Mattaj (additional)
Martin Hetzer (additional)

References 30 Referenced 208

Vasu, S. K. & Forbes, D. J. Nuclear pores and nuclear assembly. Curr. Opin. Cell Biol. 13, 363–375 (2001) (10.1016/S0955-0674(00)00221-0) / Curr. Opin. Cell Biol. by SK Vasu (2001)
Belgareh, N. et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell Biol. 154, 1147–1160 (2001) (10.1083/jcb.200101081) / J. Cell Biol. by N Belgareh (2001)
Bodoor, K. et al. Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis. J. Cell Sci. 112, 2253–2264 (1999) (10.1242/jcs.112.13.2253) / J. Cell Sci. by K Bodoor (1999)
Daigle, N. et al. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J. Cell Biol. 154, 71–84 (2001) (10.1083/jcb.200101089) / J. Cell Biol. by N Daigle (2001)
Hetzer, M. et al. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature Cell Biol. 3, 1086–1091 (2001) (10.1038/ncb1201-1086) / Nature Cell Biol. by M Hetzer (2001)
Walther, T. C. et al. The conserved Nup107–160 complex is critical for nuclear pore complex assembly. Cell 113, 195–206 (2003) (10.1016/S0092-8674(03)00235-6) / Cell by TC Walther (2003)
Harel, A. et al. Removal of a single pore subunit results in vertebrate nuclei devoid of nuclear pores. Mol. Cell 11, 853–864 (2003) (10.1016/S1097-2765(03)00116-3) / Mol. Cell by A Harel (2003)
Zhang, C. & Clarke, P. R. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science 288, 1429–1432 (2000) (10.1126/science.288.5470.1429) / Science by C Zhang (2000)
Hetzer, M., Bilbao-Cortes, D., Walther, T. C., Gruss, O. J. & Mattaj, I. W. GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol. Cell 5, 1013–1024 (2000) (10.1016/S1097-2765(00)80266-X) / Mol. Cell by M Hetzer (2000)
Bamba, C., Bobinnec, Y., Fukuda, M. & Nishida, E. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr. Biol. 12, 503–507 (2002) (10.1016/S0960-9822(02)00741-8) / Curr. Biol. by C Bamba (2002)
Askjaer, P., Galy, V., Hannak, E. & Mattaj, I. W. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol. Biol. Cell 13, 4355–4370 (2002) (10.1091/mbc.e02-06-0346) / Mol. Biol. Cell by P Askjaer (2002)
Zhang, C., Goldberg, M. W., Moore, W. J., Allen, T. D. & Clarke, P. R. Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. Eur. J. Cell Biol. 81, 623–633 (2002) (10.1078/0171-9335-00288) / Eur. J. Cell Biol. by C Zhang (2002)
Ryan, K. J., McCaffery, J. M. & Wente, S. R. The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J. Cell Biol. 160, 1041–1053 (2003) (10.1083/jcb.200209116) / J. Cell Biol. by KJ Ryan (2003)
Davis, L. I. & Blobel, G. Identification and characterization of a nuclear pore complex protein. Cell 45, 699–709 (1986) (10.1016/0092-8674(86)90784-1) / Cell by LI Davis (1986)
Bischoff, F. R., Klebe, C., Kretschmer, J., Wittinghofer, A. & Ponstingl, H. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Natl Acad. Sci. USA 91, 2587–2591 (1994) (10.1073/pnas.91.7.2587) / Proc. Natl Acad. Sci. USA by FR Bischoff (1994)
Klebe, C., Prinz, H., Wittinghofer, A. & Goody, R. S. The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1. Biochemistry 34, 12543–12552 (1995) (10.1021/bi00039a008) / Biochemistry by C Klebe (1995)
Kessel, R. G. Annulate lamellae: a last frontier in cellular organelles. Int. Rev. Cytol. 133, 43–120 (1992) (10.1016/S0074-7696(08)61858-6) / Int. Rev. Cytol. by RG Kessel (1992)
Dabauvalle, M. C., Loos, K., Merkert, H. & Scheer, U. Spontaneous assembly of pore complex-containing membranes (“annulate lamellae”) in Xenopus egg extract in the absence of chromatin. J. Cell Biol. 112, 1073–1082 (1991) (10.1083/jcb.112.6.1073) / J. Cell Biol. by MC Dabauvalle (1991)
