DOI: 10.1038/370218a0. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

10.1038/370218a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Mohler, K. M., Sleath, P. R., Fitzner, J. N., Cerretti, D. P., Alderson, M., Kerwar, S. S., Torranee, D. S., Otten-Evans, C., Greenstreet, T., Weerawarna, K., Kronheim, S. R., Petersen, M., Gerhart, M., Kozlosky, C. J., March, C. J., & Black, R. A. (1994). Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature, 370(6486), 218â220.

Authors 16

Kendall M. Mohler (first)
Paul R. Sleath (additional)
Jeffrey N. Fitzner (additional)
Douglas Pat Cerretti (additional)
Mark Alderson (additional)
Suresh S. Kerwar (additional)
Dauphine S. Torranee (additional)
Carol Otten-Evans (additional)
Teresa Greenstreet (additional)
Kumudini Weerawarna (additional)
Shirley R. Kronheim (additional)
Melissa Petersen (additional)
Mary Gerhart (additional)
Carl J. Kozlosky (additional)
Carl J. March (additional)
Roy A. Black (additional)

References 24 Referenced 483

Sherry, B. & Cerami, A. J. Cell Biol. 107, 1269–1277 (1988). (10.1083/jcb.107.4.1269) / J. Cell Biol. by B Sherry (1988)
Kriegler, M., Perez, C., DeFay, K., Albert, I. & Lu, S. D. Cell 53, 45–53 (1988). (10.1016/0092-8674(88)90486-2) / Cell by M Kriegler (1988)
Jue, D.-M., Sherry, B., Leudke, C., Manogue, K. R. & Cerami, A. Biochemistry 29, 8371–8377 (1990). (10.1021/bi00488a025) / Biochemistry by D-M Jue (1990)
Karp, S. E. et al. J. Immun. 149, 2076–2081 (1992). (10.4049/jimmunol.149.6.2076) / J. Immun. by SE Karp (1992)
Birkland, T. P., Sypek, J. P. & Wyler, D. J. J. Leuk. Biol. 51, 296–299 (1992). (10.1002/jlb.51.3.296) / J. Leuk. Biol. by TP Birkland (1992)
Vilcek, J. & Lee, T. H. J. biol. Chem. 266, 7313–7316 (1991). (10.1016/S0021-9258(20)89445-9) / J. biol. Chem. by J Vilcek (1991)
Aggarwal, B. B. et al. J. biol. Chem. 260, 2345–2354 (1985). (10.1016/S0021-9258(18)89560-6) / J. biol. Chem. by BB Aggarwal (1985)
Wang, A. M. et al. Science 228, 149–154 (1985). (10.1126/science.3856324) / Science by AM Wang (1985)
Mohler, K. M. et al. J. Immun. 151, 1548–1561 (1993). (10.4049/jimmunol.151.3.1548) / J. Immun. by KM Mohler (1993)
Goodwin, R. G. et al. Eur. J. Immun. 23, 2631–2641 (1993). (10.1002/eji.1830231037) / Eur. J. Immun. by RG Goodwin (1993)
Armitage, R. J. et al. Nature 357, 80–82 (1992). (10.1038/357080a0) / Nature by RJ Armitage (1992)
Smith, C. A. et al. Cell 73, 1349–1360 (1993). (10.1016/0092-8674(93)90361-S) / Cell by CA Smith (1993)
Lehmann, V., Freudenberg, M. A. & Galanos, C. J. exp. Med. 165, 657–663 (1987). (10.1084/jem.165.3.657) / J. exp. Med. by V Lehmann (1987)
Lesslauer, W. et al. Eur. J. Immun. 21, 2883–2886 (1991). (10.1002/eji.1830211134) / Eur. J. Immun. by W Lesslauer (1991)
Proc. 12th American Peptide Symposium, Cambridge, MA, June 16–21, 1991 (Escom, Leiden, The Netherlands, 1992).
Field, G. B., Van Wart, H. E. & Birkedal-Hansen, H. J. biol. Chem. 262, 6221–6226 (1987). (10.1016/S0021-9258(18)45559-7) / J. biol. Chem. by GB Field (1987)
Woessner, J. F. Jr FASEB J. 5, 2145–2154 (1991). (10.1096/fasebj.5.8.1850705) / FASEB J. by JF Woessner Jr (1991)
Roques, B. P. & Beaumont, A. Trends pharmac. Sci. 11, 245–249 (1990). (10.1016/0165-6147(90)90252-4) / Trends pharmac. Sci. by BP Roques (1990)
Kronheim, S. R. et al. Archs Biochem. Biophys. 296, 698–703 (1992). (10.1016/0003-9861(92)90629-B) / Archs Biochem. Biophys. by SR Kronheim (1992)
Maeda, T., Balakrishnan, K. & Mehdi, S. G. Biochim. biophys. Acta 731, 115–120 (1983). (10.1016/0005-2736(83)90404-2) / Biochim. biophys. Acta by T Maeda (1983)
Hopp, T. P. et al. BioTechnology 6, 1204–1210 (1987). (10.1038/nbt1088-1204) / BioTechnology by TP Hopp (1987)
Maliszewski, C., Baker, P., Cosman, D., Gillis, S. & Cerretti, D. P. Molec. Immun. 25, 429–437 (1987). (10.1016/0161-5890(88)90162-9) / Molec. Immun. by C Maliszewski (1987)
Libby, R. T. et al. DNA 6, 221–229 (1987). (10.1089/dna.1987.6.221) / DNA by RT Libby (1987)
Black, R. A. et al. J. biol. Chem. 263, 9437–9442 (1988). (10.1016/S0021-9258(19)76559-4) / J. biol. Chem. by RA Black (1988)

