Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
10.1038/77060
Crossref journal-article
Springer Science and Business Media LLC
Nature Genetics (297)
Bibliography

Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., & Suzuki, T. (2000). Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nature Genetics, 25(3), 302–305.

Authors 11
  1. Hideki Shimura (first)
  2. Nobutaka Hattori (additional)
  3. Shin-ichiro Kubo (additional)
  4. Yoshikuni Mizuno (additional)
  5. Shuichi Asakawa (additional)
  6. Shinsei Minoshima (additional)
  7. Nobuyoshi Shimizu (additional)
  8. Kazuhiro Iwai (additional)
  9. Tomoki Chiba (additional)
  10. Keiji Tanaka (additional)
  11. Toshiaki Suzuki (additional)
References 30 Referenced 1,616
  1. Mizuno, Y., Hattori, N. & Matsumine, H. Neurochemical and neurogenetic correlates of Parkinson's disease. J. Neurochem. 71, 893–902 (1998). (10.1046/j.1471-4159.1998.71030893.x) / J. Neurochem. by Y Mizuno (1998)
  2. Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605–608 (1998). (10.1038/33416) / Nature by T Kitada (1998)
  3. Mayer, R.J., Landon, M. & Lowe, J. Ubiquitin and the molecular pathology of human disease. in Ubiquitin and the Biology of the Cell. (eds Peters, J.-M., Harris, J.R. & Finley, D.) 429–462 (Plenum, New York, 1998). (10.1007/978-1-4899-1922-9_15) / Ubiquitin and the Biology of the Cell by RJ Mayer (1998)
  4. Alves-Rodrigues, A., Gregori, L. & Figueiredo-Pereira, M.E. Ubiquitin, cellular inclusions and their role in neurodegeneration. Trends Neurosci. 21, 516–520 (1998). (10.1016/S0166-2236(98)01276-4) / Trends Neurosci. by A Alves-Rodrigues (1998)
  5. Floyd, J.A. & Hamilton, B.A. Intranuclear inclusions and the ubiquitin-proteasome pathway: digestion of a red herring? Neuron 24, 765–766 (1999). (10.1016/S0896-6273(00)81022-3) / Neuron by JA Floyd (1999)
  6. Pallares-Trujillo, J., Lopez-Soriano, F.J. & Argiles, J.M. The involvement of the ubiquitin system in Alzheimer's disease. Int. J. Mol. Med. 2, 3–15 (1998). / Int. J. Mol. Med. by J Pallares-Trujillo (1998)
  7. DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990–1993 (1997). (10.1126/science.277.5334.1990) / Science by M DiFiglia (1997)
  8. Cummings, C.J. et al. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 24, 879–892 (1999). (10.1016/S0896-6273(00)81035-1) / Neuron by CJ Cummings (1999)
  9. Leigh, P.N. et al. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. Brain 114, 775–788 (1991). (10.1093/brain/114.2.775) / Brain by PN Leigh (1991)
  10. Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M. & Ihara, Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta. Neuropathol. (Berl) 75, 345–353 (1988). (10.1007/BF00687787) / Acta. Neuropathol. (Berl) by S Kuzuhara (1988)
  11. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425–479 (1998). (10.1146/annurev.biochem.67.1.425) / Annu. Rev. Biochem. by A Hershko (1998)
  12. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405–439 (1996). (10.1146/annurev.genet.30.1.405) / Annu. Rev. Genet. by M Hochstrasser (1996)
  13. Coux, O., Tanaka, K. & Goldberg, A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65, 801–847 (1996). (10.1146/annurev.bi.65.070196.004101) / Annu. Rev. Biochem. by O Coux (1996)
  14. Leroy, E. et al. The ubiquitin pathway in Parkinson's disease. Nature 395, 451–452 (1998). (10.1038/26652) / Nature by E Leroy (1998)
  15. Polymeropoulos, M.H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997). (10.1126/science.276.5321.2045) / Science by MH Polymeropoulos (1997)
