DOI: 10.1038/mt.2008.233. Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

10.1038/mt.2008.233

Crossref journal-article

Elsevier BV

Molecular Therapy (78)

Bibliography

HÃ¤ndel, E.-M., Alwin, S., & Cathomen, T. (2009). Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity. Molecular Therapy, 17(1), 104â111.

Authors 3

Eva-Maria Händel (first)
Stephen Alwin (additional)
Toni Cathomen (additional)

References 37 Referenced 119

10.1073/pnas.91.13.6064 / Proc Natl Acad Sci USA / Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells by Rouet (1994)
10.1128/MCB.15.4.1968 / Mol Cell Biol / Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae by Choulika (1995)
10.1038/mt.2008.114 / Mol Ther / Zinc-finger nucleases: the next generation emerges by Cathomen (2008)
10.1073/pnas.93.3.1156 / Proc Natl Acad Sci USA / Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain by Kim (1996)
10.1073/pnas.95.18.10570 / Proc Natl Acad Sci USA / FokI dimerization is required for DNA cleavage by Bitinaite (1998)
10.1006/jmbi.2001.4635 / J Mol Biol / FokI requires two specific DNA sites for cleavage by Vanamee (2001)
10.1093/nar/28.17.3361 / Nucleic Acids Res / Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains by Smith (2000)
10.1016/j.bbrc.2005.07.021 / Biochem Biophys Res Commun / Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage by Mani (2005)
10.1126/science.2028256 / Science / Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A by Pavletich (1991)
10.1073/pnas.0800940105 / Proc Natl Acad Sci USA / Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases by Santiago (2008)
10.1126/science.1079512 / Science / Enhancing gene targeting with designed zinc finger nucleases by Bibikova (2003)
10.1534/genetics.105.052829 / Genetics / Efficient gene targeting in Drosophila with zinc-finger nucleases by Beumer (2006)
10.1073/pnas.0605633103 / Proc Natl Acad Sci USA / Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells by Morton (2006)
10.1073/pnas.0409339102 / Proc Natl Acad Sci USA / Targeted mutagenesis using zinc-finger nucleases in Arabidopsis by Lloyd (2005)
10.1111/j.1365-313X.2005.02551.x / Plant J / High-frequency homologous recombination in plants mediated by zinc-finger nucleases by Wright (2005)
10.1038/nature03556 / Nature / Highly efficient endogenous human gene correction using designed zinc-finger nucleases by Urnov (2005)
10.1038/nbt1353 / Nat Biotechnol / Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery by Lombardo (2007)
10.1128/MCB.23.10.3558-3565.2003 / Mol Cell Biol / Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks by Porteus (2003)
10.1016/j.ymthe.2005.06.094 / Mol Ther / Custom zinc-finger nucleases for use in human cells by Alwin (2005)
10.1016/j.ymthe.2005.08.003 / Mol Ther / Mammalian gene targeting with designed zinc finger nucleases by Porteus (2006)
10.1038/nbt1319 / Nat Biotechnol / An improved zinc-finger nuclease architecture for highly specific genome editing by Miller (2007)
10.1038/nbt1317 / Nat Biotechnol / Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases by Szczepek (2007)
10.1038/sj.mt.6300357 / Mol Ther / DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases by Cornu (2008)
10.1128/MCB.21.1.289-297.2001 / Mol Cell Biol / Stimulation of homologous recombination through targeted cleavage by chimeric nucleases by Bibikova (2001)
10.1126/science.1078395 / Science / Chimeric nucleases stimulate gene targeting in human cells by Porteus (2003)
10.1038/nmeth0508-374 / Nat Methods / Unexpected failure rates for modular assembly of engineered zinc fingers by Ramirez (2008)
10.1073/pnas.0611478104 / Proc Natl Acad Sci USA / Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases by Moehle (2007)
10.1073/pnas.2135381100 / Proc Natl Acad Sci USA / Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection by Hurt (2003)
10.1038/sj.mt.6300345 / Mol Ther / Targeted genome modifications using integrase-deficient lentiviral vectors by Cornu (2007)
10.1016/S0969-2126(96)00125-6 / Structure / Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions by Elrod-Erickson (1996)
10.1038/40446 / Nature / Structure of the multimodular endonuclease FokI bound to DNA by Wah (1997)
10.1038/nprot.2006.231 / Nat Protoc / Design, construction and in vitro testing of zinc finger nucleases by Carroll (2006)
10.1128/MCB.24.21.9305-9316.2004 / Mol Cell Biol / Genetic steps of mammalian homologous repair with distinct mutagenic consequences by Stark (2004)
10.1126/science.275.5300.657 / Science / A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites by Greisman (1997)
10.1038/90264 / Nat Biotechnol / A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter by Isalan (2001)
10.1093/nar/gki912 / Nucleic Acids Res / Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells by Durai (2005)
10.1016/j.molcel.2008.06.016 / Mol Cell / Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification by Maeder (2008)

Dates

Type	When
Created	16 years, 9 months ago (Nov. 11, 2008, 10:05 a.m.)
Deposited	3 years, 1 month ago (July 12, 2022, 11:28 p.m.)
Indexed	1 week ago (Aug. 31, 2025, 6:15 a.m.)
Issued	16 years, 8 months ago (Jan. 1, 2009)
Published	16 years, 8 months ago (Jan. 1, 2009)
Published Print	16 years, 8 months ago (Jan. 1, 2009)

Funders 1

Bundesministerium für Bildung und Forschung 10.13039/501100002347
Region: Europe
gov (National government)
Labels2
1. Federal Ministry of Education and Research
2. BMBF

BibTeX

@article{H_ndel_2009, title={Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity}, volume={17}, ISSN={1525-0016}, url={http://dx.doi.org/10.1038/mt.2008.233}, DOI={10.1038/mt.2008.233}, number={1}, journal={Molecular Therapy}, publisher={Elsevier BV}, author={Händel, Eva-Maria and Alwin, Stephen and Cathomen, Toni}, year={2009}, month=jan, pages={104–111} }

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