DOI: 10.1038/371243a0. Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel

Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel

10.1038/371243a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Lu, Z., & MacKinnon, R. (1994). Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel. Nature, 371(6494), 243â246.

Authors 2

Zhe Lu (first)
Roderick MacKinnon (additional)

References 29 Referenced 249

Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 1991). / Ionic Channels of Excitable Membranes by B Hille (1991)
Trautwein, W. & Dudel, J. Pflügers Arch. 266, 324–334 (1958). (10.1007/BF00416781) / Pflügers Arch. by W Trautwein (1958)
Noma, A., Peper, K. & Trautwein, W. Pflügers Arch. 400, 424–431 (1983). / Pflügers Arch. by A Noma (1983)
Sakmann, B., Noma, A. & Trautwein, W. Nature 303, 250–253 (1983). (10.1038/303250a0) / Nature by B Sakmann (1983)
Seojima, M. & Noma, A. Pflügers Arch. 400, 424–431 (1984). (10.1007/BF00587544) / Pflügers Arch. by M Seojima (1984)
Ashcroft, F. M. & Rorsman, P. Biochem. Soc. Trans. 18, 109–111 (1990). (10.1042/bst0180109) / Biochem. Soc. Trans. by FM Ashcroft (1990)
Horie, M., Isisawa, H. & Noma, A. J. Physiol. 387, 251–272 (1987). (10.1113/jphysiol.1987.sp016572) / J. Physiol. by M Horie (1987)
Matsuda, H., Saigusa, A. & Isisawa, H. Nature 325, 156–159 (1987). (10.1038/325156a0) / Nature by H Matsuda (1987)
Vandenberg, C. A. Proc. natn. Acad. Sci. U.S.A. 84, 2560–2564 (1987). (10.1073/pnas.84.8.2560) / Proc. natn. Acad. Sci. U.S.A. by CA Vandenberg (1987)
Matsuda, H. J. Physiol. 435, 83–99 (1991). (10.1113/jphysiol.1991.sp018499) / J. Physiol. by H Matsuda (1991)
Ho, K. et al. Nature 362, 31–38 (1993). (10.1038/362031a0) / Nature by K Ho (1993)
Nichols, C. G., Ho, K. & Hebert, S. J. Physiol. 476, 399–409 (1994). (10.1113/jphysiol.1994.sp020141) / J. Physiol. by CG Nichols (1994)
Kubo, Y., Baldwin, T. J., Yan, Y. N. & Jan, L. Y. Nature 362, 127–132 (1993). (10.1038/362127a0) / Nature by Y Kubo (1993)
Miller, C. Science 252, 1092–1096 (1991). (10.1126/science.252.5009.1092) / Science by C Miller (1991)
Choi, K. L., Mossman, C., Aube, J. & Yellen, G. Neuron 10, 533–541 (1993). (10.1016/0896-6273(93)90340-W) / Neuron by KL Choi (1993)
Kirsch, G. E., Shieh, C. C., Drewe, J. A., Vener, D. F. & Brown, A. M. Neuron 11, 503–512 (1993). (10.1016/0896-6273(93)90154-J) / Neuron by GE Kirsch (1993)
Slesinger, P. A., Jan, Y. N. & Jan, L. Y. Neuron 11, 739–749 (1993). (10.1016/0896-6273(93)90083-4) / Neuron by PA Slesinger (1993)
Lopez, G. A., Jan, Y. N. & Jan, L. Y. Nature 367, 179–182 (1994). (10.1038/367179a0) / Nature by GA Lopez (1994)
Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N. & Jan, L. Y. Nature 364, 802–806 (1993). (10.1038/364802a0) / Nature by Y Kubo (1993)
Dascal, N. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10235–10239 (1993). (10.1073/pnas.90.21.10235) / Proc. natn. Acad. Sci. U.S.A. by N Dascal (1993)
Stanfield, P. R. et al. J. Physiol. 475, 1–7 (1994). (10.1113/jphysiol.1994.sp020044) / J. Physiol. by PR Stanfield (1994)
Kurachi, Y. J. Physiol. 366, 365–385 (1985). (10.1113/jphysiol.1985.sp015803) / J. Physiol. by Y Kurachi (1985)
Ishihara, K., Mitsuiye, T., Noma, A. & Takano, T. J. Physiol. 419, 297–320 (1989). (10.1113/jphysiol.1989.sp017874) / J. Physiol. by K Ishihara (1989)
Silver, M. R. & DeCoursey, T. E. J. gen. Physiol. 96, 109–133 (1990). (10.1085/jgp.96.1.109) / J. gen. Physiol. by MR Silver (1990)
Taglialatela, M., Wibb, B. A., Caporaso, R. & Brown, A. M. Science 264, 844–847 (1994). (10.1126/science.8171340) / Science by M Taglialatela (1994)
Creighton, T. E. Proteins: Structures and Molecular Properties 2nd edn (Freeman, New York, 1993). / Proteins: Structures and Molecular Properties by TE Creighton (1993)
MacKinnon, R., Reinhart, P. H. & White, M. M. Neuron 1, 997–1001 (1988). (10.1016/0896-6273(88)90156-0) / Neuron by R MacKinnon (1988)
Goldman, D. E. J. gen. Physiol. 27, 37–60 (1943). (10.1085/jgp.27.1.37) / J. gen. Physiol. by DE Goldman (1943)
Grahame, D. Chem. Rev. 41, 441–501 (1947). (10.1021/cr60130a002) / Chem. Rev. by D Grahame (1947)

