DOI: 10.1038/ki.1972.47. The regulation of cerebrospinal fluid pH

The regulation of cerebrospinal fluid pH

10.1038/ki.1972.47

Crossref journal-article

Elsevier BV

Kidney International (78)

Bibliography

SiesjÃ¶, B. K. (1972). The regulation of cerebrospinal fluid pH. Kidney International, 1(5), 360â374.

Authors 1

Bo K. Siesjö (first)

References 95 Referenced 105

10.1152/ajplegacy.1965.208.3.436 / Am.J.Physiol / Role of cerebral fluids in control of respiration as studied in unanesthetized goats by Pappenheimer (1965)
10.1152/jappl.1965.20.3.443 / J.Appl.Physiol / Stability of cerebrospinal fluid pH in chronic acid-base disturbances in blood by Mitchell (1965)
10.1152/ajplegacy.1966.210.3.459 / Am.J.Physiol / Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid by Fencl (1966)
Pappenheimer, J. R.: The ionic composition of cerebral extracellular fluid and its relation to control of breathing in The Harvey Lectures 1965–1966, New York and London, Academic Press, 1967, p. 71.
10.1161/01.RES.19.2.274 / Circ.Res / Cerebral blood flow at high altitude by Severinghaus (1966)
10.1111/j.1600-0404.1966.tb01211.x / Acta Neurol.Scand / Regulation of cerebral blood flow as a single function of the interstitial pH in the brain by Skinhøj (1966)
10.1152/jappl.1967.23.5.726 / J.Appl.Physiol / Cerebral cortical blood flow during changes of acid-base equilibrium of the brain by Betz (1967)
10.1161/01.RES.20.2.272 / Circ.Res / Step hypocapnia to separate arterial from tissue PCO2 in the regulation of cerebral blood flow by Severinghaus (1967)
10.3109/00365516809167060 / Scand.J.Clin.Lab.Invest / Brain extracellular pH: The main factor controlling cerebral blood flow by Lassen (1968)
10.1152/jappl.1969.27.1.67 / J.Appl.Physiol / Respiration and cerebral blood flow in metabolic acidosis and alkalosis in humans by Fencl (1969)
10.1152/jappl.1963.18.6.1155 / J.Appl.Physiol / Respiratory control at high altitude suggesting active transport regulation of CSF pH by Severinghaus (1963)
10.3109/00365516909080124 / Scand.J.Clin.Lab.Invest / A new theory for the regulation of the extracellular pH in the brain by Siesjö (1969)
Wyke, B.: Brain Function and Metabolic Disorders. London, Butterworths, 1963.
10.1056/NEJM196709212771201 / New Engl.J.Med / Spinal fluid pH and neurologic symptoms in acidosis by Posner (1967)
Davson, H.: Physiology of the Cerebrospinal Fluid, London, J. & A. Churchill Ltd., 1967.
Edsall, J. T., and Wyman, J.: Biophysical Chemistry, Vol.1, New York, Academic Press, 1958, p. 699. (10.1016/B978-1-4832-2946-1.50005-1)
10.1016/S0021-9258(18)84448-9 / J.Biol.Chem / The carbon dioxide tension of cerebrospinal fluid by Shohl (1926)
10.1016/S0021-9258(18)64409-6 / J.Biol.Chem / The pK′ of carbonic acid in cerebrospinal fluid by Alexander (1961)
10.1111/j.1748-1716.1962.tb02447.x / Acta Physiol.Scand / The solubility of carbon dioxide in cerebral cortical tissue from the cat at 37.5°C.With a note on the solubility of carbon dioxide in water, 0.16 M NaCl and in cerebrospinal fluid by Siesjö (1962)
10.1111/j.1600-0404.1962.tb01083.x / Acta Neurol.Scand / The bicarbonate/carbonic acid buffer system of the cerebral cortex of cats, as studied in tissue homogenates.II.The pK′1 of carbonic acid at 37.5° C, and the relation between carbon dioxide tension and pH by Siesjö (1962)
10.1152/jappl.1965.20.1.27 / J.Appl.Physiol / Acid-base constants and temperature coefficients for cerebrospinal fluid by Mitchell (1965)
10.6028/jres.066A.016 / J.Res.Natl.Bur.Stand.A / Revised standard values for pH measurements from 0 to 95° C by Bates (1962)
10.1007/BF01481247 / Klin.Wochenschr / Das Saure-Basen-Gleichgewicht im arteriellen Blut und Liquor cerebrospinalis bei chronischer Niereninsuffizienz by Schwab (1962)
