DOI: 10.1038/36038. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

10.1038/36038

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Lee, J.-O., Russo, A. A., & Pavletich, N. P. (1998). Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature, 391(6670), 859â865.

Authors 3

Jie-Oh Lee (first)
Alicia A. Russo (additional)
Nikola P. Pavletich (additional)

References 48 Referenced 391

Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323–330 (1995). (10.1016/0092-8674(95)90385-2) / Cell by RA Weinberg (1995)
Yandell, D. W. et al. Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. New Engl. J. Med. 321, 1689–1695 (1989). (10.1056/NEJM198912213212501) / New Engl. J. Med. by DW Yandell (1989)
Horowotiz, J. M. et al. Point mutational inactivation of the retinoblastoma antioncogene. Science 243, 937–940 (1989). (10.1126/science.2521957) / Science by JM Horowotiz (1989)
Kaye, F. J., Kratzke, R. A., Ferster, J. L. & Horowitz, J. M. Asingle amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl Acad. Sci. USA 87, 6922–6926 (1990). (10.1073/pnas.87.17.6922) / Proc. Natl Acad. Sci. USA by FJ Kaye (1990)
Onadim, Z., Hogg, A., Baird, P. N. & Cowell, J. K. Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. Proc. Natl Acad. Sci. USA 89, 6177–6181 (1992). (10.1073/pnas.89.13.6177) / Proc. Natl Acad. Sci. USA by Z Onadim (1992)
Dyson, N., Howley, P. M., Munger, K. & Harlow, E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243, 934–937 (1989). (10.1126/science.2537532) / Science by N Dyson (1989)
zur Hausen, H. Papillomavirus infections: a major cause of human cancers. Biochim. Biophys. Acta 1288, f55–f58 (1996). / Biochim. Biophys. Acta by H zur Hausen (1996)
Bookstein, R., Shew, J. Y., Chen, P. L., Scully, P. & Lee, W. H. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247, 712–715 (1990). (10.1126/science.2300823) / Science by R Bookstein (1990)
Huang, H. J. et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242, 1563–1566 (1988). (10.1126/science.3201247) / Science by HJ Huang (1988)
Qin, X. Q., Chittenden, T., Livingston, D. M. & Kaelin, W. G. J Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6, 953–964 (1992). (10.1101/gad.6.6.953) / Genes Dev. by XQ Qin (1992)
Goodrich, D. W., Wang, N. P., Qian, Y. W., Lee, E. Y. & Lee, W. H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67, 293–302 (1991). (10.1016/0092-8674(91)90181-W) / Cell by DW Goodrich (1991)
Hinds, P. W. et al. Regulation of the retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993–1006 (1992). (10.1016/0092-8674(92)90249-C) / Cell by PW Hinds (1992)
Buchkovich, K., Duffy, L. A. & Harlow, E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58, 1097–1105 (1989). (10.1016/0092-8674(89)90508-4) / Cell by K Buchkovich (1989)
Helin, K. et al. AcDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70, 33–50 (1992). (10.1016/0092-8674(92)90107-N) / Cell by K Helin (1992)
Kaelin, W. G. J et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70, 351–364 (1992). (10.1016/0092-8674(92)90108-O) / Cell by WGJ Kaelin (1992)
Hiebert, S. W., Chellappan, S. P., Horowitz, J. M. & Nevins, J. R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes. Dev. 6, 177–185 (1992). (10.1101/gad.6.2.177) / Genes. Dev. by SW Hiebert (1992)
Flemington, E. K., Speck, S. H. & Kaelin, W. G. J E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl Acad. Sci. USA 90, 6914–6918 (1993). (10.1073/pnas.90.15.6914) / Proc. Natl Acad. Sci. USA by EK Flemington (1993)
Helin, K., Harlow, E. & Fattaey, A. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13, 6501–6508 (1993). (10.1128/MCB.13.10.6501) / Mol. Cell. Biol. by K Helin (1993)
Weintraub, S. J. et al. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812–815 (1995). (10.1038/375812a0) / Nature by SJ Weintraub (1995)