Dates

Type	When
Created	22 years ago (Aug. 11, 2003, 9:40 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:26 p.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 12:59 a.m.)
Issued	31 years ago (Sept. 1, 1994)
Published	31 years ago (Sept. 1, 1994)
Published Print	31 years ago (Sept. 1, 1994)

Funders 0

None

BibTeX

@article{Lu_1994, title={Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel}, volume={371}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/371243a0}, DOI={10.1038/371243a0}, number={6494}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Lu, Zhe and MacKinnon, Roderick}, year={1994}, month=sep, pages={243–246} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T04:59:57Z",
    "timestamp": 1755925197854
  },
  "reference-count": 29,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6494",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1994,
            9,
            1
          ]
        ],
        "date-time": "1994-09-01T00:00:00Z",
        "timestamp": 778377600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        9
      ]
    ]
  },
  "DOI": "10.1038/371243a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        8,
        12
      ]
    ],
    "date-time": "2003-08-12T01:40:27Z",
    "timestamp": 1060652427000
  },
  "page": "243-246",
  "source": "Crossref",
  "is-referenced-by-count": 249,
  "title": "Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel",
  "prefix": "10.1038",
  "volume": "371",
  "author": [
    {
      "given": "Zhe",
      "family": "Lu",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Roderick",
      "family": "MacKinnon",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF371243a0_CR1",
      "volume-title": "Ionic Channels of Excitable Membranes",
      "author": "B Hille",
      "year": "1991",
      "unstructured": "Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 1991)."
    },
    {
      "key": "BF371243a0_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "324",
      "DOI": "10.1007/BF00416781",
      "volume": "266",
      "author": "W Trautwein",
      "year": "1958",
      "unstructured": "Trautwein, W. & Dudel, J. Pfl\u00fcgers Arch. 266, 324\u2013334 (1958).",
      "journal-title": "Pfl\u00fcgers Arch."
    },
    {
      "key": "BF371243a0_CR3",
      "first-page": "424",
      "volume": "400",
      "author": "A Noma",
      "year": "1983",
      "unstructured": "Noma, A., Peper, K. & Trautwein, W. Pfl\u00fcgers Arch. 400, 424\u2013431 (1983).",
      "journal-title": "Pfl\u00fcgers Arch."
    },
    {
      "key": "BF371243a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "250",
      "DOI": "10.1038/303250a0",
      "volume": "303",
      "author": "B Sakmann",
      "year": "1983",
      "unstructured": "Sakmann, B., Noma, A. & Trautwein, W. Nature 303, 250\u2013253 (1983).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "424",
      "DOI": "10.1007/BF00587544",
      "volume": "400",
      "author": "M Seojima",
      "year": "1984",
      "unstructured": "Seojima, M. & Noma, A. Pfl\u00fcgers Arch. 400, 424\u2013431 (1984).",
      "journal-title": "Pfl\u00fcgers Arch."
    },
    {
      "key": "BF371243a0_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "109",
      "DOI": "10.1042/bst0180109",
      "volume": "18",
      "author": "FM Ashcroft",
      "year": "1990",
      "unstructured": "Ashcroft, F. M. & Rorsman, P. Biochem. Soc. Trans. 18, 109\u2013111 (1990).",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "BF371243a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "251",
      "DOI": "10.1113/jphysiol.1987.sp016572",
      "volume": "387",
      "author": "M Horie",
      "year": "1987",
      "unstructured": "Horie, M., Isisawa, H. & Noma, A. J. Physiol. 387, 251\u2013272 (1987).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "156",