{'key': '10.1038/ki.1972.47_bb0125', 'first-page': '427', 'article-title': 'Die Beziehungen zwischen Blut und Liquor cerebrospinalis bei Störungen des Säure-Basen-Gleichgewichtes', 'volume': '11', 'author': 'Bühlmann', 'year': '1963', 'journal-title': 'Schweiz.Med.Voch.Schr'} / Schweiz.Med.Voch.Schr / Die Beziehungen zwischen Blut und Liquor cerebrospinalis bei Störungen des Säure-Basen-Gleichgewichtes by Bühlmann (1963)
10.1016/0009-8981(61)90156-5 / Clin.Chim.Acta / A micromethod for the determination pf pH and PCO2 in human cerebrospinal fluid by Heijst (1961)
10.1152/jappl.1961.16.3.485 / J.Appl.Physiol / Total CO2, PCO2, and pH in human spinal fluid by Merril (1961)
{'key': '10.1038/ki.1972.47_bb0140', 'first-page': '339', 'article-title': 'Simultaneous cerebrospinal fluid and serum acid-base balance, ionic patterns and ionic and osmolality distribution ratios', 'volume': '108', 'author': 'Stueck', 'year': '1961', 'journal-title': 'Bull.Johns Hopkins Hosp'} / Bull.Johns Hopkins Hosp / Simultaneous cerebrospinal fluid and serum acid-base balance, ionic patterns and ionic and osmolality distribution ratios by Stueck (1961)
10.1056/NEJM196108172650702 / New Engl.J.Med / Acid-base relations between blood and cerebrospinal fluid in normal subjects and patients with respiratory insufficiency by Merwarth (1961)
10.1113/jphysiol.1962.sp006853 / J.Physiol / A comparison of certain acid-base characteristics of arterial bleod, jugular venous blood and cerebrospinal fluid in man, and the effect on them of some acute and chronic acid-base disturbances by Bradley (1962)
{'key': '10.1038/ki.1972.47_bb0155', 'first-page': '128', 'article-title': 'Acid-base relations between serum and cerebrospinal fluid in man under normal and abnormal conditions', 'volume': '59', 'author': 'Manfredi', 'year': '1962', 'journal-title': 'J.Lab.Clin.Med'} / J.Lab.Clin.Med / Acid-base relations between serum and cerebrospinal fluid in man under normal and abnormal conditions by Manfredi (1962)
10.1007/BF02104140 / Klin.Wochschr / Die scheinbare erste Dissoziationskonstante (pK′1) der Kohlensäure im Liquor cerebrospinalis by Schwab (1962)
10.1007/BF00362485 / Pflügers Arch.ges.Physiol / Comparison of the acid-base balance in cisternal and lumbar cerebrospinal fluid by Heijst (1966)
10.1172/JCI101995 / J.Clin.Invest / The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men by Kety (1948)
10.1152/jappl.1961.16.3.473 / J.Appl.Physiol / H+ and PCO2 as chemical factors in respiratory and cerebral circulatory control by Lambertsen (1961)
10.1152/jappl.1967.23.2.183 / J.Appl.Physiol / Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man by Cohen (1967)
10.1152/jappl.1963.18.4.712 / J.Appl.Physiol / Cerebrospinal fluid acid-base balance during a changing ventilatory state in man by Fisher (1963)
{'issue': 'Suppl', 'key': '10.1038/ki.1972.47_bb0190', 'first-page': '1 B', 'article-title': 'Inhomogeneity of cisternal and lumbar CSF acid-base balance during acute metabolite alterations', 'volume': '102', 'author': 'Plum', 'year': '1968', 'journal-title': 'Scand.J.Clin.Lab.Invest.'} / Scand.J.Clin.Lab.Invest. / Inhomogeneity of cisternal and lumbar CSF acid-base balance during acute metabolite alterations by Plum (1968)
10.1016/S0021-9258(18)72512-X / J.Biol.Chem / Arterial and cerebral venous blood.Arterial-venous differences in man by Gibbs (1942)
{'key': '10.1038/ki.1972.47_bb0200', 'series-title': 'Brain Edema', 'first-page': '388', 'article-title': 'Carbon dioxide and acid-base equilibria in brain tissue', 'author': 'Siesjö', 'year': '1967'} / Brain Edema / Carbon dioxide and acid-base equilibria in brain tissue by Siesjö (1967)
10.1111/j.1748-1716.1966.tb03294.x / Acta Physiol.Scand / Gradients of CO2 tension in the brain by Pontén (1966)
10.1113/jphysiol.1967.sp008120 / J.Physiol / Mean carbon dioxide tension in the brain after carbonic anhydrase inhibition by Brzezinski (1967)
