DOI: 10.1038/jcbfm.1987.12. GABA and Benzodiazepine Receptors in the Gerbil Brain after Transient Ischemia: Demonstration by Quantitative Receptor Autoradiography

GABA and Benzodiazepine Receptors in the Gerbil Brain after Transient Ischemia: Demonstration by Quantitative Receptor Autoradiography

10.1038/jcbfm.1987.12

Crossref journal-article

SAGE Publications

Journal of Cerebral Blood Flow & Metabolism (179)

Abstract

Quantitative receptor autoradiography was used to measure the binding of γ-aminobutyric acid (GABA) and benzodiazepine receptors after ischemia by means of transient occlusion of bilateral common carotid arteries in the gerbil. [3H]Muscimol was used to label the GABAAreceptors and [3H]funitrazepam to label central type benzodiazepine receptors. In the superolateral convexities of the frontal cortices, [3H]muscimol binding was increased in 60% of the animals killed 3 days after ischemia, and decreased in 67% of the animals killed 27 days after ischemia. Twenty-seven days after ischemia, [3H]funitrazepam binding in the substantia nigra pars reticulata increased to 252% of the control, though the increase in [3H]muscimol binding was not significant. In the dorsolateral region of the caudate putamen, marked neuronal necrosis and depletion of both [3H]muscimol and [3H]funitrazepam binding sites were observed 27 days after ischemia, the ventromedial region being left intact. In spite of the depletion of pyramidal cells in the CA1 region of the hippocampus, both [3H]muscimol and [3H]funitrazepam binding sites were preserved 27 days after ischemia. Since our previous study revealed that adenosine A1binding sites were depleted in the CA1 subfield of the hippocampus after ischemia correlating with neuronal damage, GABAAand benzodiazepine receptors may not be distributed predominantly on the pyramidal cells in the CA1 region.

Bibliography

Onodera, H., Sato, G., & Kogure, K. (1987). GABA and Benzodiazepine Receptors in the Gerbil Brain after Transient Ischemia: Demonstration by Quantitative Receptor Autoradiography. Journal of Cerebral Blood Flow & Metabolism, 7(1), 82â88.

Authors 3

Hiroshi Onodera (first)
Gen Sato (additional)
Kyuya Kogure (additional)

References 26 Referenced 66

10.1073/pnas.74.9.3805
10.1002/ana.410050206
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{'key': 'bibr14-jcbfm.1987.12', 'first-page': '245', 'volume': '22', 'author': 'Olsen RW', 'year': '1982', 'journal-title': 'Acta Pharmacol Toxicol (Copenh)'} / Acta Pharmacol Toxicol (Copenh) by Olsen RW (1982)
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Dates

Type	When
Created	14 years, 4 months ago (April 8, 2011, 12:44 a.m.)
Deposited	5 months, 2 weeks ago (March 10, 2025, 10:29 p.m.)
Indexed	5 months, 2 weeks ago (March 10, 2025, 11:40 p.m.)
Issued	38 years, 6 months ago (Feb. 1, 1987)
Published	38 years, 6 months ago (Feb. 1, 1987)
Published Online	38 years, 6 months ago (Feb. 1, 1987)
Published Print	38 years, 6 months ago (Feb. 1, 1987)

Funders 0

None

BibTeX

@article{Onodera_1987, title={GABA and Benzodiazepine Receptors in the Gerbil Brain after Transient Ischemia: Demonstration by Quantitative Receptor Autoradiography}, volume={7}, ISSN={1559-7016}, url={http://dx.doi.org/10.1038/jcbfm.1987.12}, DOI={10.1038/jcbfm.1987.12}, number={1}, journal={Journal of Cerebral Blood Flow & Metabolism}, publisher={SAGE Publications}, author={Onodera, Hiroshi and Sato, Gen and Kogure, Kyuya}, year={1987}, month=feb, pages={82–88} }

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