DOI: 10.1038/jcbfm.1989.111. Glycolysis-Induced Discordance between Glucose Metabolic Rates Measured with Radiolabeled Fluorodeoxyglucose and Glucose

Glycolysis-Induced Discordance between Glucose Metabolic Rates Measured with Radiolabeled Fluorodeoxyglucose and Glucose

10.1038/jcbfm.1989.111

Crossref journal-article

SAGE Publications

Journal of Cerebral Blood Flow & Metabolism (179)

Abstract

We have developed an autoradiographic method for estimating the oxidative and glycolytic components of local CMRglc (LCMRglc), using sequentially administered [18F]fIuorodeoxyglucose (FDG) and [14C]-6-glucose (GLC). FDG-6-phosphate accumulation is proportional to the rate of glucose phosphorylation, which occurs before the divergence of glycolytic ( GMg) and oxidative ( GMo) glucose metabolism and is therefore related to total cerebral glucose metabolism GMt: GMg + GMo = GMt. With oxidative metabolism, the 14C label of GLC is temporarily retained in Krebs cycle-related substrate pools. We hypothesize that with glycolytic metabolism, however, a significant fraction of the 14C label is lost from the brain via lactate production and efflux from the brain. Thus, cerebral GLC metabolite concentration may be more closely related to GMo than to GMt If true, the glycolytic metabolic rate will be related to the difference between FDG- and GLC-derived LCMRglc. Thus far, we have studied normal awake rats, rats with limbic activation induced by kainic acid (KA), and rats visually stimulated with 16-Hz flashes. In KA-treated rats, significant discordance between FDG and GLC accumulation, which we attribute to glycolysis, occurred only in activated limbic structures. In visually stimulated rats, significant discordance occurred only in the optic tectum.

Authors 2

Robert F. Ackermann (first)
James L. Lear (additional)

References 64 Referenced 111

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Dates

Type	When
Created	14 years, 4 months ago (April 8, 2011, 1:44 p.m.)
Deposited	5 months, 3 weeks ago (March 10, 2025, 5:39 p.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:18 p.m.)
Issued	35 years, 9 months ago (Dec. 1, 1989)
Published	35 years, 9 months ago (Dec. 1, 1989)
Published Online	35 years, 9 months ago (Dec. 1, 1989)
Published Print	35 years, 9 months ago (Dec. 1, 1989)

Funders 0

None

BibTeX

@article{Ackermann_1989, title={Glycolysis-Induced Discordance between Glucose Metabolic Rates Measured with Radiolabeled Fluorodeoxyglucose and Glucose}, volume={9}, ISSN={1559-7016}, url={http://dx.doi.org/10.1038/jcbfm.1989.111}, DOI={10.1038/jcbfm.1989.111}, number={6}, journal={Journal of Cerebral Blood Flow & Metabolism}, publisher={SAGE Publications}, author={Ackermann, Robert F. and Lear, James L.}, year={1989}, month=dec, pages={774–785} }

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  "abstract": "<jats:p> We have developed an autoradiographic method for estimating the oxidative and glycolytic components of local CMR<jats:sub>glc</jats:sub> (LCMR<jats:sub>glc</jats:sub>), using sequentially administered [<jats:sup>18</jats:sup>F]fIuorodeoxyglucose (FDG) and [<jats:sup>14</jats:sup>C]-6-glucose (GLC). FDG-6-phosphate accumulation is proportional to the rate of glucose phosphorylation, which occurs before the divergence of glycolytic ( GM<jats:sub>g</jats:sub>) and oxidative ( GM<jats:sub>o</jats:sub>) glucose metabolism and is therefore related to total cerebral glucose metabolism GM<jats:sub>t</jats:sub>: GM<jats:sub>g</jats:sub> + GM<jats:sub>o</jats:sub> = GM<jats:sub>t</jats:sub>. With oxidative metabolism, the <jats:sup>14</jats:sup>C label of GLC is temporarily retained in Krebs cycle-related substrate pools. We hypothesize that with glycolytic metabolism, however, a significant fraction of the <jats:sup>14</jats:sup>C label is lost from the brain via lactate production and efflux from the brain. Thus, cerebral GLC metabolite concentration may be more closely related to GM<jats:sub>o</jats:sub> than to GM<jats:sub>t</jats:sub> If true, the glycolytic metabolic rate will be related to the difference between FDG- and GLC-derived LCMR<jats:sub>glc</jats:sub>. Thus far, we have studied normal awake rats, rats with limbic activation induced by kainic acid (KA), and rats visually stimulated with 16-Hz flashes. In KA-treated rats, significant discordance between FDG and GLC accumulation, which we attribute to glycolysis, occurred only in activated limbic structures. In visually stimulated rats, significant discordance occurred only in the optic tectum. </jats:p>",
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