DOI: 10.1038/nature01254. Computational systems biology

Computational systems biology

10.1038/nature01254

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Kitano, H. (2002). Computational systems biology. Nature, 420(6912), 206â210.

Authors 1

Hiroaki Kitano (first)

References 71 Referenced 1,643

Baldi, P. & Brunak, S. Bioinformatics: The Machine Learning Approach 2nd edn (MIT Press, Cambridge, MA, 2001). / Bioinformatics: The Machine Learning Approach by P Baldi (2001)
Onami, S., Kyoda, K., Morohashi, M. & Kitano, H. in Foundations of Systems Biology (ed. Kitano, H.) 59–75 (MIT Press, Cambridge, MA, 2001). (10.7551/mitpress/3087.003.0007) / Foundations of Systems Biology by S Onami (2001)
Ideker, T. E., Thorsson, V. & Karp, R. M. in Pac. Symp. Biocomput. (eds Altman, R. B., Dunker, A. K., Hunter, L., Lauderdale, K. & Klein, T. E.) 305–316 (World Scientific, Singapore, 2000). / Pac. Symp. Biocomput. by TE Ideker (2000)
Ideker, T. et al. Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics 18 (Suppl. 1), S233–S240 (2002). (10.1093/bioinformatics/18.suppl_1.S233) / Bioinformatics by T Ideker (2002)
Ideker, T. et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292, 929–934 (2001). (10.1126/science.292.5518.929) / Science by T Ideker (2001)
Borisuk, M. T. & Tyson, J. J. Bifurcation analysis of a model of mitotic control in frog eggs. J. Theor. Biol. 195, 69–85 (1998). (10.1006/jtbi.1998.0781) / J. Theor. Biol. by MT Borisuk (1998)
Chen, K. C. et al. Kinetic analysis of a molecular model of the budding yeast cell cycle. Mol. Biol. Cell 11, 369–391 (2000). (10.1091/mbc.11.1.369) / Mol. Biol. Cell by KC Chen (2000)
Edwards, J. S., Ibarra, R. U. & Palsson, B. O. In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nature Biotechnol. 19, 125–130 (2001). (10.1038/84379) / Nature Biotechnol. by JS Edwards (2001)
Fell, D. Understanding the Control of Metabolism (Portland, London, 1997). / Understanding the Control of Metabolism by D Fell (1997)
Morohashi, M. et al. Robustness as a measure of plausibility in models of biochemical networks. J. Theor. Biol. 216, 19–30 (2002). (10.1006/jtbi.2002.2537) / J. Theor. Biol. by M Morohashi (2002)
Kitano, H. Standards for modeling. Nature Biotechnol. 20, 337 (2002). (10.1038/nbt0402-337a) / Nature Biotechnology by Hiroaki Kitano (2002)
Hucka, M. et al. in in Pac. Symp. Biocomput. (eds Altman, R. B., Dunker, A. K., Hunter, L. & Klein, T. E.) 450–461 (World Scientific, Singapore, 2002). / Pac. Symp. Biocomput. by M Hucka (2002)
Kanehisa, M. & Goto, S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27–30 (2000). (10.1093/nar/28.1.27) / Nucleic Acids Res. by M Kanehisa (2000)
Alliance for Cellular Signaling 〈http://www.AfCS.org/〉 (2002).
Signal Transduction Knowledge Environment 〈http://www.stke.org/〉 (2002).
Wiener, N. Cybernetics: Or Control and Communication in the Animal and the Machine (MIT Press, Cambridge, MA, 1948). / Cybernetics: Or Control and Communication in the Animal and the Machine by N Wiener (1948)
Bertalanffy, L. v. General System Theory (Braziller, New York, 1968). / General System Theory by Lv Bertalanffy (1968)
Kitano, H. Systems biology: a brief overview. Science 295, 1662–1664 (2002). (10.1126/science.1069492) / Science by H Kitano (2002)
Kitano, H. in Foundations of Systems Biology (ed. Kitano, H.) 1–36 (MIT Press, Cambridge, MA, 2001). (10.7551/mitpress/3087.001.0001) / Foundations of Systems Biology by H Kitano (2001)
Alon, U. et al. Robustness in bacterial chemotaxis. Nature 397, 168–171 (1999). (10.1038/16483) / Nature by U Alon (1999)
Yi, T. M. et al. Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl Acad. Sci. USA 97, 4649–4653 (2000). (10.1073/pnas.97.9.4649) / Proc. Natl Acad. Sci. USA by TM Yi (2000)
Barkai, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913–917 (1997). (10.1038/43199) / Nature by N Barkai (1997)
Weng, G., Bhalla, U. S. & Iyengar, R. Complexity in biological signaling systems. Science 284, 92–96 (1999). (10.1126/science.284.5411.92) / Science by G Weng (1999)
Levine, K., Tinkelenberg, A. & Cross, F. in Progress in Cell Cycle Research (eds Meijer, L., Guidet, S. & Lim Tung, H. Y.) 101–114 (Plenum, New York, 1995). (10.1007/978-1-4615-1809-9_8) / Progress in Cell Cycle Research by K Levine (1995)