Dates

Type	When
Created	22 years ago (Aug. 11, 2003, 9:11 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:22 p.m.)
Indexed	1 month ago (July 24, 2025, 7:21 a.m.)
Issued	31 years, 1 month ago (July 1, 1994)
Published	31 years, 1 month ago (July 1, 1994)
Published Print	31 years, 1 month ago (July 1, 1994)

Funders 0

None

BibTeX

@article{Mohler_1994, title={Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing}, volume={370}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/370218a0}, DOI={10.1038/370218a0}, number={6486}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Mohler, Kendall M. and Sleath, Paul R. and Fitzner, Jeffrey N. and Cerretti, Douglas Pat and Alderson, Mark and Kerwar, Suresh S. and Torranee, Dauphine S. and Otten-Evans, Carol and Greenstreet, Teresa and Weerawarna, Kumudini and Kronheim, Shirley R. and Petersen, Melissa and Gerhart, Mary and Kozlosky, Carl J. and March, Carl J. and Black, Roy A.}, year={1994}, month=jul, pages={218–220} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        24
      ]
    ],
    "date-time": "2025-07-24T11:21:06Z",
    "timestamp": 1753356066716
  },
  "reference-count": 24,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6486",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1994,
            7,
            1
          ]
        ],
        "date-time": "1994-07-01T00:00:00Z",
        "timestamp": 773020800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  },
  "DOI": "10.1038/370218a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        8,
        12
      ]
    ],
    "date-time": "2003-08-12T01:11:25Z",
    "timestamp": 1060650685000
  },
  "page": "218-220",
  "source": "Crossref",
  "is-referenced-by-count": 483,
  "title": "Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing",
  "prefix": "10.1038",
  "volume": "370",
  "author": [
    {
      "given": "Kendall M.",
      "family": "Mohler",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Paul R.",
      "family": "Sleath",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jeffrey N.",
      "family": "Fitzner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Douglas Pat",
      "family": "Cerretti",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mark",
      "family": "Alderson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Suresh S.",
      "family": "Kerwar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dauphine S.",
      "family": "Torranee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carol",
      "family": "Otten-Evans",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Teresa",
      "family": "Greenstreet",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kumudini",
      "family": "Weerawarna",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shirley R.",
      "family": "Kronheim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Melissa",
      "family": "Petersen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mary",
      "family": "Gerhart",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carl J.",
      "family": "Kozlosky",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carl J.",
      "family": "March",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Roy A.",
      "family": "Black",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF370218a0_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "1269",
      "DOI": "10.1083/jcb.107.4.1269",
      "volume": "107",
      "author": "B Sherry",
      "year": "1988",
      "unstructured": "Sherry, B. & Cerami, A. J. Cell Biol. 107, 1269\u20131277 (1988).",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "BF370218a0_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "45",
      "DOI": "10.1016/0092-8674(88)90486-2",
      "volume": "53",
      "author": "M Kriegler",
      "year": "1988",
      "unstructured": "Kriegler, M., Perez, C., DeFay, K., Albert, I. & Lu, S. D. Cell 53, 45\u201353 (1988).",
      "journal-title": "Cell"
    },
    {
      "key": "BF370218a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "8371",