  16. Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106–108 (1998). (10.1038/ng0298-106) / Nature Genet. by R Kruger (1998)
  17. Larsen, C.N., Krantz, B.A. & Wilkinson, K.D. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry 37, 3358–3368 (1998). (10.1021/bi972274d) / Biochemistry by CN Larsen (1998)
  18. Spillantini, M.G. et al. α-synuclein in Lewy bodies. Nature 388, 839–840 (1997). (10.1038/42166) / Nature by MG Spillantini (1997)
  19. Bennett, M.C. et al. Degradation of α-synuclein by proteasome. J. Biol. Chem. 274, 33855–33858 (1999). (10.1074/jbc.274.48.33855) / J. Biol. Chem. by MC Bennett (1999)
  20. Morett, E. & Bork, P. A novel transactivation domain in parkin. Trends Biochem. Sci. 24, 229–231 (1999). (10.1016/S0968-0004(99)01381-X) / Trends Biochem. Sci. by E Morett (1999)
  21. Joazeiro, C.A.P. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309–312 (1999). (10.1126/science.286.5438.309) / Science by CAP Joazeiro (1999)
  22. Xie, Y. & Varshavsky, A. The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain. EMBO J. 18, 6832–6844 (1999). (10.1093/emboj/18.23.6832) / EMBO J. by Y Xie (1999)
  23. Harper, J.W. & Elledge, S.J. Skipping into the E2F1-destruction pathway. Nature Cell Biol. 1, E5–E7 (1999). (10.1038/8952) / Nature Cell Biol. by JW Harper (1999)
  24. Deshaies, R.J. SCF and Cullin/RING-H2-based ubiquitin-ligases. Annu. Rev. Cell Dev. Biol. 15, 435–467 (1999). (10.1146/annurev.cellbio.15.1.435) / Annu. Rev. Cell Dev. Biol. by RJ Deshaies (1999)
  25. Lorick, K.L. et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA 96, 11364–11369 (1999). (10.1073/pnas.96.20.11364) / Proc. Natl Acad. Sci. USA by KL Lorick (1999)
  26. Moynihan, T.P. et al. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. J. Biol. Chem. 274, 30963–30968 (1999). (10.1074/jbc.274.43.30963) / J. Biol. Chem. by TP Moynihan (1999)
  27. Martinez-Noel, G., Niedenthal, R., Tamura, T. & Harbers, K. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 454, 257–261 (1999). (10.1016/S0014-5793(99)00823-6) / FEBS Lett. by G Martinez-Noel (1999)
  28. Hattori, N. et al. Point mutations (Thr240Arg and Gln311Stop) in the parkin gene. Biochem. Biophys. Res. Commun. 249, 754–758 (1998). (10.1006/bbrc.1998.9134) / Biochem. Biophys. Res. Commun. by N Hattori (1998)
  29. Rock, K.L. et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761–771 (1994). (10.1016/S0092-8674(94)90462-6) / Cell by KL Rock (1994)
  30. Suzuki, H. et al. IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2. Biochem. Biophys. Res. Commun. 256, 127–132 (1999). (10.1006/bbrc.1999.0289) / Biochem. Biophys. Res. Commun. by H Suzuki (1999)
Dates
Type When
Created 23 years ago (July 26, 2002, 4:50 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 4:42 p.m.)
Indexed 11 minutes ago (Aug. 24, 2025, 1:57 p.m.)
Issued 25 years, 1 month ago (July 1, 2000)
Published 25 years, 1 month ago (July 1, 2000)
Published Print 25 years, 1 month ago (July 1, 2000)
Funders 0

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@article{Shimura_2000, title={Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase}, volume={25}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/77060}, DOI={10.1038/77060}, number={3}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Shimura, Hideki and Hattori, Nobutaka and Kubo, Shin-ichiro and Mizuno, Yoshikuni and Asakawa, Shuichi and Minoshima, Shinsei and Shimizu, Nobuyoshi and Iwai, Kazuhiro and Chiba, Tomoki and Tanaka, Keiji and Suzuki, Toshiaki}, year={2000}, month=jul, pages={302–305} }