Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo
10.1038/77548
Crossref journal-article
Springer Science and Business Media LLC
Nature Medicine (297)
Bibliography

Tretter, Y. P., Hertel, M., Munz, B., Bruggencate, G. ten, Werner, S., & Alzheimer, C. (2000). Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nature Medicine, 6(7), 812–815.

Authors 6
  1. Yvonne P. Tretter (first)
  2. Moritz Hertel (additional)
  3. Barbara Munz (additional)
  4. Gerrit ten Bruggencate (additional)
  5. Sabine Werner (additional)
  6. Christian Alzheimer (additional)
References 25 Referenced 135
  1. Ay, H., Ay, I., Koroshetz, W.J. & Finklestein, S.P. Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovasc. Dis. 9, 131–135 (1999). (10.1159/000015941) / Cerebrovasc. Dis. by H Ay (1999)
  2. Bethel, A., Kirsch, J.R., Koehler, R.C., Finklestein, S.P. & Traystman, R.J. Intravenous basic fibroblast growth factor decreases brain injury resulting from focal ischemia in cats . Stroke 28, 609–615 (1997). (10.1161/01.STR.28.3.609) / Stroke by A Bethel (1997)
  3. Kirschner, P.B. et al. Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. J. Cereb. Blood Flow Metab. 15, 619–623 (1995). (10.1038/jcbfm.1995.76) / J. Cereb. Blood Flow Metab by PB Kirschner (1995)
  4. Anderson, K.J., Dam, D. Lee, S. & Cotman, C.W. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo. Nature 332, 360–361 ( 1988). (10.1038/332360a0) / Nature by KJ Anderson (1988)
  5. Peterson, D.A., Lucidi-Phillipi, C.A., Murphy, D.P. Ray, J. & Gage, F.H. Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death. J. Neurosci. 16, 886–898 (1996). (10.1523/JNEUROSCI.16-03-00886.1996) / J. Neurosci. by DA Peterson (1996)
  6. Nadler, J.V., Perry, B.W., Gentry, C. & Cotman, C.W. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid . J. Comp. Neurol. 192, 333– 359 (1980). (10.1002/cne.901920209) / J. Comp. Neurol. by JV Nadler (1980)
  7. Tretter, Y.P. et al. Strong induction of activin expression after hippocampal lesion . Neuroreport 7, 1819–1823 (1996). (10.1097/00001756-199607290-00026) / Neuroreport by YP Tretter (1996)
  8. Munz, B., Hübner, G., Tretter, Y., Alzheimer, C. & Werner, S. A novel role of activin in inflammation and repair. J. Endocrinol. 161, 187– 193 (1999). (10.1677/joe.0.1610187) / J. Endocrinol. by B Munz (1999)
  9. McDowell, N., Zorn, A.M., Crease, D.J. & Gurdon, J.B. Activin has direct long-range signaling activity and can form a concentration gradient by diffusion . Curr. Biol. 7, 671–681 (1997). (10.1016/S0960-9822(06)00294-6) / Curr. Biol. by N McDowell (1997)
  10. Munz, B. et al. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 18, 5205– 5215 (1999). (10.1093/emboj/18.19.5205) / EMBO J. by B Munz (1999)
  11. Krieglstein, K., Suter-Crazzolara, C., Fischer, W.H. & Unsicker, K. TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. 14, 736–742 (1995). (10.1002/j.1460-2075.1995.tb07052.x) / EMBO J. by K Krieglstein (1995)
  12. Wu, D.D. et al. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Brain Res. 835, 369– 378 (1999). (10.1016/S0006-8993(99)01638-8) / Brain Res. by DD Wu (1999)
  13. Hughes, P.E., Alexi, T., Williams, C.E., Clark, R.G. & Gluckman, P.D. Administration of recombinant human activin-A has powerful neurotrophic effect on select striatal phenotypes in the quinolinic acid lesion model of Huntington's disease. Neuroscience 92, 197–209 ( 1999). (10.1016/S0306-4522(98)00724-6) / Neuroscience by PE Hughes (1999)