Macaulay, C., Meier, E. & Forbes, D. J. Differential mitotic phosphorylation of proteins of the nuclear pore complex. J. Biol. Chem. 270, 254–262 (1995) (10.1074/jbc.270.1.254) / J. Biol. Chem. by C Macaulay (1995)
Murray, A. in Cell Cycle Extracts in Xenopus laevis. Practical Uses in Cell and Molecular Biology (eds Kay, B. K. & Peng, H. B.) 581–605 (Academic, San Diego, 1991) (10.1016/S0091-679X(08)60298-8) / Cell Cycle Extracts in Xenopus laevis. Practical Uses in Cell and Molecular Biology by A Murray (1991)
Dreier, L. & Rapoport, T. A. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction. J. Cell Biol. 148, 883–898 (2000) (10.1083/jcb.148.5.883) / J. Cell Biol. by L Dreier (2000)
Rout, M. P. & Aitchison, J. D. The nuclear pore complex as a transport machine. J. Biol. Chem. 276, 16593–16596 (2001) (10.1074/jbc.R100015200) / J. Biol. Chem. by MP Rout (2001)
Kutay, U., Izaurralde, E., Bischoff, F. R., Mattaj, I. W. & Gorlich, D. Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16, 1153–1163 (1997) (10.1093/emboj/16.6.1153) / EMBO J. by U Kutay (1997)
Hinkle, B. et al. Chromosomal association of Ran during meiotic and mitotic divisions. J. Cell Sci. 115, 4685–4693 (2002) (10.1242/jcs.00136) / J. Cell Sci. by B Hinkle (2002)
Bayliss, R., Littlewood, T., Strawn, L. A., Wente, S. R. & Stewart, M. GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta. J. Biol. Chem. 277, 50597–50606 (2002) (10.1074/jbc.M209037200) / J. Biol. Chem. by R Bayliss (2002)
Zhang, C., Hutchins, J. R., Muhlhausser, P., Kutay, U. & Clarke, P. R. Role of importin-beta in the control of nuclear envelope assembly by Ran. Curr. Biol. 12, 498–502 (2002) (10.1016/S0960-9822(02)00714-5) / Curr. Biol. by C Zhang (2002)
Lusk, C. P., Makhnevych, T., Marelli, M., Aitchison, J. D. & Wozniak, R. W. Karyopherins in nuclear pore biogenesis: a role for Kap121 in the assembly of Nup53p into nuclear pore complexes. J. Cell Biol. 159, 267–278 (2002) (10.1083/jcb.200203079) / J. Cell Biol. by CP Lusk (2002)
Demeter, J., Morphew, M. & Sazer, S. A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast. Proc. Natl Sci. USA 92, 1436–1440 (1995) (10.1073/pnas.92.5.1436) / Proc. Natl Sci. USA by J Demeter (1995)
Griffiths, G. Fine Structure Immuno-cytochemistry 137–191 (Springer, Berlin, 1993) (10.1007/978-3-642-77095-1_5) / Fine Structure Immuno-cytochemistry by G Griffiths (1993)
Timmons, L. & Fire, A. Specific interference by ingested dsRNA. Nature 395, 854–857 (1998) (10.1038/27579) / Nature by L Timmons (1998)

Dates

Type	When
Created	22 years, 1 month ago (Aug. 1, 2003, 7:17 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 2:17 p.m.)
Indexed	3 days, 2 hours ago (Sept. 3, 2025, 6:50 a.m.)
Issued	22 years, 1 month ago (July 30, 2003)
Published	22 years, 1 month ago (July 30, 2003)
Published Online	22 years, 1 month ago (July 30, 2003)
Published Print	22 years, 1 month ago (Aug. 1, 2003)

Funders 0

None

BibTeX

@article{Walther_2003, title={RanGTP mediates nuclear pore complex assembly}, volume={424}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature01898}, DOI={10.1038/nature01898}, number={6949}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Walther, Tobias C. and Askjaer, Peter and Gentzel, Marc and Habermann, Anja and Griffiths, Gareth and Wilm, Matthias and Mattaj, Iain W. and Hetzer, Martin}, year={2003}, month=jul, pages={689–694} }

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