Sellers, W. R., Rodgers, J. W. & Kaelin, W. G. J Apotent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl Acad. Sci. USA 92, 11544–11548 (1995). (10.1073/pnas.92.25.11544) / Proc. Natl Acad. Sci. USA by WR Sellers (1995)
Herber, R., Liem, A., Pitot, H. & Lambert, P. F. Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J. Virol. 70, 1873–1881 (1996). (10.1128/JVI.70.3.1873-1881.1996) / J. Virol. by R Herber (1996)
Chellappan, S. et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl Acad. Sci. USA 89, 4549–4553 (1992). (10.1073/pnas.89.10.4549) / Proc. Natl Acad. Sci. USA by S Chellappan (1992)
Munger, K. et al. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8, 4099–4105 (1989). (10.1002/j.1460-2075.1989.tb08594.x) / EMBO J. by K Munger (1989)
DeCaprio, J. A. et al. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54, 275–283 (1988). (10.1016/0092-8674(88)90559-4) / Cell by JA DeCaprio (1988)
Whyte, P. et al. Association between an oncogene and an anti-oncogene: the advenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334, 124–129 (1988). (10.1038/334124a0) / Nature by P Whyte (1988)
Gulliver, G. A., Herber, R. L., Liem, A. & Lambert, P. F. Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice. J. Virol. 71, 5905–5914 (1977). (10.1128/JVI.71.8.5905-5914.1997) / J. Virol. by GA Gulliver (1977)
Shan, B., Durfee, T. & Lee, W. H. Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl Acad. Sci. USA 93, 679–684 (1996). (10.1073/pnas.93.2.679) / Proc. Natl Acad. Sci. USA by B Shan (1996)
Hu, Q. J., Dyson, N. & Harlow, E. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9, 1147–1155 (1990). (10.1002/j.1460-2075.1990.tb08221.x) / EMBO J. by QJ Hu (1990)
Kaelin, W. G. J, Ewen, M. E. & Livingston, D. M. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10, 3761–3769 (1990). (10.1128/MCB.10.7.3761) / Mol. Cell. Biol. by WGJ Kaelin (1990)
Huang, S., Wang, N. P., Tseng, B. Y., Lee, W. H. & Lee, E. H. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9, 1815–1822 (1990). (10.1002/j.1460-2075.1990.tb08306.x) / EMBO J. by S Huang (1990)
Jones, R. E. et al. Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J. Biol. Chem. 265, 12782–12785 (1990). (10.1016/S0021-9258(19)38226-2) / J. Biol. Chem. by RE Jones (1990)
Chow, K. N. & Dean, D. C. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol. Cell. Biol. 16, 4862–4868 (1996). (10.1128/MCB.16.9.4862) / Mol. Cell. Biol. by KN Chow (1996)
Kim, H. Y. & Cho, Y. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Nature Struct. Biol. 4, 390–395 (1997). (10.1038/nsb0597-390) / Nature Struct. Biol. by HY Kim (1997)
Gibson, T. J., Thompson, J. D., Blocker, A. & Kouzarides, T. Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. Nucleic Acids Res. 22, 946–952 (1994). (10.1093/nar/22.6.946) / Nucleic Acids Res. by TJ Gibson (1994)
Jeffrey, P. D. et al. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376, 313–320 (1995). (10.1038/376313a0) / Nature by PD Jeffrey (1995)
Nikolov, D. B. et al. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377, 119–128 (1995). (10.1038/377119a0) / Nature by DB Nikolov (1995)
Grafi, G. et al. Amaize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. Proc. Natl Acad. Sci. USA 93, 8962–8967 (1996). (10.1073/pnas.93.17.8962) / Proc. Natl Acad. Sci. USA by G Grafi (1996)
Dyson, N., Buchkovich, K., Whyte, P. & Harlow, E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58, 249–255 (1989). (10.1016/0092-8674(89)90839-8) / Cell by N Dyson (1989)
Kratzke, R. A. et al. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene 9, 1321–1326 (1994). / Oncogene by RA Kratzke (1994)
Kitagawa, M. et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15, 7060–7069 (1996). (10.1002/j.1460-2075.1996.tb01097.x) / EMBO J. by M Kitagawa (1996)
Knudsen, E. S. & Wang, J. Y. J. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271, 8313–8320 (1996). (10.1074/jbc.271.14.8313) / J. Biol. Chem. by ES Knudsen (1996)
