DOI: 10.1038/emboj.2010.167. ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

10.1038/emboj.2010.167

Crossref journal-article

Springer Science and Business Media LLC

The EMBO Journal (297)

Bibliography

Kuhn, P.-H., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., RoÃner, S., & Lichtenthaler, S. F. (2010). ADAM10 is the physiologically relevant, constitutive Î±-secretase of the amyloid precursor protein in primary neurons. The EMBO Journal, 29(17), 3020â3032.

Authors 9

Peer-Hendrik Kuhn (first)
Huanhuan Wang (additional)
Bastian Dislich (additional)
Alessio Colombo (additional)
Ulrike Zeitschel (additional)
Joachim W Ellwart (additional)
Elisabeth Kremmer (additional)
Steffen Roßner (additional)
Stefan F Lichtenthaler (additional)

References 55 Referenced 490

10.1111/j.1432-1033.2004.04184.x
10.1016/S0006-291X(02)02999-6
10.2174/092986707782360060
10.1074/jbc.273.43.27765
10.1042/BJ20090549
10.1128/MCB.00406-09
10.1074/jbc.M500219200
10.1083/JCB.200104045
10.1126/science.2111583
10.2174/156720507781788837
10.1177/0891988708327810
10.1111/j.1742-4658.2009.06889.x
10.1046/j.1471-4159.1996.67051882.x
10.1038/sj.emboj.7600061
10.1038/nm1295-1291
10.1093/hmg/11.21.2615
10.1038/nbt831
10.1093/hmg/ddp323
10.1523/JNEUROSCI.2913-08.2008
10.1042/0264-6021:3430371
10.1096/fj.05-4812fje / FASEB J by Kojro E (2006)
10.1016/S0021-9258(17)32449-3 / J Biol Chem by Koo EH (1994)
10.1073/pnas.96.7.3922
10.1091/mbc.E08-11-1135
10.1073/pnas.95.21.12683
10.1016/j.jmb.2007.12.036
10.1074/jbc.M508340200
10.1038/nature07767
10.1074/jbc.M708754200
10.1021/bi00159a038
{'key': 'emboj2010167-b31', 'unstructured': ''}
10.1172/JCI20864 / J Clin Invest by Postina R (2004)
10.1016/j.semcdb.2008.09.005
10.1038/sj.emboj.7600548
10.1016/j.semcdb.2008.11.002
10.1074/jbc.274.6.3531
10.1083/jcb.200307137
10.1093/embo-reports/kve180
10.1074/jbc.M801531200
10.1016/j.ijdevneu.2005.11.003
10.1146/annurev.pharmtox.43.100901.140248
10.1016/S0304-3940(99)00929-5
10.1523/JNEUROSCI.16-03-00899.1996 / J Neurosci by Simons M (1996)
10.1073/pnas.89.13.6075
10.1074/jbc.275.4.2568
10.1042/0264-6021:3570787
10.1021/jm049379g
10.1523/JNEUROSCI.2211-04.2004
10.1074/jbc.M109.032599
10.1074/jbc.M109.055608
10.1074/jbc.M109.006775
10.1126/science.286.5440.735
10.1128/MCB.22.5.1537-1544.2002
10.1038/ni1399
10.1126/science.1132341

Dates

Type	When
Created	15 years ago (July 30, 2010, 10:09 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 4:10 p.m.)
Indexed	15 hours ago (Aug. 24, 2025, 6:56 p.m.)
Issued	15 years ago (July 30, 2010)
Published	15 years ago (July 30, 2010)
Published Online	15 years ago (July 30, 2010)
Published Print	14 years, 11 months ago (Sept. 1, 2010)

