DOI: 10.1038/374542a0. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

10.1038/374542a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F., & Julius, D. (1995). Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature, 374(6522), 542â546.

Authors 7

Laurence H. Tecott (first)
Linda M. Sun (additional)
Susan F. Akana (additional)
Alison M. Strack (additional)
Daniel H. Lowenstein (additional)
Mary F. Dallman (additional)
David Julius (additional)

References 30 Referenced 1,021

Jacobs, B. L. in Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives (ed. Jacobs, B. L.) 183–202 (Raven, New York, 1984). / Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives by BL Jacobs (1984)
Sleight, A. J., Pierce, P. A., Schmidt, A. W., Hekmatpanah, C. R. & Peroutka, S. J. in Serotonin Receptor Subtypes: Basic and Clinical Aspects (ed. Peroutka, S. J.) 211–227 (Wiley-Liss, New York, 1991). / Serotonin Receptor Subtypes: Basic and Clinical Aspects by AJ Sleight (1991)
Wilkinson, L. O. & Dourish, C. T. in Serotonin Receptor Subtypes: Basic and Clinical Aspects (ed. Peroutka, S. J.) 147–210 (Wiley-Liss, New York, 1991). / Serotonin Receptor Subtypes: Basic and Clinical Aspects by LO Wilkinson (1991)
Tecott, L. H. & Julius, D. J. Curr. Opin. Neurobiol. 3, 310–315 (1993). (10.1016/0959-4388(93)90122-F) / Curr. Opin. Neurobiol. by LH Tecott (1993)
Julius, D., MacDermott, A. B., Axel, R. & Jessell, T. M. Science, 241, 558–564 (1988). (10.1126/science.3399891) / Science by D Julius (1988)
Molineaux, S., Jessell, T., Axel, R. & Julius, D. Proc. natn. Acad. Sci. U.S.A. 86, 6793–6797 (1989). (10.1073/pnas.86.17.6793) / Proc. natn. Acad. Sci. U.S.A. by S Molineaux (1989)
Hoffman, B. J. & Mezey, E. FEBS Lett. 247, 453–462 (1989). (10.1016/0014-5793(89)81390-0) / FEBS Lett. by BJ Hoffman (1989)
Pompeiano, M., Palacios, J. M. & Mengod, G. Molec. Brain Res. 23, 163–178 (1994). (10.1016/0169-328X(94)90223-2) / Molec. Brain Res. by M Pompeiano (1994)
Yu, L. et al. Molec. Brain Res. 11, 143–149 (1991). (10.1016/0169-328X(91)90116-F) / Molec. Brain Res. by L Yu (1991)
Milatovich, A. et al. Hum. molec. Genet. 1, 681–684 (1992). (10.1093/hmg/1.9.681) / Hum. molec. Genet. by A Milatovich (1992)
Thomas, L., Power, B., Hudson, P., Schreiber, G. & Dziadek, M. Devl Biol. 128, 415–427 (1988). (10.1016/0012-1606(88)90303-X) / Devl Biol. by L Thomas (1988)