Chang, D. E., Smalley, D. J. & Conway, T. Gene expression profiling of Escherichia coli growth transitions: an expanded stringent response model. Mol. Microbiol. 45, 289–306 (2002). (10.1046/j.1365-2958.2002.03001.x) / Mol. Microbiol. by DE Chang (2002)
Little, J. W., Shepley, D. P. & Wert, D. W. Robustness of a gene regulatory circuit. EMBO J. 18, 4299–4307 (1999). (10.1093/emboj/18.15.4299) / EMBO J. by JW Little (1999)
Gonze, D., Halloy, J. & Goldbeter, A. Robustness of circadian rhythms with respect to molecular noise. Proc. Natl Acad. Sci. USA 99, 673–678 (2002). (10.1073/pnas.022628299) / Proc. Natl Acad. Sci. USA by D Gonze (2002)
von Dassow, G. et al. The segment polarity network is a robust developmental module. Nature 406, 188–192 (2000). (10.1038/35018085) / Nature by G von Dassow (2000)
Eldar, A. et al. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419, 304–308 (2002). (10.1038/nature01061) / Nature by A Eldar (2002)
Carlson, J. M. & Doyle, J. Highly optimized tolerance: a mechanism for power laws in designed systems. Phys. Rev. E 60, 1412–1427 (1999). (10.1103/PhysRevE.60.1412) / Phys. Rev. E by JM Carlson (1999)
Carlson, J. M. & Doyle, J. Complexity and robustness. Proc. Natl Acad. Sci. USA 99, 2538–2545 (2002). (10.1073/pnas.012582499) / Proc. Natl Acad. Sci. USA by JM Carlson (2002)
Jeong, H. et al. The large-scale organization of metabolic networks. Nature 407, 651–654 (2000). (10.1038/35036627) / Nature by H Jeong (2000)
Jeong, H. et al. Lethality and centrality in protein networks. Nature 411, 41–42 (2001). (10.1038/35075138) / Nature by H Jeong (2001)
Albert, R., Jeong, H. & Barabasi, A. L. Error and attack tolerance of complex networks. Nature 406, 378–382 (2000). (10.1038/35019019) / Nature by R Albert (2000)
Podani, J. et al. Comparable system-level organization of Archaea and Eukaryotes. Nature Genet. 29, 54–56 (2001). (10.1038/ng708) / Nature Genet. by J Podani (2001)
Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000). (10.1038/35042675) / Nature by B Vogelstein (2000)
Adamic, L. A., Lukose, R. M., Puniyani, A. R. & Huberman, B. A. Search in power-law networks. Phys. Rev. E 64, 046135-1–046135-8 (2001). (10.1103/PhysRevE.64.046135) / Phys. Rev. E by LA Adamic (2001)
Higgins, J. The theory of oscillating reactions. Ind. Eng. Chem. 59, 18–62 (1967). (10.1021/ie50689a006) / Ind. Eng. Chem. by J Higgins (1967)
Berridge, M. J. & Rapp, P. E. A comparative survey of the function, mechanism and control of cellular oscillators. J. Exp. Biol. 81, 217–279 (1979). (10.1242/jeb.81.1.217) / J. Exp. Biol. by MJ Berridge (1979)
Goldbeter, A. Biochemical Oscillations and Cellular Rhythms (Cambirdge Univ. Press, Cambridge, 1996). (10.1017/CBO9780511608193) / Biochemical Oscillations and Cellular Rhythms by A Goldbeter (1996)
Tyson, J. J. in Computatoinal Cell Biology (eds Fall, C. P., Marland, E. S., Wagner, J. M. & Tyson, J. J.) 230–260 (Springer, New York, 2002). / Computatoinal Cell Biology by JJ Tyson (2002)
Jordan, J. D., Landau, E. M. & Iyengar, R. Signaling networks: the origins of cellular multitasking. Cell 103, 193–200 (2000). (10.1016/S0092-8674(00)00112-4) / Cell by JD Jordan (2000)
Bhalla, U. S. & Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 283, 381–387 (1999). (10.1126/science.283.5400.381) / Science by US Bhalla (1999)
Hartwell, L. H. et al. From molecular to modular cell biology. Nature 402, C47–C52 (1999). (10.1038/35011540) / Nature by LH Hartwell (1999)
Csete, M. E. & Doyle, J. C. Reverse engineering of biological complexity. Science 295, 1664–1669 (2002). (10.1126/science.1069981) / Science by ME Csete (2002)
Edelman, G. M. & Gally, J. A. Degeneracy and complexity in biological systems. Proc. Natl Acad. Sci. USA 98, 13763–13768 (2001). (10.1073/pnas.231499798) / Proc. Natl Acad. Sci. USA by GM Edelman (2001)
Shen-Orr, S. S. et al. Network motifs in the transcriptional regulation network of Escherichia coli. Nature Genet. 31, 64–68 (2002). (10.1038/ng881) / Nature Genet. by SS Shen-Orr (2002)
Cascante, M. et al. Metabolic control analysis in drug discovery and disease. Nature Biotechnol. 20, 243–249 (2002). (10.1038/nbt0302-243) / Nature Biotechnol. by M Cascante (2002)