      "DOI": "10.1038/325156a0",
      "volume": "325",
      "author": "H Matsuda",
      "year": "1987",
      "unstructured": "Matsuda, H., Saigusa, A. & Isisawa, H. Nature 325, 156\u2013159 (1987).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "2560",
      "DOI": "10.1073/pnas.84.8.2560",
      "volume": "84",
      "author": "CA Vandenberg",
      "year": "1987",
      "unstructured": "Vandenberg, C. A. Proc. natn. Acad. Sci. U.S.A. 84, 2560\u20132564 (1987).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF371243a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "83",
      "DOI": "10.1113/jphysiol.1991.sp018499",
      "volume": "435",
      "author": "H Matsuda",
      "year": "1991",
      "unstructured": "Matsuda, H. J. Physiol. 435, 83\u201399 (1991).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "31",
      "DOI": "10.1038/362031a0",
      "volume": "362",
      "author": "K Ho",
      "year": "1993",
      "unstructured": "Ho, K. et al. Nature 362, 31\u201338 (1993).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "399",
      "DOI": "10.1113/jphysiol.1994.sp020141",
      "volume": "476",
      "author": "CG Nichols",
      "year": "1994",
      "unstructured": "Nichols, C. G., Ho, K. & Hebert, S. J. Physiol. 476, 399\u2013409 (1994).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "127",
      "DOI": "10.1038/362127a0",
      "volume": "362",
      "author": "Y Kubo",
      "year": "1993",
      "unstructured": "Kubo, Y., Baldwin, T. J., Yan, Y. N. & Jan, L. Y. Nature 362, 127\u2013132 (1993).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "1092",
      "DOI": "10.1126/science.252.5009.1092",
      "volume": "252",
      "author": "C Miller",
      "year": "1991",
      "unstructured": "Miller, C. Science 252, 1092\u20131096 (1991).",
      "journal-title": "Science"
    },
    {
      "key": "BF371243a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "533",
      "DOI": "10.1016/0896-6273(93)90340-W",
      "volume": "10",
      "author": "KL Choi",
      "year": "1993",
      "unstructured": "Choi, K. L., Mossman, C., Aube, J. & Yellen, G. Neuron 10, 533\u2013541 (1993).",
      "journal-title": "Neuron"
    },
    {
      "key": "BF371243a0_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "503",
      "DOI": "10.1016/0896-6273(93)90154-J",
      "volume": "11",
      "author": "GE Kirsch",
      "year": "1993",
      "unstructured": "Kirsch, G. E., Shieh, C. C., Drewe, J. A., Vener, D. F. & Brown, A. M. Neuron 11, 503\u2013512 (1993).",
      "journal-title": "Neuron"
    },
    {
      "key": "BF371243a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "739",
      "DOI": "10.1016/0896-6273(93)90083-4",
      "volume": "11",
      "author": "PA Slesinger",
      "year": "1993",
      "unstructured": "Slesinger, P. A., Jan, Y. N. & Jan, L. Y. Neuron 11, 739\u2013749 (1993).",
      "journal-title": "Neuron"
    },
    {
      "key": "BF371243a0_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "179",
      "DOI": "10.1038/367179a0",
      "volume": "367",
      "author": "GA Lopez",
      "year": "1994",
      "unstructured": "Lopez, G. A., Jan, Y. N. & Jan, L. Y. Nature 367, 179\u2013182 (1994).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "802",
      "DOI": "10.1038/364802a0",
      "volume": "364",
      "author": "Y Kubo",
      "year": "1993",
      "unstructured": "Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N. & Jan, L. Y. Nature 364, 802\u2013806 (1993).",
      "journal-title": "Nature"
    },
    {
      "key": "BF371243a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "10235",
      "DOI": "10.1073/pnas.90.21.10235",
      "volume": "90",