O'Connor, R. J. & Hearing, P. Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. J. Virol. 68, 6848–6862 (1994). (10.1128/JVI.68.11.6848-6862.1994) / J. Virol. by RJ O'Connor (1994)
Wu, E. W., Clemens, K. E., Heck, D. V. & Munger, K. The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein. J. Virol. 67, 2402–2407 (1993). (10.1128/JVI.67.4.2402-2407.1993) / J. Virol. by EW Wu (1993)
Ikeda, M. A. & Nevins, J. R. Identification of distinct roles for separate E1A domains in disruption of E2F complexes. Mol. Cell. Biol. 13, 7029–7035 (1993). (10.1128/MCB.13.11.7029) / Mol. Cell. Biol. by MA Ikeda (1993)
Fattaey, A. R., Harlow, E. & Helin, K. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13, 7267–7277 (1993). (10.1128/MCB.13.12.7267) / Mol. Cell. Biol. by AR Fattaey (1993)
Collaborative Computational Project B. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760–763 (1994). (10.1107/S0907444994003112)
Jones, T. A., Zhou, J.-Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of erros in these models. Acta Crystallogr. A 47, 110–119 (1991). (10.1107/S0108767390010224) / Acta Crystallogr. A by TA Jones (1991)
Brunger, A. T. X-PLOR, a System for Crystallography and NMR(Yale Univ. Press, New Haven, CT, 1991). / X-PLOR, a System for Crystallography and NMR by AT Brunger (1991)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:37 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:23 p.m.)
Indexed	1 week, 2 days ago (Aug. 19, 2025, 7:04 a.m.)
Issued	27 years, 6 months ago (Feb. 1, 1998)
Published	27 years, 6 months ago (Feb. 1, 1998)
Published Print	27 years, 6 months ago (Feb. 1, 1998)

Funders 0

None

BibTeX

@article{Lee_1998, title={Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7}, volume={391}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/36038}, DOI={10.1038/36038}, number={6670}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Lee, Jie-Oh and Russo, Alicia A. and Pavletich, Nikola P.}, year={1998}, month=feb, pages={859–865} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        19
      ]
    ],
    "date-time": "2025-08-19T11:04:18Z",
    "timestamp": 1755601458344
  },
  "reference-count": 48,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6670",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            2,
            1
          ]
        ],
        "date-time": "1998-02-01T00:00:00Z",
        "timestamp": 886291200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        2
      ]
    ]
  },
  "DOI": "10.1038/36038",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T08:37:13Z",
    "timestamp": 1027672633000
  },
  "page": "859-865",
  "source": "Crossref",
  "is-referenced-by-count": 391,
  "title": "Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7",
  "prefix": "10.1038",
  "volume": "391",
  "author": [
    {
      "given": "Jie-Oh",
      "family": "Lee",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Alicia A.",
      "family": "Russo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nikola P.",
      "family": "Pavletich",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF36038_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "323",
      "DOI": "10.1016/0092-8674(95)90385-2",
      "volume": "81",
      "author": "RA Weinberg",
      "year": "1995",
      "unstructured": "Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323\u2013330 (1995).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "1689",
      "DOI": "10.1056/NEJM198912213212501",
      "volume": "321",
      "author": "DW Yandell",
      "year": "1989",
      "unstructured": "Yandell, D. W. et al. Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. New Engl. J. Med. 321, 1689\u20131695 (1989).",
      "journal-title": "New Engl. J. Med."
