DOI: 10.1038/embor.2008.83. Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by <i>Streptomyces</i>

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

10.1038/embor.2008.83

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

Members of the soil‐dwelling prokaryotic genus Streptomyces produce many secondary metabolites, including antibiotics and anti‐tumour agents. Their formation is coupled with the onset of development, which is triggered by the nutrient status of the habitat. We propose the first complete signalling cascade from nutrient sensing to development and antibiotic biosynthesis. We show that a high concentration of N‐acetylglucosamine—perhaps mimicking the accumulation of N‐acetylglucosamine after autolytic degradation of the vegetative mycelium—is a major checkpoint for the onset of secondary metabolism. The response is transmitted to antibiotic pathway‐specific activators through the pleiotropic transcriptional repressor DasR, the regulon of which also includes all N‐acetylglucosamine‐related catabolic genes. The results allowed us to devise a new strategy for activating pathways for secondary metabolite biosynthesis. Such ‘cryptic’ pathways are abundant in actinomycete genomes, thereby offering new prospects in the fight against multiple drug‐resistant pathogens and cancers.

Bibliography

Rigali, S., Titgemeyer, F., Barends, S., Mulder, S., Thomae, A. W., Hopwood, D. A., & van Wezel, G. P. (2008). Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Reports, 9(7), 670â675. Portico.

Authors 7

Sébastien Rigali (first)
Fritz Titgemeyer (additional)
Sharief Barends (additional)
Suzanne Mulder (additional)
Andreas W Thomae (additional)
David A Hopwood (additional)
Gilles P van Wezel (additional)

References 32 Referenced 348

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{'key': 'e_1_2_6_6_1', 'first-page': '149', 'article-title': 'Mycelial life style of Streptomyces coelicolor A3(2) and its relatives', 'author': 'Chater KF', 'year': '1997', 'journal-title': 'Bacteria as Multicellular Organisms'} / Bacteria as Multicellular Organisms / Mycelial life style of Streptomyces coelicolor A3(2) and its relatives by Chater KF (1997)
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KieserT BibbMJ ButtnerMJ ChaterKF HopwoodDA(2000)Practical Streptomyces Genetics. Norwich UK: John Innes Foundation
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Dates

Type	When
Created	17 years, 3 months ago (May 30, 2008, 6:35 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:57 p.m.)
Indexed	2 days, 12 hours ago (Sept. 4, 2025, 9:39 a.m.)
Issued	17 years, 3 months ago (May 30, 2008)
Published	17 years, 3 months ago (May 30, 2008)
Published Online	17 years, 3 months ago (May 30, 2008)
Published Print	17 years, 2 months ago (July 1, 2008)

Funders 0

None

BibTeX

@article{Rigali_2008, title={Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces}, volume={9}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/embor.2008.83}, DOI={10.1038/embor.2008.83}, number={7}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Rigali, Sébastien and Titgemeyer, Fritz and Barends, Sharief and Mulder, Suzanne and Thomae, Andreas W and Hopwood, David A and van Wezel, Gilles P}, year={2008}, month=may, pages={670–675} }

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