DOI: 10.1038/359288a0. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

10.1038/359288a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C.-C., Herrup, K., Lee, W.-H., & Bradley, A. (1992). Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature, 359(6393), 288â294.

Authors 8

Eva Y.-H. P. Lee (first)
Chi-Yao Chang (additional)
Nanpin Hu (additional)
Yi-Chun J. Wang (additional)
Chen-Ching Lai (additional)
Karl Herrup (additional)
Wen-Hwa Lee (additional)
Allan Bradley (additional)

References 50 Referenced 969

Knudson, A. G. Birth Defects 25, 15–27 (1989). / Birth Defects by AG Knudson (1989)
Lee, W.-H. in Tumour Suppressor Genes and Oncogenes (eds Knudson, A. G., Stanbridge, E. J., Sugimura, T., Terada, M. & Watanabe, S.) 159–170 (Taylor and Francis, London and Bristol, 1990). / Tumour Suppressor Genes and Oncogenes by W-H Lee (1990)
Vogel, F. Hum. Genet. 52, 1–54 (1979). (10.1007/BF00295569) / Hum. Genet. by F Vogel (1979)
Knudson, A. G. Proc. natn. Acad. Sci. U.S.A. 68, 820–823 (1971). (10.1073/pnas.68.4.820) / Proc. natn. Acad. Sci. U.S.A. by AG Knudson (1971)
Cavenee, W. K. et al. Nature 305, 779–784 (1983). (10.1038/305779a0) / Nature by WK Cavenee (1983)
Dryja, T. P., Rapaport, J. M., Joyce, J. M. & Petersen, R. A. Proc. natn. Acad. Sci. U.S.A. 83, 7391–7394 (1986). (10.1073/pnas.83.19.7391) / Proc. natn. Acad. Sci. U.S.A. by TP Dryja (1986)
Friend, S. H. et al. Nature 323, 643–646 (1986). (10.1038/323643a0) / Nature by SH Friend (1986)
Fung, Y. K. T. et al. Science 236, 1657–1661 (1987). (10.1126/science.2885916) / Science by YKT Fung (1987)
Lee, W.-H. et al. Science 235, 1394–1399 (1987). (10.1126/science.3823889) / Science by W-H Lee (1987)
Abramson, D. H., Ellsworth, R. M., Kitchin, D. & Tung, G. Ophthalmology 91, 1351–1355 (1984). (10.1016/S0161-6420(84)34127-6) / Ophthalmology by DH Abramson (1984)
Friend, S. H. et al. Proc. natn. Acad. Sci. USA. 84, 9059–9063 (1987). (10.1073/pnas.84.24.9059) / Proc. natn. Acad. Sci. USA. by SH Friend (1987)
Lee, W.-H. et al. Nature 329, 642–645 (1987). (10.1038/329642a0) / Nature by W-H Lee (1987)
Lee, E. Y.-H. P., Huang, S., Shew, J.-Y., Donoso, L. A. & Lee, W.-H. in Molecular Biology of the Retina: Basic and Clinically Relevant Studies (eds Faber, D. B. & Chader, G. J.) 221–240 (Wiley-Liss, New York, 1991). / Molecular Biology of the Retina: Basic and Clinically Relevant Studies by EY-HP Lee (1991)
Bookstein, R., Shew, J.-Y., Chen, P.-L., Scully, P. & Lee, W.-H. Science 247, 712–715 (1990). (10.1126/science.2300823) / Science by R Bookstein (1990)
Goodrich, D. W., Chen, Y.-M., Scully, P. & Lee, W.-H. Cancer Res. 52, 1968–1973 (1992). / Cancer Res. by DW Goodrich (1992)
Huang, H.-J. S. et al. Science 242, 1563–1566 (1988). (10.1126/science.3201247) / Science by H-JS Huang (1988)
Sumegi, J., Uzvolgyi, E. & Klein, G. Cell Growth Differ. 1, 247–250 (1990). / Cell Growth Differ. by J Sumegi (1990)
Takahashi, R. et al. Proc. natn. Acad Sci. U.S.A. 88, 5257–5261 (1991). (10.1073/pnas.88.12.5257) / Proc. natn. Acad Sci. U.S.A. by R Takahashi (1991)
Lees, J. A., Buchkovich, K. J., Marshak, D. R., Anderson, C. W. & Harlow, E. EMBO J. 10, 4279–4289 (1991). (10.1002/j.1460-2075.1991.tb05006.x) / EMBO J. by JA Lees (1991)
Lin, B. T.-Y., Gruenwald, S., Morla, A. O., Lee, W.-H. & Wang, J. Y. J. EMBO J. 10, 857–864 (1991). (10.1002/j.1460-2075.1991.tb08018.x) / EMBO J. by BT-Y Lin (1991)