Bailey, J. E. Lessons from metabolic engineering for functional genomics and drug discovery. Nature Biotechnol. 17, 616–618 (1999). (10.1038/10794) / Nature Biotechnol. by JE Bailey (1999)
Bailey, J. E. Reflections on the scope and the future of metabolic engineering and its connections to functional genomics and drug discovery. Metab. Eng, 3, 111–114 (2001). (10.1006/mben.2001.0184) / Metab. Eng, by JE Bailey (2001)
Lipinski, C. A. et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3–26 (2001). (10.1016/S0169-409X(00)00129-0) / Adv. Drug Deliv. Rev. by CA Lipinski (2001)
Butina, D., Segall, M. D. & Frankcombe, K. Predicting ADME properties in silico: methods and models. Drug Discov. Today 7, S83–S88 (2002). (10.1016/S1359-6446(02)02288-2) / Drug Discov. Today by D Butina (2002)
Ekins, S. & Rose, J. In silico ADME/Tox: the state of the art. J. Mol. Graph. Model. 20, 305–309 (2002). (10.1016/S1093-3263(01)00127-9) / J. Mol. Graph. Model. by S Ekins (2002)
Selick, H. E., Beresford, A. P. & Tarbit, M. H. The emerging importance of predictive ADME simulation in drug discovery. Drug Discov. Today 7, 109–116 (2002). (10.1016/S1359-6446(01)02100-6) / Drug Discov. Today by HE Selick (2002)
Li, A. P. & Segall, M. Early ADME/Tox studies and in silico screening. Drug Discov. Today 7, 25–27 (2002). (10.1016/S1359-6446(01)02117-1) / Drug Discov. Today by AP Li (2002)
Ekins, S. et al. Progress in predicting human ADME parameters in silico. J. Pharmacol. Toxicol. Methods 44, 251–272 (2000). (10.1016/S1056-8719(00)00109-X) / J. Pharmacol. Toxicol. Methods by S Ekins (2000)
Ueda, H. R., Hagiwara, M. & Kitano, H. Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J. Theor. Biol. 210, 401–406 (2001). (10.1006/jtbi.2000.2226) / J. Theor. Biol. by HR Ueda (2001)
Leloup, J. C., Gonze, D. & Goldbeter, A. Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. J. Biol. Rhythms 14, 433–448 (1999). (10.1177/074873099129000948) / J. Biol. Rhythms by JC Leloup (1999)
Schoeberl, B. et al. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nature Biotechnol. 20, 370–375 (2002). (10.1038/nbt0402-370) / Nature Biotechnol. by B Schoeberl (2002)
Tyson, J. J. & Novak, B. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. J. Theor. Biol. 210, 249–263 (2001). (10.1006/jtbi.2001.2293) / J. Theor. Biol. by JJ Tyson (2001)
Novak, B. et al. Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophys. Chem. 72, 185–200 (1998). (10.1016/S0301-4622(98)00133-1) / Biophys. Chem. by B Novak (1998)
Ni, T. C. & Savageau, M. A. Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells. J. Theor. Biol. 179, 329–368 (1996). (10.1006/jtbi.1996.0072) / J. Theor. Biol. by TC Ni (1996)
Ni, T. C. & Savageau, M. A. Application of biochemical systems theory to metabolism in human red blood cells. Signal propagation and accuracy of representation. J. Biol. Chem. 271, 7927–7941 (1996). (10.1074/jbc.271.14.7927) / J. Biol. Chem. by TC Ni (1996)
Jamshidi, N. et al. Dynamic simulation of the human red blood cell metabolic network. Bioinformatics 17, 286–287 (2001). (10.1093/bioinformatics/17.3.286) / Bioinformatics by N Jamshidi (2001)
Edwards, J. S. & Palsson, B. O. Robustness analysis of the Escherichia coli metabolic network. Biotechnol. Prog. 16, 927–939 (2000). (10.1021/bp0000712) / Biotechnol. Prog. by JS Edwards (2000)
Bassingthwaighte, J. B. Strategies for the physiome project. Ann. Biomed. Eng. 28, 1043–1058 (2000). (10.1114/1.1313771) / Ann. Biomed. Eng. by JB Bassingthwaighte (2000)
Rudy, Y. From genome to physiome: integrative models of cardiac excitation. Ann. Biomed. Eng. 28, 945–950 (2000). (10.1114/1.1308484) / Ann. Biomed. Eng. by Y Rudy (2000)
Noble, D. Modeling the heart—from genes to cells to the whole organ. Science 295, 1678–1682 (2002). (10.1126/science.1069881) / Science by D Noble (2002)
Guet, C. C. et al. Combinatorial synthesis of genetic networks. Science 296, 1466–1470 (2002). (10.1126/science.1067407) / Science by CC Guet (2002)
Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339–342 (2000). (10.1038/35002131) / Nature by TS Gardner (2000)
Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335–338 (2000). (10.1038/35002125) / Nature by MB Elowitz (2000)

