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Bibliography

Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K. P., & Xiao, Z.-X. J. (2002). The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature, 419(6909), 849–853.

Authors 10
  1. Hongwu Zheng (first)
  2. Han You (additional)
  3. Xiao Zhen Zhou (additional)
  4. Stephen A. Murray (additional)
  5. Takafumi Uchida (additional)
  6. Gerburg Wulf (additional)
  7. Ling Gu (additional)
  8. Xiaoren Tang (additional)
  9. Kun Ping Lu (additional)
  10. Zhi-Xiong Jim Xiao (additional)
References 30 Referenced 321
  1. Lakin, N. D. & Jackson, S. P. Regulation of p53 in response to DNA damage. Oncogene 18, 7644–7655 (1999) (10.1038/sj.onc.1203015) / Oncogene by ND Lakin (1999)
  2. Woods, D. B. & Vousden, K. H. Regulation of p53 function. Exp. Cell Res. 264, 56–66 (2001) (10.1006/excr.2000.5141) / Exp. Cell Res. by DB Woods (2001)
  3. Meek, D. W. Mechanisms of switching on p53: a role for covalent modification. Oncogene 18, 7666–7675 (1999) (10.1038/sj.onc.1202951) / Oncogene by DW Meek (1999)
  4. Hunter, T. Prolyl isomerases and nuclear function. Cell 92, 141–143 (1998) (10.1016/S0092-8674(00)80906-X) / Cell by T Hunter (1998)
  5. Lu, K. P. Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism. Prog. Cell Cycle Res. 4, 83–96 (2000) (10.1007/978-1-4615-4253-7_8) / Prog. Cell Cycle Res. by KP Lu (2000)
  6. Lu, K. P., Hanes, S. D. & Hunter, T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380, 544–547 (1996) (10.1038/380544a0) / Nature by KP Lu (1996)
  7. Yaffe, M. B. et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science 278, 1957–1960 (1997) (10.1126/science.278.5345.1957) / Science by MB Yaffe (1997)
  8. Ranganathan, R., Lu, K. P., Hunter, T. & Noel, J. P. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89, 875–886 (1997) (10.1016/S0092-8674(00)80273-1) / Cell by R Ranganathan (1997)
  9. Stukenberg, P. T. & Kirschner, M. W. Pin1 acts catalytically to promote a conformational change in cdc25. Mol. Cell 7, 1071–1083 (2001) (10.1016/S1097-2765(01)00245-3) / Mol. Cell by PT Stukenberg (2001)
  10. Nigg, E. A. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17, 471–480 (1995) (10.1002/bies.950170603) / Bioessays by EA Nigg (1995)
  11. Sudol, M. & Hunter, T. New wrinkles for an old domain. Cell 103, 1001–1004 (2000) (10.1016/S0092-8674(00)00203-8) / Cell by M Sudol (2000)
  12. Davis, F. M., Tsao, T. Y., Fowler, S. K. & Rao, P. N. Monoclonal antibodies to mitotic cells. Proc. Natl Acad. Sci. USA 80, 2926–2930 (1983) (10.1073/pnas.80.10.2926) / Proc. Natl Acad. Sci. USA by FM Davis (1983)
  13. Shen, M., Stukenberg, P. T., Kirschner, M. W. & Lu, K. P. The essential mitotic peptidyl-prolyl isomerase Pin1 binds to and regulates mitosis-specific phosphoproteins. Genes Dev. 12, 706–720 (1998) (10.1101/gad.12.5.706) / Genes Dev. by M Shen (1998)
  14. Lu, P. J., Zhou, X. Z., Shen, M. & Lu, K. P. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325–1328 (1999) (10.1126/science.283.5406.1325) / Science by PJ Lu (1999)
  15. Bulavin, D. V. et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18, 6845–6854 (1999) (10.1093/emboj/18.23.6845) / EMBO J. by DV Bulavin (1999)
  16. Sanchez-Prieto, R., Rojas, J. M., Taya, Y. & Gutkind, J. S. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 60, 2464–2472 (2000) / Cancer Res. by R Sanchez-Prieto (2000)