Buchkovich, K., Duffy, L. A. & Harlow, E. Cell 58, 1097–1105 (1989). (10.1016/0092-8674(89)90508-4) / Cell by K Buchkovich (1989)
Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y.-J. & Lee, W.-H. Cell 58, 1193–1198 (1989). (10.1016/0092-8674(89)90517-5) / Cell by P-L Chen (1989)
Ludlow, J. W., Shon, J., Pipas, J. M., Livingston, D. M. & DeCaprio, J. A. Cell 60, 387–396 (1990). (10.1016/0092-8674(90)90590-B) / Cell by JW Ludlow (1990)
Mihara, K. et al. Science 246, 1300–1303 (1989). (10.1126/science.2588006) / Science by K Mihara (1989)
Xu, H.-J., Hu, S.-X., Hashimoto, T., Takahashi, R. & Benedict, W. F. Oncogene 4, 807–812 (1989). / Oncogene by H-J Xu (1989)
Goodrich, D. W., Wang, N. P., Qian, Y., Lee, E. Y.-H. P. & Lee, W.-H. Cell 67, 293–302 (1991). (10.1016/0092-8674(91)90181-W) / Cell by DW Goodrich (1991)
DeCaprio, J. A. et al. Cell 54, 275–283 (1988). (10.1016/0092-8674(88)90559-4) / Cell by JA DeCaprio (1988)
Dyson, N., Howley, P. M., Munger, K. & Harlow, E. Science 243, 934–937 (1989). (10.1126/science.2537532) / Science by N Dyson (1989)
Whyte, P. et al. Nature 334, 124–129 (1988). (10.1038/334124a0) / Nature by P Whyte (1988)
Rustgi, A. K., Dyson, N. & Bernards, R. Nature 352, 541–544 (1991). (10.1038/352541a0) / Nature by AK Rustgi (1991)
Bagchi, S., Weinmann, R. & Raychaudhuri, P. Cell 65, 1063–1072 (1991). (10.1016/0092-8674(91)90558-G) / Cell by S Bagchi (1991)
Bandara, L. R. & La Thangue, N. B. Nature 351, 494–497 (1991). (10.1038/351494a0) / Nature by LR Bandara (1991)
Chellappan, S. P., Hiebert, S., Mudryji, M., Horowitz, J. M. & Nevins, J. R. Cell 65, 1053–1061 (1991). (10.1016/0092-8674(91)90557-F) / Cell by SP Chellappan (1991)
Chittenden, T., Livingston, D. M. & W. G. Kaelin, J. Cell 65, 1073–1082 (1991). (10.1016/0092-8674(91)90559-H) / Cell by T Chittenden (1991)
Hu, Q., Dyson, N. & Harlow, E. EMBO J. 9, 1147–1155 (1990). (10.1002/j.1460-2075.1990.tb08221.x) / EMBO J. by Q Hu (1990)
Huang, S., Wang, N.-P., Tseng, B. Y., Lee, W.-H. & Lee, E. Y.-H. P. EMBO J. 9, 1815–1822 (1990). (10.1002/j.1460-2075.1990.tb08306.x) / EMBO J. by S Huang (1990)
Kaelin, W. G. Jr, Ewen, M. E. & Livingston, D. M. Molec. cell. Biol. 10, 3761–3769 (1990). (10.1128/MCB.10.7.3761) / Molec. cell. Biol. by WG Kaelin Jr (1990)
Shew, J.-Y. et al. Proc. natn. Acad. Sci. U.S.A. 87, 6–10 (1990). (10.1073/pnas.87.1.6) / Proc. natn. Acad. Sci. U.S.A. by J-Y Shew (1990)
Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348–352 (1988). (10.1038/336348a0) / Nature by SL Mansour (1988)
Adra, C. N., Boer, P. H. & McBurney, M. W. Gene 60, 65–74 (1987). (10.1016/0378-1119(87)90214-9) / Gene by CN Adra (1987)
Thomas, K. R. & Capecchi, M. R. Cell 51, 503–512 (1987). (10.1016/0092-8674(87)90646-5) / Cell by KR Thomas (1987)
McMahon, A. P. & Bradley, A. Cell 62, 1073–1085 (1990). (10.1016/0092-8674(90)90385-R) / Cell by AP McMahon (1990)
Jacks, T. et al. Nature 359, 295–300 (1992). (10.1038/359295a0) / Nature by T Jacks (1992)
Bernards, R. et al. Proc. natn. Acad. Sci. U.S.A. 86, 6474–6478 (1989). (10.1073/pnas.86.17.6474) / Proc. natn. Acad. Sci. U.S.A. by R Bernards (1989)
Clarke, A. R. et al. Nature 359, 328–330 (1992). (10.1038/359328a0) / Nature by AR Clarke (1992)
Moore, M. A. S. & Metcalf, D. Br. J. Haemat 18, 279–296 (1970). (10.1111/j.1365-2141.1970.tb01443.x) / Br. J. Haemat by MAS Moore (1970)