Dates

Type	When
Created	22 years, 9 months ago (Nov. 13, 2002, 2:44 p.m.)
Deposited	1 year, 7 months ago (Jan. 7, 2024, 6 p.m.)
Indexed	1 day, 10 hours ago (Sept. 2, 2025, 6:35 a.m.)
Issued	22 years, 10 months ago (Nov. 1, 2002)
Published	22 years, 10 months ago (Nov. 1, 2002)
Published Print	22 years, 10 months ago (Nov. 1, 2002)

Funders 0

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BibTeX

@article{Kitano_2002, title={Computational systems biology}, volume={420}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature01254}, DOI={10.1038/nature01254}, number={6912}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Kitano, Hiroaki}, year={2002}, month=nov, pages={206–210} }

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      "year": "2000",
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      "year": "2001",
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      "year": "2001",
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      "author": "B Vogelstein",
      "year": "2000",
      "unstructured": "Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307\u2013310 (2000).",
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      "author": "LA Adamic",
      "year": "2001",
      "unstructured": "Adamic, L. A., Lukose, R. M., Puniyani, A. R. & Huberman, B. A. Search in power-law networks. Phys. Rev. E 64, 046135-1\u2013046135-8 (2001).",
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      "doi-asserted-by": "publisher",
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      "DOI": "10.1021/ie50689a006",
      "volume": "59",
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      "year": "1967",
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    },
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      "key": "BFnature01254_CR39",
      "doi-asserted-by": "crossref",
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      "year": "1979",
      "unstructured": "Berridge, M. J. & Rapp, P. E. A comparative survey of the function, mechanism and control of cellular oscillators. J. Exp. Biol. 81, 217\u2013279 (1979).",
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    },
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      "key": "BFnature01254_CR40",
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      "first-page": "230",
      "volume-title": "Computatoinal Cell Biology",
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      "author": "JD Jordan",
      "year": "2000",
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    },
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      "year": "2002",
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      "year": "2002",
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      "year": "2001",
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      "key": "BFnature01254_CR51",
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      "year": "2001",
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      "year": "2002",
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      "author": "S Ekins",
      "year": "2000",
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      "year": "2001",
      "unstructured": "Ueda, H. R., Hagiwara, M. & Kitano, H. Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J. Theor. Biol. 210, 401\u2013406 (2001).",
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      "unstructured": "Leloup, J. C., Gonze, D. & Goldbeter, A. Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. J. Biol. Rhythms 14, 433\u2013448 (1999).",
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      "year": "2001",
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      "year": "1998",
      "unstructured": "Novak, B. et al. Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophys. Chem. 72, 185\u2013200 (1998).",
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      "year": "1996",
      "unstructured": "Ni, T. C. & Savageau, M. A. Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells. J. Theor. Biol. 179, 329\u2013368 (1996).",
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    },
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      "author": "JS Edwards",
      "year": "2000",
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