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Bibliography

Brummelkamp, T. R., Nijman, S. M. B., Dirac, A. M. G., & Bernards, R. (2003). Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature, 424(6950), 797–801.

Authors 4
  1. Thijn R. Brummelkamp (first)
  2. Sebastian M. B. Nijman (additional)
  3. Annette M. G. Dirac (additional)
  4. René Bernards (additional)
References 27 Referenced 807
  1. Wilkinson, K. D. Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome. Semin. Cell Dev. Biol. 11, 141–148 (2000) (10.1006/scdb.2000.0164) / Semin. Cell Dev. Biol. by KD Wilkinson (2000)
  2. Chung, C. H. & Baek, S. H. Deubiquitinating enzymes: Their diversity and emerging roles. Biochem. Biophys. Res. Commun. 266, 633–640 (1999) (10.1006/bbrc.1999.1880) / Biochem. Biophys. Res. Commun. by CH Chung (1999)
  3. D'Andrea, A. & Pellman, D. Deubiquitinating enzymes: A new class of biological regulators. Crit. Rev. Biochem. Mol. Biol. 33, 337–352 (1998) (10.1080/10409239891204251) / Crit. Rev. Biochem. Mol. Biol. by A D'Andrea (1998)
  4. Bignell, G. R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nature Genet. 25, 160–165 (2000) (10.1038/76006) / Nature Genet. by GR Bignell (2000)
  5. Yin, M. J., Yamamoto, Y. & Gaynor, R. B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396, 77–80 (1998) (10.1038/23948) / Nature by MJ Yin (1998)
  6. Nakamura, T., Hillova, J., Mariage-Samson, R. & Hill, M. Molecular cloning of a novel oncogene generated by DNA recombination during transfection. Oncogene Res. 2, 357–370 (1988) / Oncogene Res. by T Nakamura (1988)
  7. Papa, F. R. & Hochstrasser, M. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature 366, 313–319 (1993) (10.1038/366313a0) / Nature by FR Papa (1993)
  8. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002) (10.1126/science.1068999) / Science by TR Brummelkamp (2002)
  9. Karin, M., Cao, Y., Greten, F. R. & Li, Z. W. NF-κB in cancer: From innocent bystander to major culprit. Nature Rev. Cancer 2, 301–310 (2002) (10.1038/nrc780) / Nature Rev. Cancer by M Karin (2002)
  10. Smahi, A. et al. The NF-κB signalling pathway in human diseases: From incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum. Mol. Genet. 11, 2371–2375 (2002) (10.1093/hmg/11.20.2371) / Hum. Mol. Genet. by A Smahi (2002)
  11. Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-kB activation by TNFR family members. Nature 424, 793–796 (2003) (10.1038/nature01803) / Nature by E Trompouki (2003)
  12. Bradley, J. R. & Pober, J. S. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20, 6482–6491 (2001) (10.1038/sj.onc.1204788) / Oncogene by JR Bradley (2001)
  13. Chung, J. Y., Park, Y. C., Ye, H. & Wu, H. All TRAFs are not created equal: Common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci. 115, 679–688 (2002) (10.1242/jcs.115.4.679) / J. Cell Sci. by JY Chung (2002)
  14. Shi, C. S. & Kehrl, J. H. TNF-induced GCKR and SAPK activation depends upon the E2/E3 complex Ubc13-Uev1A/TRAF2. J. Biol. Chem. 18, 15429–15434 (2003) (10.1074/jbc.M211796200) / J. Biol. Chem. by CS Shi (2003)
  15. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346–351 (2001) (10.1038/35085597) / Nature by C Wang (2001)
  16. Holtmann, H., Hahn, T. & Wallach, D. Interrelated effects of tumor necrosis factor and interleukin 1 on cell viability. Immunobiology 177, 7–22 (1988) (10.1016/S0171-2985(88)80087-1) / Immunobiology by H Holtmann (1988)
  17. Wang, C. Y., Mayo, M. W. & Baldwin, A. S. Jr TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB. Science 274, 784–787 (1996) (10.1126/science.274.5288.784) / Science by CY Wang (1996)
  18. Liu, Z. G., Hsu, H., Goeddel, D. V. & Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87, 565–576 (1996) (10.1016/S0092-8674(00)81375-6) / Cell by ZG Liu (1996)
  19. De Smaele, E. et al. Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling. Nature 414, 308–313 (2001) (10.1038/35104560) / Nature by E De Smaele (2001)
  20. Baud, V. & Karin, M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11, 372–377 (2001) (10.1016/S0962-8924(01)02064-5) / Trends Cell Biol. by V Baud (2001)
  21. Rossi, A. et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403, 103–108 (2000) (10.1038/47520) / Nature by A Rossi (2000)
  22. Dajee, M. et al. NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421, 639–643 (2003) (10.1038/nature01283) / Nature by M Dajee (2003)
  23. van Balkom, I. D. & Hennekam, R. C. Dermal eccrine cylindromatosis. J. Med. Genet. 31, 321–324 (1994) (10.1136/jmg.31.4.321) / J. Med. Genet. by ID van Balkom (1994)
  24. Schmidt-Ullrich, R. et al. NF-κB activity in transgenic mice: Developmental regulation and tissue specificity. Development 122, 2117–2128 (1996) (10.1242/dev.122.7.2117) / Development by R Schmidt-Ullrich (1996)
  25. Schmidt-Ullrich, R. et al. Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices. Development 128, 3843–3853 (2001) (10.1242/dev.128.19.3843) / Development by R Schmidt-Ullrich (2001)
  26. Agami, R. & Bernards, R. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55–66 (2000) (10.1016/S0092-8674(00)00010-6) / Cell by R Agami (2000)
  27. Chen, G., Cao, P. & Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol. Cell 9, 401–410 (2002) (10.1016/S1097-2765(02)00450-1) / Mol. Cell by G Chen (2002)
Dates
Type When
Created 22 years ago (Aug. 13, 2003, 12:28 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 2:16 p.m.)
Indexed 1 hour, 5 minutes ago (Aug. 27, 2025, 12:30 p.m.)
Issued 22 years ago (Aug. 1, 2003)
Published 22 years ago (Aug. 1, 2003)
Published Print 22 years ago (Aug. 1, 2003)
Funders 0

None

@article{Brummelkamp_2003, title={Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB}, volume={424}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature01811}, DOI={10.1038/nature01811}, number={6950}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Brummelkamp, Thijn R. and Nijman, Sebastian M. B. and Dirac, Annette M. G. and Bernards, René}, year={2003}, month=aug, pages={797–801} }