DOI: 10.1038/85525. Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

10.1038/85525

Crossref journal-article

Springer Science and Business Media LLC

Nature Medicine (297)

Bibliography

Bacskai, B. J., Kajdasz, S. T., Christie, R. H., Carter, C., Games, D., Seubert, P., Schenk, D., & Hyman, B. T. (2001). Imaging of amyloid-Î² deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Medicine, 7(3), 369â372.

Authors 8

Brian J. Bacskai (first)
Stephen T. Kajdasz (additional)
Richard H. Christie (additional)
Cordelia Carter (additional)
Dora Games (additional)
Peter Seubert (additional)
Dale Schenk (additional)
Bradley T. Hyman (additional)

References 14 Referenced 370

Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239–259 (1991). (10.1007/BF00308809) / Acta Neuropathol. by H Braak (1991)
Gomez-Isla, T. et al. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16, 4491–4500 (1996). (10.1523/JNEUROSCI.16-14-04491.1996) / J. Neurosci. by T Gomez-Isla (1996)
Davis, D.G., Schmitt, F.A., Wekstein, D.R. & Markesbery, W.R. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J. Neuropathol. Exp. Neurol. 58, 376–388 (1999). (10.1097/00005072-199904000-00008) / J. Neuropathol. Exp. Neurol. by DG Davis (1999)
Naslund, J. et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283, 1571–1577 (2000). (10.1001/jama.283.12.1571) / JAMA by J Naslund (2000)
Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523–527 (1995). (10.1038/373523a0) / Nature by D Games (1995)
Irizarry, M.C. et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17, 7053–7059 (1997). (10.1523/JNEUROSCI.17-18-07053.1997) / J. Neurosci. by MC Irizarry (1997)
Schenk, D. et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999). (10.1038/22124) / Nature by D Schenk (1999)
Denk, W., Strickler, J.H. & Webb, W.W. Two-photon laser scanning fluorescence microscopy. Science 248, 73–76 (1990). (10.1126/science.2321027) / Science by W Denk (1990)
Svoboda, K., Denk, W., Kleinfeld, D. & Tank, D.W. In vivo dendritic calcium dynamics in neocortical pyramidal neurons. Nature 385, 161–165 (1997). (10.1038/385161a0) / Nature by K Svoboda (1997)
Yang, X. et al. Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proc. Natl. Acad. Sci. USA 95, 7715–7720 (1998). (10.1073/pnas.95.13.7715) / Proc. Natl. Acad. Sci. USA by X Yang (1998)
Hyman, B.T., Tanzi, R.E., Marzloff, K., Barbour, R. & Schenk, D. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 51, 76–83 (1992). (10.1097/00005072-199201000-00009) / J. Neuropathol. Exp. Neurol. by BT Hyman (1992)
Vigo-Pelfry, C. et al. Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease. Neurology 45, 788–793 (1995). (10.1212/WNL.45.4.788) / Neurology by C Vigo-Pelfry (1995)
Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916–919 (2000). (10.1038/78682) / Nature Med. by F Bard (2000)
Solomon, B. et al. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl. Acad. Sci. USA 93, 452–455 (1996). (10.1073/pnas.93.1.452) / Proc. Natl. Acad. Sci. USA by B Solomon (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:48 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 6:04 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:44 a.m.)
Issued	24 years, 6 months ago (March 1, 2001)
Published	24 years, 6 months ago (March 1, 2001)
Published Print	24 years, 6 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Bacskai_2001, title={Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy}, volume={7}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/85525}, DOI={10.1038/85525}, number={3}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Bacskai, Brian J. and Kajdasz, Stephen T. and Christie, Richard H. and Carter, Cordelia and Games, Dora and Seubert, Peter and Schenk, Dale and Hyman, Bradley T.}, year={2001}, month=mar, pages={369–372} }

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