DOI: 10.1038/jcbfm.1988.111. Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images

Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images

10.1038/jcbfm.1988.111

Crossref journal-article

SAGE Publications

Journal of Cerebral Blood Flow & Metabolism (179)

Abstract

Intersubject averaging and change-distribution analysis of subtracted positron emission tomographic (PET) images were developed and tested. The purpose of these techniques is to increase the sensitivity and objectivity of functional mapping of the human brain with PET. To permit image averaging, all primary tomographic images were converted to anatomically standardized three-dimensional images using stereotactic anatomical localization and interslice interpolation. Image noise, measured in control-minus-control subtractions, was strongly suppressed by averaging. Signal-to-noise ratio, measured in stimulus-minus-control subtractions (hand vibration minus eyes-closed rest), rose steadily with averaging, confirming the accuracy of our method of anatomical standardization. Distribution analysis of CBF change images (outlier detection by gamma-2 statistic) was assessed as an omnibus test for state-dependent changes in regional neuronal activity. Sensitivity in detecting the somatosensory response rose steadily with averaging, increasing from 50% in individual images to 100% when three or more images were averaged. Specificity was 100% at all averaging levels. Although described here as a technique for functional brain mapping with H215O CBF images, image averaging, and change-distribution analysis are more generally applicable techniques, not limited to a single purpose or tracer.

Bibliography

Fox, P. T., Mintun, M. A., Reiman, E. M., & Raichle, M. E. (1988). Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images. Journal of Cerebral Blood Flow & Metabolism, 8(5), 642â653.

Authors 4

Peter T. Fox (first)
Mark A. Mintun (additional)
Eric M. Reiman (additional)
Marcus E. Raichle (additional)

References 20 Referenced 390

{'key': 'bibr1-jcbfm.1988.111', 'first-page': '1,429', 'volume': '12', 'author': 'Burton H', 'year': '1986', 'journal-title': 'Soc Neurosci Abst'} / Soc Neurosci Abst by Burton H (1986)
10.1093/biomet/58.2.341
{'key': 'bibr3-jcbfm.1988.111', 'first-page': '669', 'volume': '58', 'author': "D'Agostino RB", 'year': '1971', 'journal-title': 'Biometrika'} / Biometrika by D'Agostino RB (1971)
10.1038/jcbfm.1984.49
10.3171/jns.1987.67.1.0034
10.1523/JNEUROSCI.07-03-00913.1987
10.1038/323806a0
10.1097/00004728-198501000-00025
10.1152/jn.1984.51.5.1109
10.1073/pnas.83.4.1140
10.1080/00401706.1969.10490657
{'key': 'bibr12-jcbfm.1988.111', 'first-page': '782', 'volume': '14', 'author': 'Herscovitch P', 'year': '1983', 'journal-title': 'J Nucl Med'} / J Nucl Med by Herscovitch P (1983)
10.1038/jcbfm.1987.102
Pearson ES, Hartley HO, (1966) Biometrika Tables for Statisticians, Vol. 1, 3rd edition. Cambridge, England, Cambridge University Press, p 264
10.1038/331585a0
{'key': 'bibr16-jcbfm.1988.111', 'first-page': '790', 'volume': '24', 'author': 'Raichle ME', 'year': '1983', 'journal-title': 'J Nucl Med'} / J Nucl Med by Raichle ME (1983)
Snedecor GW, Cochran WG, (1982) Statistical Methods, 7th ed. Ames, Iowa, Iowa State University Press, pp. 75–82, 492
{'volume-title': "Atlas d'Anatomie Stéréotaxique du Télencéphale", 'year': '1967', 'author': 'Talairach J', 'key': 'bibr18-jcbfm.1988.111'} / Atlas d'Anatomie Stéréotaxique du Télencéphale by Talairach J (1967)
10.1109/TNS.1982.4335901
Zar JH, (1984) Biostatistical Analysis, 2nd ed. Englewood Cliffs, New Jersey, Prentice-Hall, pp. 79–95, 118–120, 582

Dates

Type	When
Created	14 years, 4 months ago (April 8, 2011, 1:42 p.m.)
Deposited	5 months, 2 weeks ago (March 10, 2025, 11:26 p.m.)
Indexed	3 months ago (May 28, 2025, 6:29 a.m.)
Issued	36 years, 10 months ago (Oct. 1, 1988)
Published	36 years, 10 months ago (Oct. 1, 1988)
Published Online	36 years, 10 months ago (Oct. 1, 1988)
Published Print	36 years, 10 months ago (Oct. 1, 1988)

Funders 0

None

BibTeX

@article{Fox_1988, title={Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images}, volume={8}, ISSN={1559-7016}, url={http://dx.doi.org/10.1038/jcbfm.1988.111}, DOI={10.1038/jcbfm.1988.111}, number={5}, journal={Journal of Cerebral Blood Flow & Metabolism}, publisher={SAGE Publications}, author={Fox, Peter T. and Mintun, Mark A. and Reiman, Eric M. and Raichle, Marcus E.}, year={1988}, month=oct, pages={642–653} }

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