  17. Buschmann, T. et al. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell Biol. 21, 2743–2754 (2001) (10.1128/MCB.21.8.2743-2754.2001) / Mol. Cell Biol. by T Buschmann (2001)
  18. Milner, J., Cook, A. & Mason, J. p53 is associated with p34 cdc2 in transformed cells. EMBO J. 9, 2885–2889 (1990) (10.1002/j.1460-2075.1990.tb07478.x) / EMBO J. by J Milner (1990)
  19. Wang, Y. & Prives, C. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376, 88–91 (1995) (10.1038/376088a0) / Nature by Y Wang (1995)
  20. Blaydes, J. P. et al. Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. J. Biol. Chem. 276, 4699–4708 (2001) (10.1074/jbc.M003485200) / J. Biol. Chem. by JP Blaydes (2001)
  21. Rippmann, J. F. et al. Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumour cell survival and entry into mitosis. Cell Growth Differ. 11, 409–416 (2000) / Cell Growth Differ. by JF Rippmann (2000)
  22. Flores, E. R. et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416, 560–564 (2002) (10.1038/416560a) / Nature by ER Flores (2002)
  23. Hsu, T., McRackan, D., Vincent, T. S. & Gert De Couet, H. Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nature Cell Biol. 3, 538–543 (2001) (10.1038/35078508) / Nature Cell Biol. by T Hsu (2001)
  24. Winkler, K. E., Swenson, K. I., Kornbluth, S. & Means, A. R. Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science 287, 1644–1647 (2000) (10.1126/science.287.5458.1644) / Science by KE Winkler (2000)
  25. You, H. et al. IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. J. Cell Biochem. 84, 211–216 (2002) (10.1002/jcb.10037) / J. Cell Biochem. by H You (2002)
  26. Ryo, A., Nakamura, M., Wulf, G. G., Liou, Y.-C. & Lu, K. L. Prolyl isomerase Pin1 regulates turnover and subcellular localization of b-catenin by inhibiting its interaction with APC. Nature Cell Biol. 3, 793–801 (2001) (10.1038/ncb0901-793) / Nature Cell Biol. by A Ryo (2001)
  27. Wulf, G. M. et al. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 20, 3459–3472 (2001) (10.1093/emboj/20.13.3459) / EMBO J. by GM Wulf (2001)
  28. Liou, Y. C. et al. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Natl Acad. Sci. USA 22, 1335–1340 (2002) (10.1073/pnas.032404099) / Proc. Natl Acad. Sci. USA by YC Liou (2002)
  29. Xiao, Z. X. et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375, 694–698 (1995) (10.1038/375694a0) / Nature by ZX Xiao (1995)
  30. He, T. C. et al. A simplified system for generating recombinant adenoviruses. Proc. Natl Acad. Sci. USA 95, 2509–2514 (1998) (10.1073/pnas.95.5.2509) / Proc. Natl Acad. Sci. USA by TC He (1998)
Dates
Type When
Created 22 years, 10 months ago (Oct. 24, 2002, 7:59 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 2:10 p.m.)
Indexed 1 month, 1 week ago (July 24, 2025, 8:21 a.m.)
Issued 22 years, 11 months ago (Oct. 2, 2002)
Published 22 years, 11 months ago (Oct. 2, 2002)
Published Online 22 years, 11 months ago (Oct. 2, 2002)
Published Print 22 years, 10 months ago (Oct. 24, 2002)
Funders 0

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@article{Zheng_2002, title={The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response}, volume={419}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/nature01116}, DOI={10.1038/nature01116}, number={6909}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Zheng, Hongwu and You, Han and Zhou, Xiao Zhen and Murray, Stephen A. and Uchida, Takafumi and Wulf, Gerburg and Gu, Ling and Tang, Xiaoren and Lu, Kun Ping and Xiao, Zhi-Xiong Jim}, year={2002}, month=oct, pages={849–853} }