DOI: 10.1038/82565. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

10.1038/82565

Crossref journal-article

Springer Science and Business Media LLC

Nature Genetics (297)

Bibliography

Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves-Guerra, M.-C., Goubern, M., Surwit, R., Bouillaud, F., Richard, D., Collins, S., & Ricquier, D. (2000). Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nature Genetics, 26(4), 435â439.

Authors 14

Denis Arsenijevic (first)
Hiroki Onuma (additional)
Claire Pecqueur (additional)
Serge Raimbault (additional)
Brian S. Manning (additional)
Bruno Miroux (additional)
Elodie Couplan (additional)
Marie-Clotilde Alves-Guerra (additional)
Marc Goubern (additional)
Richard Surwit (additional)
Frédéric Bouillaud (additional)
Denis Richard (additional)
Sheila Collins (additional)
Daniel Ricquier (additional)

References 28 Referenced 891

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Boss, O., Hagen, T. & Lowell, B.B. Uncoupling proteins 2 and 3. Potential regulators of mitochondrial energy metabolism. Diabetes 49, 143–156 (2000). (10.2337/diabetes.49.2.143) / Diabetes by O Boss (2000)
Laloi, M. et al. A plant cold-induced uncoupling protein. Nature 389, 135–136 (1997). (10.1038/38156) / Nature by M Laloi (1997)
Fleury, C. et al. Uncoupling-protein-2: a novel gene linked to obesity and hyperinsulinemia . Nature Genet. 15, 269– 272 (1997). (10.1038/ng0397-269) / Nature Genet. by C Fleury (1997)
Gimeno, R.E. et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46, 900–906 ( 1997). (10.2337/diab.46.5.900) / Diabetes by RE Gimeno (1997)
Rial, E. et al. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. EMBO J. 21, 5827– 5833 (1999). (10.1093/emboj/18.21.5827) / EMBO J. by E Rial (1999)
Larrouy, D. et al. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver. Biochem. Biophys. Res. Commun. 235, 760–764 (1997). (10.1006/bbrc.1997.6852) / Biochem. Biophys. Res. Commun. by D Larrouy (1997)
Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90– 94 (1997). (10.1038/387090a0) / Nature by S Enerback (1997)
Nègre-Salvayre, A. et al. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 11, 809–815 (1997). (10.1096/fasebj.11.10.9271366) / FASEB J. by A Nègre-Salvayre (1997)
Skulachev, V.P. Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta 1363, 100–124 (1998). (10.1016/S0005-2728(97)00091-1) / Biochim. Biophys. Acta by VP Skulachev (1998)
Nicholls, D.G. & Budd, S.L. Mitochondria and neuronal survival. Physiol. Rev. 80, 315 –360 (2000). (10.1152/physrev.2000.80.1.315) / Physiol. Rev. by DG Nicholls (2000)
Arsenijevic, D., Girardier, L., Seydoux, J., Chang, H.R. & Dulloo, A.G. Altered energy balance and cytokine gene expression in a murine model of chronic infection with Toxoplasma gondii. Am. J. Physiol. 272, E908–917 (1997). / Am. J. Physiol. by D Arsenijevic (1997)
Richard, D. et al. Distribution of the uncoupling protein 2 mRNA in the mouse brain. J. Comp. Neurol. 397, 549– 560 (1998). (10.1002/(SICI)1096-9861(19980810)397:4<549::AID-CNE7>3.0.CO;2-1) / J. Comp. Neurol. by D Richard (1998)
Murray, H.W., Juangbhanich, C.W., Nathan, C.F. & Cohn, Z.A. Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J. Exp. Med. 150, 950– 964 (1979). (10.1084/jem.150.4.950) / J. Exp. Med. by HW Murray (1979)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:34 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 5:20 p.m.)
Indexed	23 hours, 11 minutes ago (Sept. 3, 2025, 6:36 a.m.)
Issued	24 years, 9 months ago (Dec. 1, 2000)
Published	24 years, 9 months ago (Dec. 1, 2000)
Published Print	24 years, 9 months ago (Dec. 1, 2000)

Funders 0

None

BibTeX

@article{Arsenijevic_2000, title={Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production}, volume={26}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/82565}, DOI={10.1038/82565}, number={4}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Arsenijevic, Denis and Onuma, Hiroki and Pecqueur, Claire and Raimbault, Serge and Manning, Brian S. and Miroux, Bruno and Couplan, Elodie and Alves-Guerra, Marie-Clotilde and Goubern, Marc and Surwit, Richard and Bouillaud, Frédéric and Richard, Denis and Collins, Sheila and Ricquier, Daniel}, year={2000}, month=dec, pages={435–439} }

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