Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
10.1038/89044
Crossref journal-article
Springer Science and Business Media LLC
Nature Medicine (297)
Bibliography

Khan, J., Wei, J. S., Ringnér, M., Saal, L. H., Ladanyi, M., Westermann, F., Berthold, F., Schwab, M., Antonescu, C. R., Peterson, C., & Meltzer, P. S. (2001). Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nature Medicine, 7(6), 673–679.

Authors 11
  1. Javed Khan (first)
  2. Jun S. Wei (additional)
  3. Markus Ringnér (additional)
  4. Lao H. Saal (additional)
  5. Marc Ladanyi (additional)
  6. Frank Westermann (additional)
  7. Frank Berthold (additional)
  8. Manfred Schwab (additional)
  9. Cristina R. Antonescu (additional)
  10. Carsten Peterson (additional)
  11. Paul S. Meltzer (additional)
References 40 Referenced 1,993
  1. Pizzo, P.A. Principles and practice of pediatric oncology. (Lippincott-Raven, Philadelphia, 1997). / Principles and practice of pediatric oncology by PA Pizzo (1997)
  2. Triche, T.J. & Askin, F.B. Neuroblastoma and the differential diagnosis of small-, round-, blue- cell tumors. Hum. Pathol. 14, 569–595 (1983). (10.1016/S0046-8177(83)80202-0) / Hum. Pathol. by TJ Triche (1983)
  3. Taylor, C. et al. Diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumour based on the detection of t(11;22) using fluorescence in situ hybridisation. Br. J. Cancer 67, 128–133 (1993). (10.1038/bjc.1993.22) / Br. J. Cancer by C Taylor (1993)
  4. McManus, A.P., Gusterson, B.A., Pinkerton, C.R. & Shipley, J.M. The molecular pathology of small round-cell tumours—relevance to diagnosis, prognosis, and classification. J. Pathol. 178, 116–121 (1996). (10.1002/(SICI)1096-9896(199602)178:2<116::AID-PATH494>3.0.CO;2-H) / J. Pathol. by AP McManus (1996)
  5. Khan, J. et al. Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res. 58, 5009–5013 (1998). / Cancer Res. by J Khan (1998)
  6. Alizadeh, A.A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511 (2000). (10.1038/35000501) / Nature by AA Alizadeh (2000)
  7. Bittner, M. et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536–540 (2000). (10.1038/35020115) / Nature by M Bittner (2000)
  8. Golub, T.R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531–537 (1999). (10.1126/science.286.5439.531) / Science by TR Golub (1999)
  9. Bishop, C.M. Neural Networks for Pattern Recognition. (Clarendon Press, Oxford, 1995). (10.1093/oso/9780198538493.001.0001) / Neural Networks for Pattern Recognition by CM Bishop (1995)
  10. Heden, B., Ohlin, H., Rittner, R. & Edenbrandt, L. Acute myocardial infarction detected in the 12-lead ECG by artificial neural networks. Circulation 96, 1798–1802 (1997). (10.1161/01.CIR.96.6.1798) / Circulation by B Heden (1997)
  11. Silipo, R., Gori, M., Taddei, A., Varanini, M. & Marchesi, C. Classification of arrhythmic events in ambulatory electrocardiogram, using artificial neural networks. Comput. Biomed. Res. 28, 305–318 (1995). (10.1006/cbmr.1995.1021) / Comput. Biomed. Res. by R Silipo (1995)
  12. Ashizawa, K. et al. Artificial neural networks in chest radiography: application to the differential diagnosis of interstitial lung disease. Acad. Radiol. 6, 2–9 (1999). (10.1016/S1076-6332(99)80055-5) / Acad. Radiol. by K Ashizawa (1999)
  13. Abdolmaleki, P. et al. Neural network analysis of breast cancer from MRI findings. Radiat. Med. 15, 283–293 (1997). / Radiat. Med. by P Abdolmaleki (1997)
  14. Eisen, M.B., Spellman, P.T., Brown, P.O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14863–14868 (1998). (10.1073/pnas.95.25.14863) / Proc. Natl. Acad. Sci. USA by MB Eisen (1998)
  15. deLapeyriere, O. et al. Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo. Development 118, 601–611 (1993). (10.1242/dev.118.2.601) / Development by O deLapeyriere (1993)
  16. Jaakkola, S. et al. Amplification of fgfr4 gene in human breast and gynecological cancers. Int. J. Cancer. 54, 378–382 (1993). (10.1002/ijc.2910540305) / Int. J. Cancer. by S Jaakkola (1993)
  17. Shaoul, E., Reich-Slotky, R., Berman, B. & Ron, D. Fibroblast growth factor receptors display both common and distinct signaling pathways. Oncogene 10, 1553–1561 (1995). / Oncogene by E Shaoul (1995)
  18. Kovar, H. et al. Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. Oncogene 5, 1067–1070 (1990). / Oncogene by H Kovar (1990)
  19. Kumar, S., Perlman, E., Harris, C.A., Raffeld, M. & Tsokos, M. Myogenin is a specific marker for rhabdomyosarcoma: an immunohistochemical study in paraffin-embedded tissues. Mod. Pathol. 13, 988–993 (2000). (10.1038/modpathol.3880179) / Mod. Pathol. by S Kumar (2000)
  20. DeRisi, J. et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genet. 14, 457–460 (1996). (10.1038/ng1296-457) / Nature Genet. by J DeRisi (1996)
  21. Perou, C.M. et al. Molecular portraits of human breast tumours. Nature 406, 747–752 (2000). (10.1038/35021093) / Nature by CM Perou (2000)