Funders 0

None

BibTeX

@article{Kuhn_2010, title={ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons}, volume={29}, ISSN={1460-2075}, url={http://dx.doi.org/10.1038/emboj.2010.167}, DOI={10.1038/emboj.2010.167}, number={17}, journal={The EMBO Journal}, publisher={Springer Science and Business Media LLC}, author={Kuhn, Peer-Hendrik and Wang, Huanhuan and Dislich, Bastian and Colombo, Alessio and Zeitschel, Ulrike and Ellwart, Joachim W and Kremmer, Elisabeth and Roßner, Steffen and Lichtenthaler, Stefan F}, year={2010}, month=jul, pages={3020–3032} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        24
      ]
    ],
    "date-time": "2025-08-24T22:56:49Z",
    "timestamp": 1756076209984
  },
  "reference-count": 55,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "17",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2015,
            9,
            1
          ]
        ],
        "date-time": "2015-09-01T00:00:00Z",
        "timestamp": 1441065600000
      },
      "content-version": "tdm",
      "delay-in-days": 1859,
      "URL": "http://doi.wiley.com/10.1002/tdm_license_1.1"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2010,
        9,
        1
      ]
    ]
  },
  "DOI": "10.1038/emboj.2010.167",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        7,
        30
      ]
    ],
    "date-time": "2010-07-30T14:09:22Z",
    "timestamp": 1280498962000
  },
  "page": "3020-3032",
  "source": "Crossref",
  "is-referenced-by-count": 490,
  "title": "ADAM10 is the physiologically relevant, constitutive \u03b1-secretase of the amyloid precursor protein in primary neurons",
  "prefix": "10.1038",
  "volume": "29",
  "author": [
    {
      "given": "Peer-Hendrik",
      "family": "Kuhn",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Huanhuan",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bastian",
      "family": "Dislich",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alessio",
      "family": "Colombo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ulrike",
      "family": "Zeitschel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joachim W",
      "family": "Ellwart",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Elisabeth",
      "family": "Kremmer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Steffen",
      "family": "Ro\u00dfner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stefan F",
      "family": "Lichtenthaler",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2010,
        7,
        30
      ]
    ]
  },
  "reference": [
    {
      "key": "emboj2010167-b1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.2004.04184.x"
    },
    {
      "key": "emboj2010167-b2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-291X(02)02999-6"
    },
    {
      "key": "emboj2010167-b3",
      "doi-asserted-by": "publisher",
      "DOI": "10.2174/092986707782360060"
    },
    {
      "key": "emboj2010167-b4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.43.27765"
    },
    {
      "key": "emboj2010167-b5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/BJ20090549"
    },
    {
      "key": "emboj2010167-b6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.00406-09"
    },
    {
      "key": "emboj2010167-b7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M500219200"
    },
    {
      "key": "emboj2010167-b8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/JCB.200104045"
    },
    {
      "key": "emboj2010167-b9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2111583"
    },
    {
      "key": "emboj2010167-b10",
      "doi-asserted-by": "publisher",
      "DOI": "10.2174/156720507781788837"
    },
    {
      "key": "emboj2010167-b11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1177/0891988708327810"
    },
    {
      "key": "emboj2010167-b12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1742-4658.2009.06889.x"
    },
    {
      "key": "emboj2010167-b13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1471-4159.1996.67051882.x"
    },
    {
      "key": "emboj2010167-b14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.emboj.7600061"
    },
    {
      "key": "emboj2010167-b15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nm1295-1291"
    },
    {
      "key": "emboj2010167-b16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/11.21.2615"
    },
    {
      "key": "emboj2010167-b17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nbt831"
    },
    {
      "key": "emboj2010167-b18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddp323"
    },
    {
      "key": "emboj2010167-b19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.2913-08.2008"
    },
    {
      "key": "emboj2010167-b20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/0264-6021:3430371"
    },
    {
      "key": "emboj2010167-b21",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1096/fj.05-4812fje",
      "volume": "20",
      "author": "Kojro E",
      "year": "2006",
      "journal-title": "FASEB J"
    },
    {
      "key": "emboj2010167-b22",
      "doi-asserted-by": "crossref",
      "first-page": "17386",