Orloff, M. J., Williams, H. L. & Pfeiffer, C. C. Proc. Soc. exp. Biol. Med. 70, 254–257 (1949). (10.3181/00379727-70-16891) / Proc. Soc. exp. Biol. Med. by MJ Orloff (1949)
Blundell, J. E. Am. J. clin. Nutr. 55, 155–159S (1992). (10.1093/ajcn/55.1.155s) / Am. J. clin. Nutr. by JE Blundell (1992)
Wurtman, J. et al. Neuropsychopharmacology 9, 201–210 (1993). (10.1038/npp.1993.56) / Neuropsychopharmacology by J Wurtman (1993)
Samanin, R. et al. Naunyn-Schmiedebergs Arch. Pharmac. 308, 159–163 (1979). (10.1007/BF00499059) / Naunyn-Schmiedebergs Arch. Pharmac. by R Samanin (1979)
Kennett, G. A. & Curzon, G. Br. J. Pharmac. 103, 2016–2020 (1991). (10.1111/j.1476-5381.1991.tb12369.x) / Br. J. Pharmac. by GA Kennett (1991)
Kitchener, S. J. & Dourish, C. T. Psychopharmacology 113, 369–377 (1994). (10.1007/BF02245211) / Psychopharmacology by SJ Kitchener (1994)
Parkinson, W. L. & Weingarten, H. P. Am. J. Physiol. 259, R829–R835 (1990). / Am. J. Physiol. by WL Parkinson (1990)
Himms-Hagen, J. Front. Neuroendocr. 12, 38–93 (1991). / Front. Neuroendocr. by J Himms-Hagen (1991)
Kilian, M. & Frey, H. H. Neuropharmacology 12, 681–692 (1973). (10.1016/0028-3908(73)90121-4) / Neuropharmacology by M Kilian (1973)
Jobe, P. C. Picchioni, A. L. & Chin, L. Life Sci. 13, 1–13 (1973). (10.1016/0024-3205(73)90271-3) / Life Sci. by PC Jobe (1973)
Sparks, D. L. & Buckholtz, N. S. Pharmac. Biochem. Behav. 23, 753–757 (1985). (10.1016/0091-3057(85)90067-X) / Pharmac. Biochem. Behav. by DL Sparks (1985)
Dailey, J. W., Slater, K., Crable, D. J. & Jobe, P. C. Fedn Proc. 46, 2282 (1987). / Fedn Proc. by JW Dailey (1987)
Engel, J. Seizures and Epilepsy (Davis, Philadelphia, 1989). / Seizures and Epilepsy by J Engel (1989)
Friedman, J. M. & Leibel, R. L. Cell 69, 217–220 (1992). (10.1016/0092-8674(92)90402-X) / Cell by JM Friedman (1992)
Flier, J. S. Cell 80, 15–18 (1995). (10.1016/0092-8674(95)90445-X) / Cell by JS Flier (1995)
Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348–352 (1988). (10.1038/336348a0) / Nature by SL Mansour (1988)
Tecott, L., Maricq, A. & Julius, D. Proc. natn. Acad. Sci. U.S.A. 90, 1430–1434 (1993). (10.1073/pnas.90.4.1430) / Proc. natn. Acad. Sci. U.S.A. by L Tecott (1993)
Brake, A. J., Wagenbach, M. J. & Julius, D. Nature 371, 519–523 (1994). (10.1038/371519a0) / Nature by AJ Brake (1994)
Strack, A. M., Bradbury, M. J. & Dallman, M. F. Am. J. Physiol. 268, R183–191 (1995). / Am. J. Physiol. by AM Strack (1995)