Turner, D. L. & Cepko, C. L. 328, 131–136 (1988).
Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Cell 64, 693–702 (1991). (10.1016/0092-8674(91)90499-O) / Cell by P Soriano (1991)
Bradford, M. M. Analyt. Biochem. 72, 248–254 (1976). (10.1016/0003-2697(76)90527-3) / Analyt. Biochem. by MM Bradford (1976)
Huang, S., Lee, W.-H. & Lee, E. Y.-H. P. Nature 350, 160–162 (1991). (10.1038/350160a0) / Nature by S Huang (1991)

Dates

Type	When
Created	22 years, 2 months ago (June 12, 2003, 7:48 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:17 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 5, 2025, 8:25 a.m.)
Issued	32 years, 11 months ago (Sept. 1, 1992)
Published	32 years, 11 months ago (Sept. 1, 1992)
Published Print	32 years, 11 months ago (Sept. 1, 1992)

Funders 0

None

BibTeX

@article{Lee_1992, title={Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis}, volume={359}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/359288a0}, DOI={10.1038/359288a0}, number={6393}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Lee, Eva Y.-H. P. and Chang, Chi-Yao and Hu, Nanpin and Wang, Yi-Chun J. and Lai, Chen-Ching and Herrup, Karl and Lee, Wen-Hwa and Bradley, Allan}, year={1992}, month=sep, pages={288–294} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T12:25:07Z",
    "timestamp": 1754396707618
  },
  "reference-count": 50,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6393",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1992,
            9,
            1
          ]
        ],
        "date-time": "1992-09-01T00:00:00Z",
        "timestamp": 715305600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1992,
        9
      ]
    ]
  },
  "DOI": "10.1038/359288a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        6,
        12
      ]
    ],
    "date-time": "2003-06-12T23:48:09Z",
    "timestamp": 1055461689000
  },
  "page": "288-294",
  "source": "Crossref",
  "is-referenced-by-count": 969,
  "title": "Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis",
  "prefix": "10.1038",
  "volume": "359",
  "author": [
    {
      "given": "Eva Y.-H. P.",
      "family": "Lee",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Chi-Yao",
      "family": "Chang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nanpin",
      "family": "Hu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yi-Chun J.",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chen-Ching",
      "family": "Lai",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Karl",
      "family": "Herrup",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wen-Hwa",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Allan",
      "family": "Bradley",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF359288a0_CR1",
      "first-page": "15",
      "volume": "25",
      "author": "AG Knudson",
      "year": "1989",
      "unstructured": "Knudson, A. G. Birth Defects 25, 15\u201327 (1989).",
      "journal-title": "Birth Defects"
    },
    {
      "key": "BF359288a0_CR2",
      "first-page": "159",
      "volume-title": "Tumour Suppressor Genes and Oncogenes",
      "author": "W-H Lee",
      "year": "1990",
      "unstructured": "Lee, W.-H. in Tumour Suppressor Genes and Oncogenes (eds Knudson, A. G., Stanbridge, E. J., Sugimura, T., Terada, M. & Watanabe, S.) 159\u2013170 (Taylor and Francis, London and Bristol, 1990)."