      "author": "N Dascal",
      "year": "1993",
      "unstructured": "Dascal, N. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10235\u201310239 (1993).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF371243a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1113/jphysiol.1994.sp020044",
      "volume": "475",
      "author": "PR Stanfield",
      "year": "1994",
      "unstructured": "Stanfield, P. R. et al. J. Physiol. 475, 1\u20137 (1994).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "365",
      "DOI": "10.1113/jphysiol.1985.sp015803",
      "volume": "366",
      "author": "Y Kurachi",
      "year": "1985",
      "unstructured": "Kurachi, Y. J. Physiol. 366, 365\u2013385 (1985).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "297",
      "DOI": "10.1113/jphysiol.1989.sp017874",
      "volume": "419",
      "author": "K Ishihara",
      "year": "1989",
      "unstructured": "Ishihara, K., Mitsuiye, T., Noma, A. & Takano, T. J. Physiol. 419, 297\u2013320 (1989).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF371243a0_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "109",
      "DOI": "10.1085/jgp.96.1.109",
      "volume": "96",
      "author": "MR Silver",
      "year": "1990",
      "unstructured": "Silver, M. R. & DeCoursey, T. E. J. gen. Physiol. 96, 109\u2013133 (1990).",
      "journal-title": "J. gen. Physiol."
    },
    {
      "key": "BF371243a0_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "844",
      "DOI": "10.1126/science.8171340",
      "volume": "264",
      "author": "M Taglialatela",
      "year": "1994",
      "unstructured": "Taglialatela, M., Wibb, B. A., Caporaso, R. & Brown, A. M. Science 264, 844\u2013847 (1994).",
      "journal-title": "Science"
    },
    {
      "key": "BF371243a0_CR26",
      "volume-title": "Proteins: Structures and Molecular Properties",
      "author": "TE Creighton",
      "year": "1993",
      "unstructured": "Creighton, T. E. Proteins: Structures and Molecular Properties 2nd edn (Freeman, New York, 1993)."
    },
    {
      "key": "BF371243a0_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "997",
      "DOI": "10.1016/0896-6273(88)90156-0",
      "volume": "1",
      "author": "R MacKinnon",
      "year": "1988",
      "unstructured": "MacKinnon, R., Reinhart, P. H. & White, M. M. Neuron 1, 997\u20131001 (1988).",
      "journal-title": "Neuron"
    },
    {
      "key": "BF371243a0_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "37",
      "DOI": "10.1085/jgp.27.1.37",
      "volume": "27",
      "author": "DE Goldman",
      "year": "1943",
      "unstructured": "Goldman, D. E. J. gen. Physiol. 27, 37\u201360 (1943).",
      "journal-title": "J. gen. Physiol."
    },
    {
      "key": "BF371243a0_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "441",
      "DOI": "10.1021/cr60130a002",
      "volume": "41",
      "author": "D Grahame",
      "year": "1947",
      "unstructured": "Grahame, D. Chem. Rev. 41, 441\u2013501 (1947).",
      "journal-title": "Chem. Rev."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/371243a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/371243a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/371243a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:26:46Z",
    "timestamp": 1684290406000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/371243a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        9
      ]
    ]
  },
  "references-count": 29,
  "journal-issue": {
    "issue": "6494",
    "published-print": {
      "date-parts": [
        [
          1994,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "BF371243a0"
  ],
  "URL": "http://dx.doi.org/10.1038/371243a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1994,
        9
      ]
    ]
  }
}