Dates

Type	When
Created	22 years ago (Sept. 2, 2003, 10:11 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:47 p.m.)
Indexed	2 days, 21 hours ago (Sept. 3, 2025, 6:42 a.m.)
Issued	30 years, 5 months ago (April 1, 1995)
Published	30 years, 5 months ago (April 1, 1995)
Published Print	30 years, 5 months ago (April 1, 1995)

Funders 0

None

BibTeX

@article{Tecott_1995, title={Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors}, volume={374}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/374542a0}, DOI={10.1038/374542a0}, number={6522}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Tecott, Laurence H. and Sun, Linda M. and Akana, Susan F. and Strack, Alison M. and Lowenstein, Daniel H. and Dallman, Mary F. and Julius, David}, year={1995}, month=apr, pages={542–546} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:42:30Z",
    "timestamp": 1756896150754
  },
  "reference-count": 30,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6522",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1995,
            4,
            1
          ]
        ],
        "date-time": "1995-04-01T00:00:00Z",
        "timestamp": 796694400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1995,
        4
      ]
    ]
  },
  "DOI": "10.1038/374542a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        9,
        2
      ]
    ],
    "date-time": "2003-09-02T14:11:49Z",
    "timestamp": 1062511909000
  },
  "page": "542-546",
  "source": "Crossref",
  "is-referenced-by-count": 1021,
  "title": "Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors",
  "prefix": "10.1038",
  "volume": "374",
  "author": [
    {
      "given": "Laurence H.",
      "family": "Tecott",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Linda M.",
      "family": "Sun",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Susan F.",
      "family": "Akana",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alison M.",
      "family": "Strack",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Daniel H.",
      "family": "Lowenstein",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mary F.",
      "family": "Dallman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David",
      "family": "Julius",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF374542a0_CR1",
      "first-page": "183",
      "volume-title": "Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives",
      "author": "BL Jacobs",
      "year": "1984",
      "unstructured": "Jacobs, B. L. in Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives (ed. Jacobs, B. L.) 183\u2013202 (Raven, New York, 1984)."
    },
    {
      "key": "BF374542a0_CR2",
      "first-page": "211",
      "volume-title": "Serotonin Receptor Subtypes: Basic and Clinical Aspects",
      "author": "AJ Sleight",
      "year": "1991",
      "unstructured": "Sleight, A. J., Pierce, P. A., Schmidt, A. W., Hekmatpanah, C. R. & Peroutka, S. J. in Serotonin Receptor Subtypes: Basic and Clinical Aspects (ed. Peroutka, S. J.) 211\u2013227 (Wiley-Liss, New York, 1991)."
    },
    {
      "key": "BF374542a0_CR3",
      "first-page": "147",
      "volume-title": "Serotonin Receptor Subtypes: Basic and Clinical Aspects",
      "author": "LO Wilkinson",
      "year": "1991",
      "unstructured": "Wilkinson, L. O. & Dourish, C. T. in Serotonin Receptor Subtypes: Basic and Clinical Aspects (ed. Peroutka, S. J.) 147\u2013210 (Wiley-Liss, New York, 1991)."
    },
    {
      "key": "BF374542a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "310",
      "DOI": "10.1016/0959-4388(93)90122-F",
      "volume": "3",
      "author": "LH Tecott",
      "year": "1993",
      "unstructured": "Tecott, L. H. & Julius, D. J. Curr. Opin. Neurobiol. 3, 310\u2013315 (1993).",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "BF374542a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "558",
      "DOI": "10.1126/science.3399891",
      "volume": "241",
      "author": "D Julius",
      "year": "1988",
      "unstructured": "Julius, D., MacDermott, A. B., Axel, R. & Jessell, T. M. Science, 241, 558\u2013564 (1988).",
      "journal-title": "Science"
    },
    {
      "key": "BF374542a0_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "6793",
      "DOI": "10.1073/pnas.86.17.6793",
      "volume": "86",
      "author": "S Molineaux",
      "year": "1989",