10.1152/jn.1964.27.4.645 / J.Neurophysiol / Extracellular space as a pathway for exchange between blood and neurons in the central nervous system of the leech: ionic composition of glial cells and neurons by Nicholls (1964)
10.1016/0024-3205(62)90104-2 / Life Sci / Extracellular space of brain as determined by diffusion of inulin from the ventricular system by Rail (1962)
{'key': '10.1038/ki.1972.47_bb0225', 'first-page': '273', 'article-title': 'Physiology of the choroid plexus', 'volume': '51', 'author': 'Cserr', 'year': '1971', 'journal-title': 'Phys.Rev'} / Phys.Rev / Physiology of the choroid plexus by Cserr (1971)
10.1152/jn.1964.27.4.672 / J.Neurophysiol / Na, K, Ca, Mg and Cl concentrations in choroid plexus fluid and cisternal fluid compared with plasma ultrafiltrate by Ames (1964)
{'key': '10.1038/ki.1972.47_bb0235', 'series-title': 'Ion Homeostasis of the Brain', 'first-page': '290', 'article-title': 'The effect of acetazolamide on HCO-3 and Cl- uptake into cerebrospinal fluid of cat and dogfish', 'author': 'Maren', 'year': '1971'} / Ion Homeostasis of the Brain / The effect of acetazolamide on HCO-3 and Cl- uptake into cerebrospinal fluid of cat and dogfish by Maren (1971)
10.1007/BF00362114 / Pflügers Arch.ges.Physiol / Über Bestandpotentiale im Gebiete der Medulla oblongata by Loeschke (1956)
10.1007/BF00363284 / Pflügers Arch.ges.Physiol / Messungen des transmeningealen Potentials der Katze bei Änderung des CO2-Drucks und der H+-Ionen-Konzentration im Blut by Mottschall (1963)
10.1152/ajplegacy.1958.195.1.7 / Am.J.Physiol / Slowly changing bioelectric potentials associated with the blood-brain barrier by Tschirgi (1958)
10.1152/jn.1964.27.5.942 / J.Neurophysiol / Electrical potential of cerebrospinal fluid by Held (1964)
10.1111/j.1748-1716.1970.tb04642.x / Acta Physiol.Scand / The CSF/blood potential in sustained acid-base changes in the rat.With calculations of electrochemical potential differences for H+ and HCO-3 by Kjällquist (1970)
10.1152/ajplegacy.1970.219.1.68 / Am.J.Physiol / Effect of cerebral acidosis on the CSF-blood potential difference by Sørensen (1970)
10.1111/j.1748-1716.1971.tb05046.x / Acta Physiol.Scand / The DC potential between CSF and plasma in respiratory acidosis by Messeter (1971)
{'key': '10.1038/ki.1972.47_bb0275', 'series-title': 'Ion Homeostasis of the Brain', 'first-page': '119', 'article-title': 'Discussion remarks', 'author': 'Cameron', 'year': '1971'} / Ion Homeostasis of the Brain / Discussion remarks by Cameron (1971)
10.1111/j.1748-1716.1971.tb04895.x / Acta Physiol.Scand / Changes in the electrochemical potential difference for HCO3- between blood and cerebrospinal fluid and in cerebrospinal fluid lactate concentration during isocarbic hypoxia by Mines (1971)
10.1111/j.1748-1716.1971.tb04896.x / Acta Physiol.Scand / The effect of isocarbic metabolic acidosis in blood on [H+] and [HCO-3] in CSF with deductions about the regulation of an active transport of H+/HCO-3 between blood and CSF by Mines (1971)
10.1111/j.1748-1716.1971.tb05047.x / Acta Physiol.Scand / Regulation of the CSF pH in acute and sustained respiratory acidosis by Messeter (1971)
10.1007/BF01484588 / Klin.Wochenschr / Säure-Basen-Gleichgewicht des Liquor cerebrospinalis und des arteriellen Blutes bei Niereninsuffizienz by Agrest (1962)
10.1152/jappl.1962.17.6.993 / J.Appl.Physiol / Chronic derangements of cerebrospinal fluid acid-base components in man by Pauli (1962)
10.1001/archneur.1965.00460290035006 / Arch.Neurol / Acid-base balance in cerebrospinal fluid by Posner (1965)
{'key': '10.1038/ki.1972.47_bb0310', 'first-page': '273', 'article-title': 'The maintenance of acid-base balance between cerebrospinal fluid and arterial blood in patients with chronic respiratory disorders', 'volume': '31', 'author': 'Huang', 'year': '1966', 'journal-title': 'Clin.Sci'} / Clin.Sci / The maintenance of acid-base balance between cerebrospinal fluid and arterial blood in patients with chronic respiratory disorders by Huang (1966)
