DOI: 10.1038/383443a0. TRAF6 is a signal transducer for interleukin-1

TRAF6 is a signal transducer for interleukin-1

10.1038/383443a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., & Goeddel, D. V. (1996). TRAF6 is a signal transducer for interleukin-1. Nature, 383(6599), 443â446.

Authors 5

Zhaodan Cao (first)
Jessie Xiong (additional)
Masahiro Takeuchi (additional)
Takeshi Kurama (additional)
David V. Goeddel (additional)

References 28 Referenced 1,056

Baeuerle, P. A. & Henkel, T. Annu. Rev. Immunol. 12, 141–179 (1994). (10.1146/annurev.iy.12.040194.001041) / Annu. Rev. Immunol. by PA Baeuerle (1994)
Rothe, M., Sarma, V., Dixit, V. M. & Goeddel, D. V. Science 269, 1424–1427 (1995). (10.1126/science.7544915) / Science by M Rothe (1995)
Hsu, H., Shu, H. B., Pan, M. G. & Goeddel, D. V. Cell 84, 299–308 (1996). (10.1016/S0092-8674(00)80984-8) / Cell by H Hsu (1996)
Nakano, H. et al. J. Biol. Chem. 271, 14661–14664 (1996). (10.1074/jbc.271.25.14661) / J. Biol. Chem. by H Nakano (1996)
Takeuchi, M., Rothe, M. & Goeddel, D. V. J. Biol. Chem. 271, 19935–19942 (1996). (10.1074/jbc.271.33.19935) / J. Biol. Chem. by M Takeuchi (1996)
Cao, Z., Henzel, W. J. & Gao, X. Science 271, 1128–1131 (1996). (10.1126/science.271.5252.1128) / Science by Z Cao (1996)
McDonald, P. P. et al. Eur. J. Immunol. 25, 2870–2876 (1995). (10.1002/eji.1830251024) / Eur. J. Immunol. by PP McDonald (1995)
Berberich, I., Shu, G. L. & Clark, E. A. J. Immunol. 153, 4357–4366 (1994). (10.4049/jimmunol.153.10.4357) / J. Immunol. by I Berberich (1994)
Sarma, V. et al. J. Biol. Chem. 270, 12343–12346 (1995). (10.1074/jbc.270.21.12343) / J. Biol. Chem. by V Sarma (1995)
Messer, G., Weiss, E. H. & Baeuerle, P. A. Cytokine 2, 389–397 (1990). (10.1016/1043-4666(90)90046-V) / Cytokine by G Messer (1990)
Gruss, H.-J. & Dower, S. K. Blood 85, 3378–3404 (1995). (10.1182/blood.V85.12.3378.bloodjournal85123378) / Blood by H-J Gruss (1995)
Dinarello, C. Blood 87, 2095–2147 (1996). (10.1182/blood.V87.6.2095.bloodjournal8762095) / Blood by C Dinarello (1996)
Ulevitch, R. J. & Tobias, P. S. Annu. Rev. Immunol. 13, 437–457 (1995). (10.1146/annurev.iy.13.040195.002253) / Annu. Rev. Immunol. by RJ Ulevitch (1995)
Rothe, M., Wong, S. C., Henzel, W. J. & Goeddel, D. V. Cell 78, 681–692 (1994). (10.1016/0092-8674(94)90532-0) / Cell by M Rothe (1994)
Cheng, G. et al. Science 267, 1494–1498 (1995). (10.1126/science.7533327) / Science by G Cheng (1995)
Hu, H. M., O'Rourke, K., Boguski, M. S. & Dixit, V. M. J. Biol. Chem. 269, 30069–30072 (1994). (10.1016/S0021-9258(18)43772-6) / J. Biol. Chem. by HM Hu (1994)
Mosialos, G. et al. Cell 80, 389–399 (1995). (10.1016/0092-8674(95)90489-1) / Cell by G Mosialos (1995)
Sato, T., Irie, S. & Reed, J. C. FEBS Lett. 358, 113–118 (1995). (10.1016/0014-5793(94)01406-Q) / FEBS Lett. by T Sato (1995)
Song, H. Y. & Donner, D. B. Biochem. J. 309, 825–829 (1995). (10.1042/bj3090825) / Biochem. J. by HY Song (1995)
Shelton, C. A. & Wasserman, S. A. Cell 72, 515–525 (1993). (10.1016/0092-8674(93)90071-W) / Cell by CA Shelton (1993)
Hsu, H., Huang, J., Shu, H.-B., Baichwal, V. & Goeddel, D. V. Immunity 4, 387–396 (1996). (10.1016/S1074-7613(00)80252-6) / Immunity by H Hsu (1996)
Rothe, M., Pan, M.-G., Henzel, W. J., Ayres, T. M. & Goeddel, D. V. Cell 83, 1243–1252 (1995). (10.1016/0092-8674(95)90149-3) / Cell by M Rothe (1995)
Schall, T. J. et al. Cell 61, 361–370 (1990). (10.1016/0092-8674(90)90816-W) / Cell by TJ Schall (1990)
Ausubel, F. M. et al. Curr. Prot. Mol. Biol. 1, 9.1.1–9.1.3 (1994). / Curr. Prot. Mol. Biol. by FM Ausubel (1994)
Schütze, S. et al. Cell 71, 765–776 (1992). (10.1016/0092-8674(92)90553-O) / Cell by S Schütze (1992)
Schindler, U. & Baichwal, V. R. Mol. Cell. Biol. 14, 5820–5831 (1994). (10.1128/MCB.14.9.5820) / Mol. Cell. Biol. by U Schindler (1994)
Croston, G. E., Cao, Z. & Goeddel, D. V. J. Biol. Chem. 270, 16514–16517 (1995). (10.1074/jbc.270.28.16514) / J. Biol. Chem. by GE Croston (1995)
Regnier, C. H. et al. J. Biol. Chem. 270, 25715–25721 (1995). (10.1074/jbc.270.43.25715) / J. Biol. Chem. by CH Regnier (1995)

Dates

Type	When
Created	22 years ago (Aug. 11, 2003, 10:15 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:50 p.m.)
Indexed	4 days, 10 hours ago (Aug. 19, 2025, 6:11 a.m.)
Issued	28 years, 10 months ago (Oct. 1, 1996)
Published	28 years, 10 months ago (Oct. 1, 1996)
Published Print	28 years, 10 months ago (Oct. 1, 1996)

Funders 0

None

BibTeX

@article{Cao_1996, title={TRAF6 is a signal transducer for interleukin-1}, volume={383}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/383443a0}, DOI={10.1038/383443a0}, number={6599}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Cao, Zhaodan and Xiong, Jessie and Takeuchi, Masahiro and Kurama, Takeshi and Goeddel, David V.}, year={1996}, month=oct, pages={443–446} }

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