  14. Nakamura, T. et al. Activin-binding protein from rat ovary is follistatin. Science 247, 836–838 ( 1990). (10.1126/science.2106159) / Science by T Nakamura (1990)
  15. de Winter, J.P. et al. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors. Mol. Cell. Endocrinol. 116, 105–114 ( 1996). (10.1016/0303-7207(95)03705-5) / Mol. Cell. Endocrinol. by JP de Winter (1996)
  16. Lai, M., Gluckman, P., Dragunow, M. & Hughes, P.E. Focal brain injury increases activinβ A mRNA expression in hippocampal neurons. Neuroreport 8, 2691– 2694 (1997). (10.1097/00001756-199708180-00011) / Neuroreport by M Lai (1997)
  17. Riva, M.A., Donati, E., Tascedda, F., Zolli, M. & Racagni, G. Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection . Neuroscience 59, 55–65 (1994). (10.1016/0306-4522(94)90098-1) / Neuroscience by MA Riva (1994)
  18. Fainsod, A. et al. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. Mech. Dev. 63, 39– 50 (1997). (10.1016/S0925-4773(97)00673-4) / Mech. Dev. by A Fainsod (1997)
  19. Iemura, S.-I. et al. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc. Natl. Acad. Sci. USA 95, 9337–9342 (1998). (10.1073/pnas.95.16.9337) / Proc. Natl. Acad. Sci. USA by S-I Iemura (1998)
  20. Sugino, H., Sugino, K., Hashimoto, O., Shoji, H. & Nakamura, T. Follistatin and its role as an activin-binding protein. J. Med. Invest. 44, 1–14 (1997). / J. Med. Invest. by H Sugino (1997)
  21. Krieglstein, K., Reuss, B., Maysinger, D. & Unsicker K. Transforming growth factor-β mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons. Eur. J. Neurosci. 10, 2746–2750 (1998). (10.1046/j.1460-9568.1998.00324.x) / Eur. J. Neurosci. by K Krieglstein (1998)
  22. Yasuda, H. et al. Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J. Clin. Invest. 92, 1491–1496 (1993). (10.1172/JCI116727) / J. Clin. Invest. by H Yasuda (1993)
  23. Werner, S. et al. Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J. 12, 2635–2643 (1993). (10.1002/j.1460-2075.1993.tb05924.x) / EMBO J. by S Werner (1993)
  24. Wisden, W., Morris, B.J. & Hunt, S.P. in Molecular Neurobiology—A Practical Approach (eds. Chad, J. & Wheal, H.) 205–225 (Oxford University Press, New York, 1991). (10.1093/oso/9780199631087.003.0010) / in Molecular Neurobiology—A Practical Approach by W Wisden (1991)
  25. Hübner, G. & Werner, S. Serum growth factors and proinflammatory cytokines are potent inducers of activin expression in cultured keratinocytes. Exp. Cell Res. 228, 106–113 (1996). (10.1006/excr.1996.0305) / Exp. Cell Res. by G Hübner (1996)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:34 a.m.)
Deposited 1 year, 8 months ago (Jan. 3, 2024, 6:25 a.m.)
Indexed 1 week ago (Aug. 28, 2025, 8:04 a.m.)
Issued 25 years, 2 months ago (July 1, 2000)
Published 25 years, 2 months ago (July 1, 2000)
Published Print 25 years, 2 months ago (July 1, 2000)
Funders 0

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@article{Tretter_2000, title={Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo}, volume={6}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/77548}, DOI={10.1038/77548}, number={7}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Tretter, Yvonne P. and Hertel, Moritz and Munz, Barbara and Bruggencate, Gerrit ten and Werner, Sabine and Alzheimer, Christian}, year={2000}, month=jul, pages={812–815} }