10.1111/j.1748-1716.1967.tb03713.x / Acta Physiol.Scand / Acid-base relations in arterial blood and cerebrospinal fluid of the unanesthetized rat by Pontén (1967)
{'key': '10.1038/ki.1972.47_bb0320', 'first-page': '345', 'article-title': 'Effects of chronic metabolic acid-base disturbances on the composition of cerebrospinal fluid in the dog', 'volume': '36', 'author': 'Chazan', 'year': '1969', 'journal-title': 'Clin.Sci'} / Clin.Sci / Effects of chronic metabolic acid-base disturbances on the composition of cerebrospinal fluid in the dog by Chazan (1969)
10.1172/JCI104885 / J.Clin.Invest / The response of cerebrospinal fluid composition to sustained hypercapnia by Bleich (1964)
{'key': '10.1038/ki.1972.47_bb0330', 'first-page': '39', 'article-title': 'Chemosensitivity of the respiratory center.Influence of CO2 in the cerebral ventricles on respiration', 'volume': '776', 'author': 'Leusen', 'year': '1954', 'journal-title': 'Am.J.Physiol'} / Am.J.Physiol / Chemosensitivity of the respiratory center.Influence of CO2 in the cerebral ventricles on respiration by Leusen (1954)
10.1152/ajplegacy.1953.176.1.45 / Am.J.Physiol / Chemosensitivity of the respiratory center.Influence of changes in the H+ and total buffer concentrations in the cerebral ventricles on respiration by Leusen (1954)
10.1007/BF00363036 / Pflügers Arch.ges.Physiol / Über den Einfluß von Wasserstoffionenkonzentration und CO2-Druck im Liquor cerebrospinalis auf die Atmung by Loeschke (1958)
10.1152/jappl.1963.18.3.523 / J.Appl.Physiol / Respiratory responses mediated through superficial chemosensitive areas on the medulla by Mitchell (1963)
10.1152/ajplegacy.1926.78.3.610 / Am.J.Physiol / The regulation of respiration.IV.Tissue acidity, blood acidity and pulmonary ventilation.A study of the effects of semipermeability of membranes and the buffering action of tissues with the continuous method of recording changes in acidity by Gesell (1926)
10.1152/jappl.1958.13.3.385 / J.Appl.Physiol / Acid-base relations between spinal fluid and arterial blood with special reference to control of ventilation by Robin (1958)
{'key': '10.1038/ki.1972.47_bb0360', 'first-page': '397', 'article-title': 'The influence of extracorporeal dialysis on the acid-base composition of blood and cerebrospinal fluid', 'volume': '23', 'author': 'Cowie', 'year': '1962', 'journal-title': 'Clin.Sci'} / Clin.Sci / The influence of extracorporeal dialysis on the acid-base composition of blood and cerebrospinal fluid by Cowie (1962)
10.1152/jappl.1971.31.1.28 / J.Appl.Physiol / Cerebrospinal fluid acid-base composition at high altitude by Sørensen (1971)
10.1152/ajplegacy.1964.206.1.25 / Am.J.Physiol / Arterial PCO2 and cerebral hemodynamics by Reivich (1964)
10.1097/00000542-196011000-00008 / Anesthesiology / Carbon dioxide and respiration in acid-base homeostasis by Lambertsen (1960)
10.1007/BF01484389 / Klin.Wochschr / Das Säure-Basen-Gleichgewicht im arteriellen Blut und Liquor cerebrospinalis bei Herzinsuffizienz und Cor pulmonale und seine Beeinflussung durch Carbo-anhydrase-Hemmung by Schwab (1962)
{'key': '10.1038/ki.1972.47_bb0385', 'series-title': 'Ion Homeostasis of the Brain', 'first-page': '175', 'article-title': 'Distribution of H+ and HCO-3 in cerebral fluids', 'author': 'Fencl', 'year': '1971'} / Ion Homeostasis of the Brain / Distribution of H+ and HCO-3 in cerebral fluids by Fencl (1971)
10.1111/j.1748-1716.1967.tb03732.x / Acta Physiol.Scand / The CSF/blood potential in sustained acidosis and alkalosis in the rat by Kjällquist (1967)