      "DOI": "10.1021/bi00488a025",
      "volume": "29",
      "author": "D-M Jue",
      "year": "1990",
      "unstructured": "Jue, D.-M., Sherry, B., Leudke, C., Manogue, K. R. & Cerami, A. Biochemistry 29, 8371\u20138377 (1990).",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BF370218a0_CR4",
      "doi-asserted-by": "crossref",
      "first-page": "2076",
      "DOI": "10.4049/jimmunol.149.6.2076",
      "volume": "149",
      "author": "SE Karp",
      "year": "1992",
      "unstructured": "Karp, S. E. et al. J. Immun. 149, 2076\u20132081 (1992).",
      "journal-title": "J. Immun."
    },
    {
      "key": "BF370218a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "296",
      "DOI": "10.1002/jlb.51.3.296",
      "volume": "51",
      "author": "TP Birkland",
      "year": "1992",
      "unstructured": "Birkland, T. P., Sypek, J. P. & Wyler, D. J. J. Leuk. Biol. 51, 296\u2013299 (1992).",
      "journal-title": "J. Leuk. Biol."
    },
    {
      "key": "BF370218a0_CR6",
      "doi-asserted-by": "crossref",
      "first-page": "7313",
      "DOI": "10.1016/S0021-9258(20)89445-9",
      "volume": "266",
      "author": "J Vilcek",
      "year": "1991",
      "unstructured": "Vilcek, J. & Lee, T. H. J. biol. Chem. 266, 7313\u20137316 (1991).",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "BF370218a0_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "2345",
      "DOI": "10.1016/S0021-9258(18)89560-6",
      "volume": "260",
      "author": "BB Aggarwal",
      "year": "1985",
      "unstructured": "Aggarwal, B. B. et al. J. biol. Chem. 260, 2345\u20132354 (1985).",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "BF370218a0_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "149",
      "DOI": "10.1126/science.3856324",
      "volume": "228",
      "author": "AM Wang",
      "year": "1985",
      "unstructured": "Wang, A. M. et al. Science 228, 149\u2013154 (1985).",
      "journal-title": "Science"
    },
    {
      "key": "BF370218a0_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "1548",
      "DOI": "10.4049/jimmunol.151.3.1548",
      "volume": "151",
      "author": "KM Mohler",
      "year": "1993",
      "unstructured": "Mohler, K. M. et al. J. Immun. 151, 1548\u20131561 (1993).",
      "journal-title": "J. Immun."
    },
    {
      "key": "BF370218a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "2631",
      "DOI": "10.1002/eji.1830231037",
      "volume": "23",
      "author": "RG Goodwin",
      "year": "1993",
      "unstructured": "Goodwin, R. G. et al. Eur. J. Immun. 23, 2631\u20132641 (1993).",
      "journal-title": "Eur. J. Immun."
    },
    {
      "key": "BF370218a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "80",
      "DOI": "10.1038/357080a0",
      "volume": "357",
      "author": "RJ Armitage",
      "year": "1992",
      "unstructured": "Armitage, R. J. et al. Nature 357, 80\u201382 (1992).",
      "journal-title": "Nature"
    },
    {
      "key": "BF370218a0_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "1349",
      "DOI": "10.1016/0092-8674(93)90361-S",
      "volume": "73",
      "author": "CA Smith",
      "year": "1993",
      "unstructured": "Smith, C. A. et al. Cell 73, 1349\u20131360 (1993).",
      "journal-title": "Cell"
    },
    {
      "key": "BF370218a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "657",
      "DOI": "10.1084/jem.165.3.657",
      "volume": "165",
      "author": "V Lehmann",
      "year": "1987",
      "unstructured": "Lehmann, V., Freudenberg, M. A. & Galanos, C. J. exp. Med. 165, 657\u2013663 (1987).",
      "journal-title": "J. exp. Med."
    },
    {
      "key": "BF370218a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "2883",
      "DOI": "10.1002/eji.1830211134",
      "volume": "21",
      "author": "W Lesslauer",
      "year": "1991",
      "unstructured": "Lesslauer, W. et al. Eur. J. Immun. 21, 2883\u20132886 (1991).",
      "journal-title": "Eur. J. Immun."
    },
    {
      "key": "BF370218a0_CR15",