    },
    {
      "key": "BF36038_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "937",
      "DOI": "10.1126/science.2521957",
      "volume": "243",
      "author": "JM Horowotiz",
      "year": "1989",
      "unstructured": "Horowotiz, J. M. et al. Point mutational inactivation of the retinoblastoma antioncogene. Science 243, 937\u2013940 (1989).",
      "journal-title": "Science"
    },
    {
      "key": "BF36038_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "6922",
      "DOI": "10.1073/pnas.87.17.6922",
      "volume": "87",
      "author": "FJ Kaye",
      "year": "1990",
      "unstructured": "Kaye, F. J., Kratzke, R. A., Ferster, J. L. & Horowitz, J. M. Asingle amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl Acad. Sci. USA 87, 6922\u20136926 (1990).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "6177",
      "DOI": "10.1073/pnas.89.13.6177",
      "volume": "89",
      "author": "Z Onadim",
      "year": "1992",
      "unstructured": "Onadim, Z., Hogg, A., Baird, P. N. & Cowell, J. K. Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. Proc. Natl Acad. Sci. USA 89, 6177\u20136181 (1992).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "934",
      "DOI": "10.1126/science.2537532",
      "volume": "243",
      "author": "N Dyson",
      "year": "1989",
      "unstructured": "Dyson, N., Howley, P. M., Munger, K. & Harlow, E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243, 934\u2013937 (1989).",
      "journal-title": "Science"
    },
    {
      "key": "BF36038_CR7",
      "first-page": "f55",
      "volume": "1288",
      "author": "H zur Hausen",
      "year": "1996",
      "unstructured": "zur Hausen, H. Papillomavirus infections: a major cause of human cancers. Biochim. Biophys. Acta 1288, f55\u2013f58 (1996).",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "BF36038_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "712",
      "DOI": "10.1126/science.2300823",
      "volume": "247",
      "author": "R Bookstein",
      "year": "1990",
      "unstructured": "Bookstein, R., Shew, J. Y., Chen, P. L., Scully, P. & Lee, W. H. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247, 712\u2013715 (1990).",
      "journal-title": "Science"
    },
    {
      "key": "BF36038_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "1563",
      "DOI": "10.1126/science.3201247",
      "volume": "242",
      "author": "HJ Huang",
      "year": "1988",
      "unstructured": "Huang, H. J. et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242, 1563\u20131566 (1988).",
      "journal-title": "Science"
    },
    {
      "key": "BF36038_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "953",
      "DOI": "10.1101/gad.6.6.953",
      "volume": "6",
      "author": "XQ Qin",
      "year": "1992",
      "unstructured": "Qin, X. Q., Chittenden, T., Livingston, D. M. & Kaelin, W. G. J Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6, 953\u2013964 (1992).",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BF36038_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "293",
      "DOI": "10.1016/0092-8674(91)90181-W",
      "volume": "67",
      "author": "DW Goodrich",
      "year": "1991",
      "unstructured": "Goodrich, D. W., Wang, N. P., Qian, Y. W., Lee, E. Y. & Lee, W. H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67, 293\u2013302 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "993",
      "DOI": "10.1016/0092-8674(92)90249-C",
      "volume": "70",
      "author": "PW Hinds",
      "year": "1992",
      "unstructured": "Hinds, P. W. et al. Regulation of the retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993\u20131006 (1992).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1097",
      "DOI": "10.1016/0092-8674(89)90508-4",
      "volume": "58",
      "author": "K Buchkovich",
      "year": "1989",
      "unstructured": "Buchkovich, K., Duffy, L. A. & Harlow, E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58, 1097\u20131105 (1989).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "33",
      "DOI": "10.1016/0092-8674(92)90107-N",
      "volume": "70",
      "author": "K Helin",
      "year": "1992",
      "unstructured": "Helin, K. et al. AcDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70, 33\u201350 (1992).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "351",
      "DOI": "10.1016/0092-8674(92)90108-O",
      "volume": "70",
      "author": "WGJ Kaelin",
      "year": "1992",
      "unstructured": "Kaelin, W. G. J et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70, 351\u2013364 (1992).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "177",
      "DOI": "10.1101/gad.6.2.177",
      "volume": "6",
      "author": "SW Hiebert",
      "year": "1992",
      "unstructured": "Hiebert, S. W., Chellappan, S. P., Horowitz, J. M. & Nevins, J. R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes. Dev. 6, 177\u2013185 (1992).",
      "journal-title": "Genes. Dev."
