Mea6 controls VLDL transport through the coordinated regulation of COPII assembly
10.1038/cr.2016.75
Crossref journal-article
Springer Science and Business Media LLC
Cell Research (297)
Bibliography

Wang, Y., Liu, L., Zhang, H., Fan, J., Zhang, F., Yu, M., Shi, L., Yang, L., Lam, S. M., Wang, H., Chen, X., Wang, Y., Gao, F., Shui, G., & Xu, Z. (2016). Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Research, 26(7), 787–804.

Authors 15
  1. Yaqing Wang (first)
  2. Liang Liu (additional)
  3. Hongsheng Zhang (additional)
  4. Junwan Fan (additional)
  5. Feng Zhang (additional)
  6. Mei Yu (additional)
  7. Lei Shi (additional)
  8. Lin Yang (additional)
  9. Sin Man Lam (additional)
  10. Huimin Wang (additional)
  11. Xiaowei Chen (additional)
  12. Yingchun Wang (additional)
  13. Fei Gao (additional)
  14. Guanghou Shui (additional)
  15. Zhiheng Xu (additional)
References 53 Referenced 42
  1. Goh VJ, Silver DL . The lipid droplet as a potential therapeutic target in NAFLD. Semin Liver Dis 2013; 33:312–320. (10.1055/s-0033-1358521) / Semin Liver Dis by VJ Goh (2013)
  2. Lazo M, Hernaez R, Eberhardt MS, et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 2013; 178:38–45. (10.1093/aje/kws448) / Am J Epidemiol by M Lazo (2013)
  3. Cohen JC, Horton JD, Hobbs HH . Human fatty liver disease: old questions and new insights. Science 2011; 332:1519–1523. (10.1126/science.1204265) / Science by JC Cohen (2011)
  4. Kawano Y, Cohen DE . Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol 2013; 48:434–441. (10.1007/s00535-013-0758-5) / J Gastroenterol by Y Kawano (2013)
  5. Yao Z, Zhou H, Figeys D, Wang Y, Sundaram M . Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion. Curr Opin Lipidol 2013; 24:160–170. (10.1097/MOL.0b013e32835aebe7) / Curr Opin Lipidol by Z Yao (2013)
  6. Tiwari S, Siddiqi SA . Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol 2012; 32:1079–1086. (10.1161/ATVBAHA.111.241471) / Arterioscler Thromb Vasc Biol by S Tiwari (2012)
  7. Sundaram M, Yao Z . Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) 2010; 7:35. (10.1186/1743-7075-7-35) / Nutr Metab (Lond) by M Sundaram (2010)
  8. Schonfeld G . Familial hypobetalipoproteinemia: a review. J Lipid Res 2003; 44:878–883. (10.1194/jlr.R300002-JLR200) / J Lipid Res by G Schonfeld (2003)
  9. Jornayvaz FR, Shulman GI . Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab 2012; 15:574–584. (10.1016/j.cmet.2012.03.005) / Cell Metab by FR Jornayvaz (2012)
  10. Go GW, Srivastava R, Hernandez-Ono A, et al. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab 2014; 19:209–220. (10.1016/j.cmet.2013.11.023) / Cell Metab by GW Go (2014)
  11. Chen XW, Wang H, Bajaj K, et al. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife 2013; 2:e00444. (10.7554/eLife.00444) / Elife by XW Chen (2013)
  12. Ye J, Li JZ, Liu Y, et al. Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab 2009; 9:177–190. (10.1016/j.cmet.2008.12.013) / Cell Metab by J Ye (2009)
  13. Anstee QM, Day CP . The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2. Semin Liver Dis 2015; 35:270–290. (10.1055/s-0035-1562947) / Semin Liver Dis by QM Anstee (2015)
  14. Kuehn MJ, Herrmann JM, Schekman R . COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. Nature 1998; 391:187–190. (10.1038/34438) / Nature by MJ Kuehn (1998)
  15. Barlowe C, Orci L, Yeung T, et al. COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 1994; 77:895–907. (10.1016/0092-8674(94)90138-4) / Cell by C Barlowe (1994)
  16. Adams EJ, Chen XW, O'Shea KS, Ginsburg D . Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 2014; 289:20858–20870. (10.1074/jbc.M114.566687) / J Biol Chem by EJ Adams (2014)
  17. Jones B, Jones EL, Bonney SA, et al. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet 2003; 34:29–31. (10.1038/ng1145) / Nat Genet by B Jones (2003)
  18. Gusarova V, Brodsky JL, Fisher EA . Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER. J Biol Chem 2003; 278:48051–48058. (10.1074/jbc.M306898200) / J Biol Chem by V Gusarova (2003)
