DOI: 10.1038/78682. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

10.1038/78682

Crossref journal-article

Springer Science and Business Media LLC

Nature Medicine (297)

Bibliography

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Lieberburg, I., Motter, R., Nguyen, M., Soriano, F., Vasquez, N., Weiss, K., â¦ Yednock, T. (2000). Peripherally administered antibodies against amyloid Î²-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Medicine, 6(8), 916â919.

Authors 23

Frédérique Bard (first)
Catherine Cannon (additional)
Robin Barbour (additional)
Rae-Lyn Burke (additional)
Dora Games (additional)
Henry Grajeda (additional)
Teresa Guido (additional)
Kang Hu (additional)
Jiping Huang (additional)
Kelly Johnson-Wood (additional)
Karen Khan (additional)
Dora Kholodenko (additional)
Mike Lee (additional)
Ivan Lieberburg (additional)
Ruth Motter (additional)
Minh Nguyen (additional)
Ferdie Soriano (additional)
Nicki Vasquez (additional)
Kim Weiss (additional)
Brent Welch (additional)
Peter Seubert (additional)
Dale Schenk (additional)
Ted Yednock (additional)

References 10 Referenced 1,615

Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523–527 (1995). (10.1038/373523a0) / Nature by D Games (1995)
Masliah, E. et al. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16, 5795–57811 (1996). (10.1523/JNEUROSCI.16-18-05795.1996) / J. Neurosci. by E Masliah (1996)
Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999). (10.1038/22124) / Nature by D Schenk (1999)
St. George-Hyslop, P.H. & Westaway, D.A. Alzheimer's disease: antibody clears senile plaques. Nature 400, 116–117 (1999). (10.1038/22006) / Nature by PH St. George-Hyslop (1999)
Duff, K. Curing amyloidosis: will it work in humans? Trends Neurosci. 22, 485–486 (1999). (10.1016/S0166-2236(99)01489-7) / Trends Neurosci. by K Duff (1999)
Paresce, D.M., Chung, H. & Maxfield, F.R. Slow degradation of aggregates of the Alzheimer's disease amyloid β-protein by microglial cells. J. Biol. Chem. 272, 29390–29397 (1997). (10.1074/jbc.272.46.29390) / J. Biol. Chem. by DM Paresce (1997)
Chung, H., Brazil, M.I., Soe, T.T. & Maxfield, F.R. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid β-peptide by microglial cells. J. Biol. Chem. 274, 32301–32308 (1999). (10.1074/jbc.274.45.32301) / J. Biol. Chem. by H Chung (1999)
Thompson, E.J. & Keir, G. Laboratory investigation of cerebrospinal fluid proteins. Ann. Clin. Biochem. 27, 425–435 (1990). (10.1177/000456329002700503) / Ann. Clin. Biochem. by EJ Thompson (1990)
Johnson-Wood, K. et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 1550–1555 (1997). (10.1073/pnas.94.4.1550) / Proc. Natl. Acad. Sci. USA by K Johnson-Wood (1997)
Hyman, B.T. et al. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 51, 76–83 (1992). (10.1097/00005072-199201000-00009) / J. Neuropathol. Exp. Neurol. by BT Hyman (1992)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:34 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 7:27 p.m.)
Indexed	2 days, 3 hours ago (Sept. 3, 2025, 5:58 a.m.)
Issued	25 years, 1 month ago (Aug. 1, 2000)
Published	25 years, 1 month ago (Aug. 1, 2000)
Published Print	25 years, 1 month ago (Aug. 1, 2000)

Funders 0

None

BibTeX

@article{Bard_2000, title={Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease}, volume={6}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/78682}, DOI={10.1038/78682}, number={8}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Bard, Frédérique and Cannon, Catherine and Barbour, Robin and Burke, Rae-Lyn and Games, Dora and Grajeda, Henry and Guido, Teresa and Hu, Kang and Huang, Jiping and Johnson-Wood, Kelly and Khan, Karen and Kholodenko, Dora and Lee, Mike and Lieberburg, Ivan and Motter, Ruth and Nguyen, Minh and Soriano, Ferdie and Vasquez, Nicki and Weiss, Kim and Welch, Brent and Seubert, Peter and Schenk, Dale and Yednock, Ted}, year={2000}, month=aug, pages={916–919} }

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