DOI: 10.1038/35888. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

10.1038/35888

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391(6669), 806â811.

Authors 6

Andrew Fire (first)
SiQun Xu (additional)
Mary K. Montgomery (additional)
Steven A. Kostas (additional)
Samuel E. Driver (additional)
Craig C. Mello (additional)

References 27 Referenced 11,874

Izant, J. & Weintraub, H. Inhibition of thymidine kinase gene expression by antisense RNA: a molecular approach to genetic analysis. Cell 36, 1007–1015 (1984). (10.1016/0092-8674(84)90050-3) / Cell by J Izant (1984)
Nellen, W. & Lichtenstein, C. What makes an mRNA anti-sense-itive? Trends Biochem. Sci. 18, 419–423 (1993). (10.1016/0968-0004(93)90137-C) / Trends Biochem. Sci. by W Nellen (1993)
Fire, A., Albertson, D., Harrison, S. & Moerman, D. Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle. Development 113, 503–514 (1991). (10.1242/dev.113.2.503) / Development by A Fire (1991)
Guo, S. & Kemphues, K. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 81, 611–620 (1995). (10.1016/0092-8674(95)90082-9) / Cell by S Guo (1995)
Seydoux, G. & Fire, A. Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Development 120, 2823–2834 (1994). (10.1242/dev.120.10.2823) / Development by G Seydoux (1994)
Ausubel, F. et al. Current Protocols in Molecular Biology (Wiley, New York, (1990)). / Current Protocols in Molecular Biology by F Ausubel (1990)
Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71–94 (1974). (10.1093/genetics/77.1.71) / Genetics by S Brenner (1974)
Moerman, D. & Baillie, D. Genetic organization in Caenorhabditis elegans: fine structure analysis of the unc-22 gene. Genetics 91, 95–104 (1979). (10.1093/genetics/91.1.95) / Genetics by D Moerman (1979)
Benian, G., L'Hernault, S. & Morris, M. Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabiditis elegans. Genetics 134, 1097–1104 (1993). (10.1093/genetics/134.4.1097) / Genetics by G Benian (1993)
Proud, C. PKR: a new name and new roles. Trends Biochem. Sci. 20, 241–246 (1995). (10.1016/S0968-0004(00)89025-8) / Trends Biochem. Sci. by C Proud (1995)
Epstein, H., Waterston, R. & Brenner, S. Amutant affecting the heavy chain of myosin in C. elegans. J. Mol. Biol. 90, 291–300 (1974). (10.1016/0022-2836(74)90374-X) / J. Mol. Biol. by H Epstein (1974)
Karn, J., Brenner, S. & Barnett, L. Protein structural domains in the C. elegans unc-54 myosin heavy chain gene are not separated by introns. Proc. Natl Acad. Sci. USA 80, 4253–4257 (1983). (10.1073/pnas.80.14.4253) / Proc. Natl Acad. Sci. USA by J Karn (1983)
Doniach, T. & Hodgkin, J. A. Asex-determining gene, fem-1, required for both male and hermaphrodite development in C. elegans. Dev. Biol. 106, 223–235 (1984). (10.1016/0012-1606(84)90077-0) / Dev. Biol. by T Doniach (1984)
Spence, A., Coulson, A. & Hodgkin, J. The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell–cell interactions. Cell 60, 981–990 (1990). (10.1016/0092-8674(90)90346-G) / Cell by A Spence (1990)
Krause, M., Fire, A., Harrison, S., Priess, J. & Weintraub, H. CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis. Cell 63, 907–919 (1990). (10.1016/0092-8674(90)90494-Y) / Cell by M Krause (1990)
Chen, L., Krause, M., Sepanski, M. & Fire, A. The C. elegans MyoD homolog HLH-1 is essential for proper muscle function and complete morphogenesis. Development 120, 1631–1641 (1994). (10.1242/dev.120.6.1631) / Development by L Chen (1994)
Dibb, N. J., Maruyama, I. N., Krause, M.(Author: OK?) & Karn, J. Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family. J. Mol. Biol. 205, 603–613 (1989). (10.1016/0022-2836(89)90229-5) / J. Mol. Biol. by NJ Dibb (1989)
Sulston, J., Schierenberg, E., White, J. & Thomson, J. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64–119 (1983). (10.1016/0012-1606(83)90201-4) / Dev. Biol. by J Sulston (1983)
Sulston, J. & Horvitz, H. Postembyonic cell lineages of the nematode Caenorhabiditis elegans. Dev. Biol. 82, 41–55 (1977). (10.1016/0012-1606(81)90427-9) / Dev. Biol. by J Sulston (1977)
Draper, B. W., Mello, C. C., Bowerman, B., Hardin, J. & Priess, J. R. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell 87, 205–216 (1996). (10.1016/S0092-8674(00)81339-2) / Cell by BW Draper (1996)
Sulston, J. et al. The C. elegans genome sequencing project: a beginning. Nature 356, 37–41 (1992). (10.1038/356037a0) / Nature by J Sulston (1992)
Matzke, M. & Matzke, A. How and why do plants inactivate homologous (trans) genes? Plant Physiol. 107, 679–685 (1995). (10.1104/pp.107.3.679) / Plant Physiol. by M Matzke (1995)
Ratcliff, F., Harrison, B. & Baulcombe, D. Asimilarity between viral defense and gene silencing in plants. Science 276, 1558–1560 (1997). (10.1126/science.276.5318.1558) / Science by F Ratcliff (1997)
Latham, K. Xchromosome imprinting and inactivation in the early mammalian embryo. Trends Genet. 12, 134–138 (1996). (10.1016/0168-9525(96)10017-2) / Trends Genet. by K Latham (1996)
Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. & Prasher, D. Green fluorescent protein as a marker for gene expression. Science 263, 802–805 (1994). (10.1126/science.8303295) / Science by M Chalfie (1994)
Clark, D., Suleman, D., Beckenbach, K., Gilchrist, E. & Baillie, D. Molecular cloning and characterization of the dpy-20 gene of C. elegans. Mol. Gen. Genet. 247, 367–378 (1995). (10.1007/BF00293205) / Mol. Gen. Genet. by D Clark (1995)
Mello, C. & Fire, A. DNA transformation. Methods Cell Biol. 48, 451–482 (1995). (10.1016/S0091-679X(08)61399-0) / Methods Cell Biol. by C Mello (1995)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:37 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:15 p.m.)
Indexed	5 minutes ago (Aug. 31, 2025, 5:31 a.m.)
Issued	27 years, 6 months ago (Feb. 1, 1998)
Published	27 years, 6 months ago (Feb. 1, 1998)
Published Print	27 years, 6 months ago (Feb. 1, 1998)

Funders 0

None

BibTeX

@article{Fire_1998, title={Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans}, volume={391}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35888}, DOI={10.1038/35888}, number={6669}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Fire, Andrew and Xu, SiQun and Montgomery, Mary K. and Kostas, Steven A. and Driver, Samuel E. and Mello, Craig C.}, year={1998}, month=feb, pages={806–811} }

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    "timestamp": 1684289716000
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  "container-title-short": "Nature",
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}