    },
    {
      "key": "BF359288a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1007/BF00295569",
      "volume": "52",
      "author": "F Vogel",
      "year": "1979",
      "unstructured": "Vogel, F. Hum. Genet. 52, 1\u201354 (1979).",
      "journal-title": "Hum. Genet."
    },
    {
      "key": "BF359288a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "820",
      "DOI": "10.1073/pnas.68.4.820",
      "volume": "68",
      "author": "AG Knudson",
      "year": "1971",
      "unstructured": "Knudson, A. G. Proc. natn. Acad. Sci. U.S.A. 68, 820\u2013823 (1971).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF359288a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "779",
      "DOI": "10.1038/305779a0",
      "volume": "305",
      "author": "WK Cavenee",
      "year": "1983",
      "unstructured": "Cavenee, W. K. et al. Nature 305, 779\u2013784 (1983).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "7391",
      "DOI": "10.1073/pnas.83.19.7391",
      "volume": "83",
      "author": "TP Dryja",
      "year": "1986",
      "unstructured": "Dryja, T. P., Rapaport, J. M., Joyce, J. M. & Petersen, R. A. Proc. natn. Acad. Sci. U.S.A. 83, 7391\u20137394 (1986).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF359288a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "643",
      "DOI": "10.1038/323643a0",
      "volume": "323",
      "author": "SH Friend",
      "year": "1986",
      "unstructured": "Friend, S. H. et al. Nature 323, 643\u2013646 (1986).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "1657",
      "DOI": "10.1126/science.2885916",
      "volume": "236",
      "author": "YKT Fung",
      "year": "1987",
      "unstructured": "Fung, Y. K. T. et al. Science 236, 1657\u20131661 (1987).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "1394",
      "DOI": "10.1126/science.3823889",
      "volume": "235",
      "author": "W-H Lee",
      "year": "1987",
      "unstructured": "Lee, W.-H. et al. Science 235, 1394\u20131399 (1987).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "1351",
      "DOI": "10.1016/S0161-6420(84)34127-6",
      "volume": "91",
      "author": "DH Abramson",
      "year": "1984",
      "unstructured": "Abramson, D. H., Ellsworth, R. M., Kitchin, D. & Tung, G. Ophthalmology 91, 1351\u20131355 (1984).",
      "journal-title": "Ophthalmology"
    },
    {
      "key": "BF359288a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "9059",
      "DOI": "10.1073/pnas.84.24.9059",
      "volume": "84",
      "author": "SH Friend",
      "year": "1987",
      "unstructured": "Friend, S. H. et al. Proc. natn. Acad. Sci. USA. 84, 9059\u20139063 (1987).",
      "journal-title": "Proc. natn. Acad. Sci. USA."
    },
    {
      "key": "BF359288a0_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "642",
      "DOI": "10.1038/329642a0",
      "volume": "329",
      "author": "W-H Lee",
      "year": "1987",
      "unstructured": "Lee, W.-H. et al. Nature 329, 642\u2013645 (1987).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR13",
      "first-page": "221",
      "volume-title": "Molecular Biology of the Retina: Basic and Clinically Relevant Studies",
      "author": "EY-HP Lee",
      "year": "1991",
      "unstructured": "Lee, E. Y.-H. P., Huang, S., Shew, J.-Y., Donoso, L. A. & Lee, W.-H. in Molecular Biology of the Retina: Basic and Clinically Relevant Studies (eds Faber, D. B. & Chader, G. J.) 221\u2013240 (Wiley-Liss, New York, 1991)."
    },
    {
      "key": "BF359288a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "712",
      "DOI": "10.1126/science.2300823",
      "volume": "247",
      "author": "R Bookstein",
      "year": "1990",
      "unstructured": "Bookstein, R., Shew, J.-Y., Chen, P.-L., Scully, P. & Lee, W.-H. Science 247, 712\u2013715 (1990).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR15",
      "first-page": "1968",
      "volume": "52",
      "author": "DW Goodrich",
      "year": "1992",
      "unstructured": "Goodrich, D. W., Chen, Y.-M., Scully, P. & Lee, W.-H. Cancer Res. 52, 1968\u20131973 (1992).",
      "journal-title": "Cancer Res."