  19. Fryer LG, Jones B, Duncan EJ, et al. The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. J Biol Chem 2014; 289:4244–4261. (10.1074/jbc.M113.479980) / J Biol Chem by LG Fryer (2014)
  20. Malhotra V, Erlmann P . Protein export at the ER: loading big collagens into COPII carriers. EMBO J 2011; 30:3475–3480. (10.1038/emboj.2011.255) / EMBO J by V Malhotra (2011)
  21. Gillon AD, Latham CF, Miller EA . Vesicle-mediated ER export of proteins and lipids. Biochim Biophys Acta 2012; 1821:1040–1049. (10.1016/j.bbalip.2012.01.005) / Biochim Biophys Acta by AD Gillon (2012)
  22. Guinn BA, Gilkes AF, Mufti GJ, Burnett AK, Mills KI . The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia. Br J Haematol 2006; 134:238–239. (10.1111/j.1365-2141.2006.06135.x) / Br J Haematol by BA Guinn (2006)
  23. Usener D, Schadendorf D, Koch J, Dubel S, Eichmuller S . cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. J Invest Dermatol 2003; 121:198–206. (10.1046/j.1523-1747.2003.12318.x) / J Invest Dermatol by D Usener (2003)
  24. Comtesse N, Niedermayer I, Glass B, et al. MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies. Oncogene 2002; 21:239–247. (10.1038/sj.onc.1205005) / Oncogene by N Comtesse (2002)
  25. Saito K, Yamashiro K, Ichikawa Y, et al. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Mol Biol Cell 2011; 22:2301–2308. (10.1091/mbc.e11-02-0143) / Mol Biol Cell by K Saito (2011)
  26. Saito K, Chen M, Bard F, et al. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell 2009; 136:891–902. (10.1016/j.cell.2008.12.025) / Cell by K Saito (2009)
  27. Aridor M, Weissman J, Bannykh S, Nuoffer C, Balch WE . Cargo selection by the COPII budding machinery during export from the ER. J Cell Biol 1998; 141:61–70. (10.1083/jcb.141.1.61) / J Cell Biol by M Aridor (1998)
  28. Saito K, Yamashiro K, Shimazu N, Tanabe T, Kontani K, Katada T . Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. J Cell Biol 2014; 206:751–762. (10.1083/jcb.201312062) / J Cell Biol by K Saito (2014)
  29. Wilson DG, Phamluong K, Li L, et al. Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol 2011; 193:935–951. (10.1083/jcb.201007162) / J Cell Biol by DG Wilson (2011)
  30. Boyadjiev SA, Fromme JC, Ben J, et al. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat Genet 2006; 38:1192–1197. (10.1038/ng1876) / Nat Genet by SA Boyadjiev (2006)
  31. Lewandoski M, Wassarman KM, Martin GR . Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 1997; 7:148–151. (10.1016/S0960-9822(06)00059-5) / Curr Biol by M Lewandoski (1997)
  32. Kang JH, Kim HT, Choi MS, et al. Proteome analysis of human monocytic THP-1 cells primed with oxidized low-density lipoproteins. Proteomics 2006; 6:1261–1273. (10.1002/pmic.200500290) / Proteomics by JH Kang (2006)
  33. Borensztajn J, Rone MS, Kotlar TJ . The inhibition in vivo of lipoprotein lipase (clearing-factor lipase) activity by triton WR-1339. Biochem J 1976; 156:539–543. (10.1042/bj1560539) / Biochem J by J Borensztajn (1976)
  34. Roux KJ, Kim DI, Raida M, Burke B . A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. J Cell Biol 2012; 196:801–810. (10.1083/jcb.201112098) / J Cell Biol by KJ Roux (2012)
  35. Stagg SM, LaPointe P, Razvi A, et al. Structural basis for cargo regulation of COPII coat assembly. Cell 2008; 134:474–484. (10.1016/j.cell.2008.06.024) / Cell by SM Stagg (2008)
  36. Raabe M, Veniant MM, Sullivan MA, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 1999; 103:1287–1298. (10.1172/JCI6576) / J Clin Invest by M Raabe (1999)
  37. Fei W, Yang H . Genome-wide screens for gene products regulating lipid droplet dynamics. Method Cell Biol 2012; 108:303–316. (10.1016/B978-0-12-386487-1.00014-6) / Method Cell Biol by W Fei (2012)
  38. Skinner JR, Harris LA, Shew TM, Abumrad NA, Wolins NE . Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2013; 2:80–86. (10.4161/adip.22864) / Adipocyte by JR Skinner (2013)
