HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
10.1038/35869
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Braud, V. M., Allan, D. S. J., O’Callaghan, C. A., Söderström, K., D’Andrea, A., Ogg, G. S., Lazetic, S., Young, N. T., Bell, J. I., Phillips, J. H., Lanier, L. L., & McMichael, A. J. (1998). HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature, 391(6669), 795–799.

Authors 12
  1. Veronique M. Braud (first)
  2. David S. J. Allan (additional)
  3. Christopher A. O'Callaghan (additional)
  4. Kalle Söderström (additional)
  5. Annalisa D'Andrea (additional)
  6. Graham S. Ogg (additional)
  7. Sasha Lazetic (additional)
  8. Neil T. Young (additional)
  9. John I. Bell (additional)
  10. Joseph H. Phillips (additional)
  11. Lewis L. Lanier (additional)
  12. Andrew J. McMichael (additional)
References 27 Referenced 1,793
  1. Braud, V., Jones, E. Y. & McMichael, A. The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur. J. Immunol. 27, 1164–1169 (1997). (10.1002/eji.1830270517) / Eur. J. Immunol. by V Braud (1997)
  2. Braud, V. M., Allan, D. S. J., Wilson, D. & McMichael, A. J. TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr. Biol. 8, 1–10 (1998). (10.1016/S0960-9822(98)70014-4) / Curr. Biol. by VM Braud (1998)
  3. Altman, J. D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96 (1996). (10.1126/science.274.5284.94) / Science by JD Altman (1996)
  4. Phillips, J. H. et al. CD94 and a novel associated protein (94AP) from a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity 5, 163–172 (1996). (10.1016/S1074-7613(00)80492-6) / Immunity by JH Phillips (1996)
  5. Sivori, S. et al. CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of D94 by the use of novel monoclonal antibodies.. Eur. J. Immunol. 26, 2487–2492 (1996). (10.1002/eji.1830261032) / Eur. J. Immunol. by S Sivori (1996)
  6. Sivori, S. et al. Inhibitory CD94 molecules identified by the Z199 monoclonal antibody recognize different HLA-class I molecules. Transplant. Proc. 28, 3199–3203 (1996). / Transplant. Proc. by S Sivori (1996)
  7. Wei, X. H. & Orr, H. T. Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue. Hum. Immunol. 29, 131–142 (1990). (10.1016/0198-8859(90)90076-2) / Hum. Immunol. by XH Wei (1990)
  8. Connolly, D. J. et al. AcDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. J. Immunol. 151, 6089–6098 (1993). (10.4049/jimmunol.151.11.6089) / J. Immunol. by DJ Connolly (1993)
  9. Aldrich, C. J. et al. Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell 79, 649–658 (1994). (10.1016/0092-8674(94)90550-9) / Cell by CJ Aldrich (1994)
  10. DeCloux, A., Woods, A. S., Cotter, R. J., Soloski, M. J. & Forman, J. Dominance of a single peptide bound to the class IBmolecule, Qa-1b. J. Immunol. 158, 2183–2191 (1997). (10.4049/jimmunol.158.5.2183) / J. Immunol. by A DeCloux (1997)
  11. Cotterill, L. A. et al. Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide. Eur. J. Immunol. 27, 2123–2132 (1997). (10.1002/eji.1830270902) / Eur. J. Immunol. by LA Cotterill (1997)
  12. Steven, N. M. et al. Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response. J. Exp. Med. 185, 1605–1617 (1997). (10.1084/jem.185.9.1605) / J. Exp. Med. by NM Steven (1997)
  13. Aramburu, J. et al. Anovel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody. J. Immunol. 144, 3238–3247 (1990). (10.4049/jimmunol.144.8.3238) / J. Immunol. by J Aramburu (1990)
  14. Chang, C. et al. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur. J. Immunol. 25, 2433–2437 (1995). (10.1002/eji.1830250904) / Eur. J. Immunol. by C Chang (1995)
  15. Lazetic, S., Chang, C., Houchins, J. P., Lanier, L. L. & Phillips, J. H. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 157, 4741–4745 (1996). (10.4049/jimmunol.157.11.4741) / J. Immunol. by S Lazetic (1996)
  16. Brooks, A. G., Posch, P. E., Scorzelli, C. J., Borrego, F. & Coligan, J. E. NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. J. Exp. Med. 185, 795–800 (1997). (10.1084/jem.185.4.795) / J. Exp. Med. by AG Brooks (1997)
  17. Carretero, M. et al. The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. Eur. J. Immunol. 27, 563–567 (1997). (10.1002/eji.1830270230) / Eur. J. Immunol. by M Carretero (1997)
  18. Lanier, L. L., Corliss, B. & Phillips, J. H. Arousal and inhibition of human NK cells. Immunol. Rev. 155, 145–154 (1997). (10.1111/j.1600-065X.1997.tb00947.x) / Immunol. Rev. by LL Lanier (1997)
  19. Soderstrom, K., Corliss, B., Lanier, L. L. & Phillips, J. H. CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J. Immunol. 159, 1072–1075 (1997). (10.4049/jimmunol.159.3.1072) / J. Immunol. by K Soderstrom (1997)
  20. Villar, Perez J. J. et al. The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1. J. Immunol. 158, 5736–5743 (1997). (10.4049/jimmunol.158.12.5736) / J. Immunol. by PerezJJ Villar (1997)
  21. Pende, D. et al. HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex. Eur. J. Immunol. 27, 1875–1880 (1997). (10.1002/eji.1830270809) / Eur. J. Immunol. by D Pende (1997)
  22. Ogg, G. S. et al. Quantification of HIV-specific CTL and plasma load of viral RNA. Science (in the press).
  23. Garboczi, D. N. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134–141 (1996). (10.1038/384134a0) / Nature by DN Garboczi (1996)
  24. Reyburn, H. T. et al. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature 386, 514–517 (1997). (10.1038/386514a0) / Nature by HT Reyburn (1997)
  25. Houchins, J. jP., Lanier, L. L., Niemi, E. C., Phillips, J. H. & Ryan, J. C. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J. Immunol. 158, 3603–3609 (1997). (10.4049/jimmunol.158.8.3603) / J. Immunol. by JjP Houchins (1997)
  26. Litwin, V., Gumperz, J., Parham, P., Phillips, J. H. & Lanier, L. L. Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type. J. Exp. Med. 178, 1321–1336 (1993). (10.1084/jem.178.4.1321) / J. Exp. Med. by V Litwin (1993)
  27. Robertson, M. J. et al. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp. Hematol. 24, 406–415 (1996). / Exp. Hematol. by MJ Robertson (1996)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:37 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 10:14 p.m.)
Indexed 7 hours, 4 minutes ago (Aug. 31, 2025, 6:13 a.m.)
Issued 27 years, 6 months ago (Feb. 1, 1998)
Published 27 years, 6 months ago (Feb. 1, 1998)
Published Print 27 years, 6 months ago (Feb. 1, 1998)
Funders 0

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@article{Braud_1998, title={HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C}, volume={391}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35869}, DOI={10.1038/35869}, number={6669}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Braud, Veronique M. and Allan, David S. J. and O’Callaghan, Christopher A. and Söderström, Kalle and D’Andrea, Annalisa and Ogg, Graham S. and Lazetic, Sasha and Young, Neil T. and Bell, John I. and Phillips, Joseph H. and Lanier, Lewis L. and McMichael, Andrew J.}, year={1998}, month=feb, pages={795–799} }