    },
    {
      "key": "BF359288a0_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "1563",
      "DOI": "10.1126/science.3201247",
      "volume": "242",
      "author": "H-JS Huang",
      "year": "1988",
      "unstructured": "Huang, H.-J. S. et al. Science 242, 1563\u20131566 (1988).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR17",
      "first-page": "247",
      "volume": "1",
      "author": "J Sumegi",
      "year": "1990",
      "unstructured": "Sumegi, J., Uzvolgyi, E. & Klein, G. Cell Growth Differ. 1, 247\u2013250 (1990).",
      "journal-title": "Cell Growth Differ."
    },
    {
      "key": "BF359288a0_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "5257",
      "DOI": "10.1073/pnas.88.12.5257",
      "volume": "88",
      "author": "R Takahashi",
      "year": "1991",
      "unstructured": "Takahashi, R. et al. Proc. natn. Acad Sci. U.S.A. 88, 5257\u20135261 (1991).",
      "journal-title": "Proc. natn. Acad Sci. U.S.A."
    },
    {
      "key": "BF359288a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "4279",
      "DOI": "10.1002/j.1460-2075.1991.tb05006.x",
      "volume": "10",
      "author": "JA Lees",
      "year": "1991",
      "unstructured": "Lees, J. A., Buchkovich, K. J., Marshak, D. R., Anderson, C. W. & Harlow, E. EMBO J. 10, 4279\u20134289 (1991).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF359288a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "857",
      "DOI": "10.1002/j.1460-2075.1991.tb08018.x",
      "volume": "10",
      "author": "BT-Y Lin",
      "year": "1991",
      "unstructured": "Lin, B. T.-Y., Gruenwald, S., Morla, A. O., Lee, W.-H. & Wang, J. Y. J. EMBO J. 10, 857\u2013864 (1991).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF359288a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "1097",
      "DOI": "10.1016/0092-8674(89)90508-4",
      "volume": "58",
      "author": "K Buchkovich",
      "year": "1989",
      "unstructured": "Buchkovich, K., Duffy, L. A. & Harlow, E. Cell 58, 1097\u20131105 (1989).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "1193",
      "DOI": "10.1016/0092-8674(89)90517-5",
      "volume": "58",
      "author": "P-L Chen",
      "year": "1989",
      "unstructured": "Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y.-J. & Lee, W.-H. Cell 58, 1193\u20131198 (1989).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "387",
      "DOI": "10.1016/0092-8674(90)90590-B",
      "volume": "60",
      "author": "JW Ludlow",
      "year": "1990",
      "unstructured": "Ludlow, J. W., Shon, J., Pipas, J. M., Livingston, D. M. & DeCaprio, J. A. Cell 60, 387\u2013396 (1990).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "1300",
      "DOI": "10.1126/science.2588006",
      "volume": "246",
      "author": "K Mihara",
      "year": "1989",
      "unstructured": "Mihara, K. et al. Science 246, 1300\u20131303 (1989).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR25",
      "first-page": "807",
      "volume": "4",
      "author": "H-J Xu",
      "year": "1989",
      "unstructured": "Xu, H.-J., Hu, S.-X., Hashimoto, T., Takahashi, R. & Benedict, W. F. Oncogene 4, 807\u2013812 (1989).",
      "journal-title": "Oncogene"
    },
    {
      "key": "BF359288a0_CR26",
      "doi-asserted-by": "publisher",
      "first-page": "293",
      "DOI": "10.1016/0092-8674(91)90181-W",
      "volume": "67",
      "author": "DW Goodrich",
      "year": "1991",
      "unstructured": "Goodrich, D. W., Wang, N. P., Qian, Y., Lee, E. Y.-H. P. & Lee, W.-H. Cell 67, 293\u2013302 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "275",