  39. Reddick RL, Zhang SH, Maeda N . Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb 1994; 14:141–147. (10.1161/01.ATV.14.1.141) / Arterioscler Thromb by RL Reddick (1994)
  40. Kuipers F, Jong MC, Lin Y, et al. Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes. J Clin Invest 1997; 100:2915–2922. (10.1172/JCI119841) / J Clin Invest by F Kuipers (1997)
  41. Mensenkamp AR, Jong MC, van Goor H, et al. Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. The J Biol Chem 1999; 274:35711–35718. (10.1074/jbc.274.50.35711) / The J Biol Chem by AR Mensenkamp (1999)
  42. Farese RV Jr, Ruland SL, Flynn LM, Stokowski RP, Young SG . Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci USA 1995; 92:1774–1778. (10.1073/pnas.92.5.1774) / Proc Natl Acad Sci USA by RV Farese Jr (1995)
  43. Huang LS, Voyiaziakis E, Markenson DF, Sokol KA, Hayek T, Breslow JL . Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest 1995; 96:2152–2161. (10.1172/JCI118269) / J Clin Invest by LS Huang (1995)
  44. Heckel D, Brass N, Fischer U, et al. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. Hum Mol Genet 1997; 6:2031–2041. (10.1093/hmg/6.12.2031) / Hum Mol Genet by D Heckel (1997)
  45. Pitman JL, Bonnet DJ, Curtiss LK, Gekakis N . Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites. J Lipid Res 2011; 52:1775–1786. (10.1194/jlr.M017277) / J Lipid Res by JL Pitman (2011)
  46. Liu P, Jenkins NA, Copeland NG . A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 2003; 13:476–484. (10.1101/gr.749203) / Genome Res by P Liu (2003)
  47. Liu S, Yu M, He Y, et al. Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 2008; 47:1964–1973. (10.1002/hep.22240) / Hepatology by S Liu (2008)
  48. Xu Z, Kukekov NV, Greene LA . POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J 2003; 22:252–261. (10.1093/emboj/cdg021) / EMBO J by Z Xu (2003)
  49. Yang T, Sun Y, Zhang F, et al. POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Rep 2012; 2:640–651. (10.1016/j.celrep.2012.08.007) / Cell Rep by T Yang (2012)
  50. Lam SM, Tong L, Reux B, et al. Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. J Lipid Res 2014; 55:299–306. (10.1194/jlr.P041780) / J Lipid Res by SM Lam (2014)
  51. Lam SM, Wang Y, Duan X, et al. The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiol Aging 2014; 35:2369–2381. (10.1016/j.neurobiolaging.2014.02.025) / Neurobiol Aging by SM Lam (2014)
  52. Rappsilber J, Mann M, Ishihama Y . Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc 2007; 2:1896–1906. (10.1038/nprot.2007.261) / Nat Protoc by J Rappsilber (2007)
  53. Tambor V, Hunter CL, Seymour SL, Kacerovsky M, Stulik J, Lenco J . CysTRAQ – A combination of iTRAQ and enrichment of cysteinyl peptides for uncovering and quantifying hidden proteomes. J Proteomics 2012; 75:857–867. (10.1016/j.jprot.2011.09.027) / J Proteomics by V Tambor (2012)
Dates
Type When
Created 9 years, 2 months ago (June 17, 2016, 6:42 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 9:38 a.m.)
Indexed 6 days, 11 hours ago (Aug. 23, 2025, 1:13 a.m.)
Issued 9 years, 2 months ago (June 17, 2016)
Published 9 years, 2 months ago (June 17, 2016)
Published Online 9 years, 2 months ago (June 17, 2016)
Published Print 9 years, 1 month ago (July 1, 2016)
Funders 0

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@article{Wang_2016, title={Mea6 controls VLDL transport through the coordinated regulation of COPII assembly}, volume={26}, ISSN={1748-7838}, url={http://dx.doi.org/10.1038/cr.2016.75}, DOI={10.1038/cr.2016.75}, number={7}, journal={Cell Research}, publisher={Springer Science and Business Media LLC}, author={Wang, Yaqing and Liu, Liang and Zhang, Hongsheng and Fan, Junwan and Zhang, Feng and Yu, Mei and Shi, Lei and Yang, Lin and Lam, Sin Man and Wang, Huimin and Chen, Xiaowei and Wang, Yingchun and Gao, Fei and Shui, Guanghou and Xu, Zhiheng}, year={2016}, month=jun, pages={787–804} }