    },
    {
      "key": "BF36038_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "6914",
      "DOI": "10.1073/pnas.90.15.6914",
      "volume": "90",
      "author": "EK Flemington",
      "year": "1993",
      "unstructured": "Flemington, E. K., Speck, S. H. & Kaelin, W. G. J E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl Acad. Sci. USA 90, 6914\u20136918 (1993).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "6501",
      "DOI": "10.1128/MCB.13.10.6501",
      "volume": "13",
      "author": "K Helin",
      "year": "1993",
      "unstructured": "Helin, K., Harlow, E. & Fattaey, A. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13, 6501\u20136508 (1993).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF36038_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "812",
      "DOI": "10.1038/375812a0",
      "volume": "375",
      "author": "SJ Weintraub",
      "year": "1995",
      "unstructured": "Weintraub, S. J. et al. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812\u2013815 (1995).",
      "journal-title": "Nature"
    },
    {
      "key": "BF36038_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "11544",
      "DOI": "10.1073/pnas.92.25.11544",
      "volume": "92",
      "author": "WR Sellers",
      "year": "1995",
      "unstructured": "Sellers, W. R., Rodgers, J. W. & Kaelin, W. G. J Apotent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl Acad. Sci. USA 92, 11544\u201311548 (1995).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR21",
      "doi-asserted-by": "crossref",
      "first-page": "1873",
      "DOI": "10.1128/JVI.70.3.1873-1881.1996",
      "volume": "70",
      "author": "R Herber",
      "year": "1996",
      "unstructured": "Herber, R., Liem, A., Pitot, H. & Lambert, P. F. Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J. Virol. 70, 1873\u20131881 (1996).",
      "journal-title": "J. Virol."
    },
    {
      "key": "BF36038_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "4549",
      "DOI": "10.1073/pnas.89.10.4549",
      "volume": "89",
      "author": "S Chellappan",
      "year": "1992",
      "unstructured": "Chellappan, S. et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl Acad. Sci. USA 89, 4549\u20134553 (1992).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "4099",
      "DOI": "10.1002/j.1460-2075.1989.tb08594.x",
      "volume": "8",
      "author": "K Munger",
      "year": "1989",
      "unstructured": "Munger, K. et al. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8, 4099\u20134105 (1989).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF36038_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "275",
      "DOI": "10.1016/0092-8674(88)90559-4",
      "volume": "54",
      "author": "JA DeCaprio",
      "year": "1988",
      "unstructured": "DeCaprio, J. A. et al. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54, 275\u2013283 (1988).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "124",
      "DOI": "10.1038/334124a0",
      "volume": "334",
      "author": "P Whyte",
      "year": "1988",
      "unstructured": "Whyte, P. et al. Association between an oncogene and an anti-oncogene: the advenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334, 124\u2013129 (1988).",
      "journal-title": "Nature"
    },
    {
      "key": "BF36038_CR26",
      "doi-asserted-by": "crossref",
      "first-page": "5905",
      "DOI": "10.1128/JVI.71.8.5905-5914.1997",
      "volume": "71",
      "author": "GA Gulliver",
      "year": "1977",
      "unstructured": "Gulliver, G. A., Herber, R. L., Liem, A. & Lambert, P. F. Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice. J. Virol. 71, 5905\u20135914 (1977).",
      "journal-title": "J. Virol."