      "unstructured": "Molineaux, S., Jessell, T., Axel, R. & Julius, D. Proc. natn. Acad. Sci. U.S.A. 86, 6793\u20136797 (1989).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF374542a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "453",
      "DOI": "10.1016/0014-5793(89)81390-0",
      "volume": "247",
      "author": "BJ Hoffman",
      "year": "1989",
      "unstructured": "Hoffman, B. J. & Mezey, E. FEBS Lett. 247, 453\u2013462 (1989).",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "BF374542a0_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "163",
      "DOI": "10.1016/0169-328X(94)90223-2",
      "volume": "23",
      "author": "M Pompeiano",
      "year": "1994",
      "unstructured": "Pompeiano, M., Palacios, J. M. & Mengod, G. Molec. Brain Res. 23, 163\u2013178 (1994).",
      "journal-title": "Molec. Brain Res."
    },
    {
      "key": "BF374542a0_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "143",
      "DOI": "10.1016/0169-328X(91)90116-F",
      "volume": "11",
      "author": "L Yu",
      "year": "1991",
      "unstructured": "Yu, L. et al. Molec. Brain Res. 11, 143\u2013149 (1991).",
      "journal-title": "Molec. Brain Res."
    },
    {
      "key": "BF374542a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "681",
      "DOI": "10.1093/hmg/1.9.681",
      "volume": "1",
      "author": "A Milatovich",
      "year": "1992",
      "unstructured": "Milatovich, A. et al. Hum. molec. Genet. 1, 681\u2013684 (1992).",
      "journal-title": "Hum. molec. Genet."
    },
    {
      "key": "BF374542a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "415",
      "DOI": "10.1016/0012-1606(88)90303-X",
      "volume": "128",
      "author": "L Thomas",
      "year": "1988",
      "unstructured": "Thomas, L., Power, B., Hudson, P., Schreiber, G. & Dziadek, M. Devl Biol. 128, 415\u2013427 (1988).",
      "journal-title": "Devl Biol."
    },
    {
      "key": "BF374542a0_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "254",
      "DOI": "10.3181/00379727-70-16891",
      "volume": "70",
      "author": "MJ Orloff",
      "year": "1949",
      "unstructured": "Orloff, M. J., Williams, H. L. & Pfeiffer, C. C. Proc. Soc. exp. Biol. Med. 70, 254\u2013257 (1949).",
      "journal-title": "Proc. Soc. exp. Biol. Med."
    },
    {
      "key": "BF374542a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "155",
      "DOI": "10.1093/ajcn/55.1.155s",
      "volume": "55",
      "author": "JE Blundell",
      "year": "1992",
      "unstructured": "Blundell, J. E. Am. J. clin. Nutr. 55, 155\u2013159S (1992).",
      "journal-title": "Am. J. clin. Nutr."
    },
    {
      "key": "BF374542a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "201",
      "DOI": "10.1038/npp.1993.56",
      "volume": "9",
      "author": "J Wurtman",
      "year": "1993",
      "unstructured": "Wurtman, J. et al. Neuropsychopharmacology 9, 201\u2013210 (1993).",
      "journal-title": "Neuropsychopharmacology"
    },
    {
      "key": "BF374542a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "159",
      "DOI": "10.1007/BF00499059",
      "volume": "308",
      "author": "R Samanin",
      "year": "1979",
      "unstructured": "Samanin, R. et al. Naunyn-Schmiedebergs Arch. Pharmac. 308, 159\u2013163 (1979).",
      "journal-title": "Naunyn-Schmiedebergs Arch. Pharmac."
    },
    {
      "key": "BF374542a0_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "2016",
      "DOI": "10.1111/j.1476-5381.1991.tb12369.x",
      "volume": "103",
      "author": "GA Kennett",
      "year": "1991",
      "unstructured": "Kennett, G. A. & Curzon, G. Br. J. Pharmac. 103, 2016\u20132020 (1991).",
      "journal-title": "Br. J. Pharmac."
    },
    {
      "key": "BF374542a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "369",
      "DOI": "10.1007/BF02245211",
      "volume": "113",
      "author": "SJ Kitchener",
      "year": "1994",
      "unstructured": "Kitchener, S. J. & Dourish, C. T. Psychopharmacology 113, 369\u2013377 (1994).",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "BF374542a0_CR18",
      "first-page": "R829",
      "volume": "259",
      "author": "WL Parkinson",
      "year": "1990",
      "unstructured": "Parkinson, W. L. & Weingarten, H. P. Am. J. Physiol. 259, R829\u2013R835 (1990).",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "BF374542a0_CR19",
      "first-page": "38",
      "volume": "12",
      "author": "J Himms-Hagen",
      "year": "1991",