{'key': '10.1038/ki.1972.47_bb0395', 'first-page': '178', 'article-title': 'Effect of chronic acidosis and alkalosis on rat CSF-blood potential', 'volume': '8', 'author': 'Goodrich', 'year': '1965', 'journal-title': 'Physiologist'} / Physiologist / Effect of chronic acidosis and alkalosis on rat CSF-blood potential by Goodrich (1965)
10.1016/0024-3205(71)90316-X / Life Sci / The CSF/blood potential and the regulation of the bicarbonate concentration of CSF during acidosis in the cat by Pannier (1971)
10.1152/ajplegacy.1970.218.1.275 / Am.J.Physiol / Brain potential shift with respiratory acidosis in the cat and monkey by Woody (1970)
{'key': '10.1038/ki.1972.47_bb0410', 'series-title': 'Ion Homeostasis of the Brain', 'first-page': '97', 'article-title': 'Influences of respiratory acidosis and of cerebral blood flow variations on the DC potential', 'author': 'Besson', 'year': '1971'} / Ion Homeostasis of the Brain / Influences of respiratory acidosis and of cerebral blood flow variations on the DC potential by Besson (1971)
10.1007/BF01895284 / Experientia / Factors affecting the cerebrospinal fluid (CSF) bicarbonate concentration by Siesjö (1966)
10.1111/j.1748-1716.1970.tb04707.x / Acta Physiol.Scand / The effect of hypovolemic hypotension on extra- and intracellular acid-base parameters and energy metabolites in the rat brain by Siesjö (1970)
10.1001/archneurpsyc.1944.02290290059010 / Arch.Neurol.Psychiat / Cerebral metabolism in hypoxia by Gurdjian (1944)
10.1111/j.1748-1716.1971.tb05103.x / Acta Physiol.Scand / The effect of arterial hypoxemia upon acid-base parameters in arterial blood and cisternal cerebrospinal fluid of the rat by MacMillan (1971)
10.1152/jappl.1970.28.6.832 / J.Appl.Physiol / Ventilatory responses to acute and chronic hypoxia in goats after sinus nerve section by Sørensen (1970)
10.1007/BF02104141 / Klin.Wochschr / Atmung, Säure-Basen-Gleichgewicht und Ammoniak/Ammonium in Blut und Liquor cerebrospinalis bei Lebercirrhose by Schwab (1962)
10.3109/00365517109095710 / Scand.J.Clin.Lab.Invest / Cerebral effects of acute ammonia intoxication I.The influence on intracellular and extracellular acid-base parameters by Hindfelt (1971)
10.1152/jappl.1969.26.6.745 / J.Appl.Physiol / Cerebral blood flow and metabolism during acute salicylate intoxication in the goat by Alexander (1969)
{'key': '10.1038/ki.1972.47_bb0455', 'series-title': 'Cerebrospinal Fluid and the Regulation of Ventilation', 'article-title': 'Aspects of the acid-base equilibrium between blood and cerebrospinal fluid', 'author': 'Leusen', 'year': '1965'} / Cerebrospinal Fluid and the Regulation of Ventilation / Aspects of the acid-base equilibrium between blood and cerebrospinal fluid by Leusen (1965)
{'key': '10.1038/ki.1972.47_bb0460', 'first-page': '738', 'article-title': 'Lactate in cerebrospinal fluid during hyperventilation', 'volume': '73', 'author': 'Van Vaerenbergh', 'year': '1965', 'journal-title': 'Arch.Int.Physiol'} / Arch.Int.Physiol / Lactate in cerebrospinal fluid during hyperventilation by Van Vaerenbergh (1965)
{'key': '10.1038/ki.1972.47_bb0465', 'first-page': '25', 'article-title': 'Lactate and pyruvate in the brain of rats during hyperventilation', 'volume': '74', 'author': 'Leusen', 'year': '1966', 'journal-title': 'Arch.Int.Physiol.Bioch'} / Arch.Int.Physiol.Bioch / Lactate and pyruvate in the brain of rats during hyperventilation by Leusen (1966)
10.1152/ajplegacy.1967.212.4.864 / Am.J.Physiol / Blood and cerebrospinal fluid lactate during hyperventilation by Plum (1967)
10.1111/j.1748-1716.1969.tb04495.x / Acta Physiol.Scand / The regulation of extra- and intracellular acid-base parameters in the rat brain during hyper- and hypocapnia by Kjällquist (1969)
10.1016/0034-5687(69)90056-5 / Respiration Physiol / Brain and cerebrospinal fluid lactate concentration in respiratory acidosis and alkalosis by Kazemi (1969)

