DOI: 10.1038/embor.2011.132. RodZ regulates the post‐transcriptional processing of the <i>Shigella sonnei</i> type III secretion system

RodZ regulates the post‐transcriptional processing of the Shigella sonnei type III secretion system

10.1038/embor.2011.132

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

The expression of the type III secretion system—a main determinant of virulence in Shigella—is controlled by regulator cascades VirF‐InvE (VirB) and CpxAR two‐component system. A screen for mutants that restore virulence in the cpxA background led to the isolation of a mutant of rodZ, a cytoskeletal protein that maintains the rod‐shaped morphology of bacilli. InvE is normally repressed at 30 °C because of decreased messenger RNA (mRNA) stability, but rodZ mutants markedly increase invE‐mRNA stability. Importantly, the inhibition of InvE production by RodZ can be genetically separated from its role in cell‐shape maintenance, indicating that these functions are distinguishable. Thus, we propose that RodZ is a new membrane‐bound RNA‐binding protein that provides a scaffold for post‐transcriptional regulation.

Bibliography

Mitobe, J., Yanagihara, I., Ohnishi, K., Yamamoto, S., Ohnishi, M., Ishihama, A., & Watanabe, H. (2011). RodZ regulates the postâtranscriptional processing of the Shigella sonnei type III secretion system. EMBO Reports, 12(9), 911â916. Portico.

Authors 7

Jiro Mitobe (first)
Itaru Yanagihara (additional)
Kiyouhisa Ohnishi (additional)
Shouji Yamamoto (additional)
Makoto Ohnishi (additional)
Akira Ishihama (additional)
Haruo Watanabe (additional)

References 18 Referenced 25

10.1111/j.1365-2958.1989.tb00210.x
10.1046/j.1365-2958.2003.03344.x
10.1073/pnas.0810794106
10.1046/j.1365-2958.2003.03347.x
10.1038/emboj.2008.264
10.1046/j.1365-2958.1998.00902.x
10.1016/S0092-8674(01)00287-2
10.1128/iai.57.5.1391-1398.1989 / Infect Immun / Cloning of regions required for contact hemolysis and entry into LLC‐MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes by Kato J (1989)
10.1128/iai.43.1.195-201.1984
10.1128/JB.187.1.107-113.2005
10.1074/jbc.M710108200
10.1186/1471-2180-9-110
10.1128/JB.180.14.3522-3528.1998
10.1128/jb.176.13.4187-4191.1994
10.1038/emboj.2008.234
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10.1128/jb.172.2.619-629.1990

Dates

Type	When
Created	14 years, 1 month ago (July 22, 2011, 5:34 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:55 p.m.)
Indexed	1 year, 1 month ago (July 5, 2024, 9:06 a.m.)
Issued	14 years, 1 month ago (July 22, 2011)
Published	14 years, 1 month ago (July 22, 2011)
Published Online	14 years, 1 month ago (July 22, 2011)
Published Print	13 years, 11 months ago (Sept. 1, 2011)

Funders 0

None

BibTeX

@article{Mitobe_2011, title={RodZ regulates the post‐transcriptional processing of the Shigella sonnei type III secretion system}, volume={12}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/embor.2011.132}, DOI={10.1038/embor.2011.132}, number={9}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Mitobe, Jiro and Yanagihara, Itaru and Ohnishi, Kiyouhisa and Yamamoto, Shouji and Ohnishi, Makoto and Ishihama, Akira and Watanabe, Haruo}, year={2011}, month=jul, pages={911–916} }

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