    },
    {
      "key": "BF36038_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "679",
      "DOI": "10.1073/pnas.93.2.679",
      "volume": "93",
      "author": "B Shan",
      "year": "1996",
      "unstructured": "Shan, B., Durfee, T. & Lee, W. H. Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl Acad. Sci. USA 93, 679\u2013684 (1996).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "1147",
      "DOI": "10.1002/j.1460-2075.1990.tb08221.x",
      "volume": "9",
      "author": "QJ Hu",
      "year": "1990",
      "unstructured": "Hu, Q. J., Dyson, N. & Harlow, E. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9, 1147\u20131155 (1990).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF36038_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "3761",
      "DOI": "10.1128/MCB.10.7.3761",
      "volume": "10",
      "author": "WGJ Kaelin",
      "year": "1990",
      "unstructured": "Kaelin, W. G. J, Ewen, M. E. & Livingston, D. M. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10, 3761\u20133769 (1990).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF36038_CR30",
      "doi-asserted-by": "publisher",
      "first-page": "1815",
      "DOI": "10.1002/j.1460-2075.1990.tb08306.x",
      "volume": "9",
      "author": "S Huang",
      "year": "1990",
      "unstructured": "Huang, S., Wang, N. P., Tseng, B. Y., Lee, W. H. & Lee, E. H. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9, 1815\u20131822 (1990).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF36038_CR31",
      "doi-asserted-by": "crossref",
      "first-page": "12782",
      "DOI": "10.1016/S0021-9258(19)38226-2",
      "volume": "265",
      "author": "RE Jones",
      "year": "1990",
      "unstructured": "Jones, R. E. et al. Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J. Biol. Chem. 265, 12782\u201312785 (1990).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF36038_CR32",
      "doi-asserted-by": "publisher",
      "first-page": "4862",
      "DOI": "10.1128/MCB.16.9.4862",
      "volume": "16",
      "author": "KN Chow",
      "year": "1996",
      "unstructured": "Chow, K. N. & Dean, D. C. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol. Cell. Biol. 16, 4862\u20134868 (1996).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF36038_CR33",
      "doi-asserted-by": "publisher",
      "first-page": "390",
      "DOI": "10.1038/nsb0597-390",
      "volume": "4",
      "author": "HY Kim",
      "year": "1997",
      "unstructured": "Kim, H. Y. & Cho, Y. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Nature Struct. Biol. 4, 390\u2013395 (1997).",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "BF36038_CR34",
      "doi-asserted-by": "publisher",
      "first-page": "946",
      "DOI": "10.1093/nar/22.6.946",
      "volume": "22",
      "author": "TJ Gibson",
      "year": "1994",
      "unstructured": "Gibson, T. J., Thompson, J. D., Blocker, A. & Kouzarides, T. Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. Nucleic Acids Res. 22, 946\u2013952 (1994).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF36038_CR35",
      "doi-asserted-by": "publisher",
      "first-page": "313",
      "DOI": "10.1038/376313a0",
      "volume": "376",
      "author": "PD Jeffrey",
      "year": "1995",
      "unstructured": "Jeffrey, P. D. et al. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376, 313\u2013320 (1995).",
      "journal-title": "Nature"
    },
    {
      "key": "BF36038_CR36",
      "doi-asserted-by": "publisher",
      "first-page": "119",
      "DOI": "10.1038/377119a0",
      "volume": "377",
      "author": "DB Nikolov",
      "year": "1995",
      "unstructured": "Nikolov, D. B. et al. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377, 119\u2013128 (1995).",
      "journal-title": "Nature"
    },
    {
      "key": "BF36038_CR37",
      "doi-asserted-by": "publisher",
      "first-page": "8962",
      "DOI": "10.1073/pnas.93.17.8962",
      "volume": "93",
      "author": "G Grafi",
      "year": "1996",
      "unstructured": "Grafi, G. et al. Amaize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. Proc. Natl Acad. Sci. USA 93, 8962\u20138967 (1996).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF36038_CR38",
      "doi-asserted-by": "publisher",
      "first-page": "249",
      "DOI": "10.1016/0092-8674(89)90839-8",
      "volume": "58",
      "author": "N Dyson",
      "year": "1989",
      "unstructured": "Dyson, N., Buchkovich, K., Whyte, P. & Harlow, E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58, 249\u2013255 (1989).",
