DOI: 10.1038/370650a0. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

10.1038/370650a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Lowin, B., Hahne, M., Mattmann, C., & Tschopp, J. (1994). Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature, 370(6491), 650â652.

Authors 4

Bente Lowin (first)
Michael Hahne (additional)
Chantal Mattmann (additional)
Jürg Tschopp (additional)

References 19 Referenced 810

Kägi, D. et al. Nature 369, 31–37 (1994). (10.1038/369031a0) / Nature by D Kägi (1994)
Lowin, B., Beermann, F., Schmidt, A. & Tschopp, J. Proc. natn. Acad. Sci. U.S.A. (in the press).
Itoh, N. et al. Cell 66, 233–243 (1991). (10.1016/0092-8674(91)90614-5) / Cell by N Itoh (1991)
Trauth, B. C. et al. Science 245, 301–305 (1989). (10.1126/science.2787530) / Science by BC Trauth (1989)
Itoh, N., Tsujimoto, Y. & Nagata, S. J. exp. Med. 178, 461–468 (1993). (10.1084/jem.178.2.461) / J. exp. Med. by N Itoh (1993)
Takahashi, T. et al. Cell 76, 969–976 (1994). (10.1016/0092-8674(94)90375-1) / Cell by T Takahashi (1994)
Ramsdell, F. et al. Eur. J. Immun. 24, 928–933 (1994). (10.1002/eji.1830240422) / Eur. J. Immun. by F Ramsdell (1994)
Vignaux, F. & Golstein, P. Eur. J. Immun. 24, 923–927 (1994). (10.1002/eji.1830240421) / Eur. J. Immun. by F Vignaux (1994)
Rouvier, E., Luciani, M. F. & Golstein, P. J. exp. Med. 177, 195–200 (1993). (10.1084/jem.177.1.195) / J. exp. Med. by E Rouvier (1993)
Cerottini, J. C., Engers, H. D., MacDonald, H. R. & Brunner, T. J. exp. Med. 140, 703–717 (1974). (10.1084/jem.140.3.703) / J. exp. Med. by JC Cerottini (1974)
Kupfer, A., Singer, S. J. & Dennert, G. J. exp. Med. 163, 489–498 (1986). (10.1084/jem.163.3.489) / J. exp. Med. by A Kupfer (1986)
Peters, P. et al. Eur. J. Immun. 19, 1469–1475 (1989). (10.1002/eji.1830190819) / Eur. J. Immun. by P Peters (1989)
Russell, J. H., Rush, B., Weaver, C. & Wang, R. Proc. natn. Acad. Sci. U.S.A. 90, 4409–4413 (1993). (10.1073/pnas.90.10.4409) / Proc. natn. Acad. Sci. U.S.A. by JH Russell (1993)
Suda, T., Takahashi, T., Golstein, P. & Nagata, S. Cell 75, 1169–1178 (1993). (10.1016/0092-8674(93)90326-L) / Cell by T Suda (1993)
Ogasawara, J. et al. Nature 364, 806–809 (1993). (10.1038/364806a0) / Nature by J Ogasawara (1993)
Tschopp, J., Schafer, S., Masson, D., Peitsch, M. C. & Heusser, C. Nature 337, 272–274 (1989). (10.1038/337272a0) / Nature by J Tschopp (1989)
Coligan, J. E. Current Protocols in Immunology 3121–3126 (Wiley-lnterscience, New York, 1992). / Current Protocols in Immunology by JE Coligan (1992)
Maryanski, J. L., MacDonald, H. R. & Cerottini, J. C. J. Immun. 124, 42–48 (1980). (10.4049/jimmunol.124.1.42) / J. Immun. by JL Maryanski (1980)
Ucker, D. S. et al. Molec. cell. Biol. 12, 3060–3069 (1992). (10.1128/MCB.12.7.3060) / Molec. cell. Biol. by DS Ucker (1992)

Dates

Type	When
Created	22 years ago (Aug. 11, 2003, 9:15 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:25 p.m.)
Indexed	4 days, 5 hours ago (Aug. 29, 2025, 6:46 a.m.)
Issued	31 years, 1 month ago (Aug. 1, 1994)
Published	31 years, 1 month ago (Aug. 1, 1994)
Published Print	31 years, 1 month ago (Aug. 1, 1994)

Funders 0

None

BibTeX

@article{Lowin_1994, title={Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways}, volume={370}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/370650a0}, DOI={10.1038/370650a0}, number={6491}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Lowin, Bente and Hahne, Michael and Mattmann, Chantal and Tschopp, Jürg}, year={1994}, month=aug, pages={650–652} }

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