DOI: 10.1038/417455a. HDAC6 is a microtubule-associated deacetylase

HDAC6 is a microtubule-associated deacetylase

10.1038/417455a

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002). HDAC6 is a microtubule-associated deacetylase. Nature, 417(6887), 455â458.

Authors 9

Charlotte Hubbert (first)
Amaris Guardiola (additional)
Rong Shao (additional)
Yoshiharu Kawaguchi (additional)
Akihiro Ito (additional)
Andrew Nixon (additional)
Minoru Yoshida (additional)
Xiao-Fan Wang (additional)
Tso-Pang Yao (additional)

References 21 Referenced 1,991

Piperno, G., LeDizet, M. & Chang, X. J. Microtubules containing acetylated α-tubulin in mammalian cells in culture. J. Cell Biol. 104, 289–302 (1987) (10.1083/jcb.104.2.289) / J. Cell Biol. by G Piperno (1987)
Robson, S. J. & Burgoyne, R. D. Differential localisation of tyrosinated, detyrosinated, and acetylated α-tubulins in neurites and growth cones of dorsal root ganglion neurons. Cell Motil. Cytoskel. 12, 273–282 (1989) (10.1002/cm.970120408) / Cell Motil. Cytoskel. by SJ Robson (1989)
Smith, D. S. et al. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nature Cell Biol. 2, 767–775 (2000) (10.1038/35041000) / Nature Cell Biol. by DS Smith (2000)
Wade, P. A., Pruss, D. & Wolffe, A. P. Histone acetylation: chromatin in action. Trends Biochem. Sci. 22, 128–132 (1997) (10.1016/S0968-0004(97)01016-5) / Trends Biochem. Sci. by PA Wade (1997)
Grozinger, C. M., Hassig, C. A. & Schreiber, S. L. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl Acad. Sci. USA 96, 4868–4873 (1999) (10.1073/pnas.96.9.4868) / Proc. Natl Acad. Sci. USA by CM Grozinger (1999)
Guardiola, A. R. & Yao, T. P. Molecular cloning and characterization of a novel histone deacetylase HDAC10. J. Biol. Chem. 277, 3350–3356 (2001) (10.1074/jbc.M109861200) / J. Biol. Chem. by AR Guardiola (2001)
Luo, J., Su, F., Chen, D., Shiloh, A. & Gu, W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377–381 (2000) (10.1038/35042612) / Nature by J Luo (2000)
Ito, A. et al. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 20, 1331–1340 (2001) (10.1093/emboj/20.6.1331) / EMBO J. by A Ito (2001)
Sartorelli, V. et al. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol. Cell 4, 725–734 (1999) (10.1016/S1097-2765(00)80383-4) / Mol. Cell by V Sartorelli (1999)
Kouzarides, T. Acetylation: A regulatory modification to rival phosphorylation? EMBO J. 19, 1176–1179 (2000) (10.1093/emboj/19.6.1176) / EMBO J. by T Kouzarides (2000)
Verdel, A. et al. Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm. Curr. Biol. 10, 747–749 (2000) (10.1016/S0960-9822(00)00542-X) / Curr. Biol. by A Verdel (2000)
Barlow, A. L. et al. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp. Cell Res. 265, 90–103 (2001) (10.1006/excr.2001.5162) / Exp. Cell Res. by AL Barlow (2001)
Piperno, G. & Fuller, M. T. Monoclonal antibodies specific for an acetylated form of α-tubulin recognize the antigen in cilia and flagella from a variety of organisms. J. Cell Biol. 101, 2085–2094 (1985) (10.1083/jcb.101.6.2085) / J. Cell Biol. by G Piperno (1985)
Furumai, R. et al. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc. Natl Acad. Sci. USA 98, 87–92 (2001) (10.1073/pnas.98.1.87) / Proc. Natl Acad. Sci. USA by R Furumai (2001)
Wadsworth, P. Regional regulation of microtubule dynamics in polarized, motile cells. Cell Motil. Cytoskel. 42, 48–59 (1999) (10.1002/(SICI)1097-0169(1999)42:1<48::AID-CM5>3.0.CO;2-8) / Cell Motil. Cytoskel. by P Wadsworth (1999)
Waterman-Storer, C. M. & Salmon, E. Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr. Opin. Cell Biol. 11, 61–67 (1999) (10.1016/S0955-0674(99)80008-8) / Curr. Opin. Cell Biol. by CM Waterman-Storer (1999)
Kaverina, I., Krylyshkina, O. & Small, J. V. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J. Cell Biol. 146, 1033–1044 (1999) (10.1083/jcb.146.5.1033) / J. Cell Biol. by I Kaverina (1999)
Seigneurin-Berny, D. et al. Identification of components of the murine histone deacetylase 6 complex: Link between acetylation and ubiquitination signalling pathways. Mol. Cell. Biol. 21, 8035–8044 (2001) (10.1128/MCB.21.23.8035-8044.2001) / Mol. Cell. Biol. by D Seigneurin-Berny (2001)
Hicke, L. A new ticket for entry into budding vesicles—ubiquitin. Cell 106, 527–530 (2001) (10.1016/S0092-8674(01)00485-8) / Cell by L Hicke (2001)
Eckner, R., Yao, T. P., Oldread, E. & Livingston, D. M. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10, 2478–2490 (1996) (10.1101/gad.10.19.2478) / Genes Dev. by R Eckner (1996)
Malinda, K. M., Ponce, L., Kleinman, H. K., Shackelton, L. M. & Millis, A. J. Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells. Exp. Cell Res. 250, 168–173 (1999) (10.1006/excr.1999.4511) / Exp. Cell Res. by KM Malinda (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:57 a.m.)
Deposited	2 years, 3 months ago (May 17, 2023, 8:32 p.m.)
Indexed	58 minutes ago (Aug. 29, 2025, 12:35 a.m.)
Issued	23 years, 3 months ago (May 1, 2002)
Published	23 years, 3 months ago (May 1, 2002)
Published Print	23 years, 3 months ago (May 1, 2002)

Funders 0

None

BibTeX

@article{Hubbert_2002, title={HDAC6 is a microtubule-associated deacetylase}, volume={417}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/417455a}, DOI={10.1038/417455a}, number={6887}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Hubbert, Charlotte and Guardiola, Amaris and Shao, Rong and Kawaguchi, Yoshiharu and Ito, Akihiro and Nixon, Andrew and Yoshida, Minoru and Wang, Xiao-Fan and Yao, Tso-Pang}, year={2002}, month=may, pages={455–458} }

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