      "journal-title": "Cell"
    },
    {
      "key": "BF36038_CR39",
      "first-page": "1321",
      "volume": "9",
      "author": "RA Kratzke",
      "year": "1994",
      "unstructured": "Kratzke, R. A. et al. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene 9, 1321\u20131326 (1994).",
      "journal-title": "Oncogene"
    },
    {
      "key": "BF36038_CR40",
      "doi-asserted-by": "publisher",
      "first-page": "7060",
      "DOI": "10.1002/j.1460-2075.1996.tb01097.x",
      "volume": "15",
      "author": "M Kitagawa",
      "year": "1996",
      "unstructured": "Kitagawa, M. et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15, 7060\u20137069 (1996).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF36038_CR41",
      "doi-asserted-by": "publisher",
      "first-page": "8313",
      "DOI": "10.1074/jbc.271.14.8313",
      "volume": "271",
      "author": "ES Knudsen",
      "year": "1996",
      "unstructured": "Knudsen, E. S. & Wang, J. Y. J. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271, 8313\u20138320 (1996).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF36038_CR42",
      "doi-asserted-by": "crossref",
      "first-page": "6848",
      "DOI": "10.1128/JVI.68.11.6848-6862.1994",
      "volume": "68",
      "author": "RJ O'Connor",
      "year": "1994",
      "unstructured": "O'Connor, R. J. & Hearing, P. Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. J. Virol. 68, 6848\u20136862 (1994).",
      "journal-title": "J. Virol."
    },
    {
      "key": "BF36038_CR43",
      "doi-asserted-by": "crossref",
      "first-page": "2402",
      "DOI": "10.1128/JVI.67.4.2402-2407.1993",
      "volume": "67",
      "author": "EW Wu",
      "year": "1993",
      "unstructured": "Wu, E. W., Clemens, K. E., Heck, D. V. & Munger, K. The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein. J. Virol. 67, 2402\u20132407 (1993).",
      "journal-title": "J. Virol."
    },
    {
      "key": "BF36038_CR44",
      "doi-asserted-by": "publisher",
      "first-page": "7029",
      "DOI": "10.1128/MCB.13.11.7029",
      "volume": "13",
      "author": "MA Ikeda",
      "year": "1993",
      "unstructured": "Ikeda, M. A. & Nevins, J. R. Identification of distinct roles for separate E1A domains in disruption of E2F complexes. Mol. Cell. Biol. 13, 7029\u20137035 (1993).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF36038_CR45",
      "doi-asserted-by": "publisher",
      "first-page": "7267",
      "DOI": "10.1128/MCB.13.12.7267",
      "volume": "13",
      "author": "AR Fattaey",
      "year": "1993",
      "unstructured": "Fattaey, A. R., Harlow, E. & Helin, K. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13, 7267\u20137277 (1993).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF36038_CR46",
      "doi-asserted-by": "crossref",
      "unstructured": "Collaborative Computational Project B. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760\u2013763 (1994).",
      "DOI": "10.1107/S0907444994003112"
    },
    {
      "key": "BF36038_CR47",
      "doi-asserted-by": "publisher",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "volume": "47",
      "author": "TA Jones",
      "year": "1991",
      "unstructured": "Jones, T. A., Zhou, J.-Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of erros in these models. Acta Crystallogr. A 47, 110\u2013119 (1991).",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "BF36038_CR48",
      "volume-title": "X-PLOR, a System for Crystallography and NMR",
      "author": "AT Brunger",
      "year": "1991",
      "unstructured": "Brunger, A. T. X-PLOR, a System for Crystallography and NMR(Yale Univ. Press, New Haven, CT, 1991)."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/36038.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/36038",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/doifinder/10.1038/36038",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    },
    {
      "URL": "http://www.nature.com/articles/36038.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:23:25Z",
    "timestamp": 1684290205000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/36038"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        2
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "6670",
    "published-print": {
      "date-parts": [
        [
          1998,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "BF36038"
  ],
  "URL": "http://dx.doi.org/10.1038/36038",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1998,
        2
      ]
    ]
  }
}