      "DOI": "10.1016/S0021-9258(17)32449-3",
      "volume": "269",
      "author": "Koo EH",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "emboj2010167-b23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.7.3922"
    },
    {
      "key": "emboj2010167-b24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.E08-11-1135"
    },
    {
      "key": "emboj2010167-b25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.21.12683"
    },
    {
      "key": "emboj2010167-b26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jmb.2007.12.036"
    },
    {
      "key": "emboj2010167-b27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M508340200"
    },
    {
      "key": "emboj2010167-b28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nature07767"
    },
    {
      "key": "emboj2010167-b29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M708754200"
    },
    {
      "key": "emboj2010167-b30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00159a038"
    },
    {
      "key": "emboj2010167-b31",
      "unstructured": ""
    },
    {
      "key": "emboj2010167-b32",
      "doi-asserted-by": "crossref",
      "first-page": "1456",
      "DOI": "10.1172/JCI20864",
      "volume": "113",
      "author": "Postina R",
      "year": "2004",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "emboj2010167-b33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.semcdb.2008.09.005"
    },
    {
      "key": "emboj2010167-b34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.emboj.7600548"
    },
    {
      "key": "emboj2010167-b35",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.semcdb.2008.11.002"
    },
    {
      "key": "emboj2010167-b36",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.6.3531"
    },
    {
      "key": "emboj2010167-b37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200307137"
    },
    {
      "key": "emboj2010167-b38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/embo-reports/kve180"
    },
    {
      "key": "emboj2010167-b39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M801531200"
    },
    {
      "key": "emboj2010167-b40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ijdevneu.2005.11.003"
    },
    {
      "key": "emboj2010167-b41",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.pharmtox.43.100901.140248"
    },
    {
      "key": "emboj2010167-b42",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0304-3940(99)00929-5"
    },
    {
      "key": "emboj2010167-b43",
      "doi-asserted-by": "crossref",
      "first-page": "899",
      "DOI": "10.1523/JNEUROSCI.16-03-00899.1996",
      "volume": "16",
      "author": "Simons M",
      "year": "1996",
      "journal-title": "J Neurosci"
    },
    {
      "key": "emboj2010167-b44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.13.6075"
    },
    {
      "key": "emboj2010167-b45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.4.2568"
    },
    {
      "key": "emboj2010167-b46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/0264-6021:3570787"
    },
    {
      "key": "emboj2010167-b47",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jm049379g"
    },
    {
      "key": "emboj2010167-b48",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.2211-04.2004"
    },
    {
      "key": "emboj2010167-b49",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M109.032599"
    },
    {
      "key": "emboj2010167-b50",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M109.055608"
    },
    {
      "key": "emboj2010167-b51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M109.006775"
    },
    {
      "key": "emboj2010167-b52",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.286.5440.735"
    },
    {
      "key": "emboj2010167-b53",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.5.1537-1544.2002"
    },
    {
      "key": "emboj2010167-b54",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ni1399"
    },
    {
      "key": "emboj2010167-b55",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1132341"
    }
  ],
  "container-title": "The EMBO Journal",
  "original-title": [],
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Femboj.2010.167",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        12,
        18
      ]
    ],
    "date-time": "2023-12-18T21:10:31Z",
    "timestamp": 1702933831000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://emboj.embopress.org/cgi/doi/10.1038/emboj.2010.167"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2010,
        7,
        30
      ]
    ]
  },
  "references-count": 55,
  "journal-issue": {
    "issue": "17",
    "published-online": {
      "date-parts": [
        [
          2010,
          7,
          30
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2010,
          9,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "emboj2010167"
  ],
  "URL": "http://dx.doi.org/10.1038/emboj.2010.167",
  "relation": {},
  "ISSN": [
    "0261-4189",
    "1460-2075"
  ],
  "subject": [],
  "container-title-short": "EMBO J",
  "published": {
    "date-parts": [
      [
        2010,
        7,
        30
      ]
    ]
  }
}