Dates

Type	When
Created	18 years, 2 months ago (June 20, 2007, 9:08 a.m.)
Deposited	3 years, 10 months ago (Oct. 21, 2021, 2:47 a.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 1:03 a.m.)
Issued	53 years, 4 months ago (May 1, 1972)
Published	53 years, 4 months ago (May 1, 1972)
Published Print	53 years, 4 months ago (May 1, 1972)

Funders 0

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BibTeX

@article{Siesj__1972, title={The regulation of cerebrospinal fluid pH}, volume={1}, ISSN={0085-2538}, url={http://dx.doi.org/10.1038/ki.1972.47}, DOI={10.1038/ki.1972.47}, number={5}, journal={Kidney International}, publisher={Elsevier BV}, author={Siesjö, Bo K.}, year={1972}, month=may, pages={360–374} }

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      "author": "Lassen",
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      "volume": "27",
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    {
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      "article-title": "The carbon dioxide tension of cerebrospinal fluid",
      "volume": "71",
      "author": "Shohl",
      "year": "1926",
      "journal-title": "J.Biol.Chem"
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    {
      "key": "10.1038/ki.1972.47_bb0095",
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      "DOI": "10.1016/S0021-9258(18)64409-6",
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      "volume": "236",
      "author": "Alexander",
      "year": "1961",
      "journal-title": "J.Biol.Chem"
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    {
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      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1111/j.1748-1716.1962.tb02447.x",
      "article-title": "The solubility of carbon dioxide in cerebral cortical tissue from the cat at 37.5\u00b0C.With a note on the solubility of carbon dioxide in water, 0.16 M NaCl and in cerebrospinal fluid",
      "volume": "55",
      "author": "Siesj\u00f6",
      "year": "1962",
      "journal-title": "Acta Physiol.Scand"
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      "volume": "38",
      "author": "Siesj\u00f6",
      "year": "1962",
      "journal-title": "Acta Neurol.Scand"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1152/jappl.1965.20.1.27",
      "article-title": "Acid-base constants and temperature coefficients for cerebrospinal fluid",
      "volume": "20",
      "author": "Mitchell",
      "year": "1965",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0115",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.6028/jres.066A.016",
      "article-title": "Revised standard values for pH measurements from 0 to 95\u00b0 C",
      "volume": "66",
      "author": "Bates",
      "year": "1962",
      "journal-title": "J.Res.Natl.Bur.Stand.A"
    },
    {
      "key": "10.1038/ki.1972.47_bb0120",
      "doi-asserted-by": "crossref",
      "first-page": "765",
      "DOI": "10.1007/BF01481247",
      "article-title": "Das Saure-Basen-Gleichgewicht im arteriellen Blut und Liquor cerebrospinalis bei chronischer Niereninsuffizienz",
      "volume": "40",
      "author": "Schwab",
      "year": "1962",
      "journal-title": "Klin.Wochenschr"
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    {
      "key": "10.1038/ki.1972.47_bb0125",
      "first-page": "427",
      "article-title": "Die Beziehungen zwischen Blut und Liquor cerebrospinalis bei St\u00f6rungen des S\u00e4ure-Basen-Gleichgewichtes",
      "volume": "11",
      "author": "B\u00fchlmann",
      "year": "1963",
      "journal-title": "Schweiz.Med.Voch.Schr"
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    {
      "key": "10.1038/ki.1972.47_bb0130",
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      "first-page": "589",
      "DOI": "10.1016/0009-8981(61)90156-5",
      "article-title": "A micromethod for the determination pf pH and PCO2 in human cerebrospinal fluid",
      "volume": "6",
      "author": "Heijst",
      "year": "1961",
      "journal-title": "Clin.Chim.Acta"
    },
    {
      "key": "10.1038/ki.1972.47_bb0135",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1152/jappl.1961.16.3.485",
      "article-title": "Total CO2, PCO2, and pH in human spinal fluid",
      "volume": "16",
      "author": "Merril",
      "year": "1961",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0140",
      "first-page": "339",
      "article-title": "Simultaneous cerebrospinal fluid and serum acid-base balance, ionic patterns and ionic and osmolality distribution ratios",
      "volume": "108",
      "author": "Stueck",
      "year": "1961",
      "journal-title": "Bull.Johns Hopkins Hosp"
    },
    {
      "key": "10.1038/ki.1972.47_bb0145",
      "doi-asserted-by": "crossref",
      "first-page": "310",
      "DOI": "10.1056/NEJM196108172650702",
      "article-title": "Acid-base relations between blood and cerebrospinal fluid in normal subjects and patients with respiratory insufficiency",
      "volume": "265",
      "author": "Merwarth",
      "year": "1961",
      "journal-title": "New Engl.J.Med"
    },
    {
      "key": "10.1038/ki.1972.47_bb0150",
      "doi-asserted-by": "crossref",
      "first-page": "381",
      "DOI": "10.1113/jphysiol.1962.sp006853",
      "article-title": "A comparison of certain acid-base characteristics of arterial bleod, jugular venous blood and cerebrospinal fluid in man, and the effect on them of some acute and chronic acid-base disturbances",
      "volume": "160",
      "author": "Bradley",
      "year": "1962",
      "journal-title": "J.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0155",
      "first-page": "128",
      "article-title": "Acid-base relations between serum and cerebrospinal fluid in man under normal and abnormal conditions",
      "volume": "59",
      "author": "Manfredi",
      "year": "1962",
      "journal-title": "J.Lab.Clin.Med"
    },
    {