      "DOI": "10.1016/0092-8674(88)90559-4",
      "volume": "54",
      "author": "JA DeCaprio",
      "year": "1988",
      "unstructured": "DeCaprio, J. A. et al. Cell 54, 275\u2013283 (1988).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "934",
      "DOI": "10.1126/science.2537532",
      "volume": "243",
      "author": "N Dyson",
      "year": "1989",
      "unstructured": "Dyson, N., Howley, P. M., Munger, K. & Harlow, E. Science 243, 934\u2013937 (1989).",
      "journal-title": "Science"
    },
    {
      "key": "BF359288a0_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "124",
      "DOI": "10.1038/334124a0",
      "volume": "334",
      "author": "P Whyte",
      "year": "1988",
      "unstructured": "Whyte, P. et al. Nature 334, 124\u2013129 (1988).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR30",
      "doi-asserted-by": "publisher",
      "first-page": "541",
      "DOI": "10.1038/352541a0",
      "volume": "352",
      "author": "AK Rustgi",
      "year": "1991",
      "unstructured": "Rustgi, A. K., Dyson, N. & Bernards, R. Nature 352, 541\u2013544 (1991).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR31",
      "doi-asserted-by": "publisher",
      "first-page": "1063",
      "DOI": "10.1016/0092-8674(91)90558-G",
      "volume": "65",
      "author": "S Bagchi",
      "year": "1991",
      "unstructured": "Bagchi, S., Weinmann, R. & Raychaudhuri, P. Cell 65, 1063\u20131072 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR32",
      "doi-asserted-by": "publisher",
      "first-page": "494",
      "DOI": "10.1038/351494a0",
      "volume": "351",
      "author": "LR Bandara",
      "year": "1991",
      "unstructured": "Bandara, L. R. & La Thangue, N. B. Nature 351, 494\u2013497 (1991).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR33",
      "doi-asserted-by": "publisher",
      "first-page": "1053",
      "DOI": "10.1016/0092-8674(91)90557-F",
      "volume": "65",
      "author": "SP Chellappan",
      "year": "1991",
      "unstructured": "Chellappan, S. P., Hiebert, S., Mudryji, M., Horowitz, J. M. & Nevins, J. R. Cell 65, 1053\u20131061 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR34",
      "doi-asserted-by": "publisher",
      "first-page": "1073",
      "DOI": "10.1016/0092-8674(91)90559-H",
      "volume": "65",
      "author": "T Chittenden",
      "year": "1991",
      "unstructured": "Chittenden, T., Livingston, D. M. & W. G. Kaelin, J. Cell 65, 1073\u20131082 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR35",
      "doi-asserted-by": "publisher",
      "first-page": "1147",
      "DOI": "10.1002/j.1460-2075.1990.tb08221.x",
      "volume": "9",
      "author": "Q Hu",
      "year": "1990",
      "unstructured": "Hu, Q., Dyson, N. & Harlow, E. EMBO J. 9, 1147\u20131155 (1990).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF359288a0_CR36",
      "doi-asserted-by": "publisher",
      "first-page": "1815",
      "DOI": "10.1002/j.1460-2075.1990.tb08306.x",
      "volume": "9",
      "author": "S Huang",
      "year": "1990",
      "unstructured": "Huang, S., Wang, N.-P., Tseng, B. Y., Lee, W.-H. & Lee, E. Y.-H. P. EMBO J. 9, 1815\u20131822 (1990).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF359288a0_CR37",
      "doi-asserted-by": "publisher",
      "first-page": "3761",
      "DOI": "10.1128/MCB.10.7.3761",
      "volume": "10",
      "author": "WG Kaelin Jr",
      "year": "1990",
      "unstructured": "Kaelin, W. G. Jr, Ewen, M. E. & Livingston, D. M. Molec. cell. Biol. 10, 3761\u20133769 (1990).",
      "journal-title": "Molec. cell. Biol."