      "unstructured": "Proc. 12th American Peptide Symposium, Cambridge, MA, June 16\u201321, 1991 (Escom, Leiden, The Netherlands, 1992)."
    },
    {
      "key": "BF370218a0_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "6221",
      "DOI": "10.1016/S0021-9258(18)45559-7",
      "volume": "262",
      "author": "GB Field",
      "year": "1987",
      "unstructured": "Field, G. B., Van Wart, H. E. & Birkedal-Hansen, H. J. biol. Chem. 262, 6221\u20136226 (1987).",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "BF370218a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "2145",
      "DOI": "10.1096/fasebj.5.8.1850705",
      "volume": "5",
      "author": "JF Woessner Jr",
      "year": "1991",
      "unstructured": "Woessner, J. F. Jr FASEB J. 5, 2145\u20132154 (1991).",
      "journal-title": "FASEB J."
    },
    {
      "key": "BF370218a0_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "245",
      "DOI": "10.1016/0165-6147(90)90252-4",
      "volume": "11",
      "author": "BP Roques",
      "year": "1990",
      "unstructured": "Roques, B. P. & Beaumont, A. Trends pharmac. Sci. 11, 245\u2013249 (1990).",
      "journal-title": "Trends pharmac. Sci."
    },
    {
      "key": "BF370218a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "698",
      "DOI": "10.1016/0003-9861(92)90629-B",
      "volume": "296",
      "author": "SR Kronheim",
      "year": "1992",
      "unstructured": "Kronheim, S. R. et al. Archs Biochem. Biophys. 296, 698\u2013703 (1992).",
      "journal-title": "Archs Biochem. Biophys."
    },
    {
      "key": "BF370218a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "115",
      "DOI": "10.1016/0005-2736(83)90404-2",
      "volume": "731",
      "author": "T Maeda",
      "year": "1983",
      "unstructured": "Maeda, T., Balakrishnan, K. & Mehdi, S. G. Biochim. biophys. Acta 731, 115\u2013120 (1983).",
      "journal-title": "Biochim. biophys. Acta"
    },
    {
      "key": "BF370218a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "1204",
      "DOI": "10.1038/nbt1088-1204",
      "volume": "6",
      "author": "TP Hopp",
      "year": "1987",
      "unstructured": "Hopp, T. P. et al. BioTechnology 6, 1204\u20131210 (1987).",
      "journal-title": "BioTechnology"
    },
    {
      "key": "BF370218a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "429",
      "DOI": "10.1016/0161-5890(88)90162-9",
      "volume": "25",
      "author": "C Maliszewski",
      "year": "1987",
      "unstructured": "Maliszewski, C., Baker, P., Cosman, D., Gillis, S. & Cerretti, D. P. Molec. Immun. 25, 429\u2013437 (1987).",
      "journal-title": "Molec. Immun."
    },
    {
      "key": "BF370218a0_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "221",
      "DOI": "10.1089/dna.1987.6.221",
      "volume": "6",
      "author": "RT Libby",
      "year": "1987",
      "unstructured": "Libby, R. T. et al. DNA 6, 221\u2013229 (1987).",
      "journal-title": "DNA"
    },
    {
      "key": "BF370218a0_CR24",
      "doi-asserted-by": "crossref",
      "first-page": "9437",
      "DOI": "10.1016/S0021-9258(19)76559-4",
      "volume": "263",
      "author": "RA Black",
      "year": "1988",
      "unstructured": "Black, R. A. et al. J. biol. Chem. 263, 9437\u20139442 (1988).",
      "journal-title": "J. biol. Chem."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/370218a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/370218a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/370218a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:22:24Z",
    "timestamp": 1684290144000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/370218a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  },
  "references-count": 24,
  "journal-issue": {
    "issue": "6486",
    "published-print": {
      "date-parts": [
        [
          1994,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "BF370218a0"
  ],
  "URL": "http://dx.doi.org/10.1038/370218a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  }
}