      "key": "10.1038/ki.1972.47_bb0160",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1007/BF02104140",
      "article-title": "Die scheinbare erste Dissoziationskonstante (pK\u20321) der Kohlens\u00e4ure im Liquor cerebrospinalis",
      "volume": "40",
      "author": "Schwab",
      "year": "1962",
      "journal-title": "Klin.Wochschr"
    },
    {
      "key": "10.1038/ki.1972.47_bb0165",
      "doi-asserted-by": "crossref",
      "first-page": "242",
      "DOI": "10.1007/BF00362485",
      "article-title": "Comparison of the acid-base balance in cisternal and lumbar cerebrospinal fluid",
      "volume": "287",
      "author": "Heijst",
      "year": "1966",
      "journal-title": "Pfl\u00fcgers Arch.ges.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0170",
      "doi-asserted-by": "crossref",
      "first-page": "484",
      "DOI": "10.1172/JCI101995",
      "article-title": "The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men",
      "volume": "27",
      "author": "Kety",
      "year": "1948",
      "journal-title": "J.Clin.Invest"
    },
    {
      "key": "10.1038/ki.1972.47_bb0175",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1152/jappl.1961.16.3.473",
      "article-title": "H+ and PCO2 as chemical factors in respiratory and cerebral circulatory control",
      "volume": "16",
      "author": "Lambertsen",
      "year": "1961",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0180",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1152/jappl.1967.23.2.183",
      "article-title": "Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man",
      "volume": "23",
      "author": "Cohen",
      "year": "1967",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0185",
      "doi-asserted-by": "crossref",
      "first-page": "712",
      "DOI": "10.1152/jappl.1963.18.4.712",
      "article-title": "Cerebrospinal fluid acid-base balance during a changing ventilatory state in man",
      "volume": "18",
      "author": "Fisher",
      "year": "1963",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "issue": "Suppl",
      "key": "10.1038/ki.1972.47_bb0190",
      "first-page": "1 B",
      "article-title": "Inhomogeneity of cisternal and lumbar CSF acid-base balance during acute metabolite alterations",
      "volume": "102",
      "author": "Plum",
      "year": "1968",
      "journal-title": "Scand.J.Clin.Lab.Invest."
    },
    {
      "key": "10.1038/ki.1972.47_bb0195",
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      "first-page": "325",
      "DOI": "10.1016/S0021-9258(18)72512-X",
      "article-title": "Arterial and cerebral venous blood.Arterial-venous differences in man",
      "volume": "144",
      "author": "Gibbs",
      "year": "1942",
      "journal-title": "J.Biol.Chem"
    },
    {
      "key": "10.1038/ki.1972.47_bb0200",
      "series-title": "Brain Edema",
      "first-page": "388",
      "article-title": "Carbon dioxide and acid-base equilibria in brain tissue",
      "author": "Siesj\u00f6",
      "year": "1967"
    },
    {
      "key": "10.1038/ki.1972.47_bb0205",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1111/j.1748-1716.1966.tb03294.x",
      "article-title": "Gradients of CO2 tension in the brain",
      "volume": "67",
      "author": "Pont\u00e9n",
      "year": "1966",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0210",
      "doi-asserted-by": "crossref",
      "first-page": "12",
      "DOI": "10.1113/jphysiol.1967.sp008120",
      "article-title": "Mean carbon dioxide tension in the brain after carbonic anhydrase inhibition",
      "volume": "188",
      "author": "Brzezinski",
      "year": "1967",
      "journal-title": "J.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0215",
      "doi-asserted-by": "crossref",
      "first-page": "645",
      "DOI": "10.1152/jn.1964.27.4.645",
      "article-title": "Extracellular space as a pathway for exchange between blood and neurons in the central nervous system of the leech: ionic composition of glial cells and neurons",
      "volume": "27",
      "author": "Nicholls",
      "year": "1964",
      "journal-title": "J.Neurophysiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0220",
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      "first-page": "43",
      "DOI": "10.1016/0024-3205(62)90104-2",
      "article-title": "Extracellular space of brain as determined by diffusion of inulin from the ventricular system",
      "volume": "2",
      "author": "Rail",
      "year": "1962",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1038/ki.1972.47_bb0225",
      "first-page": "273",
      "article-title": "Physiology of the choroid plexus",
      "volume": "51",
      "author": "Cserr",
      "year": "1971",
      "journal-title": "Phys.Rev"
    },
    {
      "key": "10.1038/ki.1972.47_bb0230",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1152/jn.1964.27.4.672",
      "article-title": "Na, K, Ca, Mg and Cl concentrations in choroid plexus fluid and cisternal fluid compared with plasma ultrafiltrate",
      "volume": "27",
      "author": "Ames",
      "year": "1964",
      "journal-title": "J.Neurophysiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0235",
      "series-title": "Ion Homeostasis of the Brain",
      "first-page": "290",
      "article-title": "The effect of acetazolamide on HCO-3 and Cl- uptake into cerebrospinal fluid of cat and dogfish",
      "author": "Maren",
      "year": "1971"
    },
    {
      "key": "10.1038/ki.1972.47_bb0240",
      "doi-asserted-by": "crossref",
      "first-page": "517",
      "DOI": "10.1007/BF00362114",
      "article-title": "\u00dcber Bestandpotentiale im Gebiete der Medulla oblongata",
      "volume": "262",
      "author": "Loeschke",
      "year": "1956",
      "journal-title": "Pfl\u00fcgers Arch.ges.Physiol"
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    {
      "key": "10.1038/ki.1972.47_bb0245",
      "doi-asserted-by": "crossref",
      "first-page": "662",