    },
    {
      "key": "BF359288a0_CR38",
      "doi-asserted-by": "publisher",
      "first-page": "6",
      "DOI": "10.1073/pnas.87.1.6",
      "volume": "87",
      "author": "J-Y Shew",
      "year": "1990",
      "unstructured": "Shew, J.-Y. et al. Proc. natn. Acad. Sci. U.S.A. 87, 6\u201310 (1990).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF359288a0_CR39",
      "doi-asserted-by": "publisher",
      "first-page": "348",
      "DOI": "10.1038/336348a0",
      "volume": "336",
      "author": "SL Mansour",
      "year": "1988",
      "unstructured": "Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348\u2013352 (1988).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR40",
      "doi-asserted-by": "publisher",
      "first-page": "65",
      "DOI": "10.1016/0378-1119(87)90214-9",
      "volume": "60",
      "author": "CN Adra",
      "year": "1987",
      "unstructured": "Adra, C. N., Boer, P. H. & McBurney, M. W. Gene 60, 65\u201374 (1987).",
      "journal-title": "Gene"
    },
    {
      "key": "BF359288a0_CR41",
      "doi-asserted-by": "publisher",
      "first-page": "503",
      "DOI": "10.1016/0092-8674(87)90646-5",
      "volume": "51",
      "author": "KR Thomas",
      "year": "1987",
      "unstructured": "Thomas, K. R. & Capecchi, M. R. Cell 51, 503\u2013512 (1987).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR42",
      "doi-asserted-by": "publisher",
      "first-page": "1073",
      "DOI": "10.1016/0092-8674(90)90385-R",
      "volume": "62",
      "author": "AP McMahon",
      "year": "1990",
      "unstructured": "McMahon, A. P. & Bradley, A. Cell 62, 1073\u20131085 (1990).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR43",
      "doi-asserted-by": "publisher",
      "first-page": "295",
      "DOI": "10.1038/359295a0",
      "volume": "359",
      "author": "T Jacks",
      "year": "1992",
      "unstructured": "Jacks, T. et al. Nature 359, 295\u2013300 (1992).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR44",
      "doi-asserted-by": "publisher",
      "first-page": "6474",
      "DOI": "10.1073/pnas.86.17.6474",
      "volume": "86",
      "author": "R Bernards",
      "year": "1989",
      "unstructured": "Bernards, R. et al. Proc. natn. Acad. Sci. U.S.A. 86, 6474\u20136478 (1989).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF359288a0_CR45",
      "doi-asserted-by": "publisher",
      "first-page": "328",
      "DOI": "10.1038/359328a0",
      "volume": "359",
      "author": "AR Clarke",
      "year": "1992",
      "unstructured": "Clarke, A. R. et al. Nature 359, 328\u2013330 (1992).",
      "journal-title": "Nature"
    },
    {
      "key": "BF359288a0_CR46",
      "doi-asserted-by": "publisher",
      "first-page": "279",
      "DOI": "10.1111/j.1365-2141.1970.tb01443.x",
      "volume": "18",
      "author": "MAS Moore",
      "year": "1970",
      "unstructured": "Moore, M. A. S. & Metcalf, D. Br. J. Haemat 18, 279\u2013296 (1970).",
      "journal-title": "Br. J. Haemat"
    },
    {
      "key": "BF359288a0_CR47",
      "unstructured": "Turner, D. L. & Cepko, C. L. 328, 131\u2013136 (1988)."
    },
    {
      "key": "BF359288a0_CR48",
      "doi-asserted-by": "publisher",
      "first-page": "693",
      "DOI": "10.1016/0092-8674(91)90499-O",
      "volume": "64",
      "author": "P Soriano",
      "year": "1991",
      "unstructured": "Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Cell 64, 693\u2013702 (1991).",
      "journal-title": "Cell"
    },
    {
      "key": "BF359288a0_CR49",
      "doi-asserted-by": "publisher",
      "first-page": "248",
      "DOI": "10.1016/0003-2697(76)90527-3",
      "volume": "72",
      "author": "MM Bradford",
      "year": "1976",
      "unstructured": "Bradford, M. M. Analyt. Biochem. 72, 248\u2013254 (1976).",
      "journal-title": "Analyt. Biochem."
    },
    {
      "key": "BF359288a0_CR50",
      "doi-asserted-by": "publisher",
      "first-page": "160",
      "DOI": "10.1038/350160a0",
      "volume": "350",
      "author": "S Huang",
      "year": "1991",
      "unstructured": "Huang, S., Lee, W.-H. & Lee, E. Y.-H. P. Nature 350, 160\u2013162 (1991).",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/359288a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/359288a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/359288a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:17:51Z",
    "timestamp": 1684289871000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/359288a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1992,
        9
      ]
    ]
  },
  "references-count": 50,
  "journal-issue": {
    "issue": "6393",
    "published-print": {
      "date-parts": [
        [
          1992,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "BF359288a0"
  ],
  "URL": "http://dx.doi.org/10.1038/359288a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1992,
        9
      ]
    ]
  }
}