  22. Hedenfalk, I. et al. Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med. 344, 539–548 (2001). (10.1056/NEJM200102223440801) / N. Engl. J. Med. by I Hedenfalk (2001)
  23. Brown, M.P. et al. Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc. Natl. Acad. Sci. USA 97, 262–267 (2000). (10.1073/pnas.97.1.262) / Proc. Natl. Acad. Sci. USA by MP Brown (2000)
  24. Furey, T.S. et al. Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioinformatics 16, 906–914. (2000). (10.1093/bioinformatics/16.10.906) / Bioinformatics by TS Furey (2000)
  25. Mu, J. & Roach, P.J. Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism. J. Biol. Chem. 273, 34850–34856 (1998). (10.1074/jbc.273.52.34850) / J. Biol. Chem. by J Mu (1998)
  26. Lee, M.G., Loomis, C. & Cowan, N.J. Sequence of an expressed human beta-tubulin gene containing ten Alu family members. Nucleic Acids Res. 12, 5823–5836 (1984). (10.1093/nar/12.14.5823) / Nucleic Acids Res. by MG Lee (1984)
  27. Savchenko, V.L., McKanna, J.A., Nikonenko, I.R. & Skibo, G.G. Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity. Neuroscience 96, 195–203 (2000). (10.1016/S0306-4522(99)00538-2) / Neuroscience by VL Savchenko (2000)
  28. Nagano, T. et al. Differentially expressed olfactomedin-related glycoproteins (Pancortins) in the brain. Brain Res. Mol. Brain Res. 53, 13–23 (1998). (10.1016/S0169-328X(97)00271-4) / Brain Res. Mol. Brain Res. by T Nagano (1998)
  29. Takahashi, Y., Campbell, E.A., Hirata, Y., Takayama, T. & Listowsky, I. A basis for differentiating among the multiple human Mu-glutathione S- transferases and molecular cloning of brain GSTM5. J. Biol. Chem. 268, 8893–8898 (1993). (10.1016/S0021-9258(18)52957-4) / J. Biol. Chem. by Y Takahashi (1993)
  30. Cavazzana, A.O., Miser, J.S., Jefferson, J. & Triche, T.J. Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am. J. Pathol. 127, 507–518 (1987). / Am. J. Pathol. by AO Cavazzana (1987)
  31. McKarney, L.A., Overall, M.L. & Dziadek, M. Myogenesis in cultures of uniparental mouse embryonic stem cells: differing patterns of expression of myogenic regulatory factors. Int. J. Dev. Biol. 41, 485–490 (1997). / Int. J. Dev. Biol. by LA McKarney (1997)
  32. Strohman, R.C., Micou-Eastwood, J., Glass, C.A. & Matsuda, R. Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain. Science 221, 955–957 (1983). (10.1126/science.6879193) / Science by RC Strohman (1983)
  33. Song, W.K., Wang, W., Foster, R.F., Bielser, D.A. & Kaufman, S.J. H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. J. Cell. Biol. 117, 643–657 (1992). (10.1083/jcb.117.3.643) / J. Cell. Biol. by WK Song (1992)
  34. Green, B.N. et al. Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development. Endocrinology 134, 954–962 (1994). (10.1210/endo.134.2.7507840) / Endocrinology by BN Green (1994)
  35. El-Badry, O.M. et al. Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors. Cell Growth Differ. 1, 325–331 (1990). / Cell Growth Differ. by OM El-Badry (1990)
  36. Khan, J. et al. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. Proc. Natl. Acad. Sci. USA 96, 13264–13269 (1999). (10.1073/pnas.96.23.13264) / Proc. Natl. Acad. Sci. USA by J Khan (1999)
  37. Holtrich, U., Brauninger, A., Strebhardt, K. & Rubsamen-Waigmann, H. Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. Proc. Natl. Acad. Sci. USA 88, 10411–10415 (1991). (10.1073/pnas.88.23.10411) / Proc. Natl. Acad. Sci. USA by U Holtrich (1991)
  38. Hughes, S.E. Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. J. Histochem. Cytochem. 45, 1005–1019 (1997). (10.1177/002215549704500710) / J. Histochem. Cytochem. by SE Hughes (1997)
  39. Chen, Y., Dougherty, E.R. & Bittner, M.L. Ratio-based decisions and the quantitative analysis of cDNA microarray images. Biomedical Optics 2, 364–374 (1997). (10.1117/12.281504) / Biomedical Optics by Y Chen (1997)
  40. Jollife, I.T. Principal Component Analysis. (Springer, New York, 1986). (10.1007/978-1-4757-1904-8) / Principal Component Analysis by IT Jollife (1986)
Dates
Type When
Created 23 years ago (July 26, 2002, 4:43 a.m.)
Deposited 1 year, 7 months ago (Jan. 3, 2024, 6:51 a.m.)
Indexed 3 hours, 40 minutes ago (Aug. 23, 2025, 9:51 p.m.)
Issued 24 years, 2 months ago (June 1, 2001)
Published 24 years, 2 months ago (June 1, 2001)
Published Print 24 years, 2 months ago (June 1, 2001)
Funders 0

None

@article{Khan_2001, title={Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks}, volume={7}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/89044}, DOI={10.1038/89044}, number={6}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Khan, Javed and Wei, Jun S. and Ringnér, Markus and Saal, Lao H. and Ladanyi, Marc and Westermann, Frank and Berthold, Frank and Schwab, Manfred and Antonescu, Cristina R. and Peterson, Carsten and Meltzer, Paul S.}, year={2001}, month=jun, pages={673–679} }