      "DOI": "10.1007/BF00363284",
      "article-title": "Messungen des transmeningealen Potentials der Katze bei \u00c4nderung des CO2-Drucks und der H+-Ionen-Konzentration im Blut",
      "volume": "277",
      "author": "Mottschall",
      "year": "1963",
      "journal-title": "Pfl\u00fcgers Arch.ges.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0250",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1152/ajplegacy.1958.195.1.7",
      "article-title": "Slowly changing bioelectric potentials associated with the blood-brain barrier",
      "volume": "195",
      "author": "Tschirgi",
      "year": "1958",
      "journal-title": "Am.J.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0255",
      "doi-asserted-by": "crossref",
      "first-page": "942",
      "DOI": "10.1152/jn.1964.27.5.942",
      "article-title": "Electrical potential of cerebrospinal fluid",
      "volume": "27",
      "author": "Held",
      "year": "1964",
      "journal-title": "J.Neurophysiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0260",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1111/j.1748-1716.1970.tb04642.x",
      "article-title": "The CSF/blood potential in sustained acid-base changes in the rat.With calculations of electrochemical potential differences for H+ and HCO-3",
      "volume": "78",
      "author": "Kj\u00e4llquist",
      "year": "1970",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0265",
      "doi-asserted-by": "crossref",
      "first-page": "68",
      "DOI": "10.1152/ajplegacy.1970.219.1.68",
      "article-title": "Effect of cerebral acidosis on the CSF-blood potential difference",
      "volume": "219",
      "author": "S\u00f8rensen",
      "year": "1970",
      "journal-title": "Am.J.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0270",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1111/j.1748-1716.1971.tb05046.x",
      "article-title": "The DC potential between CSF and plasma in respiratory acidosis",
      "volume": "83",
      "author": "Messeter",
      "year": "1971",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0275",
      "series-title": "Ion Homeostasis of the Brain",
      "first-page": "119",
      "article-title": "Discussion remarks",
      "author": "Cameron",
      "year": "1971"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1111/j.1748-1716.1971.tb04895.x",
      "article-title": "Changes in the electrochemical potential difference for HCO3- between blood and cerebrospinal fluid and in cerebrospinal fluid lactate concentration during isocarbic hypoxia",
      "volume": "81",
      "author": "Mines",
      "year": "1971",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0285",
      "doi-asserted-by": "crossref",
      "first-page": "234",
      "DOI": "10.1111/j.1748-1716.1971.tb04896.x",
      "article-title": "The effect of isocarbic metabolic acidosis in blood on [H+] and [HCO-3] in CSF with deductions about the regulation of an active transport of H+/HCO-3 between blood and CSF",
      "volume": "81",
      "author": "Mines",
      "year": "1971",
      "journal-title": "Acta Physiol.Scand"
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      "first-page": "21",
      "DOI": "10.1111/j.1748-1716.1971.tb05047.x",
      "article-title": "Regulation of the CSF pH in acute and sustained respiratory acidosis",
      "volume": "83",
      "author": "Messeter",
      "year": "1971",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0295",
      "doi-asserted-by": "crossref",
      "first-page": "1045",
      "DOI": "10.1007/BF01484588",
      "article-title": "S\u00e4ure-Basen-Gleichgewicht des Liquor cerebrospinalis und des arteriellen Blutes bei Niereninsuffizienz",
      "volume": "40",
      "author": "Agrest",
      "year": "1962",
      "journal-title": "Klin.Wochenschr"
    },
    {
      "key": "10.1038/ki.1972.47_bb0300",
      "doi-asserted-by": "crossref",
      "first-page": "993",
      "DOI": "10.1152/jappl.1962.17.6.993",
      "article-title": "Chronic derangements of cerebrospinal fluid acid-base components in man",
      "volume": "17",
      "author": "Pauli",
      "year": "1962",
      "journal-title": "J.Appl.Physiol"
    },
    {
      "key": "10.1038/ki.1972.47_bb0305",
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      "first-page": "479",
      "DOI": "10.1001/archneur.1965.00460290035006",
      "article-title": "Acid-base balance in cerebrospinal fluid",
      "volume": "12",
      "author": "Posner",
      "year": "1965",
      "journal-title": "Arch.Neurol"
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    {
      "key": "10.1038/ki.1972.47_bb0310",
      "first-page": "273",
      "article-title": "The maintenance of acid-base balance between cerebrospinal fluid and arterial blood in patients with chronic respiratory disorders",
      "volume": "31",
      "author": "Huang",
      "year": "1966",
      "journal-title": "Clin.Sci"
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    {
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      "first-page": "89",
      "DOI": "10.1111/j.1748-1716.1967.tb03713.x",
      "article-title": "Acid-base relations in arterial blood and cerebrospinal fluid of the unanesthetized rat",
      "volume": "71",
      "author": "Pont\u00e9n",
      "year": "1967",
      "journal-title": "Acta Physiol.Scand"
    },
    {
      "key": "10.1038/ki.1972.47_bb0320",
      "first-page": "345",
      "article-title": "Effects of chronic metabolic acid-base disturbances on the composition of cerebrospinal fluid in the dog",
      "volume": "36",
      "author": "Chazan",
      "year": "1969",
      "journal-title": "Clin.Sci"
    },
    {
      "key": "10.1038/ki.1972.47_bb0325",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1172/JCI104885",
      "article-title": "The response of cerebrospinal fluid composition to sustained hypercapnia",
      "volume": "43",
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