      "unstructured": "Himms-Hagen, J. Front. Neuroendocr. 12, 38\u201393 (1991).",
      "journal-title": "Front. Neuroendocr."
    },
    {
      "key": "BF374542a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "681",
      "DOI": "10.1016/0028-3908(73)90121-4",
      "volume": "12",
      "author": "M Kilian",
      "year": "1973",
      "unstructured": "Kilian, M. & Frey, H. H. Neuropharmacology 12, 681\u2013692 (1973).",
      "journal-title": "Neuropharmacology"
    },
    {
      "key": "BF374542a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1016/0024-3205(73)90271-3",
      "volume": "13",
      "author": "PC Jobe",
      "year": "1973",
      "unstructured": "Jobe, P. C. Picchioni, A. L. & Chin, L. Life Sci. 13, 1\u201313 (1973).",
      "journal-title": "Life Sci."
    },
    {
      "key": "BF374542a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "753",
      "DOI": "10.1016/0091-3057(85)90067-X",
      "volume": "23",
      "author": "DL Sparks",
      "year": "1985",
      "unstructured": "Sparks, D. L. & Buckholtz, N. S. Pharmac. Biochem. Behav. 23, 753\u2013757 (1985).",
      "journal-title": "Pharmac. Biochem. Behav."
    },
    {
      "key": "BF374542a0_CR23",
      "first-page": "2282",
      "volume": "46",
      "author": "JW Dailey",
      "year": "1987",
      "unstructured": "Dailey, J. W., Slater, K., Crable, D. J. & Jobe, P. C. Fedn Proc. 46, 2282 (1987).",
      "journal-title": "Fedn Proc."
    },
    {
      "key": "BF374542a0_CR24",
      "volume-title": "Seizures and Epilepsy",
      "author": "J Engel",
      "year": "1989",
      "unstructured": "Engel, J. Seizures and Epilepsy (Davis, Philadelphia, 1989)."
    },
    {
      "key": "BF374542a0_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "217",
      "DOI": "10.1016/0092-8674(92)90402-X",
      "volume": "69",
      "author": "JM Friedman",
      "year": "1992",
      "unstructured": "Friedman, J. M. & Leibel, R. L. Cell 69, 217\u2013220 (1992).",
      "journal-title": "Cell"
    },
    {
      "key": "BF374542a0_CR26",
      "doi-asserted-by": "publisher",
      "first-page": "15",
      "DOI": "10.1016/0092-8674(95)90445-X",
      "volume": "80",
      "author": "JS Flier",
      "year": "1995",
      "unstructured": "Flier, J. S. Cell 80, 15\u201318 (1995).",
      "journal-title": "Cell"
    },
    {
      "key": "BF374542a0_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "348",
      "DOI": "10.1038/336348a0",
      "volume": "336",
      "author": "SL Mansour",
      "year": "1988",
      "unstructured": "Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348\u2013352 (1988).",
      "journal-title": "Nature"
    },
    {
      "key": "BF374542a0_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "1430",
      "DOI": "10.1073/pnas.90.4.1430",
      "volume": "90",
      "author": "L Tecott",
      "year": "1993",
      "unstructured": "Tecott, L., Maricq, A. & Julius, D. Proc. natn. Acad. Sci. U.S.A. 90, 1430\u20131434 (1993).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF374542a0_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "519",
      "DOI": "10.1038/371519a0",
      "volume": "371",
      "author": "AJ Brake",
      "year": "1994",
      "unstructured": "Brake, A. J., Wagenbach, M. J. & Julius, D. Nature 371, 519\u2013523 (1994).",
      "journal-title": "Nature"
    },
    {
      "key": "BF374542a0_CR30",
      "first-page": "R183",
      "volume": "268",
      "author": "AM Strack",
      "year": "1995",
      "unstructured": "Strack, A. M., Bradbury, M. J. & Dallman, M. F. Am. J. Physiol. 268, R183\u2013191 (1995).",
      "journal-title": "Am. J. Physiol."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/374542a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/374542a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/374542a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:47:51Z",
    "timestamp": 1684291671000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/374542a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1995,
        4
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "6522",
    "published-print": {
      "date-parts": [
        [
          1995,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "BF374542a0"
  ],
  "URL": "http://dx.doi.org/10.1038/374542a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1995,